BRPI0503817A - complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturada - Google Patents
complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturadaInfo
- Publication number
- BRPI0503817A BRPI0503817A BRPI0503817-0A BRPI0503817A BRPI0503817A BR PI0503817 A BRPI0503817 A BR PI0503817A BR PI0503817 A BRPI0503817 A BR PI0503817A BR PI0503817 A BRPI0503817 A BR PI0503817A
- Authority
- BR
- Brazil
- Prior art keywords
- immunogenic complex
- present
- silica
- encapsulated
- antigen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/38—Antigens from snakes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Abstract
COMPLEXO IMUNOGêNICO FORMADO POR ANTìGENOS VACINAIS ENCAPSULADOS POR SìLICA MESOPOROSA NANOESTRUTURA A presente invenção refere-se a um produto dito "complexo imunogênico" que compreende um adjuvante caracterizado por partículas sólidas de sílica mesoporosa nanoestruturada altamente ordenada, preferentemente a sílica SBA-15, e antígenos vacinais de naturezas diversas encapsulados nos ditos adjuvantes. O complexo imunogênico da presente invenção permite a apresentação dos antígenos que o compõe aos linfócitos de maneira segura, gradual e prolongada que leva a uma memória imunológica mais eficiente, aumenta a imunogenicidade do antígeno e melhora a produção de anticorpos. Isto garante uma proteção imunológica eficiente com menores quantidades de antígenos e/ou menos repetições de doses vacinais. Alem disso as características do complexo imunogênico da presente invenção promovem efetiva indução de imunidade de maneira homogênea em indivíduos "bons e maus respondedores".
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0503817-0A BRPI0503817A (pt) | 2005-09-12 | 2005-09-12 | complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturada |
PCT/BR2006/000182 WO2007030901A1 (en) | 2005-09-12 | 2006-09-12 | Immunogenic complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica |
EP06775036.4A EP1942934B1 (en) | 2005-09-12 | 2006-09-12 | Immunogenic complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica |
JP2008530281A JP5091863B2 (ja) | 2005-09-12 | 2006-09-12 | ナノ構造のメソポーラスシリカに組み込まれたワクチン抗原からなる免疫原性複合体 |
ES06775036T ES2423892T3 (es) | 2005-09-12 | 2006-09-12 | Complejo inmun�geno formado por ant�genos de vacuna encapsulados con s�lice mesoporosa nanoestructurada |
US12/066,489 US8642258B2 (en) | 2005-09-12 | 2006-09-12 | Immunogenical complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica |
CA2621373A CA2621373C (en) | 2005-09-12 | 2006-09-12 | Immunogenic complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica |
CN2006800383996A CN101287491B (zh) | 2005-09-12 | 2006-09-12 | 由使用纳米结构的中孔二氧化硅包囊的疫苗抗原形成的免疫原性复合物 |
KR1020087007043A KR101089400B1 (ko) | 2005-09-12 | 2006-09-12 | 나노구조의 메소다공성 실리카에 의해 캡슐화된 백신항원에 의해 형성된 면역원 복합체 |
ZA200802277A ZA200802277B (en) | 2005-09-12 | 2008-03-10 | Immunogenic complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica |
HK09102975.6A HK1124791A1 (en) | 2005-09-12 | 2009-03-30 | Immunogenic complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0503817-0A BRPI0503817A (pt) | 2005-09-12 | 2005-09-12 | complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturada |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0503817A true BRPI0503817A (pt) | 2007-05-15 |
Family
ID=37864579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0503817-0A BRPI0503817A (pt) | 2005-09-12 | 2005-09-12 | complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturada |
Country Status (11)
Country | Link |
---|---|
US (1) | US8642258B2 (pt) |
EP (1) | EP1942934B1 (pt) |
JP (1) | JP5091863B2 (pt) |
KR (1) | KR101089400B1 (pt) |
CN (1) | CN101287491B (pt) |
BR (1) | BRPI0503817A (pt) |
CA (1) | CA2621373C (pt) |
ES (1) | ES2423892T3 (pt) |
HK (1) | HK1124791A1 (pt) |
WO (1) | WO2007030901A1 (pt) |
ZA (1) | ZA200802277B (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018102896A1 (pt) * | 2016-12-05 | 2018-06-14 | Universidade Estadual De Campinas - Unicamp | Vacina para haemophilus aegypus e uso |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0503817A (pt) | 2005-09-12 | 2007-05-15 | Cristalia Prod Quimicos Farm | complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturada |
EP1960009B1 (en) | 2005-12-13 | 2011-11-23 | The President and Fellows of Harvard College | Scaffolds for cell transplantation |
WO2009002401A2 (en) | 2007-06-21 | 2008-12-31 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
US10328133B2 (en) | 2008-02-13 | 2019-06-25 | President And Fellows Of Harvard College | Continuous cell programming devices |
WO2009146456A1 (en) | 2008-05-30 | 2009-12-03 | President And Fellows Of Harvard College | Controlled release of growth factors and signaling molecules for promoting angiogenesis |
DE102008033175A1 (de) * | 2008-07-15 | 2010-01-21 | Merck Patent Gmbh | Siliciumdioxid-Nanopartikel und deren Verwendung zur Vakzinierung |
JP2010083834A (ja) * | 2008-10-01 | 2010-04-15 | Naris Cosmetics Co Ltd | アレルゲン不活性化剤、及びそれを含有する化粧料。 |
WO2010120749A2 (en) | 2009-04-13 | 2010-10-21 | President And Fellow Of Harvard College | Harnessing cell dynamics to engineer materials |
AU2010278702C1 (en) | 2009-07-31 | 2016-07-14 | Forsyth Dental Infirmary For Children | Programming of cells for tolerogenic therapies |
EP2542230A4 (en) | 2010-03-05 | 2013-08-28 | Harvard College | ENHANCEMENT OF SKELETAL MUSCLE STRAIN CELL GRAFT WITH DUAL DELIVERY OF VEGF AND IGF-1 |
EP2585053A4 (en) | 2010-06-25 | 2014-02-26 | Harvard College | COMMON RELEASE OF STIMULATING AND HEMMING FACTORS FOR THE PRODUCTION OF TEMPORARY STABILIZED AND SPATULARLY LIMITED ZONES |
KR102155383B1 (ko) | 2010-10-06 | 2020-09-11 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 재료에 기초한 세포 치료를 위한 주사 가능한 기공 형성 하이드로겔 |
US9603894B2 (en) | 2010-11-08 | 2017-03-28 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
WO2012148684A1 (en) | 2011-04-27 | 2012-11-01 | President And Fellows Of Harvard College | Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation |
US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
WO2012149358A1 (en) | 2011-04-28 | 2012-11-01 | President And Fellows Of Harvard College | Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration |
AU2012261848B2 (en) | 2011-06-03 | 2017-06-15 | President And Fellows Of Harvard College | In situ antigen-generating cancer vaccine |
CN103012594B (zh) * | 2011-09-22 | 2015-09-02 | 中国农业科学院兰州兽医研究所 | 一种运载猪圆环病毒抗原表位蛋白的纳米载体及应用 |
JP5999639B2 (ja) * | 2011-11-25 | 2016-09-28 | 国立研究開発法人産業技術総合研究所 | 免疫刺激因子担持微粒子 |
PT2838515T (pt) * | 2012-04-16 | 2020-02-25 | Harvard College | Composições de sílica mesoporosa para modular respostas imunológicas |
PL2919903T3 (pl) | 2012-11-14 | 2020-12-14 | W.R. Grace & Co. - Conn. | Kompozycje zawierające materiał biologicznie aktywny i nieuporządkowany tlenek nieorganiczny |
US20160151482A1 (en) * | 2013-04-02 | 2016-06-02 | Stc. Unm | Mesoporous alum nanoparticles as a universal platform for antigen adsorption, presentation, and delivery |
CA2933910A1 (en) * | 2013-12-19 | 2015-06-25 | The University Of Queensland | Method of synthesis of silica vesicles and use thereof |
JP7348708B2 (ja) | 2014-04-30 | 2023-09-21 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 組み合わせワクチン装置および癌細胞を殺滅する方法 |
CN105267970A (zh) * | 2015-01-08 | 2016-01-27 | 浙江大学 | 一种表面具有二氧化硅的热稳定疫苗及其制备方法 |
EP3250250A4 (en) | 2015-01-30 | 2019-05-22 | President and Fellows of Harvard College | PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY |
US11150242B2 (en) | 2015-04-10 | 2021-10-19 | President And Fellows Of Harvard College | Immune cell trapping devices and methods for making and using the same |
JP6868862B2 (ja) * | 2015-08-31 | 2021-05-12 | 国立研究開発法人産業技術総合研究所 | メソポーラスシリカ粒子 |
CN105597094A (zh) * | 2015-12-31 | 2016-05-25 | 河南农业大学 | 猪传染性胃肠炎病毒纳米硅佐剂灭活疫苗及其制备方法 |
WO2017120504A1 (en) | 2016-01-08 | 2017-07-13 | Durfee Paul N | Osteotropic nanoparticles for prevention or treatment of bone metastases |
US11752238B2 (en) | 2016-02-06 | 2023-09-12 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
JP2019522486A (ja) | 2016-07-13 | 2019-08-15 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 抗原提示細胞模倣足場およびそれを作製および使用するための方法 |
GB2552704A (en) * | 2016-08-04 | 2018-02-07 | Univ Bath | Biomolecule preservation |
CN106727426A (zh) * | 2016-12-08 | 2017-05-31 | 中国药科大学 | 一种用于口服蛋白免疫载体的制备方法 |
WO2018160865A1 (en) | 2017-03-01 | 2018-09-07 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
CN114377120B (zh) * | 2022-01-10 | 2023-09-22 | 大连理工大学 | 一种以病毒样颗粒为模板的二氧化硅疫苗递送系统的构建及其应用 |
Family Cites Families (15)
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US5057296A (en) * | 1990-12-10 | 1991-10-15 | Mobil Oil Corp. | Method for synthesizing mesoporous crystalline material |
US5102643A (en) * | 1990-01-25 | 1992-04-07 | Mobil Oil Corp. | Composition of synthetic porous crystalline material, its synthesis |
AU7881000A (en) * | 1999-08-16 | 2001-03-13 | Henceforth Hibernia, Inc. | Therapeutic and prophylactic compositions including catalytic biomimetic solids and methods to prepare and use them |
US20020051794A1 (en) * | 2000-08-09 | 2002-05-02 | Alk-Abello A/S | Novel parenteral vaccine formulations and uses thereof |
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CN1193818C (zh) * | 2002-03-13 | 2005-03-23 | 华东理工大学 | 一种二氧化硅磁性微球及其制备方法 |
US20040005352A1 (en) * | 2002-04-16 | 2004-01-08 | Lopez Gabriel P. | Biologically functionalized porous microspheres |
JP2004083501A (ja) * | 2002-08-28 | 2004-03-18 | Toyota Central Res & Dev Lab Inc | 安定化抗体とこれを利用する免疫反応法及び免疫反応装置 |
JP2004155745A (ja) * | 2002-11-08 | 2004-06-03 | Kumamoto Technology & Industry Foundation | ペプチドおよびその利用 |
US20040101822A1 (en) * | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
JP2004321010A (ja) * | 2003-04-21 | 2004-11-18 | Japan Science & Technology Agency | 新規レンサ球菌タンパク質抗原 |
US20060018966A1 (en) * | 2003-07-22 | 2006-01-26 | Lin Victor S | Antimicrobial mesoporous silica nanoparticles |
US7563451B2 (en) * | 2003-07-22 | 2009-07-21 | Iowa State University Research Foundation, Inc. | Capped mesoporous silicates |
JP4429105B2 (ja) * | 2003-08-19 | 2010-03-10 | キヤノン株式会社 | 有機物固定化構造体及びその製造方法、ペプチド及びdna |
BRPI0503817A (pt) | 2005-09-12 | 2007-05-15 | Cristalia Prod Quimicos Farm | complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturada |
-
2005
- 2005-09-12 BR BRPI0503817-0A patent/BRPI0503817A/pt not_active IP Right Cessation
-
2006
- 2006-09-12 KR KR1020087007043A patent/KR101089400B1/ko not_active IP Right Cessation
- 2006-09-12 CN CN2006800383996A patent/CN101287491B/zh not_active Expired - Fee Related
- 2006-09-12 EP EP06775036.4A patent/EP1942934B1/en not_active Not-in-force
- 2006-09-12 CA CA2621373A patent/CA2621373C/en not_active Expired - Fee Related
- 2006-09-12 JP JP2008530281A patent/JP5091863B2/ja not_active Expired - Fee Related
- 2006-09-12 US US12/066,489 patent/US8642258B2/en not_active Expired - Fee Related
- 2006-09-12 WO PCT/BR2006/000182 patent/WO2007030901A1/en active Application Filing
- 2006-09-12 ES ES06775036T patent/ES2423892T3/es active Active
-
2008
- 2008-03-10 ZA ZA200802277A patent/ZA200802277B/xx unknown
-
2009
- 2009-03-30 HK HK09102975.6A patent/HK1124791A1/xx not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018102896A1 (pt) * | 2016-12-05 | 2018-06-14 | Universidade Estadual De Campinas - Unicamp | Vacina para haemophilus aegypus e uso |
Also Published As
Publication number | Publication date |
---|---|
JP5091863B2 (ja) | 2012-12-05 |
CN101287491B (zh) | 2013-01-30 |
KR101089400B1 (ko) | 2011-12-07 |
US20080286371A1 (en) | 2008-11-20 |
WO2007030901A1 (en) | 2007-03-22 |
US8642258B2 (en) | 2014-02-04 |
CN101287491A (zh) | 2008-10-15 |
KR20080047569A (ko) | 2008-05-29 |
EP1942934A1 (en) | 2008-07-16 |
CA2621373C (en) | 2014-05-27 |
ZA200802277B (en) | 2009-01-28 |
EP1942934B1 (en) | 2013-05-01 |
HK1124791A1 (en) | 2009-07-24 |
JP2009507859A (ja) | 2009-02-26 |
ES2423892T3 (es) | 2013-09-25 |
CA2621373A1 (en) | 2007-03-22 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 11/07/2017, OBSERVADAS AS CONDICOES LEGAIS. |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time | ||
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2479 DE 10-07-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |