|
US2816110A
(en)
|
1956-11-23 |
1957-12-10 |
Merck & Co Inc |
Methods for the production of substituted pteridines
|
|
GB971700A
(en)
|
1961-02-02 |
1964-09-30 |
Boots Pure Drug Co Ltd |
Anti-Inflammatory Agents
|
|
US4009197A
(en)
|
1967-01-13 |
1977-02-22 |
Syntex Corporation |
2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof
|
|
US3904682A
(en)
|
1967-01-13 |
1975-09-09 |
Syntex Corp |
2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
|
|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
JPS5927900A
(ja)
|
1982-08-09 |
1984-02-14 |
Wakunaga Seiyaku Kk |
固定化オリゴヌクレオチド
|
|
FR2540122B1
(fr)
|
1983-01-27 |
1985-11-29 |
Centre Nat Rech Scient |
Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
|
|
US4605735A
(en)
|
1983-02-14 |
1986-08-12 |
Wakunaga Seiyaku Kabushiki Kaisha |
Oligonucleotide derivatives
|
|
US4948882A
(en)
|
1983-02-22 |
1990-08-14 |
Syngene, Inc. |
Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
|
|
US4824941A
(en)
|
1983-03-10 |
1989-04-25 |
Julian Gordon |
Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
|
|
US4587044A
(en)
|
1983-09-01 |
1986-05-06 |
The Johns Hopkins University |
Linkage of proteins to nucleic acids
|
|
US5118802A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
|
|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
FR2567892B1
(fr)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
|
|
US5430136A
(en)
|
1984-10-16 |
1995-07-04 |
Chiron Corporation |
Oligonucleotides having selectably cleavable and/or abasic sites
|
|
US5258506A
(en)
|
1984-10-16 |
1993-11-02 |
Chiron Corporation |
Photolabile reagents for incorporation into oligonucleotide chains
|
|
US4828979A
(en)
|
1984-11-08 |
1989-05-09 |
Life Technologies, Inc. |
Nucleotide analogs for nucleic acid labeling and detection
|
|
US6448392B1
(en)
|
1985-03-06 |
2002-09-10 |
Chimerix, Inc. |
Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
|
|
US4762779A
(en)
|
1985-06-13 |
1988-08-09 |
Amgen Inc. |
Compositions and methods for functionalizing nucleic acids
|
|
US5317098A
(en)
|
1986-03-17 |
1994-05-31 |
Hiroaki Shizuya |
Non-radioisotope tagging of fragments
|
|
JPS638396A
(ja)
|
1986-06-30 |
1988-01-14 |
Wakunaga Pharmaceut Co Ltd |
ポリ標識化オリゴヌクレオチド誘導体
|
|
US4904582A
(en)
|
1987-06-11 |
1990-02-27 |
Synthetic Genetics |
Novel amphiphilic nucleic acid conjugates
|
|
US5585481A
(en)
|
1987-09-21 |
1996-12-17 |
Gen-Probe Incorporated |
Linking reagents for nucleotide probes
|
|
US5525465A
(en)
|
1987-10-28 |
1996-06-11 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Oligonucleotide-polyamide conjugates and methods of production and applications of the same
|
|
DE3738460A1
(de)
|
1987-11-12 |
1989-05-24 |
Max Planck Gesellschaft |
Modifizierte oligonukleotide
|
|
US5082830A
(en)
|
1988-02-26 |
1992-01-21 |
Enzo Biochem, Inc. |
End labeled nucleotide probe
|
|
US5109124A
(en)
|
1988-06-01 |
1992-04-28 |
Biogen, Inc. |
Nucleic acid probe linked to a label having a terminal cysteine
|
|
US5149782A
(en)
|
1988-08-19 |
1992-09-22 |
Tanox Biosystems, Inc. |
Molecular conjugates containing cell membrane-blending agents
|
|
US5262536A
(en)
|
1988-09-15 |
1993-11-16 |
E. I. Du Pont De Nemours And Company |
Reagents for the preparation of 5'-tagged oligonucleotides
|
|
US5512439A
(en)
|
1988-11-21 |
1996-04-30 |
Dynal As |
Oligonucleotide-linked magnetic particles and uses thereof
|
|
CA2006008C
(en)
|
1988-12-20 |
2000-02-15 |
Donald J. Kessler |
Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
|
|
US5599923A
(en)
|
1989-03-06 |
1997-02-04 |
Board Of Regents, University Of Tx |
Texaphyrin metal complexes having improved functionalization
|
|
US5457183A
(en)
|
1989-03-06 |
1995-10-10 |
Board Of Regents, The University Of Texas System |
Hydroxylated texaphyrins
|
|
CA2049028A1
(en)
|
1989-03-07 |
1990-09-08 |
Genentech, Inc. |
Covalent conjugates of lipid and oligonucleotide
|
|
US5391723A
(en)
|
1989-05-31 |
1995-02-21 |
Neorx Corporation |
Oligonucleotide conjugates
|
|
US5256775A
(en)
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
|
US4958013A
(en)
|
1989-06-06 |
1990-09-18 |
Northwestern University |
Cholesteryl modified oligonucleotides
|
|
US5411947A
(en)
|
1989-06-28 |
1995-05-02 |
Vestar, Inc. |
Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
|
|
US5451463A
(en)
|
1989-08-28 |
1995-09-19 |
Clontech Laboratories, Inc. |
Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
|
|
US5254469A
(en)
|
1989-09-12 |
1993-10-19 |
Eastman Kodak Company |
Oligonucleotide-enzyme conjugate that can be used as a probe in hybridization assays and polymerase chain reaction procedures
|
|
US5591722A
(en)
|
1989-09-15 |
1997-01-07 |
Southern Research Institute |
2'-deoxy-4'-thioribonucleosides and their antiviral activity
|
|
DE69034150T2
(de)
|
1989-10-24 |
2005-08-25 |
Isis Pharmaceuticals, Inc., Carlsbad |
2'-Modifizierte Oligonukleotide
|
|
US5292873A
(en)
|
1989-11-29 |
1994-03-08 |
The Research Foundation Of State University Of New York |
Nucleic acids labeled with naphthoquinone probe
|
|
US5486603A
(en)
|
1990-01-08 |
1996-01-23 |
Gilead Sciences, Inc. |
Oligonucleotide having enhanced binding affinity
|
|
US5670633A
(en)
|
1990-01-11 |
1997-09-23 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides that detect and modulate gene expression
|
|
US6153737A
(en)
|
1990-01-11 |
2000-11-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US5852182A
(en)
|
1990-01-11 |
1998-12-22 |
Isis Pharmaceuticals Inc. |
Thiol-derivatized oligonucleosides
|
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US5872232A
(en)
|
1990-01-11 |
1999-02-16 |
Isis Pharmaceuticals Inc. |
2'-O-modified oligonucleotides
|
|
WO1995006659A1
(en)
|
1992-07-01 |
1995-03-09 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
|
US7037646B1
(en)
|
1990-01-11 |
2006-05-02 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
|
US6783931B1
(en)
|
1990-01-11 |
2004-08-31 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
|
US5859221A
(en)
|
1990-01-11 |
1999-01-12 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
|
US5578718A
(en)
|
1990-01-11 |
1996-11-26 |
Isis Pharmaceuticals, Inc. |
Thiol-derivatized nucleosides
|
|
US6005087A
(en)
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
|
AU7579991A
(en)
|
1990-02-20 |
1991-09-18 |
Gilead Sciences, Inc. |
Pseudonucleosides and pseudonucleotides and their polymers
|
|
US5214136A
(en)
|
1990-02-20 |
1993-05-25 |
Gilead Sciences, Inc. |
Anthraquinone-derivatives oligonucleotides
|
|
GB9009980D0
(en)
|
1990-05-03 |
1990-06-27 |
Amersham Int Plc |
Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
|
|
ES2116977T3
(es)
|
1990-05-11 |
1998-08-01 |
Microprobe Corp |
Soportes solidos para ensayos de hibridacion de acidos nucleicos y metodos para inmovilizar oligonucleotidos de modo covalente.
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5688941A
(en)
|
1990-07-27 |
1997-11-18 |
Isis Pharmaceuticals, Inc. |
Methods of making conjugated 4' desmethyl nucleoside analog compounds
|
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
|
US5218105A
(en)
|
1990-07-27 |
1993-06-08 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5245022A
(en)
|
1990-08-03 |
1993-09-14 |
Sterling Drug, Inc. |
Exonuclease resistant terminally substituted oligonucleotides
|
|
US5512667A
(en)
|
1990-08-28 |
1996-04-30 |
Reed; Michael W. |
Trifunctional intermediates for preparing 3'-tailed oligonucleotides
|
|
US5420330A
(en)
|
1990-09-07 |
1995-05-30 |
Pharmacia P-L Biochemicals Inc. |
Lipo-phosphoramidites
|
|
KR930702373A
(ko)
|
1990-11-08 |
1993-09-08 |
안토니 제이. 페이네 |
합성 올리고누클레오티드에 대한 다중 리포터(Reporter)그룹의 첨합
|
|
US20020123476A1
(en)
|
1991-03-19 |
2002-09-05 |
Emanuele R. Martin |
Therapeutic delivery compositions and methods of use thereof
|
|
US6933286B2
(en)
|
1991-03-19 |
2005-08-23 |
R. Martin Emanuele |
Therapeutic delivery compositions and methods of use thereof
|
|
US5371241A
(en)
|
1991-07-19 |
1994-12-06 |
Pharmacia P-L Biochemicals Inc. |
Fluorescein labelled phosphoramidites
|
|
US6369209B1
(en)
|
1999-05-03 |
2002-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
|
US7119184B2
(en)
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
|
US5698391A
(en)
|
1991-08-23 |
1997-12-16 |
Isis Pharmaceuticals, Inc. |
Methods for synthetic unrandomization of oligomer fragments
|
|
EP0538194B1
(de)
|
1991-10-17 |
1997-06-04 |
Novartis AG |
Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte
|
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
US6235887B1
(en)
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
|
US5159079A
(en)
|
1991-12-20 |
1992-10-27 |
Eli Lilly And Company |
2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids
|
|
US5595726A
(en)
|
1992-01-21 |
1997-01-21 |
Pharmacyclics, Inc. |
Chromophore probe for detection of nucleic acid
|
|
US5565552A
(en)
|
1992-01-21 |
1996-10-15 |
Pharmacyclics, Inc. |
Method of expanded porphyrin-oligonucleotide conjugate synthesis
|
|
KR930016437A
(ko)
|
1992-01-22 |
1993-08-26 |
귀틀라인, 슈미트 |
올리고뉴클레오티드 유사체, 이의 제조방법 및 용도
|
|
FR2687679B1
(fr)
|
1992-02-05 |
1994-10-28 |
Centre Nat Rech Scient |
Oligothionucleotides.
|
|
US5543507A
(en)
|
1992-03-05 |
1996-08-06 |
Isis Pharmaceuticals, Inc. |
Covalently cross-linked oligonucleotides
|
|
EP0635023B1
(en)
|
1992-03-05 |
2002-02-06 |
Isis Pharmaceuticals, Inc. |
Covalently cross-linked oligonucleotides
|
|
US5633360A
(en)
|
1992-04-14 |
1997-05-27 |
Gilead Sciences, Inc. |
Oligonucleotide analogs capable of passive cell membrane permeation
|
|
EP0642589A4
(en)
|
1992-05-11 |
1997-05-21 |
Ribozyme Pharm Inc |
METHOD AND REAGENT TO INHIBIT VIRAL REPLICATION.
|
|
EP0577558A2
(de)
|
1992-07-01 |
1994-01-05 |
Ciba-Geigy Ag |
Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
|
|
US6172208B1
(en)
|
1992-07-06 |
2001-01-09 |
Genzyme Corporation |
Oligonucleotides modified with conjugate groups
|
|
US5272250A
(en)
|
1992-07-10 |
1993-12-21 |
Spielvogel Bernard F |
Boronated phosphoramidate compounds
|
|
ATE299509T1
(de)
|
1992-07-23 |
2005-07-15 |
Isis Pharmaceuticals Inc |
Neue 2'-o-alkyl-nukleoside und -phosphoramidite, verfahren zu ihrer herstellung und ihre verwendungen
|
|
JPH08504559A
(ja)
|
1992-12-14 |
1996-05-14 |
ハネウエル・インコーポレーテッド |
個別に制御される冗長巻線を有するモータシステム
|
|
US5574142A
(en)
|
1992-12-15 |
1996-11-12 |
Microprobe Corporation |
Peptide linkers for improved oligonucleotide delivery
|
|
US5721138A
(en)
|
1992-12-15 |
1998-02-24 |
Sandford University |
Apolipoprotein(A) promoter and regulatory sequence constructs and methods of use
|
|
US5476925A
(en)
|
1993-02-01 |
1995-12-19 |
Northwestern University |
Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
|
|
CA2159631A1
(en)
|
1993-03-30 |
1994-10-13 |
Sanofi |
Acyclic nucleoside analogs and oligonucleotide sequences containing them
|
|
DE4311944A1
(de)
|
1993-04-10 |
1994-10-13 |
Degussa |
Umhüllte Natriumpercarbonatpartikel, Verfahren zu deren Herstellung und sie enthaltende Wasch-, Reinigungs- und Bleichmittelzusammensetzungen
|
|
ATE247128T1
(de)
|
1993-09-03 |
2003-08-15 |
Isis Pharmaceuticals Inc |
Aminoderivatisierte nukleoside und oligonukleoside
|
|
US5446137B1
(en)
|
1993-12-09 |
1998-10-06 |
Behringwerke Ag |
Oligonucleotides containing 4'-substituted nucleotides
|
|
US5519134A
(en)
|
1994-01-11 |
1996-05-21 |
Isis Pharmaceuticals, Inc. |
Pyrrolidine-containing monomers and oligomers
|
|
US5587471A
(en)
|
1994-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Method of making oligonucleotide libraries
|
|
IL112920A
(en)
|
1994-03-07 |
2003-04-10 |
Dow Chemical Co |
Composition comprising a dendritic polymer complexed with at least one unit of biological response modifier and a process for the preparation thereof
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
US5597696A
(en)
|
1994-07-18 |
1997-01-28 |
Becton Dickinson And Company |
Covalent cyanine dye oligonucleotide conjugates
|
|
US5580731A
(en)
|
1994-08-25 |
1996-12-03 |
Chiron Corporation |
N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
|
|
US5597909A
(en)
|
1994-08-25 |
1997-01-28 |
Chiron Corporation |
Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
|
|
US5792747A
(en)
|
1995-01-24 |
1998-08-11 |
The Administrators Of The Tulane Educational Fund |
Highly potent agonists of growth hormone releasing hormone
|
|
US5907030A
(en)
|
1995-01-25 |
1999-05-25 |
University Of Southern California |
Method and compositions for lipidization of hydrophilic molecules
|
|
DE19502912A1
(de)
|
1995-01-31 |
1996-08-01 |
Hoechst Ag |
G-Cap Stabilisierte Oligonucleotide
|
|
US5801155A
(en)
|
1995-04-03 |
1998-09-01 |
Epoch Pharmaceuticals, Inc. |
Covalently linked oligonucleotide minor grove binder conjugates
|
|
US5756352A
(en)
|
1995-06-07 |
1998-05-26 |
Gen-Probe Incorporated |
Thiocationic lipid-nucleic acid conjugates
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
US8217015B2
(en)
|
2003-04-04 |
2012-07-10 |
Arrowhead Madison Inc. |
Endosomolytic polymers
|
|
US7144869B2
(en)
|
1995-12-13 |
2006-12-05 |
Mirus Bio Corporation |
Nucleic acid injected into hapatic vein lumen and delivered to primate liver
|
|
US5998203A
(en)
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
|
US6444806B1
(en)
|
1996-04-30 |
2002-09-03 |
Hisamitsu Pharmaceutical Co., Inc. |
Conjugates and methods of forming conjugates of oligonucleotides and carbohydrates
|
|
US20080119427A1
(en)
|
1996-06-06 |
2008-05-22 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US6111085A
(en)
|
1996-09-13 |
2000-08-29 |
Isis Pharmaceuticals, Inc. |
Carbamate-derivatized nucleosides and oligonucleosides
|
|
US6001991A
(en)
|
1996-10-04 |
1999-12-14 |
Isis Pharmaceuticals Inc. |
Antisense oligonucleotide modulation of MDR P-glycoprotein gene expression
|
|
EP2319854B1
(en)
|
1997-01-08 |
2016-11-30 |
Sigma-Aldrich Co. LLC |
Bioconjugation Of Macromolecules
|
|
US6001311A
(en)
|
1997-02-05 |
1999-12-14 |
Protogene Laboratories, Inc. |
Apparatus for diverse chemical synthesis using two-dimensional array
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
JP4236812B2
(ja)
|
1997-09-12 |
2009-03-11 |
エクシコン エ／エス |
オリゴヌクレオチド類似体
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US6686150B1
(en)
|
1998-01-27 |
2004-02-03 |
Clinical Micro Sensors, Inc. |
Amplification of nucleic acids with electronic detection
|
|
WO1999037819A2
(en)
|
1998-01-27 |
1999-07-29 |
Clinical Micro Sensors, Inc. |
Amplification of nucleic acids with electronic detection
|
|
EP1071753A2
(en)
|
1998-04-20 |
2001-01-31 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
AU765597B2
(en)
|
1998-05-06 |
2003-09-25 |
Clinical Micro Sensors, Inc. |
Electronic detection of nucleic acids using monolayers
|
|
AU763494B2
(en)
|
1998-05-06 |
2003-07-24 |
Clinical Micro Sensors, Inc. |
Electronic methods for the detection of analytes utilizing monolayers
|
|
US6300319B1
(en)
|
1998-06-16 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Targeted oligonucleotide conjugates
|
|
JP4238381B2
(ja)
|
1998-07-17 |
2009-03-18 |
株式会社島津製作所 |
ピレン修飾ｒｎａ、およびｒｎａの分析方法
|
|
US6271358B1
(en)
|
1998-07-27 |
2001-08-07 |
Isis Pharmaceuticals, Inc. |
RNA targeted 2′-modified oligonucleotides that are conformationally preorganized
|
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
|
US6166239A
(en)
|
1998-09-04 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide protecting groups
|
|
US6335437B1
(en)
|
1998-09-07 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Methods for the preparation of conjugated oligomers
|
|
CA2361201A1
(en)
|
1999-01-28 |
2000-08-03 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
|
|
ES2234563T5
(es)
|
1999-02-12 |
2018-01-17 |
Daiichi Sankyo Company, Limited |
Nuevos análogos de nucleósidos y oligonucleótidos
|
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
|
US7053207B2
(en)
|
1999-05-04 |
2006-05-30 |
Exiqon A/S |
L-ribo-LNA analogues
|
|
US6525191B1
(en)
|
1999-05-11 |
2003-02-25 |
Kanda S. Ramasamy |
Conformationally constrained L-nucleosides
|
|
US20080281041A1
(en)
|
1999-06-07 |
2008-11-13 |
Rozema David B |
Reversibly Masked Polymers
|
|
US8211468B2
(en)
|
1999-06-07 |
2012-07-03 |
Arrowhead Madison Inc. |
Endosomolytic polymers
|
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
|
EP1194593A2
(en)
|
1999-07-20 |
2002-04-10 |
Clinical Micro Sensors, Inc. |
Amplification of nucleic acids with electronic detection
|
|
JP4151751B2
(ja)
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
|
US6677445B1
(en)
|
1999-08-27 |
2004-01-13 |
Chiron Corporation |
Chimeric antisense oligonucleotides and cell transfecting formulations thereof
|
|
US6617442B1
(en)
|
1999-09-30 |
2003-09-09 |
Isis Pharmaceuticals, Inc. |
Human Rnase H1 and oligonucleotide compositions thereof
|
|
US6395437B1
(en)
|
1999-10-29 |
2002-05-28 |
Advanced Micro Devices, Inc. |
Junction profiling using a scanning voltage micrograph
|
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
|
GB0001309D0
(en)
|
2000-01-20 |
2000-03-08 |
Nestle Sa |
Valve arrangement
|
|
AU2001247414A1
(en)
|
2000-03-14 |
2001-09-24 |
Active Motif |
Oligonucleotide analogues, methods of synthesis and methods of use
|
|
US6753143B2
(en)
|
2000-05-01 |
2004-06-22 |
Clinical Micro Sensors, Inc. |
Target analyte detection using asymmetrical self-assembled monolayers
|
|
US6559279B1
(en)
|
2000-09-08 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Process for preparing peptide derivatized oligomeric compounds
|
|
US20030191075A1
(en)
|
2002-02-22 |
2003-10-09 |
Cook Phillip Dan |
Method of using modified oligonucleotides for hepatic delivery
|
|
US8138383B2
(en)
|
2002-03-11 |
2012-03-20 |
Arrowhead Madison Inc. |
Membrane active heteropolymers
|
|
US8008355B2
(en)
|
2002-03-11 |
2011-08-30 |
Roche Madison Inc. |
Endosomolytic poly(vinyl ether) polymers
|
|
JP4801348B2
(ja)
|
2002-05-06 |
2011-10-26 |
エンドサイト，インコーポレイテッド |
ビタミンを標的とした造影剤
|
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
|
US20040219565A1
(en)
|
2002-10-21 |
2004-11-04 |
Sakari Kauppinen |
Oligonucleotides useful for detecting and analyzing nucleic acids of interest
|
|
WO2004041889A2
(en)
|
2002-11-05 |
2004-05-21 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
US20050233342A1
(en)
|
2003-03-07 |
2005-10-20 |
Muthiah Manoharan |
Methods of preventing off-target gene silencing
|
|
CA2518475C
(en)
|
2003-03-07 |
2014-12-23 |
Alnylam Pharmaceuticals, Inc. |
Irna agents comprising asymmetrical modifications
|
|
US7723509B2
(en)
*
|
2003-04-17 |
2010-05-25 |
Alnylam Pharmaceuticals |
IRNA agents with biocleavable tethers
|
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
|
ES2702942T3
(es)
|
2003-04-17 |
2019-03-06 |
Alnylam Pharmaceuticals Inc |
Agentes de ARNi modificados
|
|
US8017762B2
(en)
|
2003-04-17 |
2011-09-13 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
|
AU2004263830B2
(en)
|
2003-06-13 |
2008-12-18 |
Alnylam Pharmaceuticals, Inc. |
Double-stranded ribonucleic acid with increased effectiveness in an organism
|
|
EP1661905B9
(en)
|
2003-08-28 |
2012-12-19 |
IMANISHI, Takeshi |
Novel artificial nucleic acids of n-o bond crosslinkage type
|
|
PL1667522T3
(pl)
|
2003-09-09 |
2018-06-29 |
Geron Corporation |
Zmodyfikowane oligonukleotydy do hamowania telomerazy
|
|
ATE452188T1
(de)
|
2004-02-10 |
2010-01-15 |
Sirna Therapeutics Inc |
Rna-interferenz-vermittelte hemmung der genexpression unter verwendung multifunktioneller sina (short interfering nucleic acid)
|
|
EP1768998A2
(en)
|
2004-04-27 |
2007-04-04 |
Alnylam Pharmaceuticals Inc. |
Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
|
|
US20090203132A1
(en)
|
2004-09-09 |
2009-08-13 |
Swayze Eric E |
Pyrrolidinyl groups for attaching conjugates to oligomeric compounds
|
|
ITMI20042007A1
(it)
|
2004-10-21 |
2005-01-21 |
Consiglio Nazionale Ricerche |
"modulatori del ricettore gpr17 e loro impieghi terapeutici"
|
|
CN101321868A
(zh)
|
2005-09-16 |
2008-12-10 |
科利制药公司 |
通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性
|
|
DE502005008153D1
(de)
|
2005-11-23 |
2009-10-29 |
Roche Diagnostics Gmbh |
Polynukleotid mit Phosphatmimetikum
|
|
EP1989307B1
(en)
|
2006-02-08 |
2012-08-08 |
Quark Pharmaceuticals, Inc. |
NOVEL TANDEM siRNAS
|
|
WO2007095387A2
(en)
|
2006-02-17 |
2007-08-23 |
Dharmacon, Inc. |
Compositions and methods for inhibiting gene silencing by rna interference
|
|
KR101221589B1
(ko)
|
2006-04-07 |
2013-01-15 |
이데라 파마슈티칼즈, 인코포레이티드 |
Ｔｌｒ７ 및 ｔｌｒ８에 대한 안정화된 면역 조절성 ｒｎａ〔ｓｉｍｒａ〕 화합물
|
|
JP2008167739A
(ja)
|
2006-06-14 |
2008-07-24 |
National Institute Of Advanced Industrial & Technology |
Ｒｎａ干渉効果が高い修飾型二本鎖ｒｎａ
|
|
US8017109B2
(en)
|
2006-08-18 |
2011-09-13 |
Roche Madison Inc. |
Endosomolytic poly(acrylate) polymers
|
|
CN101500548A
(zh)
|
2006-08-18 |
2009-08-05 |
弗·哈夫曼-拉罗切有限公司 |
用于体内递送多核苷酸的多缀合物
|
|
AU2007299705B2
(en)
|
2006-09-22 |
2012-09-06 |
Dharmacon, Inc. |
Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
|
|
JP5252622B2
(ja)
|
2007-01-17 |
2013-07-31 |
独立行政法人産業技術総合研究所 |
高いヌクレアーゼ耐性と優れたｒｎａ干渉効果を発現可能な二本鎖ｒｎａ
|
|
JP2008220366A
(ja)
|
2007-02-16 |
2008-09-25 |
National Institute Of Advanced Industrial & Technology |
修飾型ｐｎａ／ｒｎａ複合体
|
|
JP2010532786A
(ja)
|
2007-07-06 |
2010-10-14 |
ノースイースタン ユニバーシティ |
Ｒｎａ薬剤の両親媒性接合を含む混合ミセルおよびその使用
|
|
EP2357231A2
(en)
|
2007-07-09 |
2011-08-17 |
Idera Pharmaceuticals, Inc. |
Stabilized immune modulatory RNA (SIMRA) compounds
|
|
TW200927177A
(en)
|
2007-10-24 |
2009-07-01 |
Nat Inst Of Advanced Ind Scien |
Lipid-modified double-stranded RNA having potent RNA interference effect
|
|
WO2009073809A2
(en)
|
2007-12-04 |
2009-06-11 |
Alnylam Pharmaceuticals, Inc. |
Carbohydrate conjugates as delivery agents for oligonucleotides
|
|
WO2009082606A2
(en)
|
2007-12-04 |
2009-07-02 |
Alnylam Pharmaceuticals, Inc. |
Folate conjugates
|
|
CA2721183C
(en)
*
|
2008-04-11 |
2019-07-16 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
WO2009151600A2
(en)
|
2008-06-10 |
2009-12-17 |
Tufts University |
Smad proteins control drosha-mediated mirna maturation
|
|
EP2321414B1
(en)
|
2008-07-25 |
2018-01-10 |
Alnylam Pharmaceuticals, Inc. |
Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand
|
|
AU2009298802A1
(en)
*
|
2008-09-23 |
2010-04-08 |
Alnylam Pharmaceuticals, Inc. |
Chemical modifications of monomers and oligonucleotides with cycloaddition
|
|
AU2010221419B2
(en)
|
2009-03-02 |
2015-10-01 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
|
WO2010129672A1
(en)
*
|
2009-05-05 |
2010-11-11 |
Miragen Therapeutics |
Lipophilic polynucleotide conjugates
|
|
WO2010141511A2
(en)
|
2009-06-01 |
2010-12-09 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotides for multivalent rna interference, compositions and methods of use thereof
|
|
EP2264169A1
(en)
|
2009-06-15 |
2010-12-22 |
Qiagen GmbH |
Modified siNA
|
|
EP2470656B1
(en)
|
2009-08-27 |
2015-05-06 |
Idera Pharmaceuticals, Inc. |
Composition for inhibiting gene expression and uses thereof
|
|
SI2539451T1
(sl)
*
|
2010-02-24 |
2016-04-29 |
Arrowhead Research Corporation |
Sestavki za ciljano dostavo sirna
|
|
CN103200945B
(zh)
|
2010-03-24 |
2016-07-06 |
雷克西制药公司 |
眼部症候中的rna干扰
|
|
CN101824062B
(zh)
|
2010-04-16 |
2013-07-24 |
北京欧凯纳斯科技有限公司 |
一种用烷烃锁定的siRNA双链及锁定方法
|
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
|
EP2601204B1
(en)
|
2010-04-28 |
2016-09-07 |
Ionis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
|
JP2013541510A
(ja)
|
2010-08-31 |
2013-11-14 |
メルク・シャープ・エンド・ドーム・コーポレイション |
新規の単一の化学物質、およびオリゴヌクレオチドの送達方法
|
|
CA2812046A1
(en)
|
2010-09-15 |
2012-03-22 |
Alnylam Pharmaceuticals, Inc. |
Modified irna agents
|
|
BR112014001075A2
(pt)
|
2011-07-19 |
2016-11-29 |
Univ Idaho |
sonda, seu uso, método in vitro para associar uma sonda com um alvo e kit
|
|
WO2013033230A1
(en)
|
2011-08-29 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
KR20140091688A
(ko)
|
2011-10-06 |
2014-07-22 |
미라젠 세러퓨틱스 인코포레이티드 |
마이크로rna 조절에 의한 전신 에너지 항상성의 제어
|
|
SI3366775T2
(sl)
|
2011-11-18 |
2025-12-31 |
Alnylam Pharmaceuticals, Inc. |
Modificirana sredstva RNAI
|
|
JP6375289B2
(ja)
|
2012-04-05 |
2018-08-15 |
マサチューセッツ インスティテュート オブ テクノロジー |
免疫刺激組成物およびその使用方法
|
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
|
US20150299696A1
(en)
|
2012-05-02 |
2015-10-22 |
Sirna Therapeutics, Inc. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
|
TW201808342A
(zh)
|
2012-05-02 |
2018-03-16 |
喜納製藥公司 |
包含四ｇａｌｎａｃ之新穎結合物及傳送寡核苷酸之方法
|
|
WO2013180038A1
(ja)
|
2012-05-26 |
2013-12-05 |
株式会社ボナック |
デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子
|
|
CN104619711B
(zh)
|
2012-06-01 |
2018-02-13 |
英威达纺织（英国）有限公司 |
水解催化剂及方法
|
|
WO2014005596A1
(en)
|
2012-07-03 |
2014-01-09 |
Aarhus Universitet |
Modified payload molecules and their interactions and uses
|
|
KR102213609B1
(ko)
|
2012-07-13 |
2021-02-08 |
웨이브 라이프 사이언시스 리미티드 |
키랄 제어
|
|
AU2013296321B2
(en)
|
2012-08-03 |
2019-05-16 |
Alnylam Pharmaceuticals, Inc. |
Modified RNAi agents
|
|
EP2712870A1
(en)
|
2012-09-27 |
2014-04-02 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Novel RIG-I ligands and methods for producing them
|
|
IL292159B1
(en)
|
2012-12-05 |
2026-04-01 |
Alnylam Pharmaceuticals Inc |
PCSK9 iRNA compositions and methods of using them
|
|
CA2900238A1
(en)
|
2013-02-22 |
2014-08-28 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) molecules containing a 2' internucleoside linkage
|
|
WO2015006740A2
(en)
|
2013-07-11 |
2015-01-15 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotide-ligand conjugates and process for their preparation
|
|
US10119136B2
(en)
|
2014-01-09 |
2018-11-06 |
Alnylam Pharmaceuticals, Inc. |
RNAi agents modified at the 4′-C position
|
|
BR112016016400A2
(pt)
|
2014-01-16 |
2017-10-03 |
Wave Life Sciences Ltd |
Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos
|
|
TR201908550T4
(tr)
|
2014-06-04 |
2019-07-22 |
Exicure Inc |
Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
|
|
CA2950960A1
(en)
|
2014-06-06 |
2015-12-10 |
Solstice Biologics, Ltd. |
Polynucleotide constructs having bioreversible and non-bioreversible groups
|
|
IL316808A
(en)
|
2014-08-20 |
2025-01-01 |
Alnylam Pharmaceuticals Inc |
Modified double-stranded RNA materials and their uses
|
|
RU2708237C2
(ru)
|
2014-08-22 |
2019-12-05 |
Общество с ограниченной ответственностью "НооГен" |
Модифицированные олигонуклеотиды и способ их получения
|
|
WO2016057597A1
(en)
|
2014-10-09 |
2016-04-14 |
Albert Einstein College Of Medicine, Inc. |
Programmed cargo release using nucleic acid-stabilized micelles
|
|
WO2016057693A1
(en)
|
2014-10-10 |
2016-04-14 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhalation delivery of conjugated oligonucleotide
|
|
KR102545316B1
(ko)
*
|
2014-11-10 |
2023-06-22 |
알닐람 파마슈티칼스 인코포레이티드 |
Ｂ형 간염 바이러스(ｈｂｖ) ｉｒｎａ 조성물 및 그의 이용 방법
|
|
JP2018504380A
(ja)
|
2014-12-18 |
2018-02-15 |
アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
Ｒｅｖｅｒｓｉｒ（商標）化合物
|
|
CA2973702A1
(en)
|
2015-01-14 |
2016-07-21 |
Exicure, Inc. |
Nucleic acid nanostructures with core motifs
|
|
CA3205381A1
(en)
|
2015-07-17 |
2017-01-26 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
|
IL320434A
(en)
|
2015-07-22 |
2025-06-01 |
Wave Life Sciences Ltd |
Oligonucleotide preparations and methods
|
|
EP3147364A1
(en)
|
2015-09-28 |
2017-03-29 |
Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS) |
Antiviral agents comprising an oligonucleotide-lipid conjugate forming g-quadruplex
|
|
IL295755A
(en)
|
2015-10-09 |
2022-10-01 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods thereof
|
|
CN105194689A
(zh)
|
2015-10-10 |
2015-12-30 |
湖南中楚博生物科技有限公司 |
一种基于siRNA的双偶联复合物
|
|
WO2017189870A1
(en)
|
2016-04-27 |
2017-11-02 |
Massachusetts Institute Of Technology |
Stable nanoscale nucleic acid assemblies and methods thereof
|
|
CN109462995A
(zh)
|
2016-05-04 |
2019-03-12 |
波涛生命科学有限公司 |
生物活性剂的方法和组合物
|
|
RU2019113301A
(ru)
|
2016-10-17 |
2020-11-17 |
Апеллис Фармасьютикалс, Инк. |
Комбинированная терапия для ингибирования с3
|
|
US11504391B1
(en)
|
2016-11-23 |
2022-11-22 |
Alnylam Pharmaceuticals, Inc. |
Modified RNA agents with reduced off-target effect
|
|
US11268093B2
(en)
|
2017-01-03 |
2022-03-08 |
Rula Zain-Luqman |
Therapeutic method for huntington's disease
|
|
EP3570892A4
(en)
|
2017-01-18 |
2020-11-25 |
Alnylam Pharmaceuticals, Inc. |
ENDOSOMAL CLIVABLE LINKS
|
|
WO2018165541A1
(en)
|
2017-03-10 |
2018-09-13 |
The Board Of Regents Of The University Of Texas System |
Treatment of fuchs' endothelial corneal dystrophy
|
|
EP3603648B1
(en)
|
2017-03-29 |
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Complex of nucleic acid medicine and multibranched lipid
|
|
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(ja)
|
2017-06-02 |
2020-07-30 |
ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． |
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|
|
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(en)
|
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|
|
JP2020531450A
(ja)
|
2017-08-17 |
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|
|
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(en)
|
2017-12-21 |
2020-10-28 |
Alnylam Pharmaceuticals Inc. |
Chirally-enriched double-stranded rna agents
|
|
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(en)
|
2018-02-28 |
2023-11-22 |
National University Corporation Tokyo Medical and Dental University |
Ischemic-lesion-site-specific gene therapy
|
|
WO2019217397A2
(en)
|
2018-05-07 |
2019-11-14 |
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|
|
JP7665509B2
(ja)
|
2018-05-11 |
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アルファ アノマリック エスアエス |
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|
|
JP7384833B2
(ja)
|
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|
|
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(zh)
|
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|
|
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(en)
|
2018-07-06 |
2022-04-20 |
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|
|
SG11202111387YA
(en)
|
2019-04-25 |
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|