CL2018000818A1 - Composición de oligonucleotidos; métodos para alterar el empalme de un transcripto blanco; y uso de la composición para tratar distrofia muscular de duchenne. - Google Patents

Composición de oligonucleotidos; métodos para alterar el empalme de un transcripto blanco; y uso de la composición para tratar distrofia muscular de duchenne.

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Publication number
CL2018000818A1
CL2018000818A1 CL2018000818A CL2018000818A CL2018000818A1 CL 2018000818 A1 CL2018000818 A1 CL 2018000818A1 CL 2018000818 A CL2018000818 A CL 2018000818A CL 2018000818 A CL2018000818 A CL 2018000818A CL 2018000818 A1 CL2018000818 A1 CL 2018000818A1
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CL
Chile
Prior art keywords
composition
methods
compositions provided
transcript
oligonucleotide compositions
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CL2018000818A
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English (en)
Inventor
Naoki Iwamoto
David Charles Donnell Butler
Sethumadhavan Divakaramenon
Christopher J Francis
Maria David Frank-Kamenetsky
Genliang Lu
Subramanian Marappan
Chandra Vargeese
Gregory L Vardine
Hailin Yang
Jason Jingxin Zhang
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Wave Life Sciences Ltd
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Publication of CL2018000818A1 publication Critical patent/CL2018000818A1/es

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Abstract

Entre otras cosas, la presente revelación se refiere a oligonucleótidos, composiciones diseñados y sus métodos. En algunas formas de realización, las composiciones oligonucleotidicas proporcionadas suministran un empalme alterado de un transcripto. En algunas formas de realización, las composiciones oligonucleotídicas proporcionadas tienen baja toxicidad. En algunas formas de realización, las composiciones oligonucleotídicas proporcionadas suministran mejores perfiles de ligación de proteínas. En algunas formas de realización, las composiciones oligonucleotidicas proporcionadas tienen mejor suministro. En algunas formas de realización, las composiciones oligonucleotídicas proporcionadas tienen mejor captación. En algunas formas de realización, la presente revelación properciona métodos para el tratamiento de enfermedades usando composiciones proporcionadas oligonucleotídicas. 
CL2018000818A 2015-10-09 2018-03-29 Composición de oligonucleotidos; métodos para alterar el empalme de un transcripto blanco; y uso de la composición para tratar distrofia muscular de duchenne. CL2018000818A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562239839P 2015-10-09 2015-10-09
US201662331966P 2016-05-04 2016-05-04
US201662331961P 2016-05-04 2016-05-04

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CL2018000818A1 true CL2018000818A1 (es) 2018-08-17

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CL2018000818A CL2018000818A1 (es) 2015-10-09 2018-03-29 Composición de oligonucleotidos; métodos para alterar el empalme de un transcripto blanco; y uso de la composición para tratar distrofia muscular de duchenne.

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US (4) US20190127733A1 (es)
EP (2) EP3359523A4 (es)
JP (3) JP2018537952A (es)
KR (1) KR20180056766A (es)
CN (3) CN108137492B (es)
AU (3) AU2016334232B2 (es)
BR (1) BR112018006636B1 (es)
CA (2) CA2999772A1 (es)
CL (1) CL2018000818A1 (es)
CO (1) CO2018004758A2 (es)
CR (1) CR20180233A (es)
EC (1) ECSP18032914A (es)
HK (1) HK1256225A1 (es)
IL (2) IL295755A (es)
MA (2) MA46427A (es)
MX (2) MX2018003992A (es)
NI (1) NI201800045A (es)
PE (1) PE20181353A1 (es)
PH (1) PH12018500719A1 (es)
SG (1) SG10201912902TA (es)
SV (1) SV2018005661A (es)
TW (1) TW201722439A (es)
WO (2) WO2017062862A2 (es)

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JP2020524485A (ja) 2017-06-02 2020-08-20 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物及びその使用方法
JP2020522265A (ja) 2017-06-02 2020-07-30 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物及びその使用方法
CN111051281A (zh) 2017-06-21 2020-04-21 波涛生命科学有限公司 用于合成的化合物、组合物和方法
WO2019002237A1 (en) 2017-06-28 2019-01-03 Roche Innovation Center Copenhagen A/S METHOD OF MULTIPLE COUPLING AND OXIDATION
WO2019032612A1 (en) 2017-08-08 2019-02-14 Wave Life Sciences Ltd. OLIGONUCLEOTIDE COMPOSITIONS AND ASSOCIATED METHODS
JP7472018B2 (ja) 2017-09-18 2024-04-22 ウェーブ ライフ サイエンシーズ リミテッド オリゴヌクレオチド調製のための技術
US11596646B2 (en) 2017-10-12 2023-03-07 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof

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