JP2019530698A5 - - Google Patents
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- JP2019530698A5 JP2019530698A5 JP2019518395A JP2019518395A JP2019530698A5 JP 2019530698 A5 JP2019530698 A5 JP 2019530698A5 JP 2019518395 A JP2019518395 A JP 2019518395A JP 2019518395 A JP2019518395 A JP 2019518395A JP 2019530698 A5 JP2019530698 A5 JP 2019530698A5
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- JP
- Japan
- Prior art keywords
- composition according
- composition
- modified sugar
- oligonucleotides
- oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091034117 Oligonucleotide Proteins 0.000 claims 27
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 10
- 238000012986 modification Methods 0.000 claims 6
- 230000004048 modification Effects 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 125000003835 nucleoside group Chemical group 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 108010069091 Dystrophin Proteins 0.000 claims 3
- 229910019142 PO4 Inorganic materials 0.000 claims 3
- 238000004132 cross linking Methods 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- 102000001039 Dystrophin Human genes 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000011574 phosphorus Substances 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- 108700024394 Exon Proteins 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239839P | 2015-10-09 | 2015-10-09 | |
| US201662331961P | 2016-05-04 | 2016-05-04 | |
| US201662331966P | 2016-05-04 | 2016-05-04 | |
| PCT/US2016/056123 WO2017062862A2 (en) | 2015-10-09 | 2016-10-07 | Oligonucleotide compositions and methods thereof |
| USPCT/US2016/056123 | 2016-10-07 | ||
| PCT/US2017/055601 WO2018067973A1 (en) | 2015-10-09 | 2017-10-06 | Oligonucleotide compositions and methods thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019530698A JP2019530698A (ja) | 2019-10-24 |
| JP2019530698A5 true JP2019530698A5 (enExample) | 2020-11-12 |
Family
ID=58488684
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517191A Active JP7511326B2 (ja) | 2015-10-09 | 2016-10-07 | オリゴヌクレオチド組成物およびその方法 |
| JP2019518395A Pending JP2019530698A (ja) | 2015-10-09 | 2017-10-06 | オリゴヌクレオチド組成物およびその方法 |
| JP2022052547A Active JP7696310B2 (ja) | 2015-10-09 | 2022-03-28 | オリゴヌクレオチド組成物およびその方法 |
| JP2024207586A Pending JP2025029016A (ja) | 2015-10-09 | 2024-11-28 | オリゴヌクレオチド組成物およびその方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517191A Active JP7511326B2 (ja) | 2015-10-09 | 2016-10-07 | オリゴヌクレオチド組成物およびその方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022052547A Active JP7696310B2 (ja) | 2015-10-09 | 2022-03-28 | オリゴヌクレオチド組成物およびその方法 |
| JP2024207586A Pending JP2025029016A (ja) | 2015-10-09 | 2024-11-28 | オリゴヌクレオチド組成物およびその方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20190127733A1 (enExample) |
| EP (2) | EP3359523A4 (enExample) |
| JP (4) | JP7511326B2 (enExample) |
| KR (1) | KR20180056766A (enExample) |
| CN (3) | CN108137492B (enExample) |
| AU (4) | AU2016334232B2 (enExample) |
| BR (1) | BR112018006636B1 (enExample) |
| CA (2) | CA2999772A1 (enExample) |
| CL (1) | CL2018000818A1 (enExample) |
| CO (1) | CO2018004758A2 (enExample) |
| CR (1) | CR20180233A (enExample) |
| EC (1) | ECSP18032914A (enExample) |
| IL (2) | IL258230B (enExample) |
| MA (2) | MA46427A (enExample) |
| MX (2) | MX2018003992A (enExample) |
| NI (1) | NI201800045A (enExample) |
| PE (1) | PE20181353A1 (enExample) |
| PH (1) | PH12018500719A1 (enExample) |
| SG (1) | SG10201912902TA (enExample) |
| SV (1) | SV2018005661A (enExample) |
| TW (1) | TW201722439A (enExample) |
| WO (2) | WO2017062862A2 (enExample) |
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