JP2015535464A - 薬剤送達装置 - Google Patents
薬剤送達装置 Download PDFInfo
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- C07—ORGANIC CHEMISTRY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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Abstract
Description
(i)米国特許出願公開第2006/0040358号(2006年2月23日公開)、第2005/0008642号(2005年1月13日公開)、第2004/0228859号(2004年11月18日公開)であって、例えば、限定するものではないが、抗体1A(DSMZ寄託番号DSM ACC2586)、抗体8(DSMZ寄託番号DSM ACC2589)、抗体23(DSMZ寄託番号DSM ACC2588)及び抗体18を例として記載する、それら文献;
(ii)国際公開第06/138729号(2006年12月28日公開)及び第05/016970号(2005年2月24日公開)、及びLu et al.,2004,J Biol.Chem.279:2856−65であって、例えば、抗体2F8、A12、及びIMC−A12を記載する、それら文献;
(iii)国際公開第07/012614号(2007年2月1日公開)、第07/000328号(2007年1月4日公開)、第06/013472号(2006年2月9日公開)、第05/058967号(2005年6月30日公開)、及び第03/059951号(2003年7月24日公開);
(iv)米国特許出願公開第2005/0084906号(2005年4月21日公開)であって、例えば、限定するものではないが、抗体7C10、キメラ抗体C7C10、抗体h7C10、抗体7H2M、キメラ抗体*7C10、抗体GM607、ヒト化抗体7C10バージョン1、ヒト化抗体7C10バージョン2、ヒト化抗体7C10バージョン3、及び抗体7H2HMを記載する、その文献;
(v)米国特許出願公開第2005/0249728号(2005年11月10日公開)、第2005/0186203号(2005年8月25日公開)、第2004/0265307号(2004年12月30日公開)、及び第2003/0235582号(2003年12月25日公開)、及びMaloney et al.,2003,Cancer Res.63:5073−83であって、例えば、抗体EM164、表面再構成(resurfaced)EM164、ヒト化EM164、huEM164v1.0、huEM164v1.1、huEM164v1.2、及びhuEM164v1.3に限定しないがこれらを記載する、それら文献;
(vi)米国特許第7、037、498号(2006年5月2日発行)、米国特許出願公開第2005/0244408号(2005年11月30日公開)、及び第2004/0086503号(2004年5月6日公開)、及びCohen,et al.,2005,Clinical Cancer Res.11:2063−73、例えば、抗体CP−751,871、例えば、限定するものではないが、ATCC寄託番号PTA−2792、PTA−2788、PTA−2790、PTA−2791、PTA−2789、PTA−2793を有するハイブリドーマによって産生される抗体、並びに抗体2.12.1、2.13.2、2.14.3、3.1.1、4.9.2、及び4.17.3、のそれぞれを記載する、それら文献;
(vii)米国特許出願公開第2005/0136063号(2005年6月23日公開)及び第2004/0018191号(2004年1月29日公開)であって、例えば、限定するものではないが、抗体19D12、及び、番号PTA−5214の下ATCCに寄託される、プラスミド15H12/19D12HCA(γ4)中でポリヌクレオチドによってコードされる重鎖と、番号PTA−5220の下ATCCに寄託される、プラスミド15H12/19D12LCF(κ)中でポリヌクレオチドによってコードされる軽鎖とを含む抗体、を記載する、それら文献;及び
(viii)米国特許出願公開第2004/0202655号(2004年10月14日公開)であって、例えば、限定するものではないが、抗体PINT−6A1、PINT−7A2、PINT−7A4、PINT−7A5、PINT−7A6、PINT−8A1、PINT−9A2、PINT−11A1、PINT−11A2、PINT−11A3、PINT−11A4、PINT−11A5、PINT−11A7、PINT−11A12、PINT−12A1、PINT−12A2、PINT−12A3、PINT−12A4、及びPINT−12A5を記載する、その文献であり;これらのそれぞれ及び全てはその全体が特に以下に関して参照により本明細書に援用されるものとし、その以下とは、IGF−1受容体を標的とする上述の抗体、ペプチボディ、及び関連タンパク質等である、文献;
Claims (47)
- ブラントカニューレの第1の端部と第2の端部の間に軸路を画成する円筒壁を有する前記ブラントカニューレであって、前記壁は、前記軸路に流体連通する開口部であってかつ前記ブラントカニューレの前記軸路を通って前記第1の端部から出る流体の流れの遮断に抵抗するように前記第1の端部で適合された開口部を画成するように少なくとも1つの第1のテーパー領域を前記第1の端部で有する、ブラントカニューレと、
前記ブラントカニューレの前記第2の端部に接続された貯留部と、
を含む、薬剤送達装置。 - 前記ブラントカニューレは、前記ブラントカニューレの前記壁に前記第1の端部で形成される少なくとも1つの側面ポートを有する、請求項1に記載の薬剤送達装置。
- 前記少なくとも側面ポートは一対の側面ポートを含む、請求項2に記載の薬剤送達装置。
- 前記一対の側面ポートは前記軸路を横切る方向にお互いに位置合わせされている、請求項3に記載の薬剤送達装置。
- 前記少なくとも1つの側面ポートは、流れが前記軸路を横断することを可能にするように前記壁に形成された円形の開口部を含む、請求項2〜4のいずれか一項に記載の薬剤送達装置。
- 前記少なくとも1つの側面ポートは、流れが前記軸路を横断することを可能にするように前記壁に形成された細長いスリットを含む、請求項2〜4のいずれか一項に記載の薬剤送達装置。
- 前記少なくとも1つの側面ポートは、流れが前記軸路を横断することを可能にするように前記壁に形成された細長いスロットを含む、請求項2〜4のいずれか一項に記載の薬剤送達装置。
- 前記少なくとも1つの側面ポートは、前記第1のテーパー領域から離れて、前記ブラントカニューレの前記第1の端部に形成される、請求項2〜7のいずれか一項に記載の薬剤送達装置。
- 前記第1のテーパー領域は少なくとも1つのベベルを含む、請求項1に記載の薬剤送達装置。
- 前記第1のテーパー領域は1つのベベルしか含まない、請求項9に記載の薬剤送達装置。
- 前記第1のテーパー領域は、お互いに交差する2つのベベルを含む、請求項9に記載の薬剤送達装置。
- 前記第1のテーパー領域は、お互いに交差する2つの反対向き又は逆ベベルを含む、請求項9に記載の薬剤送達装置。
- 前記第1の端部は、前記第1のテーパー領域における前記開口部周りに配置される或るパターンの開口部を含む、請求項1に記載の薬剤送達装置。
- 前記或るパターンの開口部は、前記壁の中に窪んだ或るパターンの凹部を含む、請求項13に記載の薬剤送達装置。
- 前記ブラントカニューレは、隣接する表面領域に対して前記軸路の方に凹設された少なくとも1つの外側凹設領域を有する、請求項1〜14のいずれか一項に記載の薬剤送達装置。
- 前記少なくとも1つの外側凹設領域は、或るパターンの畝によって画成される、請求項15に記載の薬剤送達装置。
- 前記少なくとも1つの外側凹設表面領域は、或るパターンの溝よって画成される、請求項15に記載の薬剤送達装置。
- 前記ブラントカニューレに連結された振動発生器をさらに含み、前記振動発生器は、前記ブラントカニューレの前記軸路を通って前記第1の端部から出る流体の流れの遮断に抵抗するよう作動する、請求項1〜17のいずれか一項に記載の薬剤送達装置。
- 前記貯留部を画成するように外筒と前記外筒内に配置されたプランジャーとを有する、自動注入装置、マイクロ注入器、又は注入ポンプをさらに含む、請求項1〜18のいずれか一項に記載の薬剤送達装置。
- ハウジングをさらに含み、前記ハウジングは、開口部を通して前記カニューレが作動状態で配置されるものである前記開口部を有し、前記開口部は前記カニューレの直径の2倍よりも小さい直径を有する、請求項1〜19のいずれか一項に記載の薬剤送達装置。
- ブラントカニューレの閉止状第1の端部と、第2の端部との間に軸路を画成する円筒壁を有する前記ブラントカニューレであって、前記壁は、前記軸路に流体連通する少なくとも1つの側面開口部であって前記ブラントカニューレの前記軸路を通って前記第1の端部から出る流体の流れの遮断に抵抗するように適合された側面開口部をもった前記第1の端部で第1のテーパー領域を有する、ブラントカニューレと、
前記ブラントカニューレの前記第2の端部に接続された貯留部と、
を含む、薬剤送達装置。 - ハウジングをさらに含み、前記ハウジングは、開口部を通して前記カニューレが作動状態で配置されるものである前記開口部を有し、前記開口部は前記カニューレの直径の2倍よりも小さい直径を有する、請求項21に記載の薬剤送達装置。
- ブラントカニューレの第1の端部と第2の端部の間に軸路を画成する円筒壁を有する前記ブラントカニューレであって、前記壁は、前記軸路に流体連通する開口部を画成するように第1のテーパー領域を前記第1の端部で有する、ブラントカニューレと;
前記ブラントカニューレに連結された振動発生器であって、前記ブラントカニューレの前記軸路を通って前記第1の端部から出る流体の流れの遮断に抵抗するよう作動する振動発生器と;
前記ブラントカニューレの前記第2の端部に接続された貯留部と、
を含む、薬剤送達装置。 - 前記振動発生器は、軸部と、前記軸部に取り付けられた偏心ウェイトとをもったモーターを含む、請求項23に記載の薬剤送達装置。
- 前記振動発生器は圧電振動子を含む、請求項23に記載の薬剤送達装置。
- ハウジングをさらに含み、前記ハウジングは、開口部を通して前記カニューレが作動状態で配置されるものである前記開口部を有し、前記開口部は前記カニューレの直径の2倍よりも小さい直径を有する、請求項23〜25のいずれか一項に記載の薬剤送達装置。
- 硬質針の第1の端部と第2の端部の間に軸路を画成する円筒壁を有する前記硬質針であって、前記壁は、前記軸路に流体連通する開口部であってかつ前記硬質針の前記軸路を通って前記第1の端部から出る流体の流れの遮断に抵抗するように前記第1の端部で適合された開口部を前記第1の端部で有する、硬質針と;
前記硬質針の前記第2の端部に連結された貯留部と、を含み、
前記第1の端部での前記適合は、前記第1のテーパー領域で前記開口部周りに配置された少なくとも1つの或るパターンの開口部と、隣接する表面領域に対して前記軸路の方に凹設された少なくとも1つの外側凹設領域と、
を含む、薬剤送達装置。 - 前記或るパターンの開口部は、前記壁の中に窪んだ或るパターンの凹部を含む、請求項27に記載の薬剤送達装置。
- 前記少なくとも1つの外側凹設領域は、或るパターンの畝によって画成される、請求項27に記載の薬剤送達装置。
- 前記少なくとも1つの外側凹設表面領域は、或るパターンの溝によって画成される、請求項27に記載の薬剤送達装置。
- 前記硬質針に連結された振動発生器をさらに含み、前記振動発生器は、前記硬質針の前記軸路を通って前記第1の端部から出る流体の流れの遮断に抵抗するよう作動する、請求項27〜30のいずれか一項に記載の薬剤送達装置。
- 前記貯留部を画成するように外筒と前記外筒内に配置されたプランジャーとを有する、自動注入装置、マイクロ注入器、又は注入ポンプをさらに含む、請求項27〜31のいずれか一項に記載の薬剤送達装置。
- ハウジングをさらに含み、前記ハウジングは、開口部を通して前記硬質針が作動状態で配置されるものである前記開口部を有し、前記開口部は前記硬質針の直径の2倍よりも小さい直径を有する、請求項27〜32のいずれか一項に記載の薬剤送達装置。
- 硬質針の第1の端部と第2の端部の間に軸路を画成する円筒壁を有する前記硬質針であって、前記壁は前記軸路に流体連通する開口部を前記第1の端部で有する、硬質針と;
前記硬質針に連結された振動発生器であって、前記硬質針の前記軸路を通って前記第1の端部から出る流体の流れの遮断に抵抗するよう作動する振動発生器と;
前記硬質針の前記第2の端部に連結された貯留部と、
を含む、薬剤送達装置。 - 前記振動発生器は、軸部と、前記軸部に取り付けられた偏心ウェイトとをもったモーターを含む、請求項34に記載の薬剤送達装置。
- 前記振動発生器は圧電振動子を含む、請求項34に記載の薬剤送達装置。
- ハウジングをさらに含み、前記ハウジングは、開口部を通して前記硬質針が作動状態で配置されるものである前記開口部を有し、前記開口部は前記硬質針の直径の2倍よりも小さい直径を有する、請求項34〜36のいずれか一項に記載の薬剤送達装置。
- 前記貯留部に配置されるいくらかの量の赤血球生成促進剤をさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
- 前記貯留部に配置されるいくらかの量の顆粒球コロニー刺激因子をさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
- 貯留部に配置されるいくらかの量のTNF遮断薬をさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
- 前記貯留部に配置されるいくらかの量のペグ化顆粒球コロニー刺激因子をさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
- 前記貯留部に配置されるいくらかの量のインターロイキン受容体特異的抗体をさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
- 前記貯留部に配置されるいくらかの量のIGF受容体特異的抗体をさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
- 前記貯留部に配置されるいくらかの量のTGF特異的抗体をさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
- 前記貯留部に配置されるいくらかの量のインスリンをさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
- 前記貯留部に配置されるいくらかの量のGLP−1をさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
- 前記貯留部に配置されるいくらかの量のスクレロスチン抗体をさらに含む、請求項1〜37のいずれか一項に記載の送達装置。
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