|
US4650764A
(en)
|
1983-04-12 |
1987-03-17 |
Wisconsin Alumni Research Foundation |
Helper cell
|
|
US4690915A
(en)
|
1985-08-08 |
1987-09-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adoptive immunotherapy as a treatment modality in humans
|
|
US4844893A
(en)
|
1986-10-07 |
1989-07-04 |
Scripps Clinic And Research Foundation |
EX vivo effector cell activation for target cell killing
|
|
US4980289A
(en)
|
1987-04-27 |
1990-12-25 |
Wisconsin Alumni Research Foundation |
Promoter deficient retroviral vector
|
|
US6303121B1
(en)
|
1992-07-30 |
2001-10-16 |
Advanced Research And Technology |
Method of using human receptor protein 4-1BB
|
|
US6355476B1
(en)
|
1988-11-07 |
2002-03-12 |
Advanced Research And Technologyinc |
Nucleic acid encoding MIP-1α Lymphokine
|
|
US5124263A
(en)
|
1989-01-12 |
1992-06-23 |
Wisconsin Alumni Research Foundation |
Recombination resistant retroviral helper cell and products produced thereby
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
US6319494B1
(en)
|
1990-12-14 |
2001-11-20 |
Cell Genesys, Inc. |
Chimeric chains for receptor-associated signal transduction pathways
|
|
ATE145428T1
(de)
|
1990-12-14 |
1996-12-15 |
Cell Genesys Inc |
Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen
|
|
JPH06506358A
(ja)
|
1991-03-28 |
1994-07-21 |
ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ |
ナチュラルキラー細胞に特異的なｄｎａおよびアミノ酸配列
|
|
AU6827094A
(en)
|
1993-05-07 |
1994-12-12 |
Immunex Corporation |
Cytokine designated 4-1bb ligand and human receptor that binds thereto
|
|
AU7477394A
(en)
|
1993-07-30 |
1995-03-27 |
University Of Medicine And Dentistry Of New Jersey |
Efficient gene transfer into primary lymphocytes
|
|
US5653977A
(en)
|
1993-09-09 |
1997-08-05 |
Uab Research Foundation |
Anti-idiotypic antibody that mimics the GD2 antigen
|
|
US5595756A
(en)
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
US5712149A
(en)
|
1995-02-03 |
1998-01-27 |
Cell Genesys, Inc. |
Chimeric receptor molecules for delivery of co-stimulatory signals
|
|
US6103521A
(en)
|
1995-02-06 |
2000-08-15 |
Cell Genesys, Inc. |
Multispecific chimeric receptors
|
|
DE19520729A1
(de)
|
1995-06-07 |
1996-12-12 |
Orpegen Pharma Gmbh |
Testsystem zur Erfassung der Aktivität von NK-Zellen
|
|
GB9526131D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Recombinant chimeric receptors
|
|
US7070771B1
(en)
|
1996-12-09 |
2006-07-04 |
Regents Of The University Of California |
Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
|
|
US20020018783A1
(en)
|
1997-03-20 |
2002-02-14 |
Michel Sadelain |
Fusion proteins of a single chain antibody and cd28 and uses thereof
|
|
GB9713473D0
(en)
|
1997-06-25 |
1997-09-03 |
Celltech Therapeutics Ltd |
Biological products
|
|
EP1798286B1
(en)
|
1997-08-01 |
2011-09-07 |
Schering Corporation |
Mammalian cell membrane proteins and related reagents
|
|
GB9725764D0
(en)
|
1997-12-04 |
1998-02-04 |
Isis Innovation |
HLA-E binding
|
|
ATE264911T1
(de)
|
1998-02-02 |
2004-05-15 |
Univ Johns Hopkins Med |
Eine universelle immunmodulatorische cytokin- expressierende zelllinie in wartestelling. entsprechende zusammensetzungen und methoden ihrer herstellung und verwendungen
|
|
DE19813759C1
(de)
|
1998-03-27 |
1999-07-15 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Induktion einer durch NK-Zellen vermittelten Immunantwort
|
|
GB9809658D0
(en)
|
1998-05-06 |
1998-07-01 |
Celltech Therapeutics Ltd |
Biological products
|
|
WO1999067360A2
(en)
*
|
1998-06-25 |
1999-12-29 |
Hemosol Inc. |
Media and methods for expansion of erythroid stem cells for the production of hemoglobin
|
|
WO2000014257A1
(en)
|
1998-09-04 |
2000-03-16 |
Sloan-Kettering Institute For Cancer Research |
Fusion receptors specific for prostate-specific membrane antigen and uses thereof
|
|
AU2472400A
(en)
|
1998-10-20 |
2000-05-08 |
City Of Hope |
CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
|
|
JP2002541845A
(ja)
|
1999-04-16 |
2002-12-10 |
セルテック セラピューティックス リミテッド |
合成膜貫通成分
|
|
EP1231262A4
(en)
|
1999-10-21 |
2004-09-08 |
Keisuke Teshigawara |
METHODS FOR VITRO CULTIVATION OF LYMPHOCYTES AND COMPOSITIONS FOR GENE THERAPY
|
|
JP3619853B2
(ja)
|
1999-11-26 |
2005-02-16 |
独立行政法人理化学研究所 |
ナチュラルキラー細胞の増殖方法
|
|
US6797514B2
(en)
|
2000-02-24 |
2004-09-28 |
Xcyte Therapies, Inc. |
Simultaneous stimulation and concentration of cells
|
|
JP2002045174A
(ja)
|
2000-07-31 |
2002-02-12 |
Inst Of Physical & Chemical Res |
ナチュラルキラー細胞増殖法
|
|
GB0025307D0
(en)
|
2000-10-16 |
2000-11-29 |
Celltech Chiroscience Ltd |
Biological products
|
|
US7446179B2
(en)
|
2000-11-07 |
2008-11-04 |
City Of Hope |
CD19-specific chimeric T cell receptor
|
|
US7070995B2
(en)
|
2001-04-11 |
2006-07-04 |
City Of Hope |
CE7-specific redirected immune cells
|
|
US20030129649A1
(en)
|
2001-04-24 |
2003-07-10 |
Kobilka Brian K. |
Conformational assays to detect binding to G protein-coupled receptors
|
|
KR100888915B1
(ko)
|
2001-08-15 |
2009-03-16 |
다카라 바이오 가부시키가이샤 |
항원특이적 세포상해성 ｔ 세포 확대배양방법
|
|
JP2004538331A
(ja)
|
2001-08-17 |
2004-12-24 |
ロジャー ウィリアムス ホスピタル |
インサイチュ免疫法
|
|
WO2003057171A2
(en)
|
2002-01-03 |
2003-07-17 |
The Trustees Of The University Of Pennsylvania |
Activation and expansion of t-cells using an engineered multivalent signaling platform
|
|
CA2483343A1
(en)
|
2002-04-22 |
2003-10-30 |
Fred Hutchinson Cancer Research Center |
Soluble mic polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions
|
|
US7446190B2
(en)
|
2002-05-28 |
2008-11-04 |
Sloan-Kettering Institute For Cancer Research |
Nucleic acids encoding chimeric T cell receptors
|
|
US7740871B2
(en)
|
2002-09-19 |
2010-06-22 |
Johns Hopkins University School Of Medicine |
Cancer immunotherapy with a viral antigen-defined, immunomodulator-secreting cell vaccine
|
|
GB0225279D0
(en)
|
2002-10-30 |
2002-12-11 |
Celltech R&D Ltd |
Biological products
|
|
US9068234B2
(en)
|
2003-01-21 |
2015-06-30 |
Ptc Therapeutics, Inc. |
Methods and agents for screening for compounds capable of modulating gene expression
|
|
US20050129671A1
(en)
|
2003-03-11 |
2005-06-16 |
City Of Hope |
Mammalian antigen-presenting T cells and bi-specific T cells
|
|
CA2530349A1
(en)
|
2003-06-27 |
2005-01-06 |
Dnavec Research Inc. |
Method for transplanting lymphohematopoietic cells into mammal
|
|
US20050113564A1
(en)
|
2003-11-05 |
2005-05-26 |
St. Jude Children's Research Hospital |
Chimeric receptors with 4-1BB stimulatory signaling domain
|
|
US20130266551A1
(en)
|
2003-11-05 |
2013-10-10 |
St. Jude Children's Research Hospital, Inc. |
Chimeric receptors with 4-1bb stimulatory signaling domain
|
|
US7435596B2
(en)
|
2004-11-04 |
2008-10-14 |
St. Jude Children's Research Hospital, Inc. |
Modified cell line and method for expansion of NK cell
|
|
AU2005250408B2
(en)
|
2004-05-27 |
2010-09-23 |
The Trustees Of The University Of Pennsylvania |
Novel artificial antigen presenting cells and uses therefor
|
|
ES2678094T3
(es)
|
2004-07-10 |
2018-08-08 |
Fox Chase Cancer Center |
Líneas de células asesinas naturales genéticamente modificadas
|
|
WO2006036445A2
(en)
|
2004-09-24 |
2006-04-06 |
Trustees Of Dartmouth College |
Chimeric nk receptor and methods for treating cancer
|
|
GB0426903D0
(en)
|
2004-12-08 |
2005-01-12 |
Alexis Biotech Ltd |
Complexes and methods
|
|
PA8672101A1
(es)
|
2005-04-29 |
2006-12-07 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, métodos y usos
|
|
EP1777294A1
(en)
|
2005-10-20 |
2007-04-25 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
|
|
EP1945771A1
(en)
|
2005-10-28 |
2008-07-23 |
Novo Nordisk A/S |
Fusion proteins that bind effector lymphocytes and target cells
|
|
US20070160578A1
(en)
|
2005-12-14 |
2007-07-12 |
The Gov. Of The Usa As Represented By The Secretary Of The Dep. Of Health And Human Services |
Expansion of natural killer and CD8 T-cells with IL-15R/ligand activator complexes
|
|
US7932055B2
(en)
|
2006-06-22 |
2011-04-26 |
Novo Nordisk A/S |
Soluble heterodimeric CD94/NKG2 receptors fusion proteins
|
|
US8389282B2
(en)
|
2007-03-30 |
2013-03-05 |
Memorial Sloan-Kettering Cancer Center |
Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
|
|
US20110059137A1
(en)
|
2008-03-21 |
2011-03-10 |
H. Lee Moffitt Cancer Center And Research Institutute, Inc |
Chemokine gene-modified cells for cancer immunotherapy
|
|
CA2735456C
(en)
|
2008-08-26 |
2021-11-16 |
City Of Hope |
Method and compositions for enhanced anti-tumor effector functioning of t cells
|
|
CN101684456A
(zh)
|
2008-09-28 |
2010-03-31 |
江门罗森生物制药有限公司 |
一种体外培养条件下扩增人nk细胞的方法
|
|
WO2010071836A1
(en)
|
2008-12-19 |
2010-06-24 |
Inserm |
Il-15 mediated nk and t cell maturation
|
|
JP2012521215A
(ja)
|
2009-03-26 |
2012-09-13 |
アヴァリス・アクチエボラーグ |
Ｎｋ細胞の増殖
|
|
WO2011020047A1
(en)
|
2009-08-14 |
2011-02-17 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Use of il-15 to increase thymic output and to treat lymphopenia
|
|
WO2011053321A1
(en)
|
2009-10-30 |
2011-05-05 |
University Of Arkansas For Medical Science |
Use of autologous effector cells for treatment of multiple myeloma
|
|
EP2493486A1
(en)
|
2009-10-30 |
2012-09-05 |
University Of Arkansas For Medical Science |
Use of autologous effector cells and antibodies for treatment of multiple myeloma
|
|
CA3040276A1
(en)
|
2009-12-02 |
2011-06-09 |
Imaginab, Inc. |
J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use
|
|
US20130011376A1
(en)
|
2009-12-29 |
2013-01-10 |
Gamida Cell Ltd. |
Methods for Enhancing Natural Killer Cell Proliferation and Activity
|
|
WO2011150976A1
(en)
|
2010-06-04 |
2011-12-08 |
bioMérieux |
Method and kit for the prognosis of colorectal cancer
|
|
MX342995B
(es)
|
2010-07-13 |
2016-10-21 |
Anthrogenesis Corp |
Métodos de generar células asesinas naturales.
|
|
EP3115373B1
(en)
|
2010-09-08 |
2019-08-28 |
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus |
Chimeric antigen receptors with an optimized hinge region
|
|
WO2012136231A1
(en)
|
2010-09-08 |
2012-10-11 |
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus |
Interleukin 15 as selectable marker for gene transfer in lymphocytes
|
|
JP6251570B2
(ja)
|
2010-09-21 |
2017-12-20 |
アルター・バイオサイエンス・コーポレーション |
多量体ｉｌ−１５可溶性融合分子並びにその製造及び使用方法
|
|
CA2818684C
(en)
|
2010-11-22 |
2023-02-21 |
Innate Pharma Sa |
Nk cell modulating treatments and methods for treatment of hematological malignancies
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
US20120321666A1
(en)
|
2011-05-23 |
2012-12-20 |
Cooper Laurence J N |
T cell therapy for b cell lymphoma
|
|
KR20140060541A
(ko)
|
2011-09-16 |
2014-05-20 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
암을 치료하기 위한 rna 조작된 t 세포
|
|
EP3692794A1
(en)
|
2011-09-16 |
2020-08-12 |
Baylor College of Medicine |
Targeting the tumor microenvironment using manipulated nkt cells
|
|
AU2011377617B2
(en)
|
2011-09-23 |
2018-03-08 |
Bluebird Bio, Inc. |
Improved gene therapy methods
|
|
ITMO20110270A1
(it)
|
2011-10-25 |
2013-04-26 |
Sara Caldrer |
Una cellula effettrice modificata per il trattamento di neoplasie esprimenti il disialonganglioside gd2
|
|
WO2013074916A1
(en)
*
|
2011-11-18 |
2013-05-23 |
Board Of Regents, The University Of Texas System |
Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
|
|
CN103294374A
(zh)
|
2012-02-23 |
2013-09-11 |
中兴通讯股份有限公司 |
一种触摸屏解锁方法及装置
|
|
CN102637127B
(zh)
|
2012-02-24 |
2015-04-08 |
青岛海信电器股份有限公司 |
一种控制鼠标模块的方法及电子设备
|
|
DK3578201T3
(da)
|
2012-06-28 |
2023-05-08 |
Univ Of Central Florida Research Foundation Incorporated |
Fremgangsmåder og sammensætninger til naturlige dræberceller
|
|
EP2872617A4
(en)
|
2012-07-13 |
2015-12-09 |
Univ Pennsylvania |
EPITOP SPREADING IN CONNECTION WITH CAR T CELLS
|
|
US9175266B2
(en)
|
2012-07-23 |
2015-11-03 |
Gamida Cell Ltd. |
Enhancement of natural killer (NK) cell proliferation and activity
|
|
US10626463B2
(en)
|
2012-08-03 |
2020-04-21 |
Icahn School Of Medicine At Mount Sinai |
Biomarker associated with risk of melanoma reoccurrence
|
|
WO2014055442A2
(en)
|
2012-10-01 |
2014-04-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for targeting stromal cells for the treatment of cancer
|
|
US10786532B2
(en)
|
2012-10-02 |
2020-09-29 |
Versiti Blood Research Institute Foundation, Inc. |
Method of providing cellular therapy using modified natural killer cells or T lymphocytes
|
|
RU2729401C2
(ru)
|
2012-10-02 |
2020-08-06 |
Мемориал Слоан-Кеттеринг Кэнсер Сентер |
Композиции и способы для иммунотерапии
|
|
US10117896B2
(en)
|
2012-10-05 |
2018-11-06 |
The Trustees Of The University Of Pennsylvania |
Use of a trans-signaling approach in chimeric antigen receptors
|
|
US20150329640A1
(en)
|
2012-12-20 |
2015-11-19 |
Bluebird Bio, Inc. |
Chimeric antigen receptors and immune cells targeting b cell malignancies
|
|
SG11201505858VA
(en)
|
2013-01-28 |
2015-09-29 |
St Jude Childrens Res Hospital |
A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
|
|
IL305629A
(en)
|
2013-02-15 |
2023-11-01 |
Univ California |
Chimeric antigen receptor and methods of using it
|
|
IL298125A
(en)
|
2013-02-26 |
2023-01-01 |
Memorial Sloan Kettering Cancer Center |
Preparations and methods for immunotherapy
|
|
CN103113470B
(zh)
|
2013-02-27 |
2015-04-22 |
四川大学 |
靶向人egfr的基因工程化淋巴细胞及其制备方法和用途
|
|
CN105339498A
(zh)
|
2013-03-07 |
2016-02-17 |
贝勒医学院 |
癌症中靶向cd138
|
|
HK1220614A1
(zh)
|
2013-03-10 |
2017-05-12 |
Baylor College Of Medicine |
耐化疗免疫细胞
|
|
ES2769574T3
(es)
|
2013-03-15 |
2020-06-26 |
Michael C Milone |
Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
|
|
AU2014386824B2
(en)
|
2013-03-15 |
2019-05-09 |
Memorial Sloan-Kettering Cancer Center |
Compositions and methods for immunotherapy
|
|
US9446105B2
(en)
|
2013-03-15 |
2016-09-20 |
The Trustees Of The University Of Pennsylvania |
Chimeric antigen receptor specific for folate receptor β
|
|
UY35468A
(es)
|
2013-03-16 |
2014-10-31 |
Novartis Ag |
Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
|
|
WO2014172584A1
(en)
|
2013-04-17 |
2014-10-23 |
Baylor College Of Medicine |
IMMUNOSUPPRESSIVE TGF-β SIGNAL CONVERTER
|
|
EP2997134B1
(en)
|
2013-05-14 |
2020-06-24 |
Board of Regents, The University of Texas System |
Human application of engineered chimeric antigen receptor (car) t-cells
|
|
CA2912389C
(en)
|
2013-06-10 |
2020-01-28 |
The General Hospital Corporation D/B/A Massachusetts General Hospital |
Methods and compositions for reducing immunosupression by tumor cells
|
|
US10144770B2
(en)
|
2013-10-17 |
2018-12-04 |
National University Of Singapore |
Chimeric receptors and uses thereof in immune therapy
|
|
KR102308597B1
(ko)
|
2013-10-17 |
2021-10-01 |
내셔널 유니버시티 오브 싱가포르 |
다중 종양에 대항하여 항체-의존성 세포 세포독성을 촉발시키는 키메라 수용체
|
|
US20160250258A1
(en)
|
2013-10-31 |
2016-09-01 |
Fred Hutchinson Cancer Research Center |
Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
|
|
EP3858379A1
(en)
|
2013-11-21 |
2021-08-04 |
Autolus Limited |
Cell
|
|
NZ759969A
(en)
|
2013-12-20 |
2022-12-23 |
Fred Hutchinson Cancer Center |
Tagged chimeric effector molecules and receptors thereof
|
|
WO2015092024A2
(en)
|
2013-12-20 |
2015-06-25 |
Cellectis |
Method of engineering multi-input signal sensitive t cell for immunotherapy
|
|
CN107074957B
(zh)
|
2014-01-13 |
2021-05-07 |
希望之城公司 |
在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法
|
|
CN106414723A
(zh)
|
2014-02-10 |
2017-02-15 |
纳维基因股份有限公司 |
细胞调节纳米组合物及使用方法
|
|
DK3105335T3
(da)
|
2014-02-14 |
2020-01-13 |
Univ Texas |
Kimære antigenreceptorer og fremgangsmåder til fremstilling heraf
|
|
WO2015142661A1
(en)
|
2014-03-15 |
2015-09-24 |
Novartis Ag |
Regulatable chimeric antigen receptor
|
|
GB201405845D0
(en)
|
2014-04-01 |
2014-05-14 |
Ucl Business Plc |
Signalling system
|
|
WO2015154012A1
(en)
|
2014-04-03 |
2015-10-08 |
Memorial Sloan-Kettering Cancer Center |
Clonogenic natural killer (nk) cell populations and methods of producing and using such populations
|
|
SG10201808811QA
(en)
|
2014-04-10 |
2018-11-29 |
Seattle Childrens Hospital Dba Seattle Childrens Res Inst |
Method and compositions for cellular immunotherapy
|
|
WO2015164759A2
(en)
|
2014-04-25 |
2015-10-29 |
Bluebird Bio, Inc. |
Mnd promoter chimeric antigen receptors
|
|
EP3805371A1
(en)
|
2014-05-15 |
2021-04-14 |
National University of Singapore |
Modified natural killer cells and uses thereof
|
|
RS61406B1
(sr)
|
2014-06-06 |
2021-03-31 |
Bluebird Bio Inc |
Poboljšane kompozicije t ćelija
|
|
US10550197B2
(en)
|
2014-06-18 |
2020-02-04 |
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus |
CAR-expressing NK-92 cells as cell therapeutic agents
|
|
US10738278B2
(en)
|
2014-07-15 |
2020-08-11 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
EP3180359A1
(en)
|
2014-08-14 |
2017-06-21 |
Novartis AG |
Treatment of cancer using gfr alpha-4 chimeric antigen receptor
|
|
DK3186284T3
(da)
|
2014-08-28 |
2022-05-09 |
Bioatla Inc |
Betinget aktive kimæriske antigenreceptorer til modificerede t-celler
|
|
TWI751102B
(zh)
|
2014-08-28 |
2022-01-01 |
美商奇諾治療有限公司 |
對ｃｄ１９具專一性之抗體及嵌合抗原受體
|
|
GB201415347D0
(en)
|
2014-08-29 |
2014-10-15 |
Ucl Business Plc |
Signalling system
|
|
BR112017004270B1
(pt)
|
2014-09-04 |
2023-03-07 |
Stemcell Technologies Inc |
Método de ativação de células t ou células nk
|
|
WO2016040441A1
(en)
|
2014-09-09 |
2016-03-17 |
Unum Therapeutics |
Chimeric receptors and uses thereof in immune therapy
|
|
PT3575315T
(pt)
|
2014-09-15 |
2022-12-16 |
Agc Biologics S P A |
Recetores de antigénios quiméricos
|
|
WO2016042041A1
(en)
|
2014-09-16 |
2016-03-24 |
Fundacion Publica Andaluza Progreso Y Salud |
USE OF CORD BLOOD PLASMA TO TREAT NK CELL-MEDIATED DISEASES AND IFN-γ MEDIATED DISEASES
|
|
MA41538A
(fr)
|
2014-10-17 |
2017-12-26 |
Baylor College Medicine |
Cellules immunitaires bipartites et tripartites de signalisation
|
|
AU2015339447B2
(en)
|
2014-10-27 |
2021-08-12 |
University Of Central Florida Research Foundation, Inc. |
Methods and compositions for natural killer cells
|
|
CA2964783C
(en)
|
2014-11-05 |
2024-01-23 |
Board Of Regents, The University Of Texas System |
Chimeric antigen receptors (car) to selectively target protein complexes
|
|
JP6740234B2
(ja)
|
2014-11-05 |
2020-08-12 |
ジュノー セラピューティクス インコーポレイテッド |
形質導入および細胞プロセシングのための方法
|
|
CA2964785A1
(en)
|
2014-11-05 |
2016-05-12 |
Board Of Regents, The University Of Texas System |
Gene modified immune effector cells and engineered cells for expansion of immune effector cells
|
|
EP3018200A1
(en)
|
2014-11-07 |
2016-05-11 |
Fondazione Matilde Tettamanti e Menotti de Machi Onlus |
Improved method for the generation of genetically modified cells
|
|
CA2967222C
(en)
|
2014-11-12 |
2023-10-31 |
Rinat Neuroscience Corp. |
Inhibitory chimeric antigen receptors
|
|
RU2017125531A
(ru)
|
2014-12-19 |
2019-01-21 |
Дана-Фарбер Кэнсер Инститьют, Инк. |
Химерные антигенные рецепторы и способы их применения
|
|
HK1246180A1
(zh)
|
2014-12-31 |
2018-09-07 |
Celgene Corporation |
使用自然杀伤细胞治疗血液病症、实体瘤或感染性疾病的方法
|
|
KR20230146101A
(ko)
|
2014-12-31 |
2023-10-18 |
안트로제네시스 코포레이션 |
천연 킬러 세포 및 그의 용도
|
|
US11459390B2
(en)
|
2015-01-16 |
2022-10-04 |
Novartis Ag |
Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
|
|
EP3247368A4
(en)
|
2015-01-23 |
2019-01-02 |
Musc Foundation for Research Development |
Cytokine receptor genes and the use thereof to enhance therapy
|
|
MA41433A
(fr)
|
2015-01-26 |
2017-12-05 |
Baylor College Medicine |
Cellules immunitaires universelles pour l'immunothérapie anticancéreuse
|
|
CN113862292B
(zh)
|
2015-01-29 |
2024-12-27 |
明尼苏达大学董事会 |
嵌合抗原受体、组合物以及方法
|
|
WO2016126608A1
(en)
|
2015-02-02 |
2016-08-11 |
Novartis Ag |
Car-expressing cells against multiple tumor antigens and uses thereof
|
|
GB201501936D0
(en)
|
2015-02-05 |
2015-03-25 |
Ucl Business Plc |
Signalling system
|
|
HRP20220890T1
(hr)
|
2015-02-06 |
2022-10-14 |
National University Of Singapore |
Postupci za povećanje učinkovitosti terapijskih imunosnih stanica
|
|
US20190024065A1
(en)
|
2015-02-06 |
2019-01-24 |
Cellectis |
Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles
|
|
GB201503742D0
(en)
|
2015-03-05 |
2015-04-22 |
Ucl Business Plc |
Chimeric antigen receptor
|
|
SG11201707182WA
(en)
|
2015-03-05 |
2017-10-30 |
Hutchinson Fred Cancer Res |
Immunomodulatory fusion proteins and uses thereof
|
|
EP3064507A1
(en)
|
2015-03-06 |
2016-09-07 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof
|
|
CN107708710A
(zh)
|
2015-03-17 |
2018-02-16 |
嵌合体生物工程公司 |
Smart CAR装置,DE CAR多肽,Side CAR及其使用
|
|
EP3270960A4
(en)
|
2015-03-20 |
2018-08-08 |
Bluebird Bio, Inc. |
Vector formulations
|
|
GB201504840D0
(en)
|
2015-03-23 |
2015-05-06 |
Ucl Business Plc |
Chimeric antigen receptor
|
|
WO2016154585A1
(en)
|
2015-03-26 |
2016-09-29 |
Charles Sentman |
Anti-mica antigen binding fragments, fusion molecules, cells which express and methods of using
|
|
CN108367057B
(zh)
|
2015-04-06 |
2022-11-22 |
赛通免疫股份有限公司 |
用于胶质母细胞瘤的egfr导向的car疗法
|
|
US11091546B2
(en)
*
|
2015-04-15 |
2021-08-17 |
The Scripps Research Institute |
Optimized PNE-based chimeric receptor T cell switches and uses thereof
|
|
WO2016172583A1
(en)
|
2015-04-23 |
2016-10-27 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
|
WO2016172537A1
(en)
|
2015-04-23 |
2016-10-27 |
The Trustees Of The University Of Pennsylvania |
Compositions to disrupt protein kinase a anchoring and uses thereof
|
|
GB201507111D0
(en)
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic acid construct
|
|
GB201507119D0
(en)
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic Acid Construct
|
|
GB201507104D0
(en)
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic acid construct
|
|
GB201507115D0
(en)
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic Acid Construct
|
|
GB201507108D0
(en)
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic acid construct
|
|
US20190031759A1
(en)
|
2015-04-30 |
2019-01-31 |
Technion Research & Development Foundation Limited |
Chimeric antigen receptors and methods of their use
|
|
GB201507368D0
(en)
|
2015-04-30 |
2015-06-17 |
Ucl Business Plc |
Cell
|
|
US11534460B2
(en)
|
2015-05-11 |
2022-12-27 |
University Health Network |
Method for expansion of double negative regulatory T cells
|
|
KR20230005428A
(ko)
|
2015-05-28 |
2023-01-09 |
카이트 파마 인코포레이티드 |
T 세포 요법을 위한 진단 방법
|
|
WO2016191587A1
(en)
|
2015-05-28 |
2016-12-01 |
Armo Biosciences, Inc. |
Pegylated interleukin-10 for use in treating cancer
|
|
MX2017015239A
(es)
|
2015-05-29 |
2018-02-19 |
Juno Therapeutics Inc |
Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas.
|
|
WO2016197108A1
(en)
|
2015-06-05 |
2016-12-08 |
Board Of Regents, The University Of Texas System |
Methods of treatment with natural killer cells matched for killer immunoglobulin receptor type
|
|
ES2958720T3
(es)
|
2015-06-10 |
2024-02-13 |
Immunitybio Inc |
Células NK-92 modificadas para tratar el cáncer
|
|
TWI833684B
(zh)
|
2015-06-25 |
2024-03-01 |
美商生物細胞基因治療有限公司 |
嵌合抗原受體（ｃａｒ）、組合物及其使用方法
|
|
MX2018000278A
(es)
|
2015-06-29 |
2018-03-08 |
Univ Johns Hopkins |
Terapia de receptores quimericos de puntos de control inmunitarios.
|
|
MA42895A
(fr)
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
|
WO2017023859A1
(en)
|
2015-07-31 |
2017-02-09 |
Memorial Sloan-Kettering Cancer Center |
Antigen-binding proteins targeting cd56 and uses thereof
|
|
GB201513540D0
(en)
|
2015-07-31 |
2015-09-16 |
King S College London |
Therapeutic agents
|
|
HUE067376T2
(hu)
|
2015-08-04 |
2024-10-28 |
Xyphos Biosciences Inc |
Antitestek beilleszthetõ változó fragmentumai és NKG2D ligandumok módosított a1-a2 doménjei, valamint nem természetes NKG2D receptorokat megkötõ nem természetes NKG2D ligandumok
|
|
CN108136012B
(zh)
|
2015-08-07 |
2022-10-04 |
伊麦吉纳博公司 |
靶向分子的抗原结合构建体
|
|
GB201514874D0
(en)
|
2015-08-20 |
2015-10-07 |
Autolus Ltd |
Cell
|
|
GB201514875D0
(en)
*
|
2015-08-20 |
2015-10-07 |
Autolus Ltd |
Receptor
|
|
JP6894430B2
(ja)
|
2015-08-24 |
2021-06-30 |
セレクティスＣｅｌｌｅｃｔｉｓ |
統合された制御機能を有するキメラ抗原受容体
|
|
EP3138905A1
(en)
|
2015-09-04 |
2017-03-08 |
Miltenyi Biotec GmbH |
Method for natural killer cell expansion
|
|
US20180291080A1
(en)
|
2015-09-28 |
2018-10-11 |
Trustees Of Dartmouth College |
Chimeric antigen receptor, regulatory cells and methods of use
|
|
US11365391B2
(en)
|
2015-09-28 |
2022-06-21 |
Trustees Of Dartmouth College |
Chimeric antigen receptor anti-inflammatory cells and methods of use
|
|
ES2909973T3
(es)
|
2015-11-04 |
2022-05-10 |
Hope City |
Receptores quiméricos para el antígeno que se dirigen a HER2
|
|
MX2018005618A
(es)
|
2015-11-05 |
2018-08-01 |
Juno Therapeutics Inc |
Receptores quimericos que contienen dominios inductores de traf y composiciones y metodos relacionados.
|
|
CN107109363A
(zh)
|
2015-11-09 |
2017-08-29 |
张明杰 |
增强对异常细胞杀伤力的方法和药物组合物
|
|
MX2018006789A
(es)
|
2015-12-03 |
2019-02-13 |
Juno Therapeutics Inc |
Receptores quimericos modificados y composiciones y metodos relacionados.
|
|
JP6853514B2
(ja)
|
2015-12-27 |
2021-03-31 |
国立大学法人東海国立大学機構 |
炎症性サイトカインの産生が抑制されるキメラ抗原受容体遺伝子改変リンパ球
|
|
AU2017210031C1
(en)
|
2016-01-20 |
2020-11-26 |
Fate Therapeutics, Inc. |
Compositions and methods for immune cell modulation in adoptive immunotherapies
|
|
US20190112380A1
(en)
|
2016-03-29 |
2019-04-18 |
University Of Southern California |
Chimeric antigen receptors targeting cancer
|
|
US11596699B2
(en)
|
2016-04-29 |
2023-03-07 |
CureVac SE |
RNA encoding an antibody
|
|
CN110358736B
(zh)
|
2016-05-20 |
2023-07-07 |
杭州朔溪生物医药有限公司 |
一种修饰的k562细胞、其制备方法及nk细胞培养组合物
|
|
CN118652336A
(zh)
|
2016-06-08 |
2024-09-17 |
普瑞赛格恩公司 |
Cd33特异性嵌合抗原受体
|
|
CN105985931A
(zh)
|
2016-06-21 |
2016-10-05 |
黑龙江天晴干细胞股份有限公司 |
一种nk细胞体外扩增组合物及nk细胞扩增方法
|
|
EP3487991B1
(en)
|
2016-07-25 |
2022-09-07 |
The United States of America, as represented by The Secretary, Department of Health and Human Services |
Methods of producing modified natural killer cells and methods of use
|
|
CA2937157A1
(en)
|
2016-07-25 |
2018-01-25 |
Ucl Business Ltd |
Protein-based t-cell receptor knockdown
|
|
US9916235B2
(en)
|
2016-08-09 |
2018-03-13 |
Seagate Technology Llc |
Code failure locator
|
|
CN108148862B
(zh)
|
2016-12-05 |
2019-03-08 |
上海优卡迪生物医药科技有限公司 |
一种封闭pdl1的用于抑制免疫逃脱的car-t转基因载体及其构建方法和应用
|
|
WO2018106732A1
(en)
|
2016-12-05 |
2018-06-14 |
Juno Therapeutics, Inc. |
Production of engineered cells for adoptive cell therapy
|
|
WO2018124766A2
(ko)
|
2016-12-28 |
2018-07-05 |
주식회사 녹십자랩셀 |
키메라 항원 수용체 및 이를 발현하는 자연 살해 세포
|
|
CN117363636A
(zh)
|
2017-03-27 |
2024-01-09 |
新加坡国立大学 |
一种编码嵌合受体的多核苷酸
|
|
MX2019011570A
(es)
|
2017-03-27 |
2019-11-18 |
Nat Univ Singapore |
Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales.
|
|
CA3071282A1
(en)
|
2017-08-10 |
2019-02-14 |
National University Of Singapore |
T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof
|
|
CN109554348A
(zh)
|
2017-09-27 |
2019-04-02 |
亘喜生物科技（上海）有限公司 |
可诱导分泌抗cd47抗体的工程化免疫细胞
|
|
WO2019077037A1
(en)
|
2017-10-18 |
2019-04-25 |
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus |
METHODS AND COMPOUNDS FOR ENHANCED IMMUNE CELL THERAPY
|
|
CN107827990B
(zh)
|
2017-10-30 |
2020-07-10 |
河北森朗生物科技有限公司 |
一种多肽、编码其的核酸、其修饰的t淋巴细胞及其应用
|
|
US11866731B2
(en)
|
2017-11-10 |
2024-01-09 |
Chineo Medical Technology Co., Ltd |
Modified immune cells and uses thereof
|
|
WO2019127215A1
(en)
|
2017-12-28 |
2019-07-04 |
Nanjing Legend Biotech Co., Ltd. |
Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof
|
|
CN109971712B
(zh)
|
2017-12-28 |
2023-06-20 |
上海细胞治疗研究院 |
特异性靶向cd19抗原且高水平稳定表达pd-1抗体的car-t细胞及用途
|
|
JP7360174B2
(ja)
|
2018-02-09 |
2023-10-12 |
ナショナル ユニヴァーシティー オブ シンガポール |
ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用
|
|
SG11202007183PA
(en)
|
2018-02-09 |
2020-08-28 |
Nat Univ Singapore |
Adhesion receptor constructs and uses thereof in natural killer cell immunotherapy
|
|
AU2019227979B2
(en)
*
|
2018-03-02 |
2024-09-05 |
Allogene Therapeutics, Inc. |
Inducible chimeric cytokine receptors
|
|
CN112004577B
(zh)
|
2018-03-14 |
2024-11-22 |
湖南思为康医药有限公司 |
用于降低毒性的免疫细胞修饰以及其在过继细胞疗法中的用途
|
|
US12441787B2
(en)
|
2018-04-02 |
2025-10-14 |
National University Of Singapore |
Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
|
|
WO2020044239A1
(en)
|
2018-08-29 |
2020-03-05 |
National University Of Singapore |
A method to specifically stimulate survival and expansion of genetically-modified immune cells
|
|
ES3068417T3
(en)
|
2018-09-13 |
2026-05-29 |
Nkarta Inc |
Natural killer cell compositions and immunotherapy methods for treating a liver tumor
|
|
CN111088231A
(zh)
|
2018-10-24 |
2020-05-01 |
艾生命序公司 |
Pd-l1抗体分泌的抗间皮素car-t细胞肿瘤免疫治疗
|
|
CN113226340A
(zh)
|
2018-11-26 |
2021-08-06 |
恩卡尔塔公司 |
同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途
|
|
KR20210137085A
(ko)
|
2019-03-05 |
2021-11-17 |
엔카르타, 인크. |
Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
|
|
CN114174325A
(zh)
|
2019-06-04 |
2022-03-11 |
恩卡尔塔公司 |
用于免疫疗法的工程化自然杀伤细胞和工程化t细胞的组合
|
|
AU2020315213A1
(en)
|
2019-07-17 |
2022-02-03 |
National University Of Singapore |
Functional binders synthesized and secreted by immune cells
|
|
AU2020321354A1
(en)
|
2019-07-31 |
2022-03-03 |
Nkarta, Inc. |
Methods and compositions for enhanced expansion and cytotoxicity of natural killer cells
|
|
WO2021146147A1
(en)
|
2020-01-13 |
2021-07-22 |
Nkarta, Inc. |
Bcma-directed cellular immunotherapy compositions and methods
|
|
MX2022015586A
(es)
|
2020-06-12 |
2023-03-15 |
Nkarta Inc |
Linfocitos citolíticos naturales modificados genéticamente para inmunoterapia de cáncer dirigida a cd70.
|
|
IL300903A
(en)
|
2020-09-02 |
2023-04-01 |
Nkarta Inc |
Expansion and enhanced cytotoxicity of natural killer cells and their uses
|
|
EP4255453A4
(en)
|
2020-12-03 |
2025-03-26 |
Nkarta, Inc. |
Methods for manipulating immune cells for increased potency and persistence, as well as uses of engineered cells in immunotherapy
|
|
EP4482872A4
(en)
|
2022-03-07 |
2026-03-18 |
Nkarta Inc |
Multiplex gene-edited cells for CD70-led cancer immunotherapy
|