EP3541937A4 - Massively multiplexed homologous template repair for whole-genome replacement - Google Patents

Massively multiplexed homologous template repair for whole-genome replacement Download PDF

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Publication number
EP3541937A4
EP3541937A4 EP17871613.0A EP17871613A EP3541937A4 EP 3541937 A4 EP3541937 A4 EP 3541937A4 EP 17871613 A EP17871613 A EP 17871613A EP 3541937 A4 EP3541937 A4 EP 3541937A4
Authority
EP
European Patent Office
Prior art keywords
whole
homologous template
template repair
massively multiplexed
genome replacement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17871613.0A
Other languages
German (de)
French (fr)
Other versions
EP3541937A1 (en
Inventor
Christopher Bradley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP3541937A1 publication Critical patent/EP3541937A1/en
Publication of EP3541937A4 publication Critical patent/EP3541937A4/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
EP17871613.0A 2016-11-18 2017-11-17 Massively multiplexed homologous template repair for whole-genome replacement Pending EP3541937A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662424195P 2016-11-18 2016-11-18
US201762508259P 2017-05-18 2017-05-18
US201762554738P 2017-09-06 2017-09-06
US201762567744P 2017-10-03 2017-10-03
PCT/US2017/062430 WO2018094291A1 (en) 2016-11-18 2017-11-17 Massively multiplexed homologous template repair for whole-genome replacement

Publications (2)

Publication Number Publication Date
EP3541937A1 EP3541937A1 (en) 2019-09-25
EP3541937A4 true EP3541937A4 (en) 2020-06-24

Family

ID=62145813

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17871613.0A Pending EP3541937A4 (en) 2016-11-18 2017-11-17 Massively multiplexed homologous template repair for whole-genome replacement

Country Status (4)

Country Link
EP (1) EP3541937A4 (en)
AU (1) AU2017362513A1 (en)
CA (1) CA3041554A1 (en)
WO (1) WO2018094291A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3067382A1 (en) 2017-06-15 2018-12-20 The Regents Of The University Of California Targeted non-viral dna insertions
BR112020008201A2 (en) 2017-10-27 2020-10-06 The Regents Of The University Of California target replacement of endogenous t cell receptors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015253352A1 (en) * 2014-04-28 2016-12-08 Recombinetics, Inc. Multiplex Gene Editing

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
F. J. ISAACS ET AL: "Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement", SCIENCE, vol. 333, no. 6040, 15 July 2011 (2011-07-15), pages 348 - 353, XP055208347, ISSN: 0036-8075, DOI: 10.1126/science.1205822 *
GLEB KUZNETSOV ET AL: "Optimizing complex phenotypes through model-guided multiplex genome engineering", GENOME BIOLOGY, vol. 18, no. 1, 25 May 2017 (2017-05-25), XP055693069, DOI: 10.1186/s13059-017-1217-z *
See also references of WO2018094291A1 *
TAKAMARU ISHIZU ET AL: "Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes", SCIENTIFIC REPORTS, vol. 7, no. 1, 24 August 2017 (2017-08-24), XP055693490, DOI: 10.1038/s41598-017-09716-x *

Also Published As

Publication number Publication date
EP3541937A1 (en) 2019-09-25
WO2018094291A1 (en) 2018-05-24
CA3041554A1 (en) 2018-05-24
AU2017362513A1 (en) 2019-05-16

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