RU2008118008A - Применение lactobacillus для лечения аутоиммунных заболеваний - Google Patents

Применение lactobacillus для лечения аутоиммунных заболеваний Download PDF

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RU2008118008A
RU2008118008A RU2008118008/15A RU2008118008A RU2008118008A RU 2008118008 A RU2008118008 A RU 2008118008A RU 2008118008/15 A RU2008118008/15 A RU 2008118008/15A RU 2008118008 A RU2008118008 A RU 2008118008A RU 2008118008 A RU2008118008 A RU 2008118008A
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lactobacillus
tablets
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Ян АЛЕНФАЛЛЬ (SE)
Ян АЛЕНФАЛЛЬ
Анна БЕРГЕН (SE)
Анна БЕРГЕН
Кароле РАСК (SE)
Кароле РАСК
Агнес ВОЛД (SE)
Агнес ВОЛД
Шахрам АГХАИБЕЙК-ЛАВАСАНИ (SE)
Шахрам АГХАИБЕЙК-ЛАВАСАНИ
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Проби Аб
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Abstract

1. Применение по меньшей мере одного штамма пробиотических бактерий Lactobacillus, выбранных из Lactobacillus plantarum 299, DSM 6595, Lactobacillus plantarum 299v, DSM 9843, Lactobacillus plantarum HEAL 9, DSM 15312, Lactobacillus plantarum HEAL 19, DSM 15313, и Lactobacillus plantarum HEAL 99, DSM 15316, Lactobacillus paracasei 8700:2, DSM 13434 и Lactobacillus paracasei 02A, DSM13432 для производства фармацевтической композиции для лечения и/или предотвращения аутоиммунного заболевания. ! 2. Применение по п.1, где указанное аутоиммунное заболевание выбирается из группы, состоящей из органспецифической аутоиммунной реакции, такой, как рассеяный склероз (MS), аллергия, псориаз, ревматоидный артрит, болезнь Крона, неспецифический язвенный колит, сахарный диабет типа 1, воспалительные заболевания кишечника и системная волчанка. ! 3. Применение по п.1, где, по меньшей мере, два пробиотических штамма использованы для лечения и/или профилактики указанного аутоиммунного заболевания. ! 4. Применение по п.2, где, по меньшей мере, два пробиотических штамма использованы для лечения и/или профилактики указанного аутоиммунного заболевания. ! 5. Применение по п.3, где указанные, по меньшей мере, два штамма вводятся последовательно или одновременно. ! 6. Применение по п.4, где указанные, по меньшей мере, два штамма вводятся последовательно или одновременно. ! 7. Применение по любому из пп.1-6, где указанная фармацевтическая композиция представляет собой жидкий препарат или твердый препарат. ! 8. Применение по п.7, где указанный твердый препарат выбирается из группы, состоящей из таблеток, рассасываемых таблеток, леденцов, жевательных таблеток, жевательных резинок, капсул, саше, порошков, гранул, частиц и таблеток с покрытием, таблеток и капсул с кишечно-растворимым покрытием �

Claims (19)

1. Применение по меньшей мере одного штамма пробиотических бактерий Lactobacillus, выбранных из Lactobacillus plantarum 299, DSM 6595, Lactobacillus plantarum 299v, DSM 9843, Lactobacillus plantarum HEAL 9, DSM 15312, Lactobacillus plantarum HEAL 19, DSM 15313, и Lactobacillus plantarum HEAL 99, DSM 15316, Lactobacillus paracasei 8700:2, DSM 13434 и Lactobacillus paracasei 02A, DSM13432 для производства фармацевтической композиции для лечения и/или предотвращения аутоиммунного заболевания.
2. Применение по п.1, где указанное аутоиммунное заболевание выбирается из группы, состоящей из органспецифической аутоиммунной реакции, такой, как рассеяный склероз (MS), аллергия, псориаз, ревматоидный артрит, болезнь Крона, неспецифический язвенный колит, сахарный диабет типа 1, воспалительные заболевания кишечника и системная волчанка.
3. Применение по п.1, где, по меньшей мере, два пробиотических штамма использованы для лечения и/или профилактики указанного аутоиммунного заболевания.
4. Применение по п.2, где, по меньшей мере, два пробиотических штамма использованы для лечения и/или профилактики указанного аутоиммунного заболевания.
5. Применение по п.3, где указанные, по меньшей мере, два штамма вводятся последовательно или одновременно.
6. Применение по п.4, где указанные, по меньшей мере, два штамма вводятся последовательно или одновременно.
7. Применение по любому из пп.1-6, где указанная фармацевтическая композиция представляет собой жидкий препарат или твердый препарат.
8. Применение по п.7, где указанный твердый препарат выбирается из группы, состоящей из таблеток, рассасываемых таблеток, леденцов, жевательных таблеток, жевательных резинок, капсул, саше, порошков, гранул, частиц и таблеток с покрытием, таблеток и капсул с кишечно-растворимым покрытием и рассасываемых полосок и пленок.
9. Применение по п.7, где указанный жидкий препарат выбирается из группы, состоящей из пероральных растворов, суспензий, эмульсий и сиропов.
10. Применение по любому из пп.1-6, где указанная композиция включает носитель.
11. Применение по любому из пп.1-6, где указанная фармацевтическая композиция представляет собой медицинский пищевой продукт, функциональный пищевой продукт, диетическую добавку, питательный продукт или пищевой препарат.
12. Применение по п.10, где указанный носитель независимо выбирается из группы, состоящей из овсяной муки, молочнокислых ферментированных пищевых продуктов, устойчивого крахмала, диетических волокон, углеводов, белков и гликозилированных белков.
13. Применение по п.11, где указанный носитель независимо выбирается из группы, состоящей из овсяной муки, молочнокислых ферментированных пищевых продуктов, устойчивого крахмала, диетических волокон, углеводов, белков и гликозилированных белков.
14. Применение по п.11, где указанный пищевой препарат выбирается из группы, состоящей из напитков, йогуртов, соков, мороженого, хлеба, бисквитов, продуктов из дробленого зерна, батончиков для здорового образа жизни и пастообразных продуктов.
15. Применение по любому из пп.1-6, 8, 9, 12-14, где каждый указанный штамм(ы) присутствует(ют) в композиции в количестве от приблизительно 1×106 до приблизительно 1×1014 КОЕ, предпочтительно от приблизительно 1×108 до приблизительно 1×1012 и более предпочтительно от приблизительно 1×109 до приблизительно 1×1011.
16. Способ лечения аутоиммунного заболевания, где, по меньшей мере, один штамм пробиотических бактерий Lactobacillus, выбранных из Lactobacillus plantarum 299, DSM 6595, Lactobacillus plantarum 299v, DSM 9843, Lactobacillus plantarum HEAL 9, DSM 15312, Lactobacillus plantarum HEAL 19, DSM 15313, и Lactobacillus plantarum HEAL 99, DSM 15316, Lactobacillus paracasei 8700:2, DSM 13434 и Lactobacillus paracasei 02A, DSM13432, вводится индивидууму.
17. Способ по п.16, где указанное аутоиммунное заболевание выбирается из группы, состоящей из органспецифической аутоиммунной реакции, такой как рассеянный склероз (MS), аллергия, псориаз, ревматоидный артрит, болезнь Крона, неспецифический язвенный колит, сахарный диабет типа 1, воспалительные заболевания кишечника и системная волчанка.
18. Способ по п.16 или 17, где, по меньшей мере, два штамма пробиотических бактерий вводятся индивидууму.
19. Способ по п.18, где указанные штаммы вводятся последовательно или одновременно.
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