JP2019528077A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019528077A5 JP2019528077A5 JP2019510951A JP2019510951A JP2019528077A5 JP 2019528077 A5 JP2019528077 A5 JP 2019528077A5 JP 2019510951 A JP2019510951 A JP 2019510951A JP 2019510951 A JP2019510951 A JP 2019510951A JP 2019528077 A5 JP2019528077 A5 JP 2019528077A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- host cell
- chimeric
- antigen
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022057245A JP2022106714A (ja) | 2016-08-23 | 2022-03-30 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662378614P | 2016-08-23 | 2016-08-23 | |
| US62/378,614 | 2016-08-23 | ||
| PCT/US2017/048040 WO2018039247A1 (en) | 2016-08-23 | 2017-08-22 | Proteolytically cleavable chimeric polypeptides and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022057245A Division JP2022106714A (ja) | 2016-08-23 | 2022-03-30 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528077A JP2019528077A (ja) | 2019-10-10 |
| JP2019528077A5 true JP2019528077A5 (enExample) | 2020-09-24 |
| JP7500195B2 JP7500195B2 (ja) | 2024-06-17 |
Family
ID=61245300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019510951A Active JP7500195B2 (ja) | 2016-08-23 | 2017-08-22 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
| JP2022057245A Ceased JP2022106714A (ja) | 2016-08-23 | 2022-03-30 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022057245A Ceased JP2022106714A (ja) | 2016-08-23 | 2022-03-30 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11401332B2 (enExample) |
| EP (1) | EP3504245A4 (enExample) |
| JP (2) | JP7500195B2 (enExample) |
| KR (2) | KR102637610B1 (enExample) |
| CN (1) | CN109843929B (enExample) |
| AU (1) | AU2017316649A1 (enExample) |
| CA (1) | CA3034093A1 (enExample) |
| SG (2) | SG10201913583QA (enExample) |
| WO (1) | WO2018039247A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2618821A4 (en) | 2010-09-24 | 2014-08-13 | Brigham & Womens Hospital | NANOSTRUCTURED GELS FOR CONTROLLED RELEASE OF CAPSUED MEDIUM |
| KR102606190B1 (ko) | 2015-02-20 | 2023-11-23 | 오하이오 스테이트 이노베이션 파운데이션 | Nkg2d 및 종양 연관 항원에 대해 유도된 이가 항체 |
| JP6879932B2 (ja) | 2015-04-06 | 2021-06-02 | サイトイミューン セラピューティクス， インコーポレイテッドＣｙｔｏｉｍｍｕｎｅ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｌｃ | 神経膠芽腫のためのｅｇｆｒ指向ｃａｒ療法 |
| EP3512537B1 (en) * | 2016-09-15 | 2023-11-01 | Elicera Therapeutics AB | T-cell immunotherapy |
| JP2019530456A (ja) * | 2016-09-28 | 2019-10-24 | ガビッシュ−ガリラヤ バイオ アプリケーションズ リミテッド | 癌の新規抗原性シグネチャーを標的としたｃａｒ療法のためのユニバーサルプラットフォーム |
| US11020410B2 (en) | 2017-02-03 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
| WO2018213467A1 (en) * | 2017-05-16 | 2018-11-22 | The Johns Hopkins University | Manabodies and methods of using |
| US11325957B2 (en) * | 2017-06-19 | 2022-05-10 | Cell Design Labs, Inc. | Methods and compositions for reducing the immunogenicity of chimeric notch receptors |
| GB201804291D0 (en) * | 2018-03-16 | 2018-05-02 | Evox Therapeutics Ltd | Cell-mediated exosome delivery |
| CA3092355A1 (en) * | 2018-03-16 | 2019-09-19 | Cytoimmune Therapeutics, Inc. | Bispecific antibody car cell immunotherapy |
| EP3773478A1 (en) | 2018-04-04 | 2021-02-17 | Alivio Therapeutics, Inc. | Self-assembled gels for controlled delivery of biologics and methods of making thereof |
| EP3773633A4 (en) | 2018-04-06 | 2022-01-26 | The Regents of The University of California | METHODS OF TREATMENT OF GLIOBLASTOMA |
| AU2019249215B2 (en) | 2018-04-06 | 2026-02-19 | The Regents Of The University Of California | Methods of treating EGFRvIII expressing glioblastomas |
| EP3773623A4 (en) * | 2018-04-06 | 2022-01-05 | The Regents of The University of California | TRANS ANTIGEN TARGETING IN HETEROGENIC CARCINOMA AND METHOD OF USING IT |
| AU2019252878B2 (en) * | 2018-04-10 | 2024-02-22 | Stichting Sanquin Bloedvoorziening | Chimeric Notch receptors |
| WO2020051507A1 (en) | 2018-09-06 | 2020-03-12 | The Broad Institute, Inc. | Nucleic acid assemblies for use in targeted delivery |
| EP3876956A4 (en) | 2018-11-08 | 2022-12-28 | The Regents of The University of California | SYSTEMS AND METHODS FOR TARGETING CANCER CELLS |
| WO2020118076A1 (en) * | 2018-12-06 | 2020-06-11 | The Board Of Trustees Of The Leland Stanford Junior University | Regulatable cell surface receptors and related compositions and methods |
| WO2020140973A1 (en) * | 2019-01-03 | 2020-07-09 | Nanjing Legend Biotech Co., Ltd. | Modified immune cells expressing flagellin polypeptide |
| MX2022001711A (es) * | 2019-08-09 | 2022-05-10 | A2 Biotherapeutics Inc | Receptores en la superficie celular que responden a la perdida de heterocigosidad. |
| WO2021061859A1 (en) * | 2019-09-24 | 2021-04-01 | The Regents Of The University Of California | Novel receptors for ligand-dependent transcriptional regulation |
| WO2021061791A1 (en) * | 2019-09-24 | 2021-04-01 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| EP4034254A4 (en) * | 2019-09-24 | 2023-11-01 | The Regents of the University of California | RECEPTORS WITH HETEROLOGUE TRANSMEMBRANE DOMAIN |
| JP2022548796A (ja) * | 2019-09-24 | 2022-11-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ヒンジドメインを有するノッチ受容体 |
| CN110716044B (zh) * | 2019-10-23 | 2023-04-18 | 郑州大学 | 一种用于食管鳞癌早期筛查和诊断的血清蛋白标志物、试剂盒及检测方法 |
| US12195723B2 (en) | 2019-11-08 | 2025-01-14 | The Broad Institute, Inc. | Engineered antigen presenting cells and uses thereof |
| CN110970090B (zh) * | 2019-11-18 | 2021-06-29 | 华中科技大学 | 一种用于判断待处理多肽与阳性数据集肽段相似度的方法 |
| KR20220115602A (ko) * | 2019-12-12 | 2022-08-17 | 센티 바이오사이언시스, 인코포레이티드 | 세포의 조절된 아머를 위한 방법 및 조성물 |
| EP4083213A4 (en) * | 2019-12-27 | 2024-01-10 | National University Corporation Kobe University | Cancer gene therapy drug |
| KR20220166833A (ko) * | 2020-04-09 | 2022-12-19 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 힌지 도메인을 갖는 인간화 노치 수용체 |
| WO2021257989A2 (en) * | 2020-06-18 | 2021-12-23 | Flagship Pioneering, Inc. | Methods and compositions for modulating cells and cellular membranes |
| EP4100028A4 (en) | 2020-08-20 | 2023-07-26 | A2 Biotherapeutics, Inc. | Compositions and methods for treating mesothelin positive cancers |
| EP4097486A4 (en) | 2020-08-20 | 2023-09-06 | A2 Biotherapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF POSITIVE CANCERS AT CEACAM |
| TW202237827A (zh) | 2020-12-03 | 2022-10-01 | 美商世紀治療股份有限公司 | 經基因工程改造之細胞及其用途 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| CN116635064A (zh) | 2020-12-18 | 2023-08-22 | 世纪治疗股份有限公司 | 具有适应性受体特异性的嵌合抗原受体系统 |
| US20240150755A1 (en) * | 2021-02-26 | 2024-05-09 | Salk Institute For Biological Studies | Modulating regulatory t cell function in autoimmune disease and cancer |
| WO2022204151A1 (en) * | 2021-03-23 | 2022-09-29 | The Regents Of The University Of California | Synthetic intermembrane proteolysis receptors for custom antigen-induced transcriptional regulation |
| WO2022204326A1 (en) * | 2021-03-24 | 2022-09-29 | The Regents Of The University Of California | Humanized synthetic notch receptors with augmented transactivation domains and uses thereof |
| CN114045272B (zh) * | 2021-03-24 | 2024-12-06 | 深圳市新靶向生物科技有限公司 | 一种与乳腺癌驱动基因突变相关的抗原肽组合及其应用 |
| KR20240099259A (ko) | 2021-10-14 | 2024-06-28 | 아스널 바이오사이언시스, 인크. | 공동 발현된 shrna 및 논리 게이트 시스템을 갖는 면역 세포 |
| CN114107253B (zh) * | 2021-12-17 | 2024-03-15 | 复旦大学附属华山医院 | 一种利用工程细胞进行基因编辑的系统及方法 |
| CN114736308B (zh) * | 2022-03-15 | 2022-12-27 | 四川宜美康科技有限公司 | 球虫抗原肽/il5的融合蛋白基因工程菌的制备及用途 |
| CN117510615B (zh) * | 2023-01-31 | 2025-01-07 | 上海恩凯细胞技术有限公司 | SynNotch受体及其用途 |
| WO2025076422A1 (en) * | 2023-10-05 | 2025-04-10 | The Regents Of The University Of California | Regulated expression of card11-pik3r3 fusion protein |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| GB0112818D0 (en) * | 2001-05-25 | 2001-07-18 | Lorantis Ltd | Conjugate |
| GB0220658D0 (en) | 2002-09-05 | 2002-10-16 | Lorantis Ltd | Immunotherapy |
| CA2664738C (en) | 2006-09-29 | 2017-03-07 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| US8426140B2 (en) | 2007-09-28 | 2013-04-23 | Royal College Of Surgeons In Ireland | Method of assessing colorectal cancer status in an individual |
| EP2307051B1 (en) | 2008-07-08 | 2015-02-11 | OncoMed Pharmaceuticals, Inc. | Notch-binding agents and antagonists and methods of use thereof |
| EP2558571A4 (en) | 2010-04-16 | 2014-09-24 | Immune Disease Inst Inc | DELAYED POLYPEPTIDE EXPRESSION FROM MODIFIED SYNTHETIC RNAS AND USES THEREOF |
| CN112458057A (zh) | 2012-10-02 | 2021-03-09 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| NZ758715A (en) | 2013-10-31 | 2023-01-27 | Seattle Children’S Hospital Dba Seattle Children’S Res Institute | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| US9730935B2 (en) | 2013-12-13 | 2017-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting a non-canonical notch signaling pathway for cancer treatment |
| ES2728668T3 (es) | 2014-01-08 | 2019-10-28 | Univ Leland Stanford Junior | Terapia dirigida para el cáncer de pulmón de células pequeñas |
| CN106414748B (zh) | 2014-02-14 | 2021-05-28 | 得克萨斯州大学系统董事会 | 嵌合抗原受体及制备方法 |
| EP3107552B1 (en) | 2014-02-21 | 2018-03-28 | Cellectis | Method for in situ inhibition of regulatory t cells |
| WO2015130766A1 (en) * | 2014-02-25 | 2015-09-03 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins specific for hla-a2-restricted wilms tumor 1 peptide |
| EP4205749A1 (en) * | 2014-07-31 | 2023-07-05 | Novartis AG | Subset-optimized chimeric antigen receptor-containing cells |
| ES3034398T3 (en) | 2014-08-28 | 2025-08-18 | Bioatla Inc | Conditionally active chimeric antigen receptors for modified t-cells |
| WO2016044745A1 (en) * | 2014-09-19 | 2016-03-24 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
| CN107002073B (zh) | 2014-12-09 | 2021-10-22 | 北海道公立大学法人札幌医科大学 | 肿瘤抗原肽 |
| IL287914B2 (en) | 2015-02-24 | 2025-10-01 | Univ California | Linkage-activated transcription switches and methods of using them |
| US11400116B2 (en) | 2016-05-06 | 2022-08-02 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
-
2017
- 2017-08-22 SG SG10201913583QA patent/SG10201913583QA/en unknown
- 2017-08-22 KR KR1020237006942A patent/KR102637610B1/ko active Active
- 2017-08-22 AU AU2017316649A patent/AU2017316649A1/en not_active Abandoned
- 2017-08-22 CN CN201780063755.8A patent/CN109843929B/zh active Active
- 2017-08-22 KR KR1020197005928A patent/KR20190051956A/ko not_active Ceased
- 2017-08-22 WO PCT/US2017/048040 patent/WO2018039247A1/en not_active Ceased
- 2017-08-22 CA CA3034093A patent/CA3034093A1/en active Pending
- 2017-08-22 US US16/325,657 patent/US11401332B2/en active Active
- 2017-08-22 EP EP17844296.8A patent/EP3504245A4/en active Pending
- 2017-08-22 JP JP2019510951A patent/JP7500195B2/ja active Active
- 2017-08-22 SG SG11201901528RA patent/SG11201901528RA/en unknown
-
2022
- 2022-03-30 JP JP2022057245A patent/JP2022106714A/ja not_active Ceased
- 2022-06-15 US US17/841,595 patent/US12358988B2/en active Active
-
2025
- 2025-06-10 US US19/234,169 patent/US20250304698A1/en active Pending