JP2020096957A - 注射器アセンブリ - Google Patents

注射器アセンブリ Download PDF

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JP2020096957A
JP2020096957A JP2020035805A JP2020035805A JP2020096957A JP 2020096957 A JP2020096957 A JP 2020096957A JP 2020035805 A JP2020035805 A JP 2020035805A JP 2020035805 A JP2020035805 A JP 2020035805A JP 2020096957 A JP2020096957 A JP 2020096957A
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syringe
vial
flow path
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デネンバーグ，イゴール
Denenburg Igor
ダビデ，ウリ
David Uri
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West Pharma Services IL Ltd
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
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    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
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    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
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    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
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    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
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    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/204—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
    • A61M5/3297—Needles arranged coaxially
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3114—Filling or refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M2005/3201—Coaxially assembled needle cannulas placed on top of another, e.g. needles having different diameters
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    • A61M2209/00—Ancillary equipment
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    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs

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Abstract

【課題】注射器アセンブリは、液剤内容物の投与を可能にするための一体型液剤投与デバイスを予め有する注射器を提供する。【解決手段】液剤内容物を収容する薬瓶１０に入れ子式に取り付けるための薬瓶アダプタ１０６と、を備える。薬瓶アダプタは、注射器１０２に最初に取り付けられ、また、そこから手動で取り外されて、一体型液剤投与デバイスを露出させることが意図されている。注射器は、薬瓶からの液剤内容物で注射器を充填する初期流路位置と、液剤内容物の投与を可能にするための最終流路位置と、を有する流れ制御部材を備える。薬瓶アダプタを注射器から取り外すことによって、流れ制御部材がその初期流路位置から最終流路位置まで押圧される。【選択図】図１

Description

本発明は、注射器アセンブリに関する。
即座に投与する準備ができた液剤用量を収容する予備充填注射器は、約１ｃｍの深さに至る筋肉注射のための一体型の標準筋肉ニードル、または、約２〜３ｍｍの深さに至る皮内注射のための皮内マイクロニードルを備え得る。あるいは、予備充填注射器は、標準的なルアーコネクタニードルハブの取り付けを防止するとともに液剤用量の経口投与を対象とする注射器拡大遠位先端を有し得る。予備充填されたニードルを備える注射器は、あるワクチンでは多量のワクチンの廃棄につながり得るワクチン用量に相当する０．０３ｍｌ〜０．０５ｍｌの標準的なルアーコネクタの死容積よりも非常に小さい死容積を有する。
予備充填注射器は、当該注射器を製造するための製造工程の一部として、液剤用量で充填される。一体型ニードルまたは拡大注射器遠位先端を有する注射器は、使用前に臨床医師によって液剤用量で充填され得るが、そのような手動での充填工程は、概して、時間が掛かるとともに問題があると考えられる。国際公開ＷＯ２０１４／１７４２７８として公開された注射器との標題の国際特許出願ＰＣＴ／ＧＢ２０１４／０５１２５６は、液剤用量を収容する薬瓶からの液剤用量で最初は空の注射器を充填することを補助するための注射器アセンブリを開示している。
使用直前に液剤内容物を容易に充填できる一体型液剤投与デバイスを有する注射器を備える注射器アセンブリが求められる。
本発明は、一体型液剤投与デバイスと薬瓶アダプタとが事前に備えられた注射器を備える注射器アセンブリを対象としている。一体型液剤投与デバイスは、標準的な筋肉ニードル、標準的な皮内マイクロニードル、注射器拡大遠位先端などであってもよい。薬瓶アダプタは、最初に注射器に取り付けられ、液剤内容物の投与を可能にするために、そこから手動で取り外されて一体型液剤投与デバイスを露出させることが意図されている。注射器は、薬瓶からの液剤内容物で注射器を手動で充填することを可能にするための初期流路位置と、液剤内容物を手動で投与することを可能にするための最終流路位置と、を有する流れ制御部材を備えている。薬瓶アダプタを注射器から取り外すことによって、流れ制御部材が、その初期流路位置から、その最終流路位置まで押圧される。注射器からの薬瓶アダプタの取り外しは、手動回転、または、注射器に対する薬瓶アダプタの直線的な取り外しのいずれかによるものであってもよい。
本発明の注射器アセンブリは、好ましくは、空の注射器を有して提供される。注射器アセンブリは、空の注射器に即座に吸引する用意ができた液剤内容物を収容する薬瓶とともに使用され得る。粉末状薬剤を収容する薬瓶の場合、注射器アセンブリは、好ましくは、さらに、粉末状薬剤と混合するための液体内容物を収容する液瓶に入れ子式に取り付けるための液瓶アダプタを備えていてもよい。液体内容物は、復元するためだけの希釈剤であってもよいし、あるいは、活性成分を含んでいてもよい。そのような注射器アセンブリは、次の３つの液体移送のために、その初期流路位置を採用する。１つ目は、液瓶から空の注射器へ液体内容物を吸引するための第１の液体移送である。液瓶アダプタ、および、その空の液瓶は、粉末状薬剤を収容する薬瓶に入れ子式に取り付けることを可能にするために、第１の液剤移送の後に注射器アセンブリから必ず取り外される。２つ目は、液剤内容物を形成するために注射器から薬瓶への液体内容物の注入のための第２の液体移送である。そして、３つ目は、薬瓶から空の注射器へ液剤内容物を吸引するための第３の液体移送である。
本発明を理解し、それが実際にどのように実施され得るのかを理解するために、次に、好ましい実施形態について、同様の部分に同様の番号を付した添付図面を参照して、単なる非限定的な例として説明する。
液剤内容物を収容する薬瓶とともに使用するための初期セットアップ位置にある注射器アセンブリの斜視図である。 液剤内容物を投与する用意ができた注射器アセンブリの斜視図である。 注射器アセンブリの分解図である。 図１の線Ａ−Ａに沿った注射器アセンブリの縦断面図、および、円で囲まれた領域Ａの拡大図である。 図２の線Ｂ−Ｂに沿った注射器アセンブリの縦断面図、および、円で囲まれた領域Ｂの拡大図である。 液剤内容物を投与するための注射器アセンブリの使用方法を示している。 液剤内容物を投与するための注射器アセンブリの使用方法を示している。 液剤内容物を投与するための注射器アセンブリの使用方法を示している。 液剤内容物の経口投与のための注射器拡大遠位先端の斜視図、および、円で囲まれた領域Ｃの拡大図である。 代替的な注射器アセンブリの分解図である。 図８の注射器アセンブリの流れ制御部材の後方斜視図である。 初期流路位置においてその流れ制御部材を有する図８の注射器アセンブリの縦断面図、および、円で囲まれた領域Ｄの拡大図である。 最終流路位置においてその流れ制御部材を有する図８の注射器アセンブリの縦断面図、および、円で囲まれた領域Ｅの拡大図である。 粉末状薬剤を収容する薬瓶と、液体内容物を収容する液瓶と、ともに使用するために修正された図８の注射器アセンブリの縦断面図である。 液剤内容物を復元して投与するための図１２の注射器アセンブリの使用方法を示している。 液剤内容物を復元して投与するための図１２の注射器アセンブリの使用方法を示している。 液剤内容物を復元して投与するための図１２の注射器アセンブリの使用方法を示している。 液剤内容物を復元して投与するための図１２の注射器アセンブリの使用方法を示している。 液剤内容物を復元して投与するための図１２の注射器アセンブリの使用方法を示している。 液剤内容物を復元して投与するための図１２の注射器アセンブリの使用方法を示している。 液剤内容物を復元して投与するための図１２の注射器アセンブリの使用方法を示している。
図１〜５は、薬瓶１０とともに使用するための注射器アセンブリ１００Ａを示している。薬瓶１０は、長手方向薬瓶中央線１１を有しており、また、薬瓶チューブ１２と、薬瓶クラウン開口１４を有するチューブ状の薬瓶クラウン１３と、薬瓶チューブ１２と薬瓶クラウン１３との間の小径薬瓶ネック１６と、を備えている。薬瓶１０は、薬瓶チューブ１２と薬瓶ネック１６との間に薬瓶ショルダ１７を備えている。薬瓶１０は、薬瓶クラウン開口１４を塞ぐための薬瓶ストッパ１８を備えている。薬瓶１０は、液剤内容物１９を収容する。薬瓶１０は液剤内容物で予備充填され、あるいは、液剤内容物は、注射器アセンブリ１００Ａとともに使用する前に、その中で復元される。
注射器アセンブリ１００Ａは、長手方向注射器アセンブリ中央線１０１を有しており、また、注射器近位端１０３と注射器遠位先端１０４とを有する注射器１０２と、薬瓶アダプタ１０６と、を備えている。注射器１０２は、注射器バレル近位端１０７Ａと注射器バレル遠位端１０７Ｂと注射器バレル内部１０８とを有する開放端注射器バレル１０７を備えている。注射器１０２は、親指ストッパ１１１を有するプランジャ１０９を備えている。注射器近位端１０３は、フィンガーグリップ１１２の直径対を有している。注射器遠位先端１０４は、長手方向注射器アセンブリ中央線１０１に交差する方向の環状フランジ１１３を有して形成されている。環状フランジ１１３は、雄ネジ１１４を有して形成される。注射器遠位先端１０４は、注射器バレル遠位端１０７Ｂと、注射器近位端１０３Ａに対して環状フランジ１１３の遠位側に形成された開口１１７と、の間を延在する交差方向に向けられた内腔１１６を有して形成される。
注射器遠位先端１０４は、長手方向注射器アセンブリ中央線１０１と同軸の液剤投薬内腔１１９を有している。液剤投薬内腔１１９は、標準的な皮内ニードルによって構成される一体型液剤投与デバイス１２１に適合される。注射器遠位先端１０４は、注射器バレル遠位端１０７Ｂから皮内ニードル１２１に向けてテーパ状に形成された注射器先端円錐状周囲面１２２を有している。注射器遠位先端１０４は、交差方向に向けられた内腔１１６から離間した、交差方向に向けられた内腔１２３を有している。交差方向に向けられた内腔１２３は、液剤投薬内腔１１９と、注射器遠位先端周囲面１２２の開口１２４と、の間を延在する。２つの交差方向に向けられた内腔１１６，１２３は、長手方向注射器アセンブリ中央線１０１を通る縦断面上にある。
注射器１０２は、流れ制御部材１２６を備えている。流れ制御部材１２６は、注射器遠位先端１０４と薬瓶アダプタ１０６との間にぴったりと入れ子装着されるチューブ状の構成を有している。流れ制御部材１２６は、近位上側１２７と遠位下側１２８とを有している。流れ制御部材１２６は、注射器遠位先端周囲面１２２にシール接触する流れ制御部材内面１３１を有する円錐状の貫通穴１２９を有している。下側１２８は、凹部１３２Ａ，１３２Ｂの直径対を有して形成される。流れ制御部材１２６は、次のように２つの流路位置での使用に対応するために、交差方向に向けられた内腔１１６と流れ連通するための流路の直径対を有している。１つは、初期流路位置において使用するための、長手方向注射器アセンブリ中央線１０１に対してオフセットされた長手方向に向けられた内腔１３３である。内腔１３３は、流れ制御部材内面１３１に形成された開口１３４と凹部１３２Ａとの間を延在する。もう１つは、最終流路位置において交差方向に向けられた２つの内腔１１６，１２３の間で流れ連通するための、流れ制御部材内面１３１に形成された溝１３６である。溝１３６は、溝基端１３７と溝先端１３８とを有している。開口１３４および溝基端１３７は、長手方向注射器アセンブリ中央線１０１に交差する同一平面上で直径方向に対向している。
薬瓶アダプタ１０６は、チューブ状の構成を有しており、また、直立近位ステム１３９と、薬瓶１０に入れ子式に取り付けるための下方に垂下する遠位スカート１４１と、直立ステム１３９と下方に垂下するスカート１４１との間の中間ネック１４２と、を備えている。直立ステム１３９は、雄ネジ１１４にネジ取り付けするための内向きのネジ突出部１４３の直径対を有している。薬瓶アダプタ１０６は、注射器遠位先端１０４から取り外すと同時に流れ制御部材１２６をその初期流路位置からその最終流路位置まで回転させるために、半回転させることを必要とする。直立ステム１３９および中間ネック１４２は、注射器遠位先端１０４および流れ制御部材１２６を取り囲む。スカート１４１は、薬瓶クラウン１３にスナップ嵌めするための内向きの突出部１４６を有する長手方向に向けられた開口１４４の直径対と、薬瓶１０にスナップ嵌めする際に薬瓶ストッパ１８を穿刺するための穿刺カニューレ先端１４７Ａを有する穿刺カニューレ１４７と、を備えている。ネック１４２は、凹部１３２Ａ，１３２Ｂの直径対内への対応する密着挿入のための突出部１４８Ａ，１４８Ｂの直径対を備えている。穿刺カニューレ１４７は、突出部１４８Ａの開口１５１と、穿刺カニューレ先端１４７Ａのところの開口１５２と、の間を延在する内腔１４９を備えている。
図４は、注射器アセンブリ１００Ａが、内腔１１６、内腔１３３および内腔１４９を介した注射器バレル内部１０８と穿刺カニューレ１４７との間の初期流路を有していることを示している。図５は、注射器アセンブリ１００Ａが、内腔１１６、溝１３６および液剤投薬内腔１１９を介した注射器バレル内部１０８と皮内ニードル１２１との間の最終流路を有していることを示している。
図６Ａ〜６Ｃは、注射器アセンブリ１００Ａの次のような使用方法を示している。図６Ａは、薬瓶アダプタ１０６が注射器遠位先端１０４に取り外し可能に取り付けられる初期セットアップ位置にある注射器アセンブリ１００Ａを示している。プランジャ１０９は、ピストン内に完全に挿入され、流れ制御部材１２６は、図４に示されるように、その初期流れ制御位置にある。臨床医は、薬瓶１０を穿刺するために、薬瓶アダプタ１０６を薬瓶１０に入れ子式に取り付ける。図６Ｂは、臨床医が注射器アセンブリ１００Ａおよび穿刺された薬瓶１０を逆さまにして、矢印Ａで示されるように液剤内容物１９を薬瓶１０から注射器１０２内に吸引する様子を示している。図６Ｃは、臨床医が注射器アセンブリ１００Ａおよび現在は空の薬瓶１０を、その直立位置まで逆さまにする様子を示している。臨床医は、薬瓶アダプタ１０６を半回転させて、それを空の薬瓶１０と一緒に注射器遠位先端１０４から取り外して、皮内ニードル１２１を露出させ、流れ制御部材１２６を、その最終流路位置まで押圧する。注射器１０２は、液剤内容物１９を投与する準備ができている。
図７は、注射器アセンブリ１００Ｂを示している。注射器アセンブリ１００Ｂは、液剤内容物を経口投与するための一体型液剤投与デバイスを構成する注射器拡大遠位先端１０４を有する注射器１０２を備えている。
図８〜１１は、構成および使用方法が注射器アセンブリ１００Ａと類似する注射器アセンブリ１００Ｃを示している。したがって、同様の部分には同様の符号を付してある。注射器アセンブリ１００Ｃは、液剤内容物を薬瓶から吸引して液剤内容物を投与するためのその流れ制御構造が注射器アセンブリ１００Ａと異なっている。
注射器遠位先端１０４は、長手方向注射器アセンブリ中央線１０１に対して交差する交差方向貫通穴１６１を有して形成されている。注射器遠位先端１０４は、長手方向注射器アセンブリ中央線１０１と同軸、かつ、交差方向貫通穴１６１の基端側に流れ連通する内腔１６２を備えている。注射器遠位先端１０４は、長手方向注射器アセンブリ中央線１０１と同軸、かつ、交差方向貫通穴１６１の先端側に流れ連通する液剤投薬内腔１６３を備えている。液剤投薬内腔１６３は、皮内ニードル１２１に適合される。
注射器１０２は、シール端部１６６を有する略チューブ状の流れ制御部材１６４を備えている。流れ制御部材１６４は、交差方向平坦切欠１６８と周囲溝１６９とを有する流れ制御部材周囲面１６７を備えている。平坦切欠１６８は、第１の切欠端１７１と第２の切欠端１７２とを有している。周囲溝１６９は、第２の切欠端１７２に流れ連通する。
薬瓶アダプタ１０６は、シール端部１６６に接触する内側半円状カム面１７３を備えている。カム面１７３は、起点カム面端部１７４と終点カム面端部１７６とを有している。起点カム面端部１７４は、長手方向注射器アセンブリ中央線１０１からの間隔Ｓ１を有している。終点カム面端部１７６は、長手方向注射器アセンブリ中央線１０１からの間隔Ｓ２を有している。間隔Ｓ１は、薬瓶アダプタ１０６の回転が初期流路位置から最終流路位置まで流れ制御部材１６４を押圧するように、間隔Ｓ２よりも大きい。
図１０は、シール端部１６６に接触する起点カム面端部１７４を有する、その初期流路位置にある注射器アセンブリ１００Ｃを示している。図１０は、注射器アセンブリ１００Ｃが、注射器バレル内部１０８と穿刺カニューレ１４７との間の、内腔１６２と、その第１の切欠端１７１のところの平坦切欠１６８と、周囲溝１６９と、液剤投薬内腔１６３と、を介した初期流路を有することを示している。
図１１は、長手方向注射器アセンブリ中央線１０１を交差方向に横切る流れ制御部材１６４を押圧しているカム面１６６を有する薬瓶アダプタ１０６を取り外した後のその最終流路位置にある注射器アセンブリ１００Ｃを示している。図１１は、注射器アセンブリ１００Ｃが、注射器バレル内部１０８と皮内ニードル１２１との間の、内腔１６２と、その第２の切欠端１７２のところの平坦切欠１６８と、周囲溝１６９と、液剤投薬内腔１６３と、を介した最終流路を有することを示している。
図１２は、薬瓶２０と液瓶３０とともに使用するための注射器アセンブリ１００Ｄを示している。薬瓶２０は、粉末状薬剤２１を備えている点において薬瓶１０と異なっている。液瓶３０は、長手方向液瓶中央線３１を有しており、また、液瓶チューブ３２と、液瓶クラウン開口３４を有するチューブ状液瓶クラウン３３と、液瓶チューブ３２と液瓶クラウン３３との間の小径液瓶ネック３６と、を備えている。液瓶３０は、液瓶チューブ３２と液瓶ネック３６との間の液瓶ショルダ３７を備えている。液瓶３０は、液瓶クラウン開口３４を塞ぐための液瓶ストッパ３８を備えている。液瓶３０は、粉末状薬剤２１と混合して液剤内容物１９を形成するために液体内容物３９を収容する。液体内容物３９は、復元目的のみの希釈剤であってもよいし、活性成分を含んでいてもよい。
注射器アセンブリ１００Ｄは、さらに、液瓶３０に入れ子式に取り付けるための液瓶アダプタ１８０を備えている。液瓶アダプタ１８０は、液瓶３０に入れ子式に取り付けるための下方に垂下するスカート１８２を有して形成された交差方向液瓶アダプタ頂部壁１８１を有している。液瓶アダプタ１８０は、液瓶アダプタ１８０を薬瓶アダプタ１０６に取り付けるために長手方向に向けられた開口１４４の直径対の内部に留めるためのクリップ１８３の直径対を有して形成される。クリップ１８３は、長手方向注射器アセンブリ中央線１０１に向けて圧縮力を加える際に液瓶アダプタ１８０を薬瓶アダプタ１０６から取り外すための、下方に垂下する指で操作されるリリース部材１８４を有している。液瓶アダプタ頂部壁１８１は、穿刺カニューレ１４７を受け入れるための円錐状直立ポート１８６を有して形成される。液瓶アダプタ頂部壁１８１は、液瓶アダプタ１８０を液瓶３０に入れ子式に取り付ける際に液瓶３０を穿刺するための下方に垂下する穿刺カニューレ１８７を有して形成される。ポート１８６は、穿刺カニューレ１８７に連続的に流れ連通し、それによって、流れ制御部材１６４の初期流路位置において注射器１０２と穿刺カニューレ１８７との間の流れ連通を提供する。
図１３Ａ〜１３Ｇは、液剤内容物１９を投与するための注射器アセンブリ１００Ｄの使用方法を示している。図１３Ａは、その初期流路位置にある注射器アセンブリ１００Ｄと、完全に挿入されたプランジャ１０９を有する空の注射器１０２と、を示している。臨床医は、液瓶３０を穿刺するために、液瓶アダプタ１８０を液瓶３０に入れ子式に取り付ける。図１３Ｂは、臨床医が注射器アセンブリ１００Ｄおよび穿刺された液瓶３０を逆さまにして、矢印Ｂで示すように液瓶３０から注射器１０２内へ液体内容物３９を吸引する様子を示している。図１３Ｃは、臨床医が注射器アセンブリ１００Ｄを逆さまにして、液瓶アダプタ１８０および現在は空の液瓶３０を取り外す様子を示している。図１３Ｄは、臨床医が、薬瓶２０を穿刺するために、液体内容物３９を有する注射器アセンブリ１００Ｄを薬瓶２０に入れ子式に取り付ける様子を示している。図１３Ｅは、臨床医が、矢印Ｃに示されるように液体内容物３９を薬瓶２０内に注入して、粉末状薬剤２１を復元して液剤内容物１９にする様子を示している。図１３Ｆは、臨床医が、注射器アセンブリ１００Ｄおよび穿刺された薬瓶２０を逆さまにして、矢印Ｄに示されるように液剤内容物１９を薬瓶２０から注射器１０２内へ吸引する様子を示している。図１３Ｇは、臨床医が、注射器アセンブリ１００Ｄおよび現在は空の薬瓶２０を、その直立位置まで逆さまにする様子を示している。臨床医は、薬瓶アダプタ１０６を半回転させて、それを空の薬瓶２０と一緒に注射器遠位先端１０４から取り外して皮内ニードル１２１を露出させ、流れ制御部材１６４をその最終流路位置まで押圧する。注射器１０２は、液剤内容物１９を投与する準備ができている。
限られた数の実施形態に関して本発明が説明されたが、本発明の多くの変更、修正および他の用途が、添付の特許請求の範囲の範囲内でなされ得ることが理解されよう。

Claims (5)

  1. 閉鎖端薬瓶チューブと、薬瓶クラウン開口を有するチューブ状薬瓶クラウンと、前記薬瓶クラウン開口を塞ぐための薬瓶ストッパと、を有する薬瓶とともに使用するための注射器アセンブリであって、
    前記薬瓶は、液剤内容物を収容し、
    前記注射器アセンブリは、長手方向注射器アセンブリ中央線を有し、
    前記注射器アセンブリは、
    （ａ）注射器近位端と注射器遠位先端とを有する注射器を備え、
    前記注射器は、注射器バレル近位端と注射器バレル遠位端とを有する開放端注射器バレルと、初期流路位置から最終流路位置まで変位可能な流れ制御部材と、を備え、
    前記注射器遠位先端は、前記液剤内容物を投与するための一体型液剤投与デバイスを有し、
    前記注射器アセンブリは、さらに、
    （ｂ）前記注射器遠位先端に手動で取り外し可能に取り付けられるチューブ状近位ステムと、前記薬瓶に入れ子式に取り付けるための下方に垂下する遠位スカートと、前記薬瓶アダプタを前記薬瓶に入れ子式に取り付ける際に前記薬瓶ストッパを穿刺するための穿刺カニューレと、を有する薬瓶アダプタを備え、
    前記穿刺カニューレは、前記注射器アセンブリの初期セットアップ位置にある前記流れ制御部材の前記初期流路位置において前記注射器バレルに流れ連通し、
    前記初期セットアップ位置では、前記薬瓶アダプタが前記注射器遠位先端に取り外し可能に最初に取り付けられ、
    前記注射器アセンブリは、前記薬瓶アダプタを前記注射器遠位先端から手動で取り外す際に、前記液剤内容物を投与することを可能にするために前記注射器バレルと前記一体型液剤投与デバイスとの間の流れ連通を可能にするために、前記薬瓶アダプタが前記流れ制御部材を前記初期流路位置から前記最終流路位置まで移動させるように構成された
    注射器アセンブリ。
  2. 請求項１に記載のアセンブリであって、
    前記手動の取り外しは、前記長手方向注射器アセンブリ中央線を中心として前記注射器に対して前記薬瓶アダプタを手動で回転させることを備える
    アセンブリ。
  3. 請求項２に記載のアセンブリであって、
    前記流れ制御部材は、
    前記長手方向注射器アセンブリ中央線を中心として回転可能であり、
    前記初期流路位置における前記注射器バレルと前記穿刺カニューレとの間の流れ連通のための初期流路内腔と、前記最終流路位置における前記注射器バレルと前記一体型液剤投与デバイスとの間の流れ連通のための最終流路内腔と、を備え、
    前記薬瓶アダプタの手動回転は、同時に、前記薬瓶アダプタを前記注射器遠位先端から取り外す間に、前記流れ制御部材を前記初期流路位置から前記最終流路位置まで回転させる
    アセンブリ。
  4. 請求項２に記載のアセンブリであって、
    前記流れ制御部材は、前記長手方向注射器アセンブリ中央線に対して、前記注射器バレルと前記穿刺カニューレとの流れ連通のための初期流路位置から、前記注射器バレルと前記一体型液剤投与デバイスとの間の流れ連通のための最終流路位置まで、交差方向に移動可能であり、
    前記薬瓶アダプタは、前記注射器遠位先端からの取り外しのために前記薬瓶アダプタを
    手動回転させる間に前記流れ制御部材を前記初期流路位置から前記最終流路位置まで交差方向に移動させるためのカム内面を備える
    アセンブリ。
  5. 薬剤内容物を収容する薬瓶と、液瓶と、ともに使用するための請求項１ないし請求項４のいずれか一項に記載のアセンブリであって、
    前記液瓶は、液瓶チューブと、液瓶クラウン開口を有するチューブ状液瓶クラウンと、前記液瓶クラウン開口を塞ぐための液瓶ストッパと、を備え、
    前記液瓶は、前記薬瓶内に前記液剤内容物を形成するための液剤内容物を収容し、
    前記アセンブリは、さらに、液瓶アダプタを備え、
    前記液瓶アダプタは、
    前記薬瓶アダプタから下方に垂下する前記液瓶アダプタを取り外し可能に手動で取り付けるための取り外し可能な取り付け構造と、
    前記液瓶に入れ子式に取り付けるための下方に垂下するスカートと、
    前記液瓶アダプタを前記液瓶に入れ子式に取り付ける際に前記液瓶ストッパを穿刺するための穿刺カニューレと、
    前記液瓶アダプタを前記薬瓶アダプタに取り付ける際に前記薬瓶アダプタの前記穿刺カニューレを受け入れるための円錐状ポートと、
    を備える
    アセンブリ。
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