MX2017015239A - Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas. - Google Patents

Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas.

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Publication number
MX2017015239A
MX2017015239A MX2017015239A MX2017015239A MX2017015239A MX 2017015239 A MX2017015239 A MX 2017015239A MX 2017015239 A MX2017015239 A MX 2017015239A MX 2017015239 A MX2017015239 A MX 2017015239A MX 2017015239 A MX2017015239 A MX 2017015239A
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Mexico
Prior art keywords
cells
genetically modified
methods
composition
modified cells
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MX2017015239A
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English (en)
Inventor
Odegard Valerie
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Juno Therapeutics Inc
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Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2017015239A publication Critical patent/MX2017015239A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/41—Vertebrate antigens
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Abstract

Se proporcionan células genéticamente modificadas para terapia adoptiva, que incluyen células T. También se proporcionan métodos y composiciones para genéticamente modificar y producir las células, composiciones que contienen las células, y método para su administración a sujetos. En algunas modalidades, las células, tales como células T, contienen receptores de antígeno genéticamente modificados que específicamente enlazan a antígenos, tal como un receptor de antígeno quimérico (CAR). En algunas modalidades, las células, tal como una célula T que expresa CAR, contienen un agente que es capaz de reducir un efecto inhibitorio al reprimir y/o interrumpir un gen en una célula genéticamente modificada, tal como un gen involucrado en inhibir la respuesta inmune. En algunas modalidades, las características de las células y métodos proporcionan actividad, eficacia y/o persistencia incrementada o mejorada.
MX2017015239A 2015-05-29 2016-05-27 Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas. MX2017015239A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562168721P 2015-05-29 2015-05-29
US201562244132P 2015-10-20 2015-10-20
PCT/US2016/034873 WO2016196388A1 (en) 2015-05-29 2016-05-27 Composition and methods for regulating inhibitory interactions in genetically engineered cells

Publications (1)

Publication Number Publication Date
MX2017015239A true MX2017015239A (es) 2018-02-19

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017015239A MX2017015239A (es) 2015-05-29 2016-05-27 Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas.
MX2022009849A MX2022009849A (es) 2015-05-29 2017-11-27 Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas.

Family Applications After (1)

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MX2022009849A MX2022009849A (es) 2015-05-29 2017-11-27 Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas.

Country Status (9)

Country Link
US (1) US20180161368A1 (es)
EP (1) EP3303586A1 (es)
JP (2) JP6949728B2 (es)
CN (1) CN108174607A (es)
AU (1) AU2016271147B2 (es)
CA (1) CA2986060A1 (es)
MA (1) MA43344A (es)
MX (2) MX2017015239A (es)
WO (1) WO2016196388A1 (es)

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