JP2020514323A - 短鎖デヒドロゲナーゼ活性を調節する組成物と方法 - Google Patents

短鎖デヒドロゲナーゼ活性を調節する組成物と方法 Download PDF

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JP2020514323A
JP2020514323A JP2019542115A JP2019542115A JP2020514323A JP 2020514323 A JP2020514323 A JP 2020514323A JP 2019542115 A JP2019542115 A JP 2019542115A JP 2019542115 A JP2019542115 A JP 2019542115A JP 2020514323 A JP2020514323 A JP 2020514323A
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JP2020514323A5 (enExample
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ディー． マーコウィッツ，サンフォード
ディー． マーコウィッツ，サンフォード
ユアン，イエン
チャン，ヤンユ
レディー，ジョセフ
フー，ビン
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The University of Texas System
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Priority to JP2025060076A priority patent/JP7895466B2/ja
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JP2019542115A 2017-02-06 2018-02-06 短鎖デヒドロゲナーゼ活性を調節する組成物と方法 Pending JP2020514323A (ja)

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JP2022128740A JP7660087B2 (ja) 2017-02-06 2022-08-12 短鎖デヒドロゲナーゼ活性を調節する組成物と方法
JP2025060076A JP7895466B2 (ja) 2017-02-06 2025-03-31 短鎖デヒドロゲナーゼ活性を調節する組成物と方法

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US201762455399P 2017-02-06 2017-02-06
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PCT/US2018/017044 WO2018145080A1 (en) 2017-02-06 2018-02-06 Compositions and methods of modulating short-chain dehydrogenase activity

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
JP2023535496A (ja) * 2020-07-27 2023-08-17 イスファム・バイオテック・ピーティーワイ・リミテッド 化合物
JP2023552832A (ja) * 2020-12-09 2023-12-19 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 関節の構造および機能を改善するためのプロスタグランジン分解酵素１５－ｐｇｄｈの阻害法
JP2024520689A (ja) * 2021-06-02 2024-05-24 大塚製薬株式会社 皮膚疾患治療用ピラゾロ［１，５－ａ］ピリミジン化合物
WO2025109866A1 (ja) * 2023-11-22 2025-05-30 克昭 團 血管修復機能向上用組成物、男性機能向上用組成物、医薬品、化粧品および食品または飲料
US12336982B2 (en) 2018-11-21 2025-06-24 Rodeo Therapeutics Corporation Compositions and methods of modulating short-chain dehydrogenase activity
US12616681B2 (en) 2019-04-04 2026-05-05 Case Western Reserve University Compositions and methods for treating renal injury

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016144958A1 (en) 2015-03-08 2016-09-15 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating fibrosis
CA2927730A1 (en) 2013-10-15 2015-05-07 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
JP7178360B2 (ja) 2017-04-07 2022-11-25 ケース ウエスタン リザーブ ユニバーシティ 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤
CA3110856C (en) 2018-08-26 2024-05-28 Hair Plus Health Llc Methods and compositions to increase hair growth and/or prevent hair loss
JP7575952B2 (ja) 2019-01-08 2024-10-30 杏林製薬株式会社 １５－ｐｇｄｈ阻害薬
WO2020160151A1 (en) 2019-01-31 2020-08-06 Kyorin Pharmaceutical Co., Ltd. 15-pgdh inhibitors
JP7677983B2 (ja) * 2020-01-23 2025-05-15 マイオフォルテ セラピューティクス，インク． Ｐｇｄｈ阻害剤、およびその作製と使用の方法
CR20220654A (es) 2020-05-20 2023-08-24 Rodeo Therapeutics Corp Composiciones y métodos para modular la actividad de deshidrogenasas de cadena corta
WO2021252936A1 (en) * 2020-06-11 2021-12-16 The Board Of Trustees Of The Leland Stanford Junior University Rejuvenation of aged tissues and organs by inhibition of the pge2 degrading enzyme, 15-pgdh
WO2022020889A1 (en) * 2020-07-27 2022-02-03 Esfam Biotech Pty Ltd Method of treatment of cytomegalovirus
WO2022020891A1 (en) * 2020-07-27 2022-02-03 Esfam Biotech Pty Ltd Methods of prophylaxis and treatment of corona virus
WO2022020890A1 (en) * 2020-07-27 2022-02-03 Esfam Biotech Pty Ltd Treatment of veterinary conditions associated with cd151
WO2022020887A1 (en) * 2020-07-27 2022-02-03 Esfam Biotech Pty Ltd Treatment of cd151 related disorders
WO2022032230A1 (en) * 2020-08-07 2022-02-10 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating neurodegeneration
EP4228650A4 (en) * 2020-10-15 2024-12-18 Myoforte Therapeutics Inc. INHALATED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF
PY2193067A (es) 2020-10-23 2022-06-20 Ildong Pharmaceutical Co Ltd Compuestos moduladores del cftr, composiciones y usos de estos
US20240000758A1 (en) * 2020-10-23 2024-01-04 The Board Of Trustees Of The Leland Stanford Junior University Elevation of mitochondrial biogenesis and function by inhibition of prostaglandin degrading enzyme 15-pgdh
US20230310424A1 (en) * 2020-11-20 2023-10-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for increasing nicotinamide phosphoribosyl transferase activity
WO2023076986A1 (en) * 2021-10-27 2023-05-04 The Board Of Trustees Of The Leland Stanford Junior University Regeneration or rejuvenation of tissues and organs
CN116120285A (zh) * 2021-11-08 2023-05-16 武汉人福创新药物研发中心有限公司 杂环类化合物及其制备方法和用途
WO2023137353A1 (en) * 2022-01-14 2023-07-20 Ventyx Biosciences, Inc. 15-pgdh inhibitors
CA3243368A1 (en) * 2022-01-28 2025-01-16 Scinnohub Pharmaceutical Co., Ltd. COMPOUND FOR REGULATING AND CONTROLLING THE ACTIVITY OF 15-PGDH AND ITS PREPARATION PROCESS
CN114875003B (zh) * 2022-04-06 2024-05-24 浙江大学 一种短链脱氢酶的突变体、编码基因及编码基因获得方法、突变体的应用
US20250250283A1 (en) * 2022-04-13 2025-08-07 Scinnohub Pharmaceutical Co., Ltd. Compound capable of regulating and controlling activity of 15-pgdh, and preparation method therefor
TW202404603A (zh) * 2022-04-20 2024-02-01 南韓商日東製藥股份有限公司 包含ｃｆｔｒ活化劑的組成物
WO2023204629A1 (ko) * 2022-04-20 2023-10-26 일동제약(주) Cftr 활성제 화합물을 제조하는 방법 및 이에 사용되는 중간체
WO2024099429A1 (zh) * 2022-11-11 2024-05-16 赛诺哈勃药业（成都）有限公司 一种调控15-pgdh活性的化合物及其制备方法
JP2026517842A (ja) * 2023-05-09 2026-06-02 アムジエン・インコーポレーテツド １５－プロスタグランジン脱水素酵素モジュレーターとして使用するための６，６－縮合二環式アミド及び組成物
TW202446380A (zh) * 2023-05-19 2024-12-01 大陸商成都倍特藥業股份有限公司 一種調控15-pgdh活性的化合物、包含其的藥物組合物及它們的用途
US20260125398A1 (en) * 2024-11-04 2026-05-07 Amgen Inc. 5,6-fused bicyclic alcohol compounds as 15-prostaglandin dehydrogenase modulators

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003286171A (ja) * 2002-03-28 2003-10-07 Sumitomo Pharmaceut Co Ltd Ｐａｒ阻害剤
JP2006522750A (ja) * 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法
WO2008063671A2 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
WO2009082691A1 (en) * 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
WO2010111711A2 (en) * 2009-03-27 2010-09-30 Zacharon Pharmaceuticals, Inc. Ganglioside biosynthesis modulators
WO2012146933A1 (en) * 2011-04-28 2012-11-01 Cxr Biosciences Limited Cyprodinil for use in medicine
JP2015514770A (ja) * 2012-04-16 2015-05-21 ケース ウエスタン リザーブ ユニバーシティ １５−ｐｇｄｈ活性を調節する組成物および方法
WO2016144958A1 (en) * 2015-03-08 2016-09-15 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating fibrosis
JP2016531864A (ja) * 2013-09-25 2016-10-13 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｐａｒ−２シグナル伝達経路の阻害剤として有用なイミダゾピリダジン

Family Cites Families (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3382248A (en) 1965-11-01 1968-05-07 Upjohn Co 6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines
FR2274951A1 (fr) * 1974-06-11 1976-01-09 Ciba Geigy Ag Procede de preparation d'images polymeres stables par photopolymerisation dans une matrice
GR80916B (en) * 1983-11-14 1985-03-12 Dow Chemical Co Method of preparing 1,2,4-triazolo (1,5-a)-pyrimidine-2-sulfonyl chlorides
SE8405924L (sv) 1984-11-23 1986-05-24 Pharmacia Ab Nya azoforeningar
EP0271273A3 (en) 1986-12-08 1989-07-12 Merck & Co. Inc. Thieno-and furopyridine sulfonamides
US4904672A (en) 1987-01-30 1990-02-27 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors
GB8709248D0 (en) 1987-04-16 1987-05-20 Wyeth John & Brother Ltd Azo compounds
US4910226A (en) 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
DE3812177A1 (de) 1988-04-13 1989-10-26 Bayer Ag 2-phenylsulfinyl-nitro-pyridine, verfahren zu ihrer herstellung und ihre verwendung
LU87308A1 (fr) 1988-08-01 1990-03-13 Oreal Nouveaux derives de diamino-2,4 pyrimidine oxyde-3 et leur utilisation pour le traitement et la prevention de la chute des cheveux
WO1990006100A1 (en) 1988-12-02 1990-06-14 The Upjohn Company Minoxidil and vasoconstrictor compositions for treating alopecia
EP0378508B1 (de) 1989-01-11 1995-03-01 Ciba-Geigy Ag Antidots zur Verbesserung der Kulturpflanzenvertäglichkeit agrochemischer Wirkstoffe
US5015629A (en) 1989-06-26 1991-05-14 University Of Southern California Tissue repair
FR2651122B1 (fr) 1989-08-29 1994-10-28 Oreal Compositions destinees a etre utilisees pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives de l'amino-2 pyrimidine oxyde-3 et nouveaux composes derives de l'amino-2 pyrimidine oxyde-3.
US5480913A (en) 1989-09-27 1996-01-02 Arch Development Corporation Anti-androgen compounds
EP0434624B1 (de) * 1989-12-22 1995-02-08 Ciba-Geigy Ag Triazolylsulfonamide
US5217521A (en) 1989-12-22 1993-06-08 Ciba-Geigy Corporation Triazolylsulfonamides
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
FR2662607B1 (fr) 1990-05-30 1992-08-28 Oreal Composition destinee a etre utilisee pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives d'alkyl-2 amino-4 (ou dialkyl-2-4) pyrimidine oxyde-3 .
US5411981A (en) 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2677884B1 (fr) 1991-06-20 1993-07-09 Oreal Composition pour freiner la chute des cheveux a base de pyrimidines n-oxyde trisubstitues ou leurs derives sulfoconjugues, nouveaux composes pyrimidines n-oxyde ou leurs derives sulfoconjugues.
FR2678929A1 (fr) 1991-07-11 1993-01-15 Oreal Compositions pour freiner la chute des cheveux et pour induire et stimuler leur croissance a base de derives de 2,4-diamino pyrimidine 3-oxyde, nouveaux derives 2,4-diamino pyrimidine 3-oxyde.
FR2683531B1 (fr) 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.
WO1993013664A2 (en) 1992-01-11 1993-07-22 Schering Agrochemicals Limited Biheterocyclic fungicidal compounds
US5460964A (en) 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
CA2142300C (en) 1992-10-13 2005-08-23 Allen D. Roses Methods for detecting alzheimer's disease
US5445164A (en) 1993-05-11 1995-08-29 Gynetech, Inc. Cervical tissue sampling device
WO1995005843A1 (en) 1993-08-25 1995-03-02 Systemix, Inc. Method for producing a highly enriched population of hematopoietic stem cells
TW369521B (en) 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5409813A (en) 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
FR2711060B1 (fr) 1993-10-13 1995-11-17 Oreal Procédé pour modifier la pousse des poils et/ou des cheveux et compositions utilisables à cet effet.
SE9303444D0 (sv) 1993-10-20 1993-10-20 Kabi Pharmacia Ab New use of prostaglandins
US5405842A (en) 1994-01-28 1995-04-11 Silverman; Bernard A. Treatment of steroid dependent asthmatics
FR2719481B1 (fr) 1994-05-05 1996-05-31 Oreal Composition à base de composés antifongiques et de composés antibactériens halogènes pour diminuer la chute des cheveux.
US5516779A (en) 1994-06-08 1996-05-14 Merck & Co., Inc. 17β-substituted-6-azasteroid derivatives useful as 5α-reductase inhibitors
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5807895A (en) 1994-11-29 1998-09-15 Schwarz Pharma, Inc. Use of prostaglandin E1, E2 or analogs to prevent renal failure induced by medical tests that utilize contrast media agents
US5529769A (en) 1994-12-20 1996-06-25 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cosmetic compositions containing betulinic acid
FR2732597B1 (fr) 1995-04-05 1997-05-16 Oreal Utilisation dans une composition en tant qu'activateur et/ou stabilisateur de cyclooxygenase d'au moins un derive de pyrimidine substitue en 6
US5631282A (en) 1995-06-07 1997-05-20 Merck & Co., Inc. Triterpenes
US6080772A (en) 1995-06-07 2000-06-27 Sugen, Inc. Thiazole compounds and methods of modulating signal transduction
FR2739553B1 (fr) 1995-10-06 1998-01-02 Oreal Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
EP0918518A4 (en) * 1996-04-19 2002-05-02 Univ California TREATMENT OF MIND AND MOOD DISEASES WITH GLUTAMATERGIC MODULATORS.
JP3049593B2 (ja) 1996-05-01 2000-06-05 株式会社ビメーク 育毛・養毛剤
US6281227B1 (en) 1996-12-13 2001-08-28 Aventis Pharma Deutschland Gmbh Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
DE69823852T2 (de) 1997-02-04 2005-05-19 Johnstone, Murray A., Seattle Verfahren zur förderung des haarwuchses und entwicklung des haarsystems
JP3217293B2 (ja) 1997-04-17 2001-10-09 株式会社アールテック・ウエノ 発毛・育毛剤
CA2295595A1 (en) 1997-07-09 1999-01-21 Androsolutions, Inc. Improved methods and compositions for treating male erectile dysfunction
ATE268782T1 (de) 1997-12-12 2004-06-15 Univ Southern California Zusammensetzungen zur wundheilung
US6214533B1 (en) 1998-04-10 2001-04-10 Konica Corporation Thermally developable photosensitive material
US20040241727A1 (en) 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of schizophrenia related gene transcripts in blood
US20040241726A1 (en) 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of allergies related gene transcripts in blood
US7473528B2 (en) 1999-01-06 2009-01-06 Genenews Inc. Method for the detection of Chagas disease related gene transcripts in blood
US8068897B1 (en) 1999-03-01 2011-11-29 Gazdzinski Robert F Endoscopic smart probe and method
EP1080728A1 (en) 1999-03-16 2001-03-07 Toray Industries, Inc. Prostaglandin ep4 receptor agonist and treatment method
AU7360700A (en) 1999-09-09 2001-04-10 Androsolutions, Inc. Methods and compositions for preventing and treating urinary tract disorders
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020146439A1 (en) 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
WO2001072268A1 (en) 2000-03-31 2001-10-04 Toray Industries, Inc. Hair growth or hair formation controlling agents
FR2812190B1 (fr) 2000-07-28 2003-01-31 Oreal Utilisation d'agonistes non prostanoiques des recepteurs des prostaglandines ep-2 et/ou ep-4 comme agent cosmetique permettant d'attenuer, de diminuer ou d'arreter la chute des cheveux et des poils
FR2812191B1 (fr) 2000-07-28 2003-10-17 Oreal Utilisation d'agonistes du recepteur des prostaglandines e2 (ep-3) pour attenuer, diminuer ou stopper la pousse des cheveux et des poils dans des preparations cosmetiques
GEP20053675B (en) 2001-03-30 2005-11-25 Pfizer Prod Inc Pyridazinone Aldose Reductase Inhibitors
US7004913B1 (en) 2001-05-04 2006-02-28 Cdx Laboratories, Inc. Retractable brush for use with endoscope for brush biopsy
FR2825261B1 (fr) 2001-06-01 2003-09-12 Maco Pharma Sa Ligne de prelevement du sang placentaire comprenant une poche de rincage
US20030096823A1 (en) 2001-11-16 2003-05-22 Beryl Asp Method for the treatment of cardiotoxicity induced by antitumor compounds
FR2838641B1 (fr) 2002-04-23 2005-12-23 Oreal Composition cosmetique, procede de traitement cosmetique et preparation d'une composition pour favoriser la pousse et/ou empecher ou retarder la chute des cheveux
US7320967B2 (en) 2002-04-23 2008-01-22 L'oreal Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair
ATE375349T1 (de) 2002-08-02 2007-10-15 Merck & Co Inc Substituierte furo(2,3-b)pyridin derivate
JP2004067629A (ja) * 2002-08-09 2004-03-04 Yamanouchi Pharmaceut Co Ltd ミトコンドリア機能活性化剤及び新規なベンゾイミダゾール誘導体
US20060051540A1 (en) 2002-09-20 2006-03-09 Seiji Kagawa Shape-memory polybutylene terephthalate film, production process and use thereof, and process for production of polybutylene terephthalate film
FR2845000B1 (fr) 2002-09-27 2005-05-27 Oreal Utilisation d'un compose heterocyclique ou de l'un de ses sels pour stimuler ou induire la pousse des cheveux et/ou freiner leur chute
JP2006505559A (ja) 2002-10-18 2006-02-16 エフ．ホフマン−ラ　ロシュ　アーゲー ５−ｈｔ６受容体親和性を持つ４−ピペラジニルベンゼンスルホニルインドール
FR2845917B1 (fr) 2002-10-21 2006-07-07 Negma Gild Composition pharmaceutique associant le tenatoprazole et un anti-inflammatoire
US7105117B2 (en) 2003-01-06 2006-09-12 General Motors Corporation Manufacturing method for increasing thermal and electrical conductivities of polymers
WO2004069213A2 (en) 2003-01-15 2004-08-19 L'oreal Cosmetic composition comprising a 2-alkylideneaminooxyacetamide
EP1594438B1 (fr) 2003-02-12 2013-07-17 L'Oréal Utilisation d'un inhibiteur de 15-hydroxy prostaglandine déshydrogénase pour favoriser la pigmentation de la peau ou des phanères
DE602004027171D1 (de) * 2003-04-11 2010-06-24 High Point Pharmaceuticals Llc Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase
WO2004089415A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
EP1615697A2 (en) * 2003-04-11 2006-01-18 Novo Nordisk A/S New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof
US7700583B2 (en) 2003-04-11 2010-04-20 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
US7189724B2 (en) * 2003-04-15 2007-03-13 Valeant Research And Development Quinoxaline derivatives having antiviral activity
SE0301373D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
US7777051B2 (en) * 2003-05-13 2010-08-17 Icagen, Inc. Asymmetric benzimidazoles and related compounds as potassium channel modulators
CN1589793A (zh) 2003-07-24 2005-03-09 山东绿叶天然药物研究开发有限公司 鞣酸小檗碱在制备治疗溃疡性结肠炎药物中的应用
ES2559779T3 (es) 2003-08-29 2016-02-15 Vernalis (R&D) Limited Compuestos de pirimidotiofeno
US20050187221A1 (en) 2003-09-08 2005-08-25 Japan Tobacco Inc. Method of treating ischemia reperfusion injury
CN1898563B (zh) 2003-09-24 2011-11-23 肿瘤疗法科学股份有限公司 诊断乳腺癌的方法
WO2005030773A1 (ja) 2003-09-26 2005-04-07 Dainippon Sumitomo Pharma Co., Ltd. 新規ピラゾロピリミジン誘導体
FR2860431A1 (fr) 2003-10-02 2005-04-08 Oreal Composition capillaire ou de mascara contenant un compose azoique, son utilisation pour stimuler ou induire la pousse des cheveux ou des cils et/ou freiner leur chute
US20050209181A1 (en) 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
CA2551792A1 (en) 2003-12-31 2005-07-21 Basell Poliolefine Italia S.R.L. Filled olefin polymer compositions having improved mechanical properties and scratch resistance
EP1725544B1 (en) 2004-03-09 2009-05-27 Boehringer Ingelheim Pharmaceuticals Inc. 3-[4-heterocyclyl-1,2,3-triazol-1-yl]-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases
JP2005325099A (ja) 2004-04-12 2005-11-24 Sankyo Co Ltd チエノピリジン誘導体
TW200609237A (en) 2004-04-12 2006-03-16 Sankyo Co Thienopyridine derivatives
EP1781289A1 (en) 2004-07-22 2007-05-09 PTC Therapeutics, Inc. Thienopyridines for treating hepatitis c
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
WO2006048264A2 (en) 2004-11-04 2006-05-11 Roche Diagnostics Gmbh Gene expression profiling in acute lymphoblastic leukemia (all), biphenotypic acute leukemia (bal), and acute myeloid leukemia (aml) m0
WO2006048266A2 (en) 2004-11-04 2006-05-11 Roche Diagnostics Gmbh Gene expression profiling of leukemias with mll gene rearrangements
US20070155884A1 (en) 2004-11-12 2007-07-05 Basell Poliolefine Italia S.R.L. Filled olefin polymer compositions having improved mechanical properties and scratch resistance
US8000795B2 (en) 2004-12-17 2011-08-16 Lozano Andres M Cognitive function within a human brain
MX2007008227A (es) 2005-01-05 2007-09-11 Novacea Inc Prevencion de trastornos tromboticos con compuestos de vitamina d activa o mimeticos de los mismos.
AU2006206573B9 (en) 2005-01-19 2011-09-29 Merck Sharp & Dohme Corp. Bicyclic pyrimidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
US20080254459A1 (en) 2005-03-05 2008-10-16 (Harc) Houston Advanced Research Center Methods and Biomarkers for Detecting Nanoparticle Exposure
EP1871776A2 (en) 2005-03-09 2008-01-02 Schering Corporation Fused thieno[2,3-b]pyridine and thiazolo[5,4-b]pyridine compounds for inhibiting ksp kinesin activity
AR053579A1 (es) 2005-04-15 2007-05-09 Genentech Inc Tratamiento de la enfermedad inflamatoria intestinal (eii)
US20090118337A1 (en) 2005-06-03 2009-05-07 Davis Pamela B Methods and compositions for treating inflammation
AU2006259583A1 (en) 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20070059265A1 (en) 2005-06-28 2007-03-15 L'oreal Benzylidene-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss and/or for increasing the density of keratin fibers
US20070071699A1 (en) 2005-06-28 2007-03-29 L'oreal Benzylidene-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening
EP2305811A1 (en) 2005-07-27 2011-04-06 Oncotherapy Science, Inc. Method of diagnosing smal cell lung cancer
WO2007019180A2 (en) 2005-08-04 2007-02-15 Science & Technology Corporation @ Unm Compounds for binding to eralpha/beta and gpr30, methods of treating disease states and conditions mediated through these receptors and identification thereof
AU2006284751A1 (en) 2005-09-01 2007-03-08 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
AR056200A1 (es) 2005-09-27 2007-09-26 Wyeth Corp Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa
US20070078175A1 (en) 2005-10-05 2007-04-05 L'oreal Administration of novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds for stimulating or inducing the growth of keratinous fibers and/or slowing loss thereof
CN1966500B (zh) * 2005-11-17 2011-03-30 中国科学院上海药物研究所 一类喹喔啉类衍生物、制法及用途
DE602006016643D1 (de) 2005-12-20 2010-10-14 Richter Gedeon Nyrt THIENOÄ2,3-bÜPYRIDIN DERIVATE
WO2007100775A2 (en) 2006-02-27 2007-09-07 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
WO2007101225A2 (en) 2006-02-27 2007-09-07 The Board Of Trustees Of The Leland Stanford Junior University Methods to identify inhibitors of the unfolded protein response
AU2007243466B2 (en) 2006-04-26 2012-01-19 F. Hoffmann-La Roche Ag Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
US8153798B2 (en) * 2007-03-09 2012-04-10 High Point Pharmaceuticals, Llc Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors
KR20090125246A (ko) 2007-03-09 2009-12-04 코와 가부시키가이샤 전신성 에리테마토데스의 예방 및/또는 치료제
AR060498A1 (es) 2007-04-17 2008-06-18 Richter Gedeon Vegyeszet Compuestos de tieno [2,3-b] piridinas
PE20090365A1 (es) 2007-06-14 2009-04-04 Schering Corp Imidazopirazinas como inhibidores de proteina quinasa
WO2008157500A1 (en) * 2007-06-17 2008-12-24 Kalypsys, Inc. Aminoquinazoline cannabinoid receptor modulators for treatment of disease
KR100901127B1 (ko) 2007-06-22 2009-06-08 한국과학기술연구원 독소루비신 처리에 따른, 심장독성 유발 약물 검색용마커유전자 및 이를 이용한 심장독성 유발 약물 검색 방법
BRPI0813556A2 (pt) 2007-07-10 2015-06-16 Univ Columbia Termoestabilização de proteínas
US8981060B2 (en) 2007-08-27 2015-03-17 Novelmed Therapuetics, Inc. Method of inhibiting complement activation with factor Bb specific antibodies
FR2920309B1 (fr) 2007-08-28 2010-05-28 Galderma Res & Dev Utilisation de travoprost pour traiter la chute des cheveux
DE102007049451A1 (de) 2007-10-16 2009-04-23 Merck Patent Gmbh 5-Cyano-thienopyridine
WO2009073460A2 (en) * 2007-12-03 2009-06-11 Bausch & Lomb Incorporated Inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 for ocular neuroprotection
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
JP2011512346A (ja) 2008-02-15 2011-04-21 ノボビオン オイ クルクミンの可溶性錯体
CA2753844A1 (en) 2008-03-05 2009-09-11 Vicus Therapeutics, Llc Compositions and methods for mucositis and oncology therapies
WO2009120877A2 (en) 2008-03-26 2009-10-01 The Johns Hopkins University Microrna-based diagnostic testing and therapies for inflammatory bowel disease and related diseases
US7629112B1 (en) 2008-05-30 2009-12-08 Eastman Kodak Company Color photographic materials with yellow minimum density colorants
JP5180882B2 (ja) 2008-07-29 2013-04-10 株式会社プライムポリマー ポリプロピレン樹脂組成物、およびその成形体
BRPI0918971A2 (pt) 2008-08-26 2015-12-01 Boehringer Ingelheim Int tienopirimidinas para composições farmacêuticas
US20100093764A1 (en) 2008-10-13 2010-04-15 Devraj Chakravarty AMINES AND SULFOXIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
GB2465405A (en) 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
EP2383263B1 (en) 2008-12-30 2014-04-16 Industry-academic Cooperation Foundation, Chosun University Novel thiazolidinedione derivative and use thereof
PT2385832E (pt) 2009-01-08 2015-11-02 Curis Inc Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco
US8957064B2 (en) 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines
KR20100137090A (ko) 2009-06-22 2010-12-30 조선대학교산학협력단 신규한 티아졸리딘디온 유도체 및 그의 용도
WO2011006100A1 (en) 2009-07-09 2011-01-13 Crescendo Therapeutics, Llc Method of wound healing and scar modulation
CA2775354C (en) 2009-09-29 2019-01-15 Margaret Phillips Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase
EP2308883A1 (en) 2009-10-05 2011-04-13 Centre National De La Recherche Scientifique New derivatives of thieno[2,3-b]pyridine and 5,6,7,8 tetrahydrothieno[2,3 b]quinoline in particular useful in the treatment of malaria
WO2011094847A1 (en) 2010-02-04 2011-08-11 Penn Linda Z Methods and compositions for diagnosing and treating patients having multiple myeloma that respond to statin therapy
US10231976B2 (en) 2010-02-08 2019-03-19 Prairie Pharmaceuticals LLC Methods for the use of progestogen as a glucocorticoid sensitizer
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
KR101684671B1 (ko) * 2010-09-08 2016-12-09 (주)아모레퍼시픽 신규한 자외선 흡수제용 퀴녹살린계 화합물
US8440662B2 (en) * 2010-10-31 2013-05-14 Endo Pharmaceuticals, Inc. Substituted quinazoline and pyrido-pyrimidine derivatives
JP6051632B2 (ja) 2011-07-20 2016-12-27 日立化成株式会社 研磨剤及び基板の研磨方法
GB201115635D0 (en) 2011-09-09 2011-10-26 Univ Liverpool Compositions of lopinavir and ritonavir
US20130078632A1 (en) 2011-09-23 2013-03-28 Academisch Medisch Centrum Materials and methods for prognosis of progression of barrett's esophagus
CN104066837B (zh) 2011-12-02 2020-12-08 菲特治疗公司 增强的干细胞组合物
GB201120993D0 (en) 2011-12-06 2012-01-18 Imp Innovations Ltd Novel compounds and their use in therapy
WO2013088853A1 (ja) 2011-12-15 2013-06-20 国立大学法人東京農工大学 オリゴヌクレオチド、グルココルチコイド感受性増強剤、医薬組成物、及び発現ベクター
EP2806876A4 (en) 2012-01-25 2016-03-02 Proteostasis Therapeutics Inc Proteasome activity enhancing compounds
KR101370670B1 (ko) 2012-03-12 2014-03-06 조선대학교산학협력단 플라본 화합물의 15-하이드록시프로스타글란딘 탈수소효소 활성의 억제 효능 및 그의 용도
US9801863B2 (en) 2012-04-16 2017-10-31 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
KR101244964B1 (ko) 2012-05-30 2013-03-18 조선대학교산학협력단 15-히드록시프로스타글란딘 디히드로게나제 및 ｐｇｅ2 활성을 조절하는 황칠나무 추출물의 용도
US9273033B2 (en) 2012-11-20 2016-03-01 Merck Sharp & Dohme Corp. Substituted pyridone derivatives as PDE10 inhibitors
WO2014081878A2 (en) 2012-11-21 2014-05-30 Stategics, Inc. Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival
CA2905418C (en) 2013-03-13 2023-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for modulating chemotherapeutic cytotoxicity
WO2014160947A1 (en) 2013-03-29 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof
US20160376430A1 (en) 2013-07-08 2016-12-29 Prime Polymer Co., Ltd. Propylene resin composition
CA2927730A1 (en) 2013-10-15 2015-05-07 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
WO2015077382A2 (en) 2013-11-19 2015-05-28 Fight Against Cancer Innovation Trust Combined cytology and molecular testing for early detection of esophageal adenocarcinoma
CN106458934B (zh) 2014-04-18 2019-08-16 米伦纽姆医药公司 喹喔啉化合物及其用途
EP3179995B1 (en) 2014-08-12 2018-11-07 University of Pécs (Pécsi Tudományegyetem) Methods and materials for reducing ischemia-reperfusion injury
KR102255308B1 (ko) 2014-11-18 2021-05-24 삼성전자주식회사 아세틸살리실산을 포함하는 개체의 스테로이드 부작용을 예방 또는 치료하기 위한 조성물 및 그의 용도
EP3237639A2 (en) 2014-12-23 2017-11-01 Genentech, Inc. Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
WO2016164770A1 (en) 2015-04-10 2016-10-13 Bioresponse, L.L.C. Self-emulsifying formulations of dim-related indoles
EP3283074A4 (en) 2015-04-14 2018-12-05 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
ES2733836T3 (es) 2015-05-22 2019-12-03 Borealis Ag Composición polimérica reforzada con fibra
ES2733200T3 (es) 2015-05-22 2019-11-28 Borealis Ag Composite de polipropileno - fibra de carbono
EP4538365A3 (en) 2016-03-04 2025-07-30 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for muscle regeneration using prostaglandin e2
CA3031091A1 (en) 2016-07-18 2018-01-25 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for promoting neurogenesis and inhibiting nerve cell death
KR20190086764A (ko) 2016-11-30 2019-07-23 앵스티띠 파스퇴르 사람 선천성 림프 세포 전구체: 확인, 특성화, 적용
EP3548035A4 (en) 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
CN110573154A (zh) 2017-02-06 2019-12-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
JP7178360B2 (ja) 2017-04-07 2022-11-25 ケース ウエスタン リザーブ ユニバーシティ 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤
EP3630773A1 (en) 2017-05-26 2020-04-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
GB2578539B (en) 2017-06-09 2022-08-10 Univ Leland Stanford Junior Compositions and methods for preventing or treating muscle conditions
WO2019010482A1 (en) 2017-07-07 2019-01-10 Case Western Reserve University COMPOSITIONS AND METHODS FOR MODULATING COLUMN MATURATION
EP3781154A4 (en) 2018-04-04 2022-02-23 Case Western Reserve University COMPOSITIONS AND METHODS FOR TREATMENT OF KIDNEY INJURY
JP7349450B2 (ja) 2018-04-25 2023-09-22 バイエル・アクチエンゲゼルシヤフト 殺有害生物剤としての新規ヘテロアリール－トリアゾール化合物及びヘテロアリール－テトラゾール化合物
WO2020038478A1 (zh) 2018-08-24 2020-02-27 深圳市韶音科技有限公司 一种眼镜
JP2021536458A (ja) 2018-09-04 2021-12-27 マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. アリール炭化水素レセプター・アンタゴニスト及び使用方法
EP3883570A4 (en) 2018-11-21 2022-07-13 Enanta Pharmaceuticals, Inc. FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS
WO2020106998A1 (en) 2018-11-21 2020-05-28 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
WO2020160151A1 (en) 2019-01-31 2020-08-06 Kyorin Pharmaceutical Co., Ltd. 15-pgdh inhibitors
GB2599292A (en) 2019-06-11 2022-03-30 Univ Leland Stanford Junior Methods of rejuvenating aged tissue by inhibiting 15-hydroxyprostaglandin dehydrogenase (15-PGDH)
JP7677983B2 (ja) 2020-01-23 2025-05-15 マイオフォルテ セラピューティクス，インク． Ｐｇｄｈ阻害剤、およびその作製と使用の方法
AU2021224268A1 (en) 2020-02-21 2022-09-15 Case Western Reserve University Compositions and methods for treating renal injury
CR20220654A (es) 2020-05-20 2023-08-24 Rodeo Therapeutics Corp Composiciones y métodos para modular la actividad de deshidrogenasas de cadena corta
WO2021252936A1 (en) 2020-06-11 2021-12-16 The Board Of Trustees Of The Leland Stanford Junior University Rejuvenation of aged tissues and organs by inhibition of the pge2 degrading enzyme, 15-pgdh
WO2022032230A1 (en) 2020-08-07 2022-02-10 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating neurodegeneration
JP7573869B2 (ja) 2021-03-15 2024-10-28 国立研究開発法人 海上・港湾・航空技術研究所 重質油の回収方法、回収システム、及び回収装置

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003286171A (ja) * 2002-03-28 2003-10-07 Sumitomo Pharmaceut Co Ltd Ｐａｒ阻害剤
JP2006522750A (ja) * 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法
WO2008063671A2 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
WO2009082691A1 (en) * 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
WO2010111711A2 (en) * 2009-03-27 2010-09-30 Zacharon Pharmaceuticals, Inc. Ganglioside biosynthesis modulators
WO2012146933A1 (en) * 2011-04-28 2012-11-01 Cxr Biosciences Limited Cyprodinil for use in medicine
JP2015514770A (ja) * 2012-04-16 2015-05-21 ケース ウエスタン リザーブ ユニバーシティ １５−ｐｇｄｈ活性を調節する組成物および方法
JP2016531864A (ja) * 2013-09-25 2016-10-13 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｐａｒ−２シグナル伝達経路の阻害剤として有用なイミダゾピリダジン
WO2016144958A1 (en) * 2015-03-08 2016-09-15 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating fibrosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"CAS REGISTRY NO. 348151-19-9", DATABASE REGISTRY, [ONLINE], JPN7021001626, 25 July 2001 (2001-07-25), ISSN: 0004748327 *
COTERON, JOSE M. ET AL.: "Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmod", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54(15),, JPN6023000177, 22 June 2011 (2011-06-22), pages 5540 - 5561, ISSN: 0004955509 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
US12336982B2 (en) 2018-11-21 2025-06-24 Rodeo Therapeutics Corporation Compositions and methods of modulating short-chain dehydrogenase activity
US12616681B2 (en) 2019-04-04 2026-05-05 Case Western Reserve University Compositions and methods for treating renal injury
JP2023535496A (ja) * 2020-07-27 2023-08-17 イスファム・バイオテック・ピーティーワイ・リミテッド 化合物
JP7808085B2 (ja) 2020-07-27 2026-01-28 イスファム・バイオテック・ピーティーワイ・リミテッド 化合物
JP2023552832A (ja) * 2020-12-09 2023-12-19 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 関節の構造および機能を改善するためのプロスタグランジン分解酵素１５－ｐｇｄｈの阻害法
JP2024520689A (ja) * 2021-06-02 2024-05-24 大塚製薬株式会社 皮膚疾患治療用ピラゾロ［１，５－ａ］ピリミジン化合物
JP7749033B2 (ja) 2021-06-02 2025-10-03 大塚製薬株式会社 皮膚疾患治療用ピラゾロ［１，５－ａ］ピリミジン化合物
WO2025109866A1 (ja) * 2023-11-22 2025-05-30 克昭 團 血管修復機能向上用組成物、男性機能向上用組成物、医薬品、化粧品および食品または飲料

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