JP2022501057A5 - - Google Patents

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Publication number
JP2022501057A5
JP2022501057A5 JP2021517243A JP2021517243A JP2022501057A5 JP 2022501057 A5 JP2022501057 A5 JP 2022501057A5 JP 2021517243 A JP2021517243 A JP 2021517243A JP 2021517243 A JP2021517243 A JP 2021517243A JP 2022501057 A5 JP2022501057 A5 JP 2022501057A5
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JP
Japan
Prior art keywords
seq
double
phosphate
rnai agent
stranded rnai
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JP2021517243A
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English (en)
Japanese (ja)
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JP7470107B2 (ja
JP2022501057A (ja
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Priority claimed from PCT/US2019/053050 external-priority patent/WO2020069055A1/en
Publication of JP2022501057A publication Critical patent/JP2022501057A/ja
Publication of JP2022501057A5 publication Critical patent/JP2022501057A5/ja
Application granted granted Critical
Publication of JP7470107B2 publication Critical patent/JP7470107B2/ja
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JP2021517243A 2018-09-28 2019-09-26 トランスサイレチン(TTR)iRNA組成物及びTTR関連眼疾患を治療又は予防するためのその使用方法 Active JP7470107B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862738256P 2018-09-28 2018-09-28
US62/738,256 2018-09-28
US201962844174P 2019-05-07 2019-05-07
US62/844,174 2019-05-07
PCT/US2019/053050 WO2020069055A1 (en) 2018-09-28 2019-09-26 Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases

Publications (3)

Publication Number Publication Date
JP2022501057A JP2022501057A (ja) 2022-01-06
JP2022501057A5 true JP2022501057A5 (https=) 2022-10-03
JP7470107B2 JP7470107B2 (ja) 2024-04-17

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ID=68172281

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JP2021517243A Active JP7470107B2 (ja) 2018-09-28 2019-09-26 トランスサイレチン(TTR)iRNA組成物及びTTR関連眼疾患を治療又は予防するためのその使用方法

Country Status (7)

Country Link
US (2) US20220333104A1 (https=)
EP (1) EP3856907A1 (https=)
JP (1) JP7470107B2 (https=)
AU (2) AU2019350765A1 (https=)
CA (1) CA3114396A1 (https=)
TW (1) TW202028465A (https=)
WO (1) WO2020069055A1 (https=)

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PT3329002T (pt) 2015-07-31 2021-01-12 Alnylam Pharmaceuticals Inc Composições de iarn de transtirretina (ttr) e métodos de seu uso para tratamento ou prevenção de doenças associadas à ttr
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
EP4133076A1 (en) * 2020-04-07 2023-02-15 Alnylam Pharmaceuticals, Inc. Angiotensin-converting enzyme 2 (ace2) irna compositions and methods of use thereof
EP4133077A1 (en) 2020-04-07 2023-02-15 Alnylam Pharmaceuticals, Inc. Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
CR20230308A (es) * 2020-12-11 2023-09-08 Civi Biopharma Inc Entrega oral de conjugados antisentido que tienen por blanco a pcsk9
WO2022192519A1 (en) * 2021-03-12 2022-09-15 Alnylam Pharmaceuticals, Inc. Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
WO2022232343A1 (en) * 2021-04-29 2022-11-03 Alnylam Pharmaceuticals, Inc. Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
AR126070A1 (es) 2021-06-08 2023-09-06 Alnylam Pharmaceuticals Inc Composiciones y métodos para tratar o prevenir la enfermedad de stargardt y/o trastornos asociados con la proteína transportadora de retinol 4 (rbp4)
CA3227852A1 (en) 2021-08-03 2023-02-09 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna compositions and methods of use thereof
JP2025541245A (ja) * 2022-12-16 2025-12-18 アムジェン インコーポレイテッド Ttr発現を阻害するためのrnaiコンストラクト及びその使用方法
EP4673453A1 (en) * 2023-03-01 2026-01-07 Wave Life Sciences Ltd. Double stranded oligonucleotide compositions for rna interference and methods relating thereto
US20260009029A1 (en) * 2023-04-14 2026-01-08 Rigerna Therapeutics (Suzhou) Co., Ltd. Compound for inhibiting expression of lpa gene, pharmaceutical composition and use thereof
WO2025113470A1 (en) * 2023-11-27 2025-06-05 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of transthyretin (ttr)

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