MX2019015188A - Inserciones de adn no virales orientadas. - Google Patents
Inserciones de adn no virales orientadas.Info
- Publication number
- MX2019015188A MX2019015188A MX2019015188A MX2019015188A MX2019015188A MX 2019015188 A MX2019015188 A MX 2019015188A MX 2019015188 A MX2019015188 A MX 2019015188A MX 2019015188 A MX2019015188 A MX 2019015188A MX 2019015188 A MX2019015188 A MX 2019015188A
- Authority
- MX
- Mexico
- Prior art keywords
- viral dna
- dna insertions
- targeted non
- genome
- cell
- Prior art date
Links
- 238000003780 insertion Methods 0.000 title 1
- 230000037431 insertion Effects 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se proporciona en la presente métodos y composiciones para editar el genoma de una célula. En algunas modalidades, una secuencia de nucleótidos de al menos 200 nucleótidos en longitud se inserta en una región objetivo en el genoma de una célula.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762520117P | 2017-06-15 | 2017-06-15 | |
US201762552180P | 2017-08-30 | 2017-08-30 | |
PCT/US2018/037919 WO2018232356A1 (en) | 2017-06-15 | 2018-06-15 | Targeted non-viral dna insertions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019015188A true MX2019015188A (es) | 2020-08-03 |
Family
ID=64659467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019015188A MX2019015188A (es) | 2017-06-15 | 2018-06-15 | Inserciones de adn no virales orientadas. |
Country Status (12)
Country | Link |
---|---|
US (4) | US20200362355A1 (es) |
EP (1) | EP3638317A4 (es) |
JP (2) | JP7275054B2 (es) |
KR (2) | KR20240027153A (es) |
CN (1) | CN111344020A (es) |
AU (1) | AU2018283405A1 (es) |
BR (1) | BR112019026625A2 (es) |
CA (1) | CA3067382A1 (es) |
IL (1) | IL271389A (es) |
MX (1) | MX2019015188A (es) |
SG (1) | SG11201912179SA (es) |
WO (1) | WO2018232356A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230034416A (ko) | 2017-10-27 | 2023-03-09 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 내인성 t 세포 수용체의 표적화된 대체 |
KR20210045360A (ko) | 2018-05-16 | 2021-04-26 | 신테고 코포레이션 | 가이드 rna 설계 및 사용을 위한 방법 및 시스템 |
WO2019232253A1 (en) * | 2018-05-30 | 2019-12-05 | The Regents Of The University Of California | Gene editing of monogenic disorders in human hematopoietic stem cells -- correction of x-linked agammaglobulinemia (xla) |
CN114107292B (zh) * | 2020-08-27 | 2024-03-12 | 阿思科力(苏州)生物科技有限公司 | 用于外源基因定点插入的基因编辑系统和方法 |
AU2021332334A1 (en) * | 2020-08-27 | 2023-05-04 | Tmunity Therapeutics Inc. | Vector-free process for manufacture of engineered immune cells |
CN113046381A (zh) * | 2021-04-12 | 2021-06-29 | 南华大学 | 用于分离生物体内特异性蛋白-dna复合体的方法、融合蛋白及其制备方法 |
WO2023220207A2 (en) * | 2022-05-10 | 2023-11-16 | Editas Medicine, Inc. | Genome editing of cells |
WO2024059618A2 (en) | 2022-09-13 | 2024-03-21 | Arsenal Biosciences, Inc. | Immune cells having co-expressed tgfbr shrnas |
WO2024059824A2 (en) | 2022-09-16 | 2024-03-21 | Arsenal Biosciences, Inc. | Immune cells with combination gene perturbations |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
AU2001255748B2 (en) | 2000-04-28 | 2006-08-10 | Sangamo Therapeutics, Inc. | Methods for binding an exogenous molecule to cellular chromatin |
GB0124391D0 (en) | 2001-10-11 | 2001-11-28 | Gene Expression Technologies L | Control of gene expression |
US20050136040A1 (en) | 2001-10-11 | 2005-06-23 | Imperial College Innovations Limited | Control of gene expression using a complex of an oligonucleotide and a regulatory peptide |
WO2003080809A2 (en) | 2002-03-21 | 2003-10-02 | Sangamo Biosciences, Inc. | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
ITMI20030821A1 (it) | 2003-04-18 | 2004-10-19 | Internat Ct For Genetic En Gineering And | Polipeptidi chimerici e loro uso. |
KR20060054196A (ko) | 2003-06-10 | 2006-05-22 | 주식회사 툴젠 | 전달가능한 dna-결합 단백질 |
US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
EP1774036A4 (en) | 2004-06-14 | 2008-10-15 | Univ Texas At Austin | TARGETING GENES IN EUKARYOTIC CELLS BY GROUP II INTRON RIBONUCLEOPROTEIN PARTICLES |
US10022457B2 (en) | 2005-08-05 | 2018-07-17 | Gholam A. Peyman | Methods to regulate polarization and enhance function of cells |
PT1916903E (pt) | 2005-08-26 | 2010-09-03 | Danisco | Utilização de genes associados a crispr (cas) |
AU2007284748B2 (en) | 2006-08-11 | 2013-05-16 | Corteva Agriscience Llc | Zinc finger nuclease-mediated homologous recombination |
US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
US9221886B2 (en) | 2009-04-28 | 2015-12-29 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
US9181527B2 (en) | 2009-10-29 | 2015-11-10 | The Trustees Of Dartmouth College | T cell receptor-deficient T cell compositions |
US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
TR201815882T4 (tr) | 2009-12-10 | 2018-11-21 | Univ Iowa State Res Found Inc | Tal efektörü aracılı dna modifikasyonu. |
CN102939377B (zh) | 2010-04-26 | 2016-06-08 | 桑格摩生物科学股份有限公司 | 使用锌指核酸酶对Rosa位点进行基因组编辑 |
US8876458B2 (en) | 2011-01-25 | 2014-11-04 | United Technologies Corporation | Blade outer air seal assembly and support |
US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
US20130236504A1 (en) | 2012-03-06 | 2013-09-12 | Medical University Of South Carolina | Delivery System for Enhancing Drug Efficacy |
JP6343605B2 (ja) | 2012-05-25 | 2018-06-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Rna依存性標的dna修飾およびrna依存性転写調節のための方法および組成物 |
EP2912175B1 (en) | 2012-10-23 | 2018-08-22 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
ES2769310T3 (es) | 2012-12-06 | 2020-06-25 | Sigma Aldrich Co Llc | Modificación y regulación del genoma basada en CRISPR |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
KR20150105635A (ko) | 2012-12-12 | 2015-09-17 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물 |
WO2014093701A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
EP3553174A1 (en) | 2012-12-17 | 2019-10-16 | President and Fellows of Harvard College | Rna-guided human genome engineering |
KR20140101203A (ko) | 2013-02-08 | 2014-08-19 | 이정민 | 자동 버핑장치 |
EP3865586A1 (en) | 2013-03-15 | 2021-08-18 | The General Hospital Corporation | Increasing specificity for rna-guided genome editing |
CN105208866B (zh) | 2013-03-21 | 2018-11-23 | 桑格摩生物治疗股份有限公司 | 使用工程化锌指蛋白核酸酶靶向断裂t细胞受体基因 |
US20160053274A1 (en) | 2013-04-02 | 2016-02-25 | Bayer Cropscience Nv | Targeted genome engineering in eukaryotes |
ES2883131T3 (es) | 2013-05-29 | 2021-12-07 | Cellectis | Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN |
EP3309248B1 (en) | 2013-05-29 | 2021-06-09 | Cellectis | Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system |
US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
US10822606B2 (en) | 2013-09-27 | 2020-11-03 | The Regents Of The University Of California | Optimized small guide RNAs and methods of use |
US9957526B2 (en) | 2013-10-17 | 2018-05-01 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
US9951353B2 (en) | 2013-11-15 | 2018-04-24 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Engineering neural stem cells using homologous recombination |
US10787684B2 (en) * | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
EP3079725B1 (en) | 2013-12-12 | 2019-10-16 | The Broad Institute, Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing |
AU2014361826A1 (en) | 2013-12-12 | 2016-06-23 | Massachusetts Institute Of Technology | Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using particle delivery components |
WO2015089486A2 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
KR20160097338A (ko) * | 2013-12-12 | 2016-08-17 | 더 브로드 인스티튜트, 인코퍼레이티드 | 뉴클레오티드 반복 장애에서의 crispr-cas 시스템의 조성물 및 방법 및 용도 |
EP3080256B1 (en) | 2013-12-13 | 2018-06-13 | Cellectis | Cas9 nuclease platform for microalgae genome engineering |
MX2016009771A (es) | 2014-01-31 | 2016-11-14 | Factor Bioscience Inc | Metodos y productos para la produccion y administracion de acido nucleico. |
WO2015115903A1 (en) | 2014-02-03 | 2015-08-06 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Site-specific dna break-induced genome editing using engineered nucleases |
AU2015247323B2 (en) | 2014-04-18 | 2021-07-01 | Editas Medicine, Inc. | CRISPR-Cas-related methods, compositions and components for cancer immunotherapy |
WO2016021972A1 (en) | 2014-08-06 | 2016-02-11 | College Of Medicine Pochon Cha University Industry-Academic Cooperation Foundation | Immune-compatible cells created by nuclease-mediated editing of genes encoding hla |
WO2016036754A1 (en) | 2014-09-02 | 2016-03-10 | The Regents Of The University Of California | Methods and compositions for rna-directed target dna modification |
WO2016049251A1 (en) | 2014-09-24 | 2016-03-31 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes |
CN107002078A (zh) | 2014-10-09 | 2017-08-01 | 生命技术公司 | Crispr寡核苷酸和基因剪辑 |
EP3215168B1 (en) | 2014-10-31 | 2023-08-02 | The Trustees of the University of Pennsylvania | Altering gene expression in modified t cells and uses thereof |
WO2016097751A1 (en) | 2014-12-18 | 2016-06-23 | The University Of Bath | Method of cas9 mediated genome engineering |
WO2016118697A1 (en) | 2015-01-21 | 2016-07-28 | Phaserx, Inc. | Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells |
JP6886404B2 (ja) | 2015-01-30 | 2021-06-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | 初代造血細胞におけるタンパク質送達 |
US20180200387A1 (en) | 2015-02-23 | 2018-07-19 | Crispr Therapeutics Ag | Materials and methods for treatment of human genetic diseases including hemoglobinopathies |
WO2016172359A2 (en) | 2015-04-24 | 2016-10-27 | The Regents Of The University Of California | Systems for detecting, monitoring or treating diseases or conditions using engineered cells and methods for making and using them |
JP6949728B2 (ja) | 2015-05-29 | 2021-10-13 | ジュノー セラピューティクス インコーポレイテッド | 遺伝子操作された細胞における阻害相互作用を調節するための組成物および方法 |
CA2989858A1 (en) | 2015-06-17 | 2016-12-22 | The Uab Research Foundation | Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage |
CA2989831A1 (en) | 2015-06-17 | 2016-12-22 | The Uab Research Foundation | Crispr/cas9 complex for genomic editing |
US20170000743A1 (en) | 2015-07-02 | 2017-01-05 | Vindico NanoBio Technology Inc. | Compositions and Methods for Delivery of Gene Editing Tools Using Polymeric Vesicles |
AU2016291778B2 (en) | 2015-07-13 | 2021-05-06 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
CA2996913A1 (en) | 2015-09-01 | 2017-03-09 | The Hospital For Sick Children | Method and compositions for removing duplicated copy number variations (cnvs) for genetic disorders and related uses |
WO2017053729A1 (en) | 2015-09-25 | 2017-03-30 | The Board Of Trustees Of The Leland Stanford Junior University | Nuclease-mediated genome editing of primary cells and enrichment thereof |
WO2017058751A1 (en) | 2015-09-28 | 2017-04-06 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
DK3359184T3 (da) | 2015-10-05 | 2020-06-15 | Prec Biosciences Inc | Genetisk modificerede celler, der omfatter et modificeret gen fra konstant alfaregion i human t-cellereceptor |
US20180327706A1 (en) | 2015-10-19 | 2018-11-15 | The Methodist Hospital | Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation |
WO2017070056A1 (en) | 2015-10-20 | 2017-04-27 | 10X Genomics, Inc. | Methods and systems for high throughput single cell genetic manipulation |
WO2017070429A1 (en) | 2015-10-22 | 2017-04-27 | Regents Of The University Of Minnesota | Methods involving editing polynucleotides that encode t cell receptor |
ES2953925T3 (es) | 2015-11-04 | 2023-11-17 | Fate Therapeutics Inc | Ingeniería genómica de células pluripotentes |
US20170145394A1 (en) | 2015-11-23 | 2017-05-25 | The Regents Of The University Of California | Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9 |
CN108778297B (zh) | 2015-12-18 | 2024-02-09 | 桑格摩生物治疗股份有限公司 | T细胞受体的靶向破坏 |
EP3397760A2 (en) | 2015-12-30 | 2018-11-07 | Avectas Limited | Vector-free delivery of gene editing proteins and compositions to cells and tissues |
JP2019509738A (ja) | 2016-03-11 | 2019-04-11 | ブルーバード バイオ, インコーポレイテッド | ゲノム編集された免疫エフェクター細胞 |
CA3020330A1 (en) | 2016-04-07 | 2017-10-12 | Bluebird Bio, Inc. | Chimeric antigen receptor t cell compositions |
CR20180503A (es) | 2016-04-14 | 2018-12-21 | Hutchinson Fred Cancer Res | Composiciones y métodos para programar células terapéuticas utilizando nanoportadores de ácidos nucleicos dirigidos |
US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
KR102437015B1 (ko) | 2016-04-15 | 2022-08-29 | 메모리얼 슬로안 케터링 캔서 센터 | 유전자이식 t 세포 및 키메라 항원 수용체 t 세포 조성물 및 관련 방법 |
US11499168B2 (en) * | 2016-04-25 | 2022-11-15 | Universitat Basel | Allele editing and applications thereof |
WO2017189336A1 (en) | 2016-04-25 | 2017-11-02 | The Regents Of The University Of California | Methods and compositions for genomic editing |
EP4166660A1 (en) | 2016-04-29 | 2023-04-19 | BASF Plant Science Company GmbH | Improved methods for modification of target nucleic acids using fused guide rna - donor molecules |
US20190136224A1 (en) | 2016-05-31 | 2019-05-09 | Massachusetts Institute Of Technology | Hydrodynamically Controlled Electric Fields for High Throughput Transformation & High Throughput Parallel Transformation Platform |
US11713458B2 (en) | 2016-06-20 | 2023-08-01 | Octapharma Ag | Means and methods for modifying multiple alleles |
EP3500670A4 (en) | 2016-08-17 | 2020-08-19 | The Broad Institute, Inc. | NEW CRISPR SYSTEMS AND ENZYMES |
WO2018039084A1 (en) | 2016-08-20 | 2018-03-01 | The Regents Of The University Of California | High-throughput system and method for the temporary permeablization of cells |
AU2017341736B2 (en) | 2016-10-12 | 2022-09-08 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
WO2018073391A1 (en) | 2016-10-19 | 2018-04-26 | Cellectis | Targeted gene insertion for improved immune cells therapy |
WO2018073393A2 (en) | 2016-10-19 | 2018-04-26 | Cellectis | Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy |
EP3541937A4 (en) | 2016-11-18 | 2020-06-24 | Christopher Bradley | REPAIR OF MASSIVELY MULTIPLEXED HOMOLOGICAL TEMPLATE FOR FULL GENERATION |
US20180179553A1 (en) | 2016-12-14 | 2018-06-28 | Ligandal, Inc. | Compositions and methods for nucleic acid and/or protein payload delivery |
CN110546495B (zh) | 2016-12-30 | 2022-11-01 | 加利福尼亚州立大学董事会 | 用于基因组编辑t细胞的选择和传代的方法 |
KR20230034416A (ko) | 2017-10-27 | 2023-03-09 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 내인성 t 세포 수용체의 표적화된 대체 |
EP3703712A4 (en) | 2017-10-30 | 2021-09-22 | PACT Pharma, Inc. | EDITING PRIMARY CELL GENES |
-
2018
- 2018-06-15 JP JP2019569305A patent/JP7275054B2/ja active Active
- 2018-06-15 MX MX2019015188A patent/MX2019015188A/es unknown
- 2018-06-15 KR KR1020247005507A patent/KR20240027153A/ko active Application Filing
- 2018-06-15 WO PCT/US2018/037919 patent/WO2018232356A1/en unknown
- 2018-06-15 CA CA3067382A patent/CA3067382A1/en active Pending
- 2018-06-15 SG SG11201912179SA patent/SG11201912179SA/en unknown
- 2018-06-15 CN CN201880053088.XA patent/CN111344020A/zh active Pending
- 2018-06-15 KR KR1020207001148A patent/KR20200018645A/ko not_active Application Discontinuation
- 2018-06-15 US US16/622,843 patent/US20200362355A1/en not_active Abandoned
- 2018-06-15 AU AU2018283405A patent/AU2018283405A1/en active Pending
- 2018-06-15 EP EP18817563.2A patent/EP3638317A4/en active Pending
- 2018-06-15 BR BR112019026625-9A patent/BR112019026625A2/pt unknown
-
2019
- 2019-12-12 IL IL271389A patent/IL271389A/en unknown
-
2021
- 2021-05-20 US US17/326,252 patent/US20210388362A1/en not_active Abandoned
- 2021-10-11 US US17/498,531 patent/US11814624B2/en active Active
-
2023
- 2023-05-02 JP JP2023076182A patent/JP2023100828A/ja active Pending
- 2023-09-08 US US18/463,589 patent/US20240117360A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20200362355A1 (en) | 2020-11-19 |
AU2018283405A1 (en) | 2020-01-16 |
SG11201912179SA (en) | 2020-01-30 |
IL271389A (en) | 2020-01-30 |
JP7275054B2 (ja) | 2023-05-17 |
CA3067382A1 (en) | 2018-12-20 |
KR20200018645A (ko) | 2020-02-19 |
CN111344020A (zh) | 2020-06-26 |
KR20240027153A (ko) | 2024-02-29 |
US20210388362A1 (en) | 2021-12-16 |
EP3638317A4 (en) | 2021-03-17 |
US20240117360A1 (en) | 2024-04-11 |
JP2023100828A (ja) | 2023-07-19 |
BR112019026625A2 (pt) | 2020-06-30 |
WO2018232356A1 (en) | 2018-12-20 |
EP3638317A1 (en) | 2020-04-22 |
JP2020524998A (ja) | 2020-08-27 |
US20220064653A1 (en) | 2022-03-03 |
US11814624B2 (en) | 2023-11-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2019015188A (es) | Inserciones de adn no virales orientadas. | |
MX2020013357A (es) | Polimerasas, composiciones y metodos de uso. | |
MX2020013347A (es) | Polimerasas, composiciones y metodos de uso. | |
EP3699280A3 (en) | Novel cas9 systems and methods of use | |
AU2017286122A1 (en) | Use of Cpf1 endonuclease for plant genome modifications | |
NZ738689A (en) | Engineered crispr-cas9 compositions and methods of use | |
AU2018339089A1 (en) | Polynucleotides, compositions, and methods for genome editing | |
BR112017012765A2 (pt) | ?métodos para editar uma sequência de nucleotídeos, célula e linhagem de e. coli e método para produzir uma célula de e. coli? | |
WO2018209158A3 (en) | CRISPR / RNA GUIDED NUCLEASE SYSTEMS AND METHODS | |
MX2019013259A (es) | Vectores de neoantigeno de alfavirus. | |
PH12019501130A1 (en) | Viral delivery of neoantigens | |
MX2019002725A (es) | Variantes de endonucleasas de asentamiento pd-1, composiciones y metodos de uso. | |
WO2018135838A3 (ko) | Dna 단일가닥 절단에 의한 염기 교정 비표적 위치 확인 방법 | |
WO2017053431A3 (en) | Allele selective gene editing and uses thereof | |
MX2021014368A (es) | Metodos y composiciones para la modificacion dirigida de un genoma. | |
PH12015502799A1 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
BR112017024534A2 (pt) | sistemas de rna-guia/endonuclease cas9 inovadores | |
WO2015006498A3 (en) | Therapeutic uses of genome editing with crispr/cas systems | |
AR098299A1 (es) | Locus óptimos del maíz | |
EP3633032A3 (en) | Novel cas9 proteins and guiding features for dna targeting and genome editing | |
ZA201908445B (en) | Recombinant adenoviruses carrying transgenes | |
BR112015023489A2 (pt) | uso de rnas-guia truncads (tru - grnas) para aumentar a especificidade de edição de genoma com rna guiado | |
MX2019006475A (es) | Sistemas y métodos para dirección con arn guía puntual (arngp) de adn endógeno y fuente. | |
MX2019004156A (es) | Variantes de endonucleasa homing de receptor de linfocitos t alfa (tcralpha). | |
MD4760B1 (ro) | Compoziţii şi metode de tratament al infecţiilor provocate de viruşii hepatitei B şi hepatitei D |