JP2024523265A5 - - Google Patents

Info

Publication number
JP2024523265A5
JP2024523265A5 JP2023576324A JP2023576324A JP2024523265A5 JP 2024523265 A5 JP2024523265 A5 JP 2024523265A5 JP 2023576324 A JP2023576324 A JP 2023576324A JP 2023576324 A JP2023576324 A JP 2023576324A JP 2024523265 A5 JP2024523265 A5 JP 2024523265A5
Authority
JP
Japan
Prior art keywords
purines
pyrimidines
modified
fluoro
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023576324A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024523265A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/033356 external-priority patent/WO2022266045A1/en
Publication of JP2024523265A publication Critical patent/JP2024523265A/ja
Publication of JP2024523265A5 publication Critical patent/JP2024523265A5/ja
Pending legal-status Critical Current

Links

JP2023576324A 2021-06-16 2022-06-14 Mtres1関連の疾患および障害の処置 Pending JP2024523265A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163211379P 2021-06-16 2021-06-16
US63/211,379 2021-06-16
PCT/US2022/033356 WO2022266045A1 (en) 2021-06-16 2022-06-14 Treatment of mtres1 related diseases and disorders

Publications (2)

Publication Number Publication Date
JP2024523265A JP2024523265A (ja) 2024-06-28
JP2024523265A5 true JP2024523265A5 (https=) 2025-06-20

Family

ID=84527350

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023576324A Pending JP2024523265A (ja) 2021-06-16 2022-06-14 Mtres1関連の疾患および障害の処置

Country Status (10)

Country Link
US (1) US20240287518A1 (https=)
EP (1) EP4355878A4 (https=)
JP (1) JP2024523265A (https=)
KR (1) KR20240034185A (https=)
CN (1) CN117980478A (https=)
AU (1) AU2022293669A1 (https=)
CA (1) CA3221625A1 (https=)
IL (1) IL309317A (https=)
MX (1) MX2023015242A (https=)
WO (1) WO2022266045A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250327127A1 (en) * 2022-10-25 2025-10-23 Empirico Inc. Small molecule treatment of mtres1 related diseases and disorders
EP4608981A1 (en) * 2022-10-25 2025-09-03 Empirico Inc. Gene therapy treatment of mtres1 related diseases and disorders
WO2025158407A2 (en) * 2024-01-26 2025-07-31 Empirico Inc. Treatment of mtres1 related diseases and disorders
WO2025226835A1 (en) * 2024-04-24 2025-10-30 Empirico Inc. Gene therapy treatment of mtres1 related diseases and disorders
WO2025255269A1 (en) * 2024-06-05 2025-12-11 Empirico Inc. Treatment of mtres1 related diseases and disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080279846A1 (en) * 2007-05-11 2008-11-13 Thomas Jefferson University Methods of treatment and prevention of neurodegenerative diseases and disorders
US10004814B2 (en) * 2013-11-11 2018-06-26 Sirna Therapeutics, Inc. Systemic delivery of myostatin short interfering nucleic acids (siNA) conjugated to a lipophilic moiety
WO2015138960A2 (en) * 2014-03-14 2015-09-17 The General Hospital Corporation Molecular re-engineering of excitation-inhibition balance in memory circuits
PH12018501207B1 (en) * 2015-12-21 2024-02-23 Novartis Ag Compositions and methods for decreasing tau expression
US20220267773A1 (en) * 2019-07-23 2022-08-25 University Of Rochester Targeted RNA cleavage with CRISPR-Cas

Similar Documents

Publication Publication Date Title
JP2024523265A5 (https=)
AU2018202014B2 (en) Rna interference in dermal and fibrotic indications
JP2023040012A (ja) 分岐オリゴヌクレオチド
CA3070747A1 (en) Chemically modified oligonucleotides
EP2949752B1 (en) Reduced size self-delivering rnai compounds
JP2022515193A5 (https=)
JP2023522701A5 (https=)
JP2021533804A5 (https=)
JP2022501057A5 (https=)
JP2022526419A (ja) 中枢神経系における遺伝子発現を阻害するための組成物及び方法
BR112015027369B1 (pt) compostos compreendendo um oligonucleotídeo modificado e um grupo de conjugado, composição compreendendo os referidos compostos e usos dos mesmos
WO2017007825A1 (en) Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
JP2011105761A (ja) 神経変性疾患を治療する方法
WO2011119871A1 (en) Rna interference in ocular indications
TW202246502A (zh) 抑制中樞神經系統中的基因表現之組成物及方法
EP4055167A2 (en) Chemically modified oligonucleotides targeting bromodomain containing protein 4 (brd4) for immunotherapy
TW202333750A (zh) RNAi寡核苷酸共軛體
JP2023544413A5 (https=)
TW202400792A (zh) 用於抑制mapt表現之組合物及方法
WO2023015265A2 (en) Chemically modified oligonucleotides
WO2024064769A1 (en) Induction of stem-like activated t cells
CN119630791A (zh) 用于抑制snca表达的组合物和方法
JP2024519293A5 (https=)
TW202340462A (zh) 靶定中樞神經系統的寡樹突細胞之脂質結合物
TW202335674A (zh) 靶定中樞神經系統的星狀細胞之脂質結合物