JP2019006831A5 - - Google Patents

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JP2019006831A5
JP2019006831A5 JP2018196312A JP2018196312A JP2019006831A5 JP 2019006831 A5 JP2019006831 A5 JP 2019006831A5 JP 2018196312 A JP2018196312 A JP 2018196312A JP 2018196312 A JP2018196312 A JP 2018196312A JP 2019006831 A5 JP2019006831 A5 JP 2019006831A5
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vaccine composition
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  1. メソポーラスシリカロッド；
    免疫細胞を動員するサイトカインを含む免疫細胞動員化合物；
    免疫細胞活性化化合物；および
    抗原；
    を含む、ワクチン組成物。
  2. 前記ロッドが直径2〜50nmの孔を含む、請求項1記載のワクチン組成物。
  3. 前記ロッドが直径5〜25nmの孔を含む、請求項1記載のワクチン組成物。
  4. 前記ロッドが直径5〜10nmの孔を含む、請求項1記載のワクチン組成物。
  5. 前記ロッドが直径約8nmの孔を含む、請求項1記載のワクチン組成物。
  6. 前記ロッドが5μm〜500μmの長さを含む、請求項1記載のワクチン組成物。
  7. 前記ロッドが5μm〜25μmの長さである、請求項1記載のワクチン組成物。
  8. 前記ロッドが80μm〜120μmの長さを含む、請求項1記載のワクチン組成物。
  9. 前記動員化合物が、顆粒球マクロファージコロニー刺激因子（GM-CSF）、ケモカイン（C-Cモチーフ）リガンド21（CCL-21）、ケモカイン（C-Cモチーフ）リガンド19（CCl-19）、またはFMS様チロシンキナーゼ3（Flt-3）リガンドを含む、請求項1記載のワクチン組成物。
  10. 前記動員化合物がGM-CSFを含む、請求項1記載のワクチン組成物。
  11. 前記抗原が腫瘍抗原を含む、請求項1記載のワクチン組成物。
  12. 前記抗原が腫瘍細胞溶解物を含む、請求項1記載のワクチン組成物。
  13. メソポーラスシリカロッド；
    免疫細胞を動員するサイトカインを含む免疫細胞動員化合物；
    免疫細胞活性化化合物、および
    抗原を含む、
    該抗原に対する全身性抗原特異的免疫応答を誘導するため、またはリンパ節に抗原特異的免疫細胞を戻すことを誘導するための、ワクチン組成物の使用。
  14. 対象に投与されたときに、前記メソポーラスシリカロッドが骨格組成物に自己組織化し、ここで、該骨格組成物が、免疫細胞の該骨格組成物への浸潤および該骨格組成物を介した輸送を可能にする、メソポーラスシリカロッド間の空間を含む、請求項1記載のワクチン組成物。
  15. 免疫活性化化合物がTLRアゴニストを含む、請求項1記載のワクチン組成物。
  16. TLRアゴニストが病原体関連分子パターン（PAMP）を含む、請求項15記載のワクチン組成物。
  17. PAMPが細菌由来の免疫調節物質を含む、請求項16記載のワクチン組成物。
  18. TLRアゴニストが、核酸、脂質、ポリサッカリド及びそれらの任意の組み合わせからなる群から選択される、請求項15記載のワクチン組成物。
  19. TLRアゴニストが、TLR3アゴニスト、TLR9アゴニスト及びそれらの組み合わせからなる群から選択される、請求項15記載のワクチン組成物。
  20. TLRアゴニストが、シトシン-グアノシンオリゴヌクレオチド（CpG-ODN）、ポリ（エチレンイミン）（PEI）縮合オリゴヌクレオチド（ODN）(PEI-CpG-ODN)、二本鎖デオキシリボ核酸（DNA）、ポリイノシン-ポリシチジン酸（ポリI:C）、PEIポリ（I:C）、ポリアデニル酸-ポリウリジル酸（ポリ(A:U)）、PEI-ポリ(A:U)、二本鎖リボ核酸（RNA）、モノホスホリルリピドA（MPLA）、リポポリサッカリド（LPS）、及びそれらの任意の組み合わせからなる群から選択される、請求項15記載のワクチン組成物。
  21. TLR9アゴニストが、ODN 1585、ODN 1668、ODN 1826、ODN 2006、ODN 2006-G5、ODN 2216、ODN 2336、ODN 2395、ODN M362及びそれらの任意の組み合わせからなる群から選択される、請求項19記載のワクチン組成物。
  22. 前記骨格が、前記メソポーラスシリカロッド、前記免疫細胞動員化合物及び前記免疫細胞活性化化合物が対象に投与されたあとで、自己組織化することによって形成する、請求項14記載のワクチン組成物。
  23. 前記癌抗原が、MAGE-1、MART-1／メランa、チロシナーゼ、ガングリオシド、gp100、GD-2、O-アセチル化GD-3、GM-2、ムチン-1、Sos1、プロテインキナーゼC結合タンパク質、逆転写酵素タンパク質、AKAPタンパク質、VRK1、KIAA1735、T7-1、T11-3、T11-9、ホモサピエンステロメラーゼ酵素（hTRT）、サイトケラチン-19（CYFRA21-1）、扁平上皮癌抗原1（SCCA-1）、タンパク質T4-A、扁平上皮癌抗原2（SCCA-2）、卵巣癌抗原CA125（1A1-3B）（KIAA0049）、CTCL腫瘍抗原se1-1、CTCL腫瘍抗原se14-3、CTCL腫瘍抗原se20-4、CTCL腫瘍抗原se20-9、CTCL腫瘍抗原se33-1、CTCL腫瘍抗原se37-2、CTCL腫瘍抗原se57-1、CTCL腫瘍抗原se89-1、前立腺特異的膜抗原、5T4癌胎児性栄養膜糖タンパク質、Orf73カポジ肉腫関連ヘルペスウイルス、MAGE-C1（癌／精巣抗原CT7）、MAGE-B1抗原（MAGE-XP抗原）、DAM10、MAGE-B2抗原（DAM6）、MAGE-2抗原、MAGE-4a抗原、MAGE-4b抗原、結腸癌抗原NY-CO-45、肺癌抗原NY-LU-12バリアントA、癌関連表面抗原、腺癌抗原ART1、傍腫瘍性関連脳-精巣癌抗原、癌神経抗原（onconeuronal antigen）MA2、傍腫瘍性神経抗原、神経腫瘍学的腹側抗原（Neuro-oncological ventral antigen）2（NOVA2）、肝細胞癌抗原遺伝子520、腫瘍関連抗原CO-029、腫瘍関連抗原MAGE-X2、滑膜肉腫、Xブレイクポイント2、T細胞によって認識された扁平上皮癌抗原、血清学的に定義された結腸癌抗原1、血清学的に定義された乳癌抗原NY-BR-15、血清学的に定義された乳癌抗原NY-BR-16、クロモグラニンA；副甲状腺分泌タンパク質1、DUPAN-2、CA19-9、CA72-4、CA 195、または、癌胎児性抗原（CEA）を含む請求項１記載のワクチン組成物。
  24. 前記免疫細胞が樹状細胞を含む、請求項１記載のワクチン組成物。
  25. 前記メソポーラスシリカロッドが、グリコール酸または乳酸で修飾されている、請求項１記載のワクチン組成物。
  26. 抗原に対する全身性抗原特異的免疫応答を誘導するための、請求項１〜１２及び１４〜２５のいずれか一項記載のワクチン組成物の使用。
  27. 前記ワクチン組成物が対象に投与されたときに、前記ロッドが骨格組成物に自己組織化し、ここで、該骨格組成物が、免疫細胞の骨格組成物への浸潤および骨格組成物を介した輸送を可能にする、メソポーラスシリカロッド間の空間を含む、請求項13記載の使用。
  28. 前記投与が、前記ワクチン組成物の注射を含む、請求項13記載の使用。
  29. 前記注射が皮下注射を含む、請求項２８記載の使用。
  30. 前記注射が18ゲージ針を用いる、請求項２８又は２９記載の使用。
  31. 前記抗原特異的免疫反応が、リンパ節における胚中心の形成、抗原を認識することができるCD8 + 細胞傷害性Tリンパ球（CTL）の増殖、抗原特異的CD4+ T細胞の増殖、強力かつ長期間の抗体産生またはバランスのとれたT H 1／T H 2応答、を含む、請求項２７記載の使用。
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