JP2020513824A5 - - Google Patents
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- JP2020513824A5 JP2020513824A5 JP2019551949A JP2019551949A JP2020513824A5 JP 2020513824 A5 JP2020513824 A5 JP 2020513824A5 JP 2019551949 A JP2019551949 A JP 2019551949A JP 2019551949 A JP2019551949 A JP 2019551949A JP 2020513824 A5 JP2020513824 A5 JP 2020513824A5
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- sequence
- nucleic acid
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- 150000007523 nucleic acids Chemical class 0.000 claims 94
- 239000012634 fragment Substances 0.000 claims 87
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 62
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 56
- 108020004707 nucleic acids Proteins 0.000 claims 42
- 102000039446 nucleic acids Human genes 0.000 claims 42
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 17
- 108091033409 CRISPR Proteins 0.000 claims 14
- 238000010354 CRISPR gene editing Methods 0.000 claims 13
- 108020005004 Guide RNA Proteins 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 108091026890 Coding region Proteins 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
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- 230000001105 regulatory effect Effects 0.000 claims 8
- 101150050733 Gnas gene Proteins 0.000 claims 7
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- 101001014594 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Proteins 0.000 claims 2
- 101001014610 Homo sapiens Neuroendocrine secretory protein 55 Proteins 0.000 claims 2
- 101001045218 Homo sapiens Peroxisomal multifunctional enzyme type 2 Proteins 0.000 claims 2
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- 102100023777 60S ribosomal protein L31 Human genes 0.000 claims 1
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- 101100441244 Caenorhabditis elegans csp-1 gene Proteins 0.000 claims 1
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- 101000922367 Homo sapiens Cytochrome c oxidase subunit 6B1 Proteins 0.000 claims 1
- 101000601616 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Proteins 0.000 claims 1
- 101000713613 Homo sapiens Tubulin beta-4B chain Proteins 0.000 claims 1
- 101100101580 Homo sapiens UBQLN2 gene Proteins 0.000 claims 1
- 101000607639 Homo sapiens Ubiquilin-2 Proteins 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 1
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- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091036407 Polyadenylation Proteins 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023219252A JP2024038121A (ja) | 2017-03-24 | 2023-12-26 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2017057110 | 2017-03-24 | ||
| EPPCT/EP2017/057110 | 2017-03-24 | ||
| EPPCT/EP2017/076775 | 2017-10-19 | ||
| EP2017076775 | 2017-10-19 | ||
| PCT/EP2018/057552 WO2018172556A1 (en) | 2017-03-24 | 2018-03-23 | Nucleic acids encoding crispr-associated proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023219252A Division JP2024038121A (ja) | 2017-03-24 | 2023-12-26 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020513824A JP2020513824A (ja) | 2020-05-21 |
| JP2020513824A5 true JP2020513824A5 (https=) | 2021-04-30 |
Family
ID=61801946
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551949A Pending JP2020513824A (ja) | 2017-03-24 | 2018-03-23 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
| JP2023219252A Pending JP2024038121A (ja) | 2017-03-24 | 2023-12-26 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023219252A Pending JP2024038121A (ja) | 2017-03-24 | 2023-12-26 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11739335B2 (https=) |
| EP (1) | EP3601576A1 (https=) |
| JP (2) | JP2020513824A (https=) |
| KR (1) | KR102842382B1 (https=) |
| CN (1) | CN110914433A (https=) |
| AU (1) | AU2018240515B2 (https=) |
| BR (1) | BR112019015244A2 (https=) |
| CA (1) | CA3050616A1 (https=) |
| MX (1) | MX2019011215A (https=) |
| SG (2) | SG11201906297QA (https=) |
| WO (1) | WO2018172556A1 (https=) |
Families Citing this family (137)
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| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| CA2831144A1 (en) | 2011-03-23 | 2012-09-27 | Pioneer Hi-Bred International, Inc. | Methods for producing a complex transgenic trait locus |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| MX362981B (es) | 2012-03-27 | 2019-02-28 | Curevac Ag | Moleculas artificiales de acido nucleico para la expresion mejorada de proteina o peptido. |
| US9974845B2 (en) | 2013-02-22 | 2018-05-22 | Curevac Ag | Combination of vaccination and inhibition of the PD-1 pathway |
| BR112016001192A2 (pt) | 2013-08-21 | 2017-08-29 | Curevac Ag | Vacina contra a raiva |
| AU2014310935B2 (en) | 2013-08-21 | 2019-11-21 | CureVac SE | Combination vaccine |
| BR112016003361A2 (pt) | 2013-08-21 | 2017-11-21 | Curevac Ag | vacina do vírus sincicial respiratório (rsv) |
| CN120574876A (zh) | 2013-08-22 | 2025-09-02 | 纳幕尔杜邦公司 | 使用向导rna/cas内切核酸酶系统的植物基因组修饰及其使用方法 |
| WO2015062738A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Gmbh | Modified rna with decreased immunostimulatory properties |
| CA2935878C (en) | 2014-03-12 | 2023-05-02 | Curevac Ag | Combination of vaccination and ox40 agonists |
| MX2017002930A (es) | 2014-09-12 | 2017-06-06 | Du Pont | Generacion de sitios de integracion especifica de sitio para loci de rasgos complejos en maiz y soja, y metodos de uso. |
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| EP4464338A3 (en) | 2014-11-07 | 2025-02-12 | Editas Medicine, Inc. | Systems for improving crispr/cas-mediated genome-editing |
| PT4023755T (pt) | 2014-12-12 | 2023-07-05 | CureVac SE | Moléculas de ácido nucleico artificiais para uma expressão melhorada de proteína |
| WO2016180430A1 (en) | 2015-05-08 | 2016-11-17 | Curevac Ag | Method for producing rna |
| CA2986310A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| EP4660315A3 (en) | 2015-05-29 | 2026-03-18 | CureVac Manufacturing GmbH | A method for producing and purifying rna, comprising at least one step of tangential flow filtration |
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| EP3373965A1 (en) | 2015-11-09 | 2018-09-19 | CureVac AG | Rotavirus vaccines |
| EP3701963A1 (en) | 2015-12-22 | 2020-09-02 | CureVac AG | Method for producing rna molecule compositions |
| US12612654B2 (en) | 2016-02-12 | 2026-04-28 | CureVac SE | Method for analyzing RNA |
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| US11920174B2 (en) | 2016-03-03 | 2024-03-05 | CureVac SE | RNA analysis by total hydrolysis and quantification of released nucleosides |
| US11597924B2 (en) | 2016-03-25 | 2023-03-07 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| EP4631970A3 (en) | 2016-05-04 | 2026-01-07 | CureVac SE | Nucleic acid molecules and uses thereof |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
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| WO2019089804A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Casy compositions and methods of use |
| CN111511924A (zh) | 2017-11-08 | 2020-08-07 | 库瑞瓦格股份公司 | Rna序列调整 |
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-
2018
- 2018-03-23 SG SG11201906297Q patent/SG11201906297QA/en unknown
- 2018-03-23 WO PCT/EP2018/057552 patent/WO2018172556A1/en not_active Ceased
- 2018-03-23 EP EP18713883.9A patent/EP3601576A1/en active Pending
- 2018-03-23 BR BR112019015244A patent/BR112019015244A2/pt unknown
- 2018-03-23 JP JP2019551949A patent/JP2020513824A/ja active Pending
- 2018-03-23 US US16/496,518 patent/US11739335B2/en active Active
- 2018-03-23 KR KR1020197030080A patent/KR102842382B1/ko active Active
- 2018-03-23 MX MX2019011215A patent/MX2019011215A/es unknown
- 2018-03-23 CN CN201880020941.8A patent/CN110914433A/zh active Pending
- 2018-03-23 SG SG10202110491PA patent/SG10202110491PA/en unknown
- 2018-03-23 AU AU2018240515A patent/AU2018240515B2/en active Active
- 2018-03-23 CA CA3050616A patent/CA3050616A1/en active Pending
-
2023
- 2023-07-03 US US18/346,686 patent/US12371699B2/en active Active
- 2023-12-26 JP JP2023219252A patent/JP2024038121A/ja active Pending
-
2025
- 2025-06-16 US US19/239,908 patent/US20250304976A1/en active Pending
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