MX382102B - Métodos mejorados para la elaboración de terapias celulares adoptivas. - Google Patents
Métodos mejorados para la elaboración de terapias celulares adoptivas.Info
- Publication number
- MX382102B MX382102B MX2019014009A MX2019014009A MX382102B MX 382102 B MX382102 B MX 382102B MX 2019014009 A MX2019014009 A MX 2019014009A MX 2019014009 A MX2019014009 A MX 2019014009A MX 382102 B MX382102 B MX 382102B
- Authority
- MX
- Mexico
- Prior art keywords
- adoptive cell
- cell therapies
- improved methods
- manufacturing
- manufacturing adoptive
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000011467 adoptive cell therapy Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4214—Receptors for cytokines
- A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2301—Interleukin-1 (IL-1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/855—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from receptors; from cell surface antigens; from cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Developmental Biology & Embryology (AREA)
Abstract
La presente invención se refiere a composiciones y métodos para elaborar terapias celulares adoptivas; en modalidades particulares, la invención proporciona métodos para cosechar las poblaciones de células, aislar y activar PBMC, expandir células T y administrar la célula T terapéutica a un sujeto que lo necesita.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461984558P | 2014-04-25 | 2014-04-25 | |
| PCT/US2015/027518 WO2015164745A1 (en) | 2014-04-25 | 2015-04-24 | Improved methods for manufacturing adoptive cell therapies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019014009A MX2019014009A (es) | 2020-02-05 |
| MX382102B true MX382102B (es) | 2025-03-13 |
Family
ID=54333268
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013963A MX370018B (es) | 2014-04-25 | 2015-04-24 | Metodos mejorados para la elaboracion de terapias celulares adoptivas. |
| MX2019014009A MX382102B (es) | 2014-04-25 | 2015-04-24 | Métodos mejorados para la elaboración de terapias celulares adoptivas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013963A MX370018B (es) | 2014-04-25 | 2015-04-24 | Metodos mejorados para la elaboracion de terapias celulares adoptivas. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US12291722B2 (es) |
| EP (2) | EP3738597A1 (es) |
| JP (5) | JP6817069B2 (es) |
| KR (3) | KR102161927B1 (es) |
| CN (2) | CN110819595A (es) |
| AU (2) | AU2015249376C1 (es) |
| BR (1) | BR112016024957A2 (es) |
| CA (1) | CA2946552A1 (es) |
| CY (1) | CY1123142T1 (es) |
| DK (1) | DK3134095T3 (es) |
| ES (1) | ES2800906T3 (es) |
| HR (1) | HRP20200978T1 (es) |
| HU (1) | HUE049514T2 (es) |
| IL (2) | IL248349B (es) |
| LT (1) | LT3134095T (es) |
| MX (2) | MX370018B (es) |
| NZ (1) | NZ725201A (es) |
| PL (1) | PL3134095T3 (es) |
| PT (1) | PT3134095T (es) |
| RS (1) | RS60544B1 (es) |
| RU (1) | RU2741899C2 (es) |
| SG (2) | SG10201808258SA (es) |
| SI (1) | SI3134095T1 (es) |
| SM (1) | SMT202000355T1 (es) |
| WO (1) | WO2015164745A1 (es) |
| ZA (2) | ZA201607175B (es) |
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013124474A2 (en) | 2012-02-23 | 2013-08-29 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| CN105247042B (zh) | 2013-03-15 | 2021-06-11 | 普林斯顿大学理事会 | 用于高通量纯化的方法和设备 |
| CN110186835B (zh) | 2013-03-15 | 2022-05-31 | Gpb科学有限公司 | 颗粒的片上微流体处理 |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| EP3132247B1 (en) | 2014-04-16 | 2021-08-18 | Juno Therapeutics GmbH | Methods, kits and apparatus for expanding a population of cells |
| ES2995052T3 (en) | 2014-04-23 | 2025-02-05 | Juno Therapeutics Inc | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| PL3689899T3 (pl) | 2014-04-25 | 2022-01-31 | 2Seventy Bio, Inc. | Chimeryczne receptory antygenowe promotora mnd |
| CA2946552A1 (en) | 2014-04-25 | 2015-10-29 | Bluebird Bio, Inc. | Improved methods for manufacturing adoptive cell therapies |
| DK3151672T3 (da) | 2014-06-06 | 2021-02-01 | Bluebird Bio Inc | Forbedrede t-celle-sammensætninger |
| MX2017001079A (es) * | 2014-07-24 | 2017-09-12 | Bluebird Bio Inc | Receptores de antígeno quiméricos de antígeno de maduración de células b (bcma). |
| SMT201900596T1 (it) | 2014-12-12 | 2019-11-13 | Bluebird Bio Inc | Recettori chimerici di antigene per bcma |
| EP3230441A4 (en) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
| IL253149B2 (en) | 2014-12-29 | 2023-11-01 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| WO2016168595A1 (en) | 2015-04-17 | 2016-10-20 | Barrett David Maxwell | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| MX2017014822A (es) | 2015-05-18 | 2018-04-30 | Tcr2 Therapeutics Inc | Composiciones y métodos para la reprogramación del tcr con proteínas de fusión. |
| FR3038324B1 (fr) | 2015-06-30 | 2020-10-30 | Lab Francais Du Fractionnement | Procede de cryoconservation de cellules a visee therapeutique |
| AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| TWI630934B (zh) * | 2015-10-14 | 2018-08-01 | 瑞典商神經毫微股份有限公司 | 移植醫藥設備到神經組織中的方法以及設備 |
| EP3365453A2 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods, kits, agents and apparatuses for transduction |
| EP3365678A1 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods for culturing cells and kits and apparatus for same |
| HK1254836A1 (zh) | 2015-10-30 | 2019-07-26 | Nbe-Therapeutics Ag | 抗-ror1抗体 |
| IL259576B (en) | 2015-12-04 | 2022-09-01 | Novartis Ag | grna molecule containing tracr and crrna, pharmaceutical composition containing it and method for preparing cells for immunotherapy |
| WO2017099712A1 (en) * | 2015-12-07 | 2017-06-15 | Bluebird Bio, Inc. | Improved t cell compositions |
| AU2016380262B2 (en) * | 2015-12-28 | 2023-02-09 | Novartis Ag | Methods of making chimeric antigen receptor -expressing cells |
| WO2017117384A1 (en) | 2015-12-31 | 2017-07-06 | Development Center For Biotechnology | Anti-vegfr antibody and uses thereof |
| MX2018008926A (es) | 2016-01-20 | 2019-01-10 | Scripps Research Inst | Composiciones de anticuerpo contra ror1 y métodos relacionados. |
| CA3020330A1 (en) * | 2016-04-07 | 2017-10-12 | Bluebird Bio, Inc. | Chimeric antigen receptor t cell compositions |
| WO2017176932A1 (en) * | 2016-04-08 | 2017-10-12 | Emory University | Methods of treating cancer and infectious diseases using cell based therapies |
| CN105907790A (zh) * | 2016-06-21 | 2016-08-31 | 林志国 | 特异性识别EGFRvⅢ的含CD70嵌合抗原受体修饰T细胞的制备方法 |
| CA3032498A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| MX2019003899A (es) | 2016-10-07 | 2019-08-14 | Tcr2 Therapeutics Inc | Composiciones y metodos para reprogramacion de receptores de linfocitos t mediante el uso de proteinas de fusion. |
| WO2018075940A1 (en) * | 2016-10-21 | 2018-04-26 | Georgia Tech Research Corporation | Methods and systems for t cell expansion |
| WO2018080997A1 (en) * | 2016-10-24 | 2018-05-03 | Gpb Scientific, Llc | Deterministic lateral displacement in the preparation of cells and compositions for therapeutic uses |
| BR112019009099A2 (pt) | 2016-11-04 | 2019-07-16 | Bluebird Bio Inc | composições de células t car anti-bcma |
| EP3544996A2 (en) | 2016-11-22 | 2019-10-02 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| WO2018102397A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| CN110234756A (zh) * | 2017-01-18 | 2019-09-13 | F1肿瘤医学公司 | 转导和扩增免疫细胞的方法及其用途 |
| EP3577134A1 (en) | 2017-01-31 | 2019-12-11 | Novartis AG | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| CA3054621A1 (en) | 2017-03-22 | 2018-09-27 | Novartis Ag | Compositions and methods for immunooncology |
| AU2018246143B2 (en) * | 2017-03-28 | 2025-06-05 | The Trustees Of The University Of Pennsylvania | Methods to protect transplanted tissue from rejection |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| WO2018201056A1 (en) | 2017-04-28 | 2018-11-01 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| CN109134660B (zh) * | 2017-06-16 | 2022-07-01 | 上海恒润达生生物科技股份有限公司 | 靶向Mesothelin的嵌合抗原受体并联合表达抗PD1抗体的方法及其用途 |
| CN107236762A (zh) * | 2017-06-19 | 2017-10-10 | 河北浓孚雨生物科技有限公司 | 一种微环dna转染t细胞制备临床级car‑t细胞制剂的方法 |
| WO2019009879A1 (en) * | 2017-07-03 | 2019-01-10 | Development Center For Biotechnology | ANTI-VEGFR ANTIBODIES AND USES THEREOF |
| EP3665193A1 (en) | 2017-08-07 | 2020-06-17 | NBE Therapeutics AG | Anthracycline-based antibody drug conjugates having high in vivo tolerability |
| WO2019032927A1 (en) | 2017-08-09 | 2019-02-14 | Juno Therapeutics, Inc. | METHODS FOR PRODUCING GENETICALLY MODIFIED CELL COMPOSITIONS AND COMPOSITIONS THEREOF |
| JP7393328B2 (ja) * | 2017-09-01 | 2023-12-06 | ジーピービー・サイエンティフィック・インコーポレイテッド | マイクロ流体を使用した治療的に活性な細胞を調製する方法 |
| CA3248436A1 (en) | 2017-09-01 | 2025-02-21 | Lonza Walkersville, Inc. | END-TO-END AUTOMATION OF CELL THERAPY |
| US11999802B2 (en) | 2017-10-18 | 2024-06-04 | Novartis Ag | Compositions and methods for selective protein degradation |
| WO2019089855A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| CN107893055B (zh) * | 2017-11-03 | 2020-07-17 | 深圳市默赛尔生物医学科技发展有限公司 | 一种特异性嵌合抗原受体基因修饰的自然杀伤细胞及其制备方法和用途 |
| WO2019094835A1 (en) * | 2017-11-10 | 2019-05-16 | Juno Therapeutics, Inc. | Closed-system cryogenic vessels |
| CN109776671B (zh) * | 2017-11-14 | 2022-05-27 | 杭州康万达医药科技有限公司 | 分离的t细胞受体、其修饰的细胞、编码核酸、表达载体、制备方法、药物组合物和应用 |
| SG11202004512XA (en) | 2017-11-15 | 2020-06-29 | Novartis Ag | Bcma-targeting chimeric antigen receptor, cd19-targeting chimeric antigen receptor, and combination therapies |
| CA3083949A1 (en) | 2017-11-30 | 2020-06-06 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
| WO2019113557A1 (en) * | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
| AU2018379091A1 (en) | 2017-12-08 | 2020-06-25 | Juno Therapeutics, Inc. | Serum-free media formulation for culturing cells and methods of use thereof |
| CN109609533B (zh) * | 2017-12-27 | 2020-07-10 | 赛德特生物科技开发有限公司 | 基于人源化cd276抗体的car慢病毒表达载体构建及其应用 |
| CN112218651A (zh) | 2018-01-08 | 2021-01-12 | 诺华公司 | 用于与嵌合抗原受体疗法组合的免疫增强rna |
| US12162920B2 (en) | 2018-01-26 | 2024-12-10 | Chongqing Precision Biotech Company Limited | Hinge area and use of same in constructing car skeleton |
| CN108239144B (zh) * | 2018-01-26 | 2021-05-25 | 重庆精准生物技术有限公司 | 改造的铰链及其在构建car骨架中的应用 |
| US20210038659A1 (en) | 2018-01-31 | 2021-02-11 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| US11464800B2 (en) * | 2018-02-09 | 2022-10-11 | Immatics US, Inc. | Methods for manufacturing T cells |
| DE102018108996B4 (de) | 2018-02-09 | 2021-10-21 | Immatics US, Inc. | Verfahren zur Herstellung autologer T-Zellen |
| EP3752203A1 (en) | 2018-02-13 | 2020-12-23 | Novartis AG | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| CN110272481A (zh) * | 2018-03-14 | 2019-09-24 | 中国科学院广州生物医药与健康研究院 | 识别mage1抗原短肽的t细胞受体 |
| US11141435B2 (en) * | 2018-03-14 | 2021-10-12 | Thermogenesis Corporation | Buoyancy-activated cell sorting (BACS)-compatible activation/transduction systems and methods |
| DE102018108612A1 (de) | 2018-03-21 | 2019-09-26 | Immatics US, Inc. | Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen |
| MA52533A (fr) * | 2018-04-27 | 2021-03-03 | Iovance Biotherapeutics Inc | Procédé en circuit fermé pour l'amplification et l'edition de gènes de lymphocytes d'infiltration des tumeurs et leurs utilisations en immunothérapie |
| EP3790958A1 (en) * | 2018-05-08 | 2021-03-17 | Life Technologies Corporation | Compositions and methods for culturing and expanding cells |
| CN108929862A (zh) * | 2018-08-01 | 2018-12-04 | 上海市第人民医院 | 一种恶性肿瘤肺转移伴恶性胸腔积液的t细胞制备与扩增方法及其应用 |
| CA3108657A1 (en) | 2018-08-09 | 2020-02-13 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| EP3844265A2 (en) | 2018-08-31 | 2021-07-07 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| EP3844267B1 (en) | 2018-08-31 | 2025-06-25 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| WO2020061499A1 (en) * | 2018-09-21 | 2020-03-26 | Berkeley Lights, Inc. | Functionalized well plate, methods of preparation and use thereof |
| JP7396777B2 (ja) | 2018-09-28 | 2023-12-12 | オクタン バイオテック インコーポレーテッド | 磁気分離 |
| MX2021005372A (es) | 2018-11-08 | 2021-09-14 | Neximmune Inc | Composiciones de linfocitos t con propiedades fenotípicas mejoradas. |
| SG11202104994PA (en) * | 2018-11-16 | 2021-06-29 | Celgene Corp | Improved t cell manufacturing process |
| JP7630832B2 (ja) * | 2018-11-19 | 2025-02-18 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | Carおよびtcr形質導入用のモジュール式ポリシストロニックベクター |
| JP7477091B2 (ja) | 2018-12-21 | 2024-05-01 | オクタン バイオテック インコーポレーテッド | モジュラー生物製剤生産ユニットのためのカルーセル |
| CA3123449A1 (en) | 2018-12-21 | 2020-06-25 | Lonza Walkersville, Inc. | Automated production of viral vectors |
| CN113498432A (zh) | 2019-02-08 | 2021-10-12 | 隆萨沃克斯维尔股份有限公司 | 用于自动化生物反应器的细胞浓缩方法和装置 |
| EP3930763A1 (en) | 2019-02-25 | 2022-01-05 | Novartis AG | Mesoporous silica particles compositions for viral delivery |
| US20200297768A1 (en) * | 2019-03-19 | 2020-09-24 | Immatics US, Inc. | Cd28 t cell cultures, compositions, and methods of using thereof |
| DE102019108125B4 (de) * | 2019-03-28 | 2022-02-03 | Immatics US, Inc. | Cd28 t-zellkulturen, zusammensetzungen und verfahren zu deren verwendung |
| US20230074800A1 (en) | 2019-03-21 | 2023-03-09 | Novartis Ag | Car-t cell therapies with enhanced efficacy |
| CN114072155A (zh) * | 2019-04-01 | 2022-02-18 | 豪恩·西蒙·夏 | 用于癌症免疫疗法的组合物和方法 |
| EP3945815A4 (en) * | 2019-04-03 | 2023-04-19 | Akron Biotechnology, LLC | CRYOPRESERVATION AND CELL CULTURE MEDIA |
| WO2020206061A1 (en) * | 2019-04-05 | 2020-10-08 | Bluebird Bio, Inc. | Manufacturing anti-bcma car t cells |
| US20220168389A1 (en) | 2019-04-12 | 2022-06-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| EP3959320A1 (en) | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions and methods for selective protein degradation |
| CA3140115A1 (en) | 2019-05-23 | 2020-11-26 | Massachusetts Institute Of Technology | Ligand discovery and gene delivery via retroviral surface display |
| WO2021041399A1 (en) * | 2019-08-29 | 2021-03-04 | Board Of Regents, The University Of Texas System | Cell cryopreservation medium |
| WO2021062267A1 (en) * | 2019-09-26 | 2021-04-01 | Nantbio, Inc. | Primary t-cell expansion |
| CN110747166B (zh) * | 2019-10-11 | 2021-07-09 | 厦门大学 | 一种外周血t细胞的体外扩增培养方法 |
| IL292409A (en) | 2019-10-24 | 2022-06-01 | Octane Biotech Inc | A cell culture chamber with enhanced cell contact surfaces |
| KR20220097457A (ko) | 2019-11-11 | 2022-07-07 | 론자 워커스빌 아이엔씨. | 자동화된 세포 처리를 위한 품질 관리 방법 |
| CN114761037A (zh) | 2019-11-26 | 2022-07-15 | 诺华股份有限公司 | 结合bcma和cd19的嵌合抗原受体及其用途 |
| JP2023512071A (ja) * | 2020-01-30 | 2023-03-23 | ウモジャ バイオファーマ, インコーポレイテッド | 二特異性形質導入エンハンサー |
| BR112022016633A2 (pt) | 2020-02-27 | 2022-12-13 | Novartis Ag | Métodos para produzir células que expressam receptor de antígeno quimérico |
| KR20220146530A (ko) | 2020-02-27 | 2022-11-01 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포의 제조 방법 |
| US12241086B2 (en) | 2020-04-15 | 2025-03-04 | Amgen Inc. | Process for generating genetically engineered autologous T cells |
| US12378521B2 (en) | 2020-04-15 | 2025-08-05 | Amgen Inc. | Method for enhancing production of genetically engineered autologous T cells |
| JP2023524639A (ja) * | 2020-04-22 | 2023-06-13 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 患者特異的免疫療法用細胞の製造調整システム及び調整方法 |
| KR20230024967A (ko) | 2020-06-11 | 2023-02-21 | 노파르티스 아게 | Zbtb32 억제제 및 이의 용도 |
| WO2022040586A2 (en) | 2020-08-21 | 2022-02-24 | Novartis Ag | Compositions and methods for in vivo generation of car expressing cells |
| IL305411A (en) | 2021-02-26 | 2023-10-01 | Kelonia Therapeutics Inc | Lymphocyte-targeted lentiviral vectors |
| US20240191192A1 (en) * | 2021-04-08 | 2024-06-13 | Takeda Pharmaceutical Company Limited | Method for activating t-cells |
| AU2022267891A1 (en) | 2021-04-27 | 2023-11-09 | Novartis Ag | Viral vector production system |
| WO2023021477A1 (en) * | 2021-08-20 | 2023-02-23 | Novartis Ag | Methods of making chimeric antigen receptor–expressing cells |
| CN114317435B (zh) * | 2021-12-30 | 2024-02-27 | 杭州芯递力生物科技有限公司 | 一种获得抗原特异性t细胞的方法 |
| CN119585438A (zh) | 2022-05-26 | 2025-03-07 | 再生元制药公司 | 用于维持慢病毒载体的组合物及其用途 |
| WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
| EP4665843A1 (en) * | 2023-02-17 | 2025-12-24 | LUMICKS CA Holding B.V. | Means and methods for determining cellular avidity of primary t cells and target cells |
| US20250092362A1 (en) * | 2023-09-15 | 2025-03-20 | Terumo Bct, Inc. | System And Methods For Producing Chimeric Antigen Receptor Cells |
| US20250101122A1 (en) | 2023-09-25 | 2025-03-27 | Kelonia Therapeutics, Inc. | Antigen binding polypeptides |
| US12440564B2 (en) | 2023-09-25 | 2025-10-14 | Kelonia Therapeutics, Inc. | Compositions for treating cancer |
| GB202316184D0 (en) * | 2023-10-23 | 2023-12-06 | Autolus Ltd | Method |
| CN119372143B (zh) * | 2024-12-31 | 2025-03-28 | 赛德特生物制药有限公司 | 细胞因子组合、培养基、肿瘤特异性的t细胞群及其应用 |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| DE8817132U1 (de) | 1988-01-09 | 1993-04-22 | Asta Medica AG, 6000 Frankfurt | 1,2-Bis(aminomethyl)cyclobutan-Platin-Komplexe |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US7479269B2 (en) * | 1988-11-23 | 2009-01-20 | Genetics Institute, Llc | Methods for selectively enriching TH1 and TH2 cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) * | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| EP1498427B1 (en) | 1992-08-21 | 2009-12-16 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| DK0698097T3 (da) | 1993-04-29 | 2001-10-08 | Unilever Nv | Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde |
| DE4415263C1 (de) | 1994-04-15 | 1995-11-30 | Asta Medica Ag | Cis-[trans-1,2-Cyclobutanbis(methylamin)-N,N']-[(2S)-lactato-O·1·, O·2·]-platin(II)-trihydrat (Lobaplatin-Trihydrat), seine Herstellung und arzneiliche Verwendung |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| IL125884A0 (en) * | 1996-03-04 | 1999-04-11 | Targeted Genetics Corp | Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes |
| US20020177125A1 (en) * | 1997-03-04 | 2002-11-28 | Kamb Carl Alexander | Human rhinovirus assays, and compositions therefrom |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| FR2777909B1 (fr) | 1998-04-24 | 2002-08-02 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| AU4328801A (en) * | 2000-02-24 | 2001-09-03 | Xcyte Therapies Inc | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| WO2002066516A2 (en) | 2001-02-20 | 2002-08-29 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
| AU2002257420A1 (en) | 2001-05-01 | 2002-11-11 | National Research Council Of Canada | A system for inducible expression in eukaryotic cells |
| DE10132502A1 (de) * | 2001-07-05 | 2003-01-23 | Gsf Forschungszentrum Umwelt | Angriff auf Tumorzellen mit fehlender, niedriger oder anormaler MHC-Expression durch kombinieren von nicht MHC-Restringierten T-Zellen/NK-Zellen und MHC-Restringierten Zellen |
| US7638325B2 (en) | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
| GB0224442D0 (en) * | 2002-10-21 | 2002-11-27 | Molmed Spa | A delivery system |
| DK1623017T3 (da) | 2003-05-08 | 2011-01-10 | Life Technologies Corp | Frembringelse og isolering af antigenspecifikke T-celler |
| WO2005118788A2 (en) * | 2004-05-27 | 2005-12-15 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| FR2872170B1 (fr) | 2004-06-25 | 2006-11-10 | Centre Nat Rech Scient Cnrse | Lentivirus non interactif et non replicatif, preparation et utilisations |
| WO2006039500A2 (en) | 2004-09-29 | 2006-04-13 | California Institute Of Technology | Multi-element phased array transmitter with lo phase shifting and integrated power amplifier |
| GB0503936D0 (en) | 2005-02-25 | 2005-04-06 | San Raffaele Centro Fond | Method |
| WO2006127585A2 (en) * | 2005-05-20 | 2006-11-30 | Virxsys Corporation | Transduction of primary cells |
| WO2007018318A1 (ja) | 2005-08-10 | 2007-02-15 | National University Corporation Kanazawa University | 小脳星状細胞及び/又は籠細胞特異的な遺伝子発現方法 |
| JP2010512738A (ja) | 2006-12-14 | 2010-04-30 | メディカル リサーチ カウンシル | 方法及び使用 |
| JP5666903B2 (ja) * | 2007-05-23 | 2015-02-12 | サンガモ バイオサイエンシーズ, インコーポレイテッド | 導入遺伝子の発現を増強するための方法および組成物 |
| CN101998965B (zh) | 2007-11-01 | 2014-03-12 | 安斯泰来制药有限公司 | 免疫抑制性多肽与核酸 |
| WO2009091826A2 (en) | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| EP4032552B1 (en) | 2008-08-26 | 2023-10-04 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| PL2172211T3 (pl) | 2008-10-01 | 2015-05-29 | Immatics Biotechnologies Gmbh | Kompozycja związanych z guzem peptydów i związana z tym szczepionka przeciwrakowa do leczenia glejaka (GBM) i innych rodzajów raka |
| WO2010065954A2 (en) | 2008-12-05 | 2010-06-10 | Abraxis Bioscience, Llc | Sparc binding peptides and uses thereof |
| AU2010224160A1 (en) | 2009-03-10 | 2011-09-22 | Biogen Idec Ma Inc. | Anti-BCMA antibodies |
| JP5934099B2 (ja) | 2009-10-01 | 2016-06-15 | アメリカ合衆国 | 抗血管内皮増殖因子受容体−2キメラ抗原受容体及び癌の治療のためのその使用 |
| ES2717629T3 (es) | 2009-11-03 | 2019-06-24 | Hope City | Receptor del factor de crecimiento epidérmico truncado (EGFRt) para selección de células T transducidas |
| WO2011057124A1 (en) | 2009-11-06 | 2011-05-12 | Transtarget, Inc. | Polyclonal bispecific antibody compositions and method of use |
| GB201004200D0 (en) | 2010-03-15 | 2010-04-28 | Univ Basel | Spirocyclic compounds and their use as therapeutic agents and diagnostic probes |
| EP3467101A3 (en) | 2010-09-08 | 2019-06-19 | Baylor College of Medicine | Immunotherapy of brain tumor using geneticially engineered gd2-specific t cells |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| BR112013018311A2 (pt) | 2011-01-18 | 2017-03-21 | Univ Pennsylvania | sequência de ácido nucleico isolada, receptor de antígeno quimérico isolado, célula t geneticamente modificada, vetor, e, uso de uma célula t geneticamente modificada. |
| RU2688185C2 (ru) | 2011-03-23 | 2019-05-21 | Фред Хатчинсон Кэнсер Рисерч Сентер | Способ и композиции для клеточной иммунотерапии |
| JP2014514927A (ja) * | 2011-04-13 | 2014-06-26 | イミュニカム・エイビイ | 抗原特異的t細胞の増殖のための方法 |
| SG194176A1 (en) | 2011-05-27 | 2013-12-30 | Glaxo Group Ltd | Bcma (cd269/tnfrsf17) -binding proteins |
| TR201819015T4 (tr) | 2011-06-10 | 2019-01-21 | Bluebird Bio Inc | Adrenolökodi̇strofi̇ ve adrenomi̇yelonöropati̇ i̇çi̇n gen terapi̇ vektörleri̇ |
| US20140322216A1 (en) | 2011-11-08 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
| MX2014010183A (es) * | 2012-02-22 | 2015-03-20 | Univ Pennsylvania | Composiciones y metodos para generar una poblacion persistente de celulas t utiles para el tratamiento de cancer. |
| EA201990959A1 (ru) * | 2012-04-11 | 2020-02-10 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
| US20130280220A1 (en) | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
| AU2013204923A1 (en) | 2012-06-21 | 2014-01-16 | Anthrogenesis Corporation | Modified t lymphocytes having improved specificity |
| CN112375846A (zh) | 2012-07-13 | 2021-02-19 | 宾夕法尼亚大学董事会 | 评估用于施用的转导t细胞的适用性的方法 |
| KR102264290B1 (ko) | 2012-08-20 | 2021-06-10 | 프레드 헛친슨 켄서 리서치 센터 | 세포 면역요법을 위한 방법 및 조성물 |
| AU2013312838B2 (en) * | 2012-09-04 | 2018-11-29 | Cellectis | Multi-chain chimeric antigen receptor and uses thereof |
| EP2711418B1 (en) * | 2012-09-25 | 2017-08-23 | Miltenyi Biotec GmbH | Method for polyclonal stimulation of T cells by flexible nanomatrices |
| AR092745A1 (es) * | 2012-10-01 | 2015-04-29 | Univ Pennsylvania | Composiciones que comprenden un dominio de union anti-fap y metodos para hacer blanco en celulas estromales para el tratamiento del cancer |
| CN112458057A (zh) | 2012-10-02 | 2021-03-09 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| WO2014055771A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| AU2013329186B2 (en) * | 2012-10-10 | 2019-02-14 | Sangamo Therapeutics, Inc. | T cell modifying compounds and uses thereof |
| TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Bcma抗原結合蛋白質 |
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| WO2014099671A1 (en) | 2012-12-20 | 2014-06-26 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| ES2814962T3 (es) | 2013-02-20 | 2021-03-29 | Novartis Ag | Fijación eficaz como objetivo de la leucemia humana primaria utilizando células T modificadas con receptor de antígeno quimérico anti-CD123 |
| ES3058841T3 (en) | 2013-03-15 | 2026-03-13 | Novartis Ag | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| KR20200032763A (ko) | 2014-02-04 | 2020-03-26 | 카이트 파마 인코포레이티드 | B 세포 악성종양 및 다른 암을 치료하는데 유용한 자가 t 세포 및 그의 조성물의 생산 방법 |
| JP6772063B2 (ja) | 2014-02-14 | 2020-10-21 | ベリカム ファーマシューティカルズ, インコーポレイテッド | 誘導可能なキメラポリペプチドを使用して細胞を活性化するための方法 |
| AU2015248956B2 (en) | 2014-04-14 | 2020-06-25 | Cellectis | BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy |
| PL3689899T3 (pl) | 2014-04-25 | 2022-01-31 | 2Seventy Bio, Inc. | Chimeryczne receptory antygenowe promotora mnd |
| US20170049819A1 (en) | 2014-04-25 | 2017-02-23 | Bluebird Bio, Inc. | Kappa/lambda chimeric antigen receptors |
| CA2946552A1 (en) | 2014-04-25 | 2015-10-29 | Bluebird Bio, Inc. | Improved methods for manufacturing adoptive cell therapies |
| DK3151672T3 (da) | 2014-06-06 | 2021-02-01 | Bluebird Bio Inc | Forbedrede t-celle-sammensætninger |
| MX2017001079A (es) | 2014-07-24 | 2017-09-12 | Bluebird Bio Inc | Receptores de antígeno quiméricos de antígeno de maduración de células b (bcma). |
| SMT201900596T1 (it) | 2014-12-12 | 2019-11-13 | Bluebird Bio Inc | Recettori chimerici di antigene per bcma |
| WO2016164429A1 (en) | 2015-04-06 | 2016-10-13 | The General Hospital Corporation | Anti-cspg4 chimeric antigen receptors |
| US20180147271A1 (en) | 2015-05-18 | 2018-05-31 | Bluebird Bio, Inc. | Anti-ror1 chimeric antigen receptors |
| WO2017099712A1 (en) | 2015-12-07 | 2017-06-15 | Bluebird Bio, Inc. | Improved t cell compositions |
| BR112019009099A2 (pt) | 2016-11-04 | 2019-07-16 | Bluebird Bio Inc | composições de células t car anti-bcma |
| KR20250012203A (ko) | 2017-06-30 | 2025-01-23 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 인간 도메인을 갖는 항-b 세포 성숙화 항원 키메라성 항원 수용체 |
| CN112980886B (zh) | 2019-12-02 | 2022-02-22 | 河北森朗生物科技有限公司 | 一种能高效制备且应用安全的嵌合抗原受体t细胞及其制备方法与应用 |
-
2015
- 2015-04-24 CA CA2946552A patent/CA2946552A1/en active Pending
- 2015-04-24 NZ NZ725201A patent/NZ725201A/en unknown
- 2015-04-24 AU AU2015249376A patent/AU2015249376C1/en active Active
- 2015-04-24 SM SM20200355T patent/SMT202000355T1/it unknown
- 2015-04-24 BR BR112016024957A patent/BR112016024957A2/pt active Search and Examination
- 2015-04-24 HR HRP20200978TT patent/HRP20200978T1/hr unknown
- 2015-04-24 MX MX2016013963A patent/MX370018B/es active IP Right Grant
- 2015-04-24 KR KR1020197016321A patent/KR102161927B1/ko active Active
- 2015-04-24 LT LTEP15783117.3T patent/LT3134095T/lt unknown
- 2015-04-24 EP EP20170239.6A patent/EP3738597A1/en active Pending
- 2015-04-24 PT PT157831173T patent/PT3134095T/pt unknown
- 2015-04-24 KR KR1020187026618A patent/KR101988614B1/ko active Active
- 2015-04-24 KR KR1020167032997A patent/KR20160141865A/ko not_active Ceased
- 2015-04-24 US US15/306,729 patent/US12291722B2/en active Active
- 2015-04-24 ES ES15783117T patent/ES2800906T3/es active Active
- 2015-04-24 HU HUE15783117A patent/HUE049514T2/hu unknown
- 2015-04-24 JP JP2016564075A patent/JP6817069B2/ja active Active
- 2015-04-24 SG SG10201808258SA patent/SG10201808258SA/en unknown
- 2015-04-24 PL PL15783117T patent/PL3134095T3/pl unknown
- 2015-04-24 EP EP15783117.3A patent/EP3134095B1/en not_active Revoked
- 2015-04-24 RU RU2016145968A patent/RU2741899C2/ru active
- 2015-04-24 RS RS20200744A patent/RS60544B1/sr unknown
- 2015-04-24 MX MX2019014009A patent/MX382102B/es unknown
- 2015-04-24 CN CN201911200096.5A patent/CN110819595A/zh active Pending
- 2015-04-24 CN CN201580033084.1A patent/CN106456670B/zh active Active
- 2015-04-24 SI SI201531225T patent/SI3134095T1/sl unknown
- 2015-04-24 DK DK15783117.3T patent/DK3134095T3/da active
- 2015-04-24 WO PCT/US2015/027518 patent/WO2015164745A1/en not_active Ceased
- 2015-04-24 SG SG11201608744VA patent/SG11201608744VA/en unknown
-
2016
- 2016-10-13 IL IL248349A patent/IL248349B/en active IP Right Grant
- 2016-10-18 ZA ZA2016/07175A patent/ZA201607175B/en unknown
-
2018
- 2018-03-08 JP JP2018041688A patent/JP2018087254A/ja not_active Withdrawn
- 2018-05-25 AU AU2018203687A patent/AU2018203687C1/en active Active
-
2019
- 2019-04-11 ZA ZA2019/02286A patent/ZA201902286B/en unknown
- 2019-11-01 JP JP2019199637A patent/JP7012056B2/ja active Active
-
2020
- 2020-07-20 CY CY20201100663T patent/CY1123142T1/el unknown
- 2020-08-09 IL IL276593A patent/IL276593B/en unknown
-
2022
- 2022-01-18 JP JP2022005510A patent/JP7536808B2/ja active Active
-
2024
- 2024-04-18 JP JP2024067465A patent/JP2024086948A/ja not_active Withdrawn
-
2025
- 2025-04-02 US US19/098,277 patent/US20250290041A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX382102B (es) | Métodos mejorados para la elaboración de terapias celulares adoptivas. | |
| HUS2500012I1 (hu) | B-sejtes rosszindulatú daganatok és más rákos megbetegedések kezelésére alkalmas autológ T-sejtek elõállításának módszerei és azok készítményei | |
| IL280743B (en) | Methods for enriching or producing immune cell populations for adoptive therapy | |
| NZ726989A (en) | Improved t cell compositions | |
| IL250072A0 (en) | Transgenic cells for stress cell therapy | |
| MY185016A (en) | Progenitor cells of mesodermal lineage | |
| MX2020000621A (es) | Composiciones para usarse en inmunomodulacion. | |
| MY181994A (en) | Immuno-modulatory progenitor (imp) cell | |
| IN2015DN00143A (es) | ||
| MX365403B (es) | Peptidos y metodos para usarlos. | |
| EP3224350A4 (en) | Modulation of sh2b3 to improve red blood cell production from stem cells and/or progenitor cells | |
| EP4295914A3 (en) | Genetically-engineered drug resistant t cells and methods of using the same | |
| MX363385B (es) | Métodos para el tratamiento de enfermedad de células falciformes y otras condiciones inflamatorias. | |
| MX356727B (es) | Formulaciones de liberacion modificada de viloxacina. | |
| MX2015016603A (es) | Composiciones de corticosteroides. | |
| EP3164127A4 (en) | Compositions and methods to improve adoptive cell therapies | |
| EP3194573A4 (en) | Mammalian pluripotent stem cells, methods for their production, and uses thereof | |
| HK1238292A1 (en) | Engineered cells for adoptive cell therapy | |
| HK40015045A (en) | Production of engineered cells for adoptive cell therapy | |
| HK1197560A (en) | Requlatora t cells and methods of identifying and isolating them using cd6 -expression or the combination of cd4, cd25 and cd127 | |
| EP3463401A4 (en) | ADOPTIVE CELL THERAPIES AS EARLY TREATMENT OPTIONS | |
| MX371121B (es) | Composiciones para usarse en inmunomodulación. | |
| HK1240978A1 (en) | Mammalian pluripotent stem cells, methods for their production, and uses thereof | |
| AU2015902675A0 (en) | Adoptive t cell therapy |