JP2018527323A5 - - Google Patents

Info

Publication number

JP2018527323A5

JP2018527323A5 JP2018503151A JP2018503151A JP2018527323A5 JP 2018527323 A5 JP2018527323 A5 JP 2018527323A5 JP 2018503151 A JP2018503151 A JP 2018503151A JP 2018503151 A JP2018503151 A JP 2018503151A JP 2018527323 A5 JP2018527323 A5 JP 2018527323A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

polypeptide

polypeptides

Prior art date

2016-07-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 167
• 229920001184 polypeptide Polymers 0.000 claims 165
• 102000004196 processed proteins & peptides Human genes 0.000 claims 165
• 125000003275 alpha amino acid group Chemical group 0.000 claims 114
• 150000001875 compounds Chemical class 0.000 claims 36
• 102000004169 proteins and genes Human genes 0.000 claims 30
• 108090000623 proteins and genes Proteins 0.000 claims 30
• 101000852980 Homo sapiens Interleukin-23 subunit alpha Proteins 0.000 claims 7
• 102100036705 Interleukin-23 subunit alpha Human genes 0.000 claims 7
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 6
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 6
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 6
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 6
• 102000039446 nucleic acids Human genes 0.000 claims 6
• 108020004707 nucleic acids Proteins 0.000 claims 6
• 150000007523 nucleic acids Chemical class 0.000 claims 6
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 235000004279 alanine Nutrition 0.000 claims 4
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 4
• 208000023275 Autoimmune disease Diseases 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
• 208000005777 Lupus Nephritis Diseases 0.000 claims 2
• 208000034943 Primary Sjögren syndrome Diseases 0.000 claims 2
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
• 201000009594 Systemic Scleroderma Diseases 0.000 claims 2
• 206010042953 Systemic sclerosis Diseases 0.000 claims 2
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
• 239000004473 Threonine Substances 0.000 claims 2
• 235000013922 glutamic acid Nutrition 0.000 claims 2
• 239000004220 glutamic acid Substances 0.000 claims 2
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 2
• 125000003729 nucleotide group Chemical group 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 208000002267 Anti-neutrophil cytoplasmic antibody-associated vasculitis Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1