JP2614497B2 - 置換チアゾリジンジオン誘導体及びそれを含む製薬組成物 - Google Patents

置換チアゾリジンジオン誘導体及びそれを含む製薬組成物

Info

Publication number
JP2614497B2
JP2614497B2 JP63221206A JP22120688A JP2614497B2 JP 2614497 B2 JP2614497 B2 JP 2614497B2 JP 63221206 A JP63221206 A JP 63221206A JP 22120688 A JP22120688 A JP 22120688A JP 2614497 B2 JP2614497 B2 JP 2614497B2
Authority
JP
Japan
Prior art keywords
methyl
amino
thiazolidinedione
ethoxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63221206A
Other languages
English (en)
Japanese (ja)
Other versions
JPH01131169A (ja
Inventor
リチャード・マーク・ヒンドレイ
Original Assignee
ビーチヤム・グループ・ピーエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27263577&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2614497(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB878720825A external-priority patent/GB8720825D0/en
Priority claimed from GB878727987A external-priority patent/GB8727987D0/en
Priority claimed from GB888802454A external-priority patent/GB8802454D0/en
Application filed by ビーチヤム・グループ・ピーエルシー filed Critical ビーチヤム・グループ・ピーエルシー
Publication of JPH01131169A publication Critical patent/JPH01131169A/ja
Application granted granted Critical
Publication of JP2614497B2 publication Critical patent/JP2614497B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP63221206A 1987-09-04 1988-09-03 置換チアゾリジンジオン誘導体及びそれを含む製薬組成物 Expired - Lifetime JP2614497B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB878720825A GB8720825D0 (en) 1987-09-04 1987-09-04 Compounds
GB878727987A GB8727987D0 (en) 1987-11-30 1987-11-30 Novel compounds
GB888802454A GB8802454D0 (en) 1988-02-04 1988-02-04 Compounds
GB8727987 1988-02-04
GB8802454 1988-02-04
GB8720825 1988-02-04

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP8279899A Division JPH09183772A (ja) 1987-09-04 1996-10-02 置換チアゾリジンジオン誘導体及びそれを含む製薬組成物
JP8279898A Division JP2837139B2 (ja) 1987-09-04 1996-10-02 耐糖能障害・異常の治療用及び予防用医薬剤
JP8279897A Division JP2817840B2 (ja) 1987-09-04 1996-10-02 置換チアゾリジンジオン誘導体の製造方法

Publications (2)

Publication Number Publication Date
JPH01131169A JPH01131169A (ja) 1989-05-24
JP2614497B2 true JP2614497B2 (ja) 1997-05-28

Family

ID=27263577

Family Applications (6)

Application Number Title Priority Date Filing Date
JP63221206A Expired - Lifetime JP2614497B2 (ja) 1987-09-04 1988-09-03 置換チアゾリジンジオン誘導体及びそれを含む製薬組成物
JP8279897A Expired - Lifetime JP2817840B2 (ja) 1987-09-04 1996-10-02 置換チアゾリジンジオン誘導体の製造方法
JP8279899A Pending JPH09183772A (ja) 1987-09-04 1996-10-02 置換チアゾリジンジオン誘導体及びそれを含む製薬組成物
JP8279898A Expired - Lifetime JP2837139B2 (ja) 1987-09-04 1996-10-02 耐糖能障害・異常の治療用及び予防用医薬剤
JP10029076A Pending JPH10194971A (ja) 1987-09-04 1998-01-28 置換チアゾリジンジオン誘導体を含む抗高血圧剤
JP10029075A Pending JPH10194970A (ja) 1987-09-04 1998-01-28 置換チアゾリジンジオン誘導体を含む抗高脂血剤

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP8279897A Expired - Lifetime JP2817840B2 (ja) 1987-09-04 1996-10-02 置換チアゾリジンジオン誘導体の製造方法
JP8279899A Pending JPH09183772A (ja) 1987-09-04 1996-10-02 置換チアゾリジンジオン誘導体及びそれを含む製薬組成物
JP8279898A Expired - Lifetime JP2837139B2 (ja) 1987-09-04 1996-10-02 耐糖能障害・異常の治療用及び予防用医薬剤
JP10029076A Pending JPH10194971A (ja) 1987-09-04 1998-01-28 置換チアゾリジンジオン誘導体を含む抗高血圧剤
JP10029075A Pending JPH10194970A (ja) 1987-09-04 1998-01-28 置換チアゾリジンジオン誘導体を含む抗高脂血剤

Country Status (18)

Country Link
US (1) US5002953A (https=)
EP (2) EP0842925A1 (https=)
JP (6) JP2614497B2 (https=)
KR (1) KR0164207B1 (https=)
AT (1) ATE186724T1 (https=)
AU (1) AU611938B2 (https=)
CA (1) CA1328452C (https=)
CZ (1) CZ391691A3 (https=)
DE (2) DE3856378T2 (https=)
DK (2) DK175176B1 (https=)
ES (1) ES2137915T3 (https=)
GR (1) GR3031873T3 (https=)
IE (1) IE20000683A1 (https=)
LU (1) LU90711I2 (https=)
NL (1) NL300034I2 (https=)
NZ (1) NZ226027A (https=)
PT (1) PT88410B (https=)
SG (1) SG59988A1 (https=)

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CZ391691A3 (en) 1993-03-17
NZ226027A (en) 1992-03-26
ES2137915T3 (es) 2000-01-01
HK1011029A1 (en) 1999-07-02
JPH09183771A (ja) 1997-07-15
US5002953A (en) 1991-03-26
NL300034I2 (nl) 2001-05-01
AU611938B2 (en) 1991-06-27
PT88410B (pt) 1992-10-30
JP2837139B2 (ja) 1998-12-14
DK490288A (da) 1989-03-05
JPH10194971A (ja) 1998-07-28
EP0306228A1 (en) 1989-03-08
KR890005095A (ko) 1989-05-11
NL300034I1 (nl) 2001-03-01
DK175176B1 (da) 2004-06-21
DE3856378T2 (de) 2000-05-11
ATE186724T1 (de) 1999-12-15
DE10199003I2 (https=) 2003-09-18
JPH01131169A (ja) 1989-05-24
SG59988A1 (en) 1999-02-22
GR3031873T3 (en) 2000-02-29
PT88410A (pt) 1989-07-31
JP2817840B2 (ja) 1998-10-30
DK200001556A (da) 2000-10-18
DK490288D0 (da) 1988-09-02
IE20000683A1 (en) 2002-07-24
AU2173888A (en) 1989-03-09
LU90711I2 (fr) 2001-03-05
JPH09183726A (ja) 1997-07-15
EP0306228B1 (en) 1999-11-17
JPH09183772A (ja) 1997-07-15
KR0164207B1 (ko) 1999-01-15
DE10199003I1 (de) 2003-06-12
CA1328452C (en) 1994-04-12
EP0842925A1 (en) 1998-05-20
JPH10194970A (ja) 1998-07-28
DE3856378D1 (de) 1999-12-23

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