JP2018522072A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018522072A5 JP2018522072A5 JP2018525531A JP2018525531A JP2018522072A5 JP 2018522072 A5 JP2018522072 A5 JP 2018522072A5 JP 2018525531 A JP2018525531 A JP 2018525531A JP 2018525531 A JP2018525531 A JP 2018525531A JP 2018522072 A5 JP2018522072 A5 JP 2018522072A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cells
- vivo
- cancer
- engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021149724A JP2022000036A (ja) | 2015-07-31 | 2021-09-14 | 改変された細胞および治療の方法 |
| JP2023171191A JP2024001104A (ja) | 2015-07-31 | 2023-10-02 | 改変された細胞および治療の方法 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199905P | 2015-07-31 | 2015-07-31 | |
| US62/199,905 | 2015-07-31 | ||
| US201562232983P | 2015-09-25 | 2015-09-25 | |
| US62/232,983 | 2015-09-25 | ||
| US201662286206P | 2016-01-22 | 2016-01-22 | |
| US62/286,206 | 2016-01-22 | ||
| US201662295670P | 2016-02-16 | 2016-02-16 | |
| US62/295,670 | 2016-02-16 | ||
| US201662330464P | 2016-05-02 | 2016-05-02 | |
| US62/330,464 | 2016-05-02 | ||
| US201662360245P | 2016-07-08 | 2016-07-08 | |
| US62/360,245 | 2016-07-08 | ||
| PCT/US2016/044858 WO2017023803A1 (en) | 2015-07-31 | 2016-07-29 | Modified cells and methods of therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021149724A Division JP2022000036A (ja) | 2015-07-31 | 2021-09-14 | 改変された細胞および治療の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522072A JP2018522072A (ja) | 2018-08-09 |
| JP2018522072A5 true JP2018522072A5 (https=) | 2019-09-05 |
| JP7409773B2 JP7409773B2 (ja) | 2024-01-09 |
Family
ID=57943822
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525531A Active JP7409773B2 (ja) | 2015-07-31 | 2016-07-29 | 改変された細胞および治療の方法 |
| JP2021149724A Pending JP2022000036A (ja) | 2015-07-31 | 2021-09-14 | 改変された細胞および治療の方法 |
| JP2023171191A Pending JP2024001104A (ja) | 2015-07-31 | 2023-10-02 | 改変された細胞および治療の方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021149724A Pending JP2022000036A (ja) | 2015-07-31 | 2021-09-14 | 改変された細胞および治療の方法 |
| JP2023171191A Pending JP2024001104A (ja) | 2015-07-31 | 2023-10-02 | 改変された細胞および治療の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (13) | US20170119820A1 (https=) |
| EP (2) | EP3328399B1 (https=) |
| JP (3) | JP7409773B2 (https=) |
| CN (1) | CN108472314A (https=) |
| CA (1) | CA2993431A1 (https=) |
| GB (3) | GB2592821B (https=) |
| IL (2) | IL295616A (https=) |
| WO (2) | WO2017023801A1 (https=) |
Families Citing this family (203)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
| US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
| CN115120746A (zh) * | 2013-05-15 | 2022-09-30 | 明尼苏达大学董事会 | 腺相关病毒介导的基因向中枢神经系统转移 |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| CA2946312A1 (en) | 2014-04-23 | 2015-10-29 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
| CN113846062B (zh) * | 2014-07-25 | 2025-02-21 | 赛拉福柯蒂斯公司 | 用于嵌合抗原受体分子的调控表达的慢病毒载体 |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| KR102763121B1 (ko) | 2015-02-06 | 2025-02-04 | 내셔널 유니버시티 오브 싱가포르 | 치료적 면역 세포의 효능의 향상 방법 |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US10441644B2 (en) | 2015-05-05 | 2019-10-15 | The Regents Of The University Of California | H3.3 CTL peptides and uses thereof |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| GB2592821B (en) | 2015-07-31 | 2022-01-12 | Univ Minnesota | Modified cells and methods of therapy |
| JP6816133B2 (ja) | 2015-10-05 | 2021-01-20 | プレシジョン バイオサイエンシズ，インク． | 改変ヒトｔ細胞受容体アルファ定常領域遺伝子を含む遺伝子改変細胞 |
| EP3359660B1 (en) | 2015-10-05 | 2019-12-04 | Precision Biosciences, Inc. | Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| BR112018008971A2 (pt) * | 2015-11-06 | 2018-11-27 | Crispr Therapeutics Ag | materiais e métodos para tratamento de doença de armazenamento de glicogênio tipo 1a |
| EP4628587A3 (en) | 2016-04-15 | 2026-02-25 | Memorial Sloan Kettering Cancer Center | Transgenic t cell and chimeric antigen receptor t cell compositions and related methods |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| KR102546839B1 (ko) | 2016-08-03 | 2023-06-23 | 워싱턴 유니버시티 | 키메라 항원 수용체를 이용한 t 세포 악성종양의 치료를 위한 car-t 세포의 유전자 편집 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| SG11201901306XA (en) * | 2016-08-19 | 2019-03-28 | Toolgen Inc | Artificially engineered angiogenesis regulatory system |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| US10724043B2 (en) * | 2016-10-06 | 2020-07-28 | Nantbio, Inc. | Multi-pulse transfection methods and cells |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| CN110520530A (zh) * | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
| WO2018075830A1 (en) | 2016-10-19 | 2018-04-26 | Flodesign Sonics, Inc. | Affinity cell extraction by acoustics |
| US11873511B2 (en) * | 2016-10-19 | 2024-01-16 | Cellectis | Targeted gene insertion for improved immune cells therapy |
| AU2017347854B2 (en) * | 2016-10-27 | 2022-12-08 | Intima Bioscience, Inc. | Viral methods of T cell therapy |
| EP4553082A3 (en) | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| NZ753794A (en) * | 2016-11-07 | 2023-05-26 | Genovie Ab | An engineered multi-component system for identification and characterisation of t-cell receptors, t-cell antigens and their functional interaction |
| NZ752984A (en) | 2016-11-22 | 2026-03-27 | Nat Univ Singapore | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| US20180221463A1 (en) * | 2017-01-13 | 2018-08-09 | The Chinese University Of Hong Kong | Modified NK Cells and Uses Thereof |
| US20190381157A1 (en) * | 2017-01-29 | 2019-12-19 | Zequn Tang | Methods of immune modulation against foreign and/or auto antigens |
| US11629340B2 (en) * | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| WO2018175872A1 (en) * | 2017-03-24 | 2018-09-27 | President And Fellows Of Harvard College | Methods of genome engineering by nuclease-transposase fusion proteins |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| EP3612210A4 (en) * | 2017-04-19 | 2021-01-27 | Board Of Regents, The University Of Texas System | MANIPULATED ANTIGEN RECEPTORS EXPRESSING IMMUNE CELLS |
| WO2018201144A1 (en) * | 2017-04-28 | 2018-11-01 | Precision Biosciences, Inc. | Methods for reducing dna-induced cytotoxicity and enhancing gene editing in primary cells |
| CN110785489A (zh) * | 2017-05-04 | 2020-02-11 | 宾夕法尼亚大学董事会 | 使用CRISPR/Cpf1在T细胞中进行基因编辑的组合物和方法 |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| MX2019013514A (es) | 2017-05-12 | 2020-01-20 | Crispr Therapeutics Ag | Materiales y metodos para modificar celulas por ingenieria genetica y usos de los mismos en inmunooncologia. |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111107856A (zh) * | 2017-06-23 | 2020-05-05 | 耶鲁大学 | 增强基于t细胞的免疫疗法的效力的组合物和方法 |
| EP3645038B1 (en) | 2017-06-30 | 2026-02-18 | Precision Biosciences, Inc. | Genetically-modified t cells comprising a modified intron in the t cell receptor alpha gene |
| EP3645021A4 (en) | 2017-06-30 | 2021-04-21 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| CN107475292B (zh) * | 2017-08-02 | 2018-06-15 | 山东百福基因科技有限公司 | Pd-1基因缺陷型t淋巴细胞制剂的制备方法 |
| US11331019B2 (en) | 2017-08-07 | 2022-05-17 | The Research Foundation For The State University Of New York | Nanoparticle sensor having a nanofibrous membrane scaffold |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| AU2018329741B2 (en) | 2017-09-08 | 2025-02-20 | Poseida Therapeutics, Inc. | Compositions and methods for chimeric ligand receptor (CLR)-mediated conditional gene expression |
| US20200261502A1 (en) * | 2017-09-08 | 2020-08-20 | Carsgen Therapeutics Co., Ltd. | Genetically engineered t cell and application thereof |
| KR102883778B1 (ko) | 2017-09-22 | 2025-11-12 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Ii형 점액다당류증의 치료를 위한 유전자 요법 |
| CN109628493B (zh) * | 2017-10-09 | 2021-12-07 | 广东赤萌医疗科技有限公司 | 一种用于制备可异体移植t细胞的基因编辑系统 |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| KR20200075851A (ko) * | 2017-10-19 | 2020-06-26 | 셀렉티스 | 개선된 면역 세포들 치료를 위한 nk 억제제들의 타겟인 유전자 통합 |
| US12258580B2 (en) * | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| WO2019089884A2 (en) * | 2017-11-01 | 2019-05-09 | Editas Medicine, Inc. | Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy |
| BR112020008568A2 (pt) | 2017-11-09 | 2020-10-06 | Sangamo Therapeutics, Inc. | modificação genética de gene de proteína contendo sh2 indutível por citoquina (cish) |
| CR20200251A (es) * | 2017-11-17 | 2020-07-17 | Iovance Biotherapeutics Inc | Expansión de til de aspirados con aguja fina y biopsias por punción |
| CN109837244A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种敲除pd1的靶向cd19的嵌合抗原受体t细胞及其制备方法和应用 |
| MX2020005907A (es) | 2017-12-08 | 2020-10-19 | Juno Therapeutics Inc | Formulacion de medio libre de suero para cultivar celulas y metodos de uso de la misma. |
| CN119193493A (zh) | 2017-12-08 | 2024-12-27 | 朱诺治疗学股份有限公司 | 生产工程化t细胞组合物的过程 |
| EP3724326A1 (en) * | 2017-12-11 | 2020-10-21 | Editas Medicine, Inc. | Cpf1-related methods and compositions for gene editing |
| KR102439221B1 (ko) | 2017-12-14 | 2022-09-01 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| US12473336B2 (en) | 2018-02-21 | 2025-11-18 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses thereof |
| WO2019168923A1 (en) * | 2018-03-01 | 2019-09-06 | University Of Kansas | Techniques for generating cell-based therapeutics using recombinant t cell receptor genes |
| WO2019178225A2 (en) | 2018-03-13 | 2019-09-19 | Regents Of The University Of Minnesota | Lymphohematopoietic engineering using cas9 base editors |
| US11786554B2 (en) | 2018-04-12 | 2023-10-17 | Precision Biosciences, Inc. | Optimized engineered nucleases having specificity for the human T cell receptor alpha constant region gene |
| EP3784224A4 (en) * | 2018-04-27 | 2022-08-03 | The Regents of the University of California | DE NOVO FORMATION OF THE BILIARY SYSTEM BY HEPATOCYTE TRANSDIFFERENTIATION |
| KR20210005240A (ko) * | 2018-05-03 | 2021-01-13 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 면역 관문 차단과 함께 키메라 항원 수용체를 발현하도록 가공된 천연 킬러 세포 |
| EP3790562A4 (en) * | 2018-05-11 | 2022-01-12 | The Regents of the University of California | MODIFICATION OF IMMUNE CELLS TO INCREASE ACTIVITY |
| MX2020012028A (es) | 2018-05-11 | 2021-03-29 | Crispr Therapeutics Ag | Metodos y composiciones para tratar el cancer. |
| KR20210045360A (ko) | 2018-05-16 | 2021-04-26 | 신테고 코포레이션 | 가이드 rna 설계 및 사용을 위한 방법 및 시스템 |
| US20210228630A1 (en) * | 2018-05-16 | 2021-07-29 | Research Institute At Nationwide Children's Hospital | Generation of knock-out primary and expanded human nk cells using cas9 ribonucleoproteins |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3784776A4 (en) | 2018-05-23 | 2022-01-26 | National University of Singapore | Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies |
| US20210254068A1 (en) * | 2018-06-19 | 2021-08-19 | Regents Of The University Of Minnesota | Genome engineering primary monocytes |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020023361A1 (en) | 2018-07-23 | 2020-01-30 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Enhancing anti-tumor response in melanoma cells with defective sting signaling |
| EP4678727A3 (en) | 2018-07-26 | 2026-03-11 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| CN109593771B (zh) * | 2018-07-27 | 2022-03-29 | 四川大学华西医院 | 一种人类map2k5第1100位碱基突变基因及其检测试剂盒 |
| US12516099B2 (en) | 2018-08-09 | 2026-01-06 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| US20210246472A1 (en) * | 2018-08-21 | 2021-08-12 | Sigma-Aldrich Co. Llc | Down-regulation of the cytosolic dna sensor pathway |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| EP3851528A4 (en) * | 2018-09-12 | 2023-12-06 | Institute for Basic Science | COMPOSITION FOR INDUCATING DEATH OF CELLS HAVING MUTATED GENE AND METHOD FOR INDUCATING DEATH OF CELLS HAVING MODIFIED GENE USING THE COMPOSITION |
| CN110904045A (zh) * | 2018-09-17 | 2020-03-24 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| CN111004781A (zh) * | 2018-10-08 | 2020-04-14 | 南加利福尼亚大学 | 长期扩增粒细胞-巨噬细胞祖细胞的方法及其应用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| TWI868080B (zh) * | 2018-10-18 | 2025-01-01 | 日商武田藥品工業股份有限公司 | T細胞之活性化/增殖方法 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020092839A1 (en) * | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| EP3873540A4 (en) | 2018-10-31 | 2022-07-27 | Mayo Foundation for Medical Education and Research | METHODS AND MATERIALS FOR THE TREATMENT OF CANCER |
| MX2021006208A (es) * | 2018-11-28 | 2021-10-01 | Univ Texas | Edición por multiplexación del genoma de células inmunitarias para mejorar la funcionalidad y resistencia al entorno supresor. |
| CN111349615B (zh) * | 2018-12-24 | 2024-08-13 | 上海细胞治疗集团股份有限公司 | 制备过表达外源基因的细胞的方法 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| BR112021014442A2 (pt) * | 2019-02-01 | 2021-09-21 | KSQ Therapeutics, Inc. | Composições de regulação gênica e métodos para imunoterapia aprimorada |
| CA3129613A1 (en) * | 2019-02-12 | 2020-08-20 | Provincial Health Services Authority | Compositions and methods for enhanced lymphocyte-mediated immunotherapy |
| IL285534B2 (en) | 2019-02-12 | 2025-04-01 | Pact Pharma Inc | Preparations and methods for identifying antigen-specific T cells |
| PE20211959A1 (es) | 2019-02-15 | 2021-09-30 | Editas Medicine Inc | Celulas asesinas naturales (nk) modificadas para inmunoterapia |
| CN109777782A (zh) * | 2019-02-15 | 2019-05-21 | 北京门罗生物科技有限公司 | 一种通用型car-t细胞及其制备方法和用途 |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020206046A1 (en) * | 2019-04-01 | 2020-10-08 | The Broad Institute, Inc. | Methods and compositions for cell therapy |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN110144348A (zh) * | 2019-04-22 | 2019-08-20 | 江苏医药职业学院 | 用于敲低DEAH盒解旋酶16表达的siRNA、重组载体及其应用 |
| MX2021013359A (es) | 2019-04-30 | 2022-01-31 | Crispr Therapeutics Ag | Terapia de celulas alogénicas de neoplasias malignas de células b usando células t modificadas genéticamente dirigidas a cd19. |
| AU2020283048A1 (en) | 2019-05-31 | 2021-12-23 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| JP7644722B2 (ja) * | 2019-06-01 | 2025-03-12 | シベック バイオテクノロジーズ，インコーポレイティド | 真核細胞への遺伝子編集システムの送達のための細菌プラットフォーム |
| AU2020288829A1 (en) * | 2019-06-04 | 2021-12-02 | Nkarta, Inc. | Combinations of engineered natural killer cells and engineered T cells for immunotherapy |
| GB201908729D0 (en) * | 2019-06-18 | 2019-07-31 | Imp College Innovations Ltd | RNA construct |
| WO2021007089A1 (en) * | 2019-07-08 | 2021-01-14 | Pillargo, Inc. | Homologous recombination directed genome editing in eukaryotes |
| CN114981409A (zh) | 2019-09-03 | 2022-08-30 | 美洛德生物医药公司 | 用于基因组整合的方法和组合物 |
| EP4025596A4 (en) * | 2019-09-04 | 2023-09-20 | Cedars-Sinai Medical Center | Use of calcineurin inhibitor free ctla4-ig + anti-il6/il6r for long term immunosuppression in solid organ transplant recipients |
| PH12022550542A1 (en) | 2019-09-05 | 2023-03-20 | Crispr Therapeutics Ag | Universal donor cells |
| EP4034659A4 (en) * | 2019-09-27 | 2024-10-16 | The Broad Institute, Inc. | PROGRAMMABLE POLYNUCLEOTIDE EDITORS FOR AMPLIFIED HOMOLOGOUS RECOMBINATION |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021092593A1 (en) * | 2019-11-08 | 2021-05-14 | The University Of North Carolina At Chapel Hill | Use of agonists to augment car t function in solid tumors |
| EP4065157A1 (en) | 2019-11-26 | 2022-10-05 | Novartis AG | Cd19 and cd22 chimeric antigen receptors and uses thereof |
| KR20220121814A (ko) * | 2019-11-27 | 2022-09-01 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 종양 미세 환경에서 면역 억제를 극복하기 위한 조작된 t 세포 및 종양 침윤성 림프구 |
| BR112022011795A2 (pt) | 2019-12-20 | 2022-08-30 | Instil Bio Uk Ltd | Métodos para preparar e isolar uma população terapêutica de linfócitos e para tratar câncer em um indivíduo, população terapêutica de linfócitos, bolsa criopreservada, recipiente flexível, e, sistema para extração de linfócitos |
| CN110951782A (zh) * | 2019-12-23 | 2020-04-03 | 湖南普拉特网络科技有限公司 | 一种能稳定表达Cas9蛋白的细胞株及其制备方法与应用 |
| CN110964744A (zh) * | 2019-12-23 | 2020-04-07 | 湖南普拉特泽生物科技有限公司 | 一种能稳定表达Cas9蛋白的人骨肉瘤U-2OS工具细胞株及其制备方法与应用 |
| CN111420025B (zh) * | 2020-04-28 | 2021-06-11 | 中国药科大学 | 茜草科类型环肽化合物在制备cGAS-STING信号通路激活剂的药物中的应用 |
| CA3158133A1 (en) | 2020-04-28 | 2021-11-04 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| CN115803435A (zh) * | 2020-05-06 | 2023-03-14 | 塞勒克提斯公司 | 用于在细胞基因组中靶向插入外源序列的方法 |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CN112063620A (zh) * | 2020-06-16 | 2020-12-11 | 中国人民解放军陆军军医大学 | 抑制猪流行性腹泻病毒M基因表达的shRNA |
| WO2021263070A1 (en) * | 2020-06-26 | 2021-12-30 | Csl Behring Llc | Donor t-cells with kill switch |
| WO2022026921A1 (en) * | 2020-07-30 | 2022-02-03 | Repertoire Immune Medicines, Inc. | Identification and use of t cell epitopes in designing diagnostic and therapeutic approaches for covid-19 |
| CN116322716A (zh) | 2020-09-23 | 2023-06-23 | 克里斯珀医疗股份公司 | Regnase-1和/或TGFBRII被破坏的基因工程化T细胞具有改善的功能性和持久性 |
| WO2022083667A1 (en) * | 2020-10-21 | 2022-04-28 | Nanjing Legend Biotech Co., Ltd. | Polypeptides comprising a vaccine specific tcr and a chimeric antigen receptor and uses thereof |
| AU2021368557A1 (en) * | 2020-10-27 | 2023-06-08 | Adoc Ssf, Llc | Compositions and methods for the treatment of cancer using next generation engineered t cell therapy |
| CN114457031A (zh) * | 2020-10-30 | 2022-05-10 | 未来智人再生医学研究院(广州)有限公司 | 一种表达b7-h5阻断物的多能干细胞或其衍生物及应用 |
| TW202237824A (zh) | 2020-11-23 | 2022-10-01 | 美商萊爾免疫藥物股份有限公司 | 培養免疫細胞之方法 |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| WO2022144855A1 (en) | 2020-12-31 | 2022-07-07 | Crispr Therapeutics Ag | Universal donor cells |
| CN112941105A (zh) * | 2021-02-08 | 2021-06-11 | 江西农业大学 | 一种m6A“阅读器”YTHDF2基因改造方法及其应用 |
| CN112746098A (zh) * | 2021-02-22 | 2021-05-04 | 深圳荻硕贝肯精准医学有限公司 | Kir2dl2基因分型试剂盒和分型方法 |
| EP4298208A1 (en) | 2021-02-25 | 2024-01-03 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| CN113249382B (zh) * | 2021-04-12 | 2023-05-12 | 右江民族医学院 | 下调TRIM56基因表达的siRNA及其应用 |
| BR112023023642A2 (pt) | 2021-05-11 | 2024-01-30 | Myeloid Therapeutics Inc | Métodos e composições para integração genômica |
| TW202307210A (zh) | 2021-06-01 | 2023-02-16 | 瑞士商諾華公司 | Ｃｄ１９和ｃｄ２２嵌合抗原受體及其用途 |
| US20240287506A1 (en) * | 2021-06-21 | 2024-08-29 | Westlake University | Library construction method based on long overhang sequence ligation |
| US20240301092A1 (en) * | 2021-06-29 | 2024-09-12 | Tega Therapeutics, Inc. | Heparin from modified mst cells and methods of making and using |
| CN113481184A (zh) * | 2021-08-06 | 2021-10-08 | 北京大学 | 融合蛋白以及其使用方法 |
| CN118056012B (zh) * | 2021-08-24 | 2025-05-30 | 赛斯尔擎生物技术（上海）有限公司 | 一种修饰细胞的方法 |
| US20250032617A1 (en) * | 2021-10-08 | 2025-01-30 | Baylor College Of Medicine | Transgenic t cell receptors targeting neoantigens for diagnosis, prevention, and/or treatment of hematological cancers |
| CN114196604B (zh) * | 2021-10-09 | 2024-01-23 | 上海交通大学医学院附属仁济医院 | 一种双重修饰的工程化细菌及其应用 |
| KR20240099331A (ko) | 2021-10-28 | 2024-06-28 | 라이엘 이뮤노파마, 인크. | 면역 세포를 배양하기 위한 방법 |
| CN114058619B (zh) * | 2021-11-19 | 2023-11-14 | 中国农业科学院兰州兽医研究所 | Riplet敲除细胞系的构建及作为小核糖核酸病毒科病毒疫苗生产细胞系的应用 |
| CN116162621B (zh) * | 2021-11-25 | 2025-09-16 | 中国科学院大连化学物理研究所 | Dna双链序列及应用和肺腺癌细胞增殖抑制剂或在肺腺癌药物 |
| EP4583890A1 (en) * | 2022-09-09 | 2025-07-16 | Iovance Biotherapeutics, Inc. | Processes for generating til products using pd-1/tigit talen double knockdown |
| JP2026502532A (ja) | 2023-01-12 | 2026-01-23 | ナショナル ユニバーシティ オブ シンガポール | Ｔ細胞及びｎｋ細胞悪性腫瘍の免疫療法のためのｃｄ８発現及びキメラ抗原受容体の遮断 |
| WO2024186971A1 (en) * | 2023-03-07 | 2024-09-12 | Intellia Therapeutics, Inc. | Cish compositions and methods for immunotherapy |
| WO2024206911A2 (en) | 2023-03-30 | 2024-10-03 | Children's Hospital Medical Center | Clinical-grade organoids |
| WO2024238977A2 (en) | 2023-05-18 | 2024-11-21 | Children's Hospital Medical Center | Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof |
| EP4731750A2 (en) | 2023-06-23 | 2026-04-29 | Children's Hospital Medical Center | Methods of matrix-free suspension culture |
| WO2025006811A1 (en) | 2023-06-27 | 2025-01-02 | Lyell Immunopharma, Inc. | Methods for culturing immune cells |
| CN121752724A (zh) * | 2023-08-30 | 2026-03-27 | 赋生元公司 | 在免疫检查点基因座处对表达嵌合抗原受体的免疫细胞进行工程化以用于疾病治疗的方法 |
| WO2025072803A1 (en) | 2023-09-29 | 2025-04-03 | Children's Hospital Medical Center | Ntrk2 signaling-mediated alveolar capillary injury and repair |
| WO2025179160A1 (en) * | 2024-02-21 | 2025-08-28 | Research Institute At Nationwide Children's Hospital | Methods of increasing nk cell efficacy through inhibition of v-domain ig suppressor of t cell activation (vista) |
| WO2025212920A1 (en) | 2024-04-03 | 2025-10-09 | Children's Hospital Medical Center | Multi-zonal liver organoids |
| WO2025217202A1 (en) | 2024-04-08 | 2025-10-16 | Children's Hospital Medical Center | Bile duct organoid |
| WO2026006604A1 (en) | 2024-06-26 | 2026-01-02 | Lyell Immunopharma, Inc. | Feeder cell replacement |
Family Cites Families (205)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US5906936A (en) | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
| DK1621554T4 (da) | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| JP4285766B2 (ja) | 1994-03-23 | 2009-06-24 | オハイオ ユニバーシティ | 緻密にした核酸および細胞へのデリバリ |
| US5830755A (en) | 1995-03-27 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | T-cell receptors and their use in therapeutic and diagnostic methods |
| US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| ATE283069T1 (de) | 1996-08-16 | 2004-12-15 | Univ Johns Hopkins Med | Melanomzellinien, welche immundominante melanomantigene teilen und verfahren zu deren anwendung |
| ATE229810T1 (de) | 1996-10-11 | 2003-01-15 | Univ California | Krebs immuntherapie unter verwendung von tumorzellen kombiniert mit lymphozytmischungen |
| AU780231B2 (en) | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| CA2361191A1 (en) | 1999-02-03 | 2000-08-10 | The Children's Medical Center Corporation | Gene repair involving the induction of double-stranded dna cleavage at a chromosomal target site |
| JP2000256212A (ja) | 1999-03-05 | 2000-09-19 | Tadayasu Takada | 良性間葉系腫瘍の治療剤 |
| WO2001055393A2 (en) | 2000-01-28 | 2001-08-02 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mhc class ii restricted t cell epitopes from the cancer antigen ny-eso-1 |
| CA2373110A1 (en) | 2000-03-14 | 2001-09-20 | Neurologix, Inc. | Production of chimeric capsid vectors |
| US20040072752A1 (en) | 2000-10-09 | 2004-04-15 | Andrew Nash | Modulating cytokine or hormone signalling in an animal comprising up-regulating the expression of socs sequence in the animal |
| US8716022B2 (en) | 2000-11-17 | 2014-05-06 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Modulation of meiotic recombination |
| US7723111B2 (en) | 2001-03-09 | 2010-05-25 | The United States Of America As Represented By The Department Of Health And Human Services | Activated dual specificity lymphocytes and their methods of use |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| IL160359A0 (en) | 2001-08-31 | 2004-07-25 | Avidex Ltd | Soluble t cell receptor |
| WO2003067221A2 (en) | 2002-02-08 | 2003-08-14 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune responsiveness in patients with immunological defects |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| WO2003104470A2 (en) * | 2002-06-05 | 2003-12-18 | Her Majesty In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada | Retrons for gene targeting |
| EP2345731B1 (en) | 2003-09-30 | 2015-10-21 | The Trustees of the University of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| ATE417065T1 (de) | 2004-05-19 | 2008-12-15 | Medigene Ltd | Hochaffiner ny-eso-t-zellen-rezeptor |
| AU2005246073B2 (en) | 2004-05-19 | 2010-10-28 | Adaptimmune Limited | Method of improving T cell receptors |
| EP1765361A2 (fr) | 2004-06-25 | 2007-03-28 | Institut Gustave Roussy | Produits contenant au moins un principe actif anticancereux peu diffusible et un principe actif immunostimulant |
| JP2008522951A (ja) | 2004-07-19 | 2008-07-03 | ベイラー・カレツジ・オブ・メデイシン | サイトカインシグナル伝達調節物質の調節および免疫療法のための応用 |
| US8889365B2 (en) | 2005-03-16 | 2014-11-18 | Rutgers, The State University Of New Jersey | Methods and kit for detecting breast cancer |
| ES2525067T3 (es) | 2005-04-07 | 2014-12-17 | The Trustees Of The University Of Pennsylvania | Método de incremento de la función de un vector de AAV |
| US8389708B2 (en) | 2005-06-15 | 2013-03-05 | Weiping Min | Method of cancer treatment using siRNA silencing |
| DK1910521T3 (da) | 2005-08-05 | 2011-02-07 | Helmholtz Zentrum Muenchen | Generering af allo-begrænsede, antigenspecifikke T-celler |
| DK2341149T3 (en) | 2005-08-26 | 2017-02-27 | Dupont Nutrition Biosci Aps | Use of CRISPR-associated genes (Cas) |
| WO2007027509A2 (en) | 2005-08-31 | 2007-03-08 | Biogen Idec Ma Inc. | Evaluating and treating scleroderma |
| GB0602547D0 (en) | 2006-02-08 | 2006-03-22 | Nanotecture Ltd | Improved electrochemical cell construction |
| EP2027273B1 (en) | 2006-05-17 | 2016-04-13 | F. Hoffmann-La Roche AG | Polypeptide producing cells |
| DK2426220T3 (en) | 2006-05-19 | 2016-09-26 | Dupont Nutrition Biosci Aps | Labeled microorganisms, and methods for labeling |
| EP1878744A1 (en) | 2006-07-13 | 2008-01-16 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Epitope-tag for surface-expressed T-cell receptor proteins, uses thereof and method of selecting host cells expressing them |
| JP5543207B2 (ja) | 2006-10-04 | 2014-07-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 不活性化された人工抗原提示細胞の調製および細胞治療におけるそれらの使用 |
| JP2008166438A (ja) | 2006-12-27 | 2008-07-17 | Spansion Llc | 半導体装置およびその製造方法 |
| US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
| US7750449B2 (en) | 2007-03-13 | 2010-07-06 | Micron Technology, Inc. | Packaged semiconductor components having substantially rigid support members and methods of packaging semiconductor components |
| SI2856876T1 (en) | 2007-03-30 | 2018-04-30 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes |
| US8563314B2 (en) | 2007-09-27 | 2013-10-22 | Sangamo Biosciences, Inc. | Methods and compositions for modulating PD1 |
| CA2720903C (en) | 2008-04-14 | 2019-01-15 | Sangamo Biosciences, Inc. | Linear donor constructs for targeted integration |
| WO2010011961A2 (en) | 2008-07-25 | 2010-01-28 | University Of Georgia Research Foundation, Inc. | Prokaryotic rnai-like system and methods of use |
| EP2331566B1 (en) | 2008-08-26 | 2015-10-07 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| US20100076057A1 (en) | 2008-09-23 | 2010-03-25 | Northwestern University | TARGET DNA INTERFERENCE WITH crRNA |
| US9404098B2 (en) | 2008-11-06 | 2016-08-02 | University Of Georgia Research Foundation, Inc. | Method for cleaving a target RNA using a Cas6 polypeptide |
| WO2010093784A2 (en) | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| EP2258719A1 (en) | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| US20120192298A1 (en) | 2009-07-24 | 2012-07-26 | Sigma Aldrich Co. Llc | Method for genome editing |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| US8956828B2 (en) * | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| US9546112B2 (en) | 2010-03-22 | 2017-01-17 | Association Institut De Myologie | Methods of increasing efficiency of vector penetration of target tissue |
| ES2602743T3 (es) * | 2010-09-08 | 2017-02-22 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Receptores de antígenos quiméricos con una región bisagra optimizada |
| WO2012033885A1 (en) | 2010-09-08 | 2012-03-15 | Baylor College Of Medicine | Immunotherapy of cancer using genetically engineered gd2-specific t cells |
| WO2012078540A1 (en) * | 2010-12-08 | 2012-06-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulating immune cell activity using cytokine-induced src homology 2 and/or high temperature requirement a-1 |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012112079A1 (en) | 2011-02-14 | 2012-08-23 | Vitaspero, Inc. | IMPROVING CELLULAR IMMUNOTHERAPEUTIC VACCINES EFFICACY WITH GENE SUPPRESSION IN DENDRITIC CELLS AND T-LYMPHOCYTES USING SiRNA |
| US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| US9987308B2 (en) | 2011-03-23 | 2018-06-05 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| CN103476399A (zh) | 2011-04-18 | 2013-12-25 | 独立行政法人国立精神·神经医疗研究中心 | 药剂递送粒子及其制造方法 |
| WO2012164565A1 (en) | 2011-06-01 | 2012-12-06 | Yeda Research And Development Co. Ltd. | Compositions and methods for downregulating prokaryotic genes |
| WO2012168944A1 (en) * | 2011-06-08 | 2012-12-13 | Aurigene Discovery Technologies Limited | Therapeutic compounds for immunomodulation |
| KR101307196B1 (ko) | 2011-07-15 | 2013-09-12 | 국립대학법인 울산과학기술대학교 산학협력단 | 미세 세포 배양 장치 |
| CN103946952A (zh) | 2011-09-16 | 2014-07-23 | 宾夕法尼亚大学董事会 | 用于治疗癌症的rna改造的t细胞 |
| US9593338B2 (en) | 2011-09-28 | 2017-03-14 | The Regents Of The University Of California | Synthetic transcriptional control elements and methods of generating and using such elements |
| EP2768982A4 (en) * | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS |
| US9688740B2 (en) | 2011-10-26 | 2017-06-27 | National Cancer Center | Mutant CTLA4 gene transfected T cell and composition including same for anticancer immunotherapy |
| US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| KR101749195B1 (ko) * | 2011-12-12 | 2017-06-20 | 셀 메디카 리미티드 | T 세포들을 증식시키는 방법 |
| UA115772C2 (uk) | 2011-12-16 | 2017-12-26 | Таргітджин Байотекнолоджиз Лтд | Композиція програмованого нуклеопротеїнового молекулярного комплексу і спосіб модифікування заданої послідовності нуклеїнової кислоти-мішені |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| EP2852613B1 (en) * | 2012-05-22 | 2019-01-23 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Murine anti-ny-eso-1 t cell receptors |
| US20150017136A1 (en) | 2013-07-15 | 2015-01-15 | Cellectis | Methods for engineering allogeneic and highly active t cell for immunotherapy |
| BR112014029417B1 (pt) | 2012-05-25 | 2023-03-07 | Cellectis | Método ex vivo para a preparação de células t para imunoterapia |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| WO2014006518A1 (en) | 2012-07-04 | 2014-01-09 | Indian Institute Of Science | Compounds as inhibitor of dna double-strand break repair, methods and applications thereof |
| AU2013293270B2 (en) | 2012-07-25 | 2018-08-16 | Massachusetts Institute Of Technology | Inducible DNA binding proteins and genome perturbation tools and applications thereof |
| WO2014022702A2 (en) | 2012-08-03 | 2014-02-06 | The Regents Of The University Of California | Methods and compositions for controlling gene expression by rna processing |
| BR122020002986A8 (pt) | 2012-08-20 | 2023-04-18 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Método e composições para imunoterapia celular |
| US9914930B2 (en) * | 2012-09-07 | 2018-03-13 | Dow Agrosciences Llc | FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks |
| AU2013329186B2 (en) | 2012-10-10 | 2019-02-14 | Sangamo Therapeutics, Inc. | T cell modifying compounds and uses thereof |
| US20140113375A1 (en) * | 2012-10-21 | 2014-04-24 | Lixin Liu | Transient Expression And Reverse Transcription Aided Genome Alteration System |
| AU2013335451C1 (en) | 2012-10-23 | 2024-07-04 | Toolgen Incorporated | Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof |
| GB2508414A (en) | 2012-11-30 | 2014-06-04 | Max Delbrueck Centrum | Tumour specific T cell receptors (TCRs) |
| PL3360964T3 (pl) | 2012-12-06 | 2020-03-31 | Sigma-Aldrich Co. Llc | Modyfikacja i regulacja genomu oparta na crispr |
| CN113355357B (zh) | 2012-12-12 | 2024-12-03 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| US20140186843A1 (en) | 2012-12-12 | 2014-07-03 | Massachusetts Institute Of Technology | Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| WO2014093709A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| EP3031921B1 (en) | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| EP2840140B2 (en) | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| IL239344B2 (en) | 2012-12-12 | 2024-06-01 | Broad Inst Inc | Systems engineering, methods and optimal guiding components for sequence manipulation |
| DK2931891T3 (da) | 2012-12-17 | 2019-08-19 | Harvard College | Rna-styret modificering af menneskelige genomer |
| EP2943565B1 (en) * | 2013-01-14 | 2018-03-28 | Fred Hutchinson Cancer Research Center | Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse |
| WO2014127287A1 (en) | 2013-02-14 | 2014-08-21 | Massachusetts Institute Of Technology | Method for in vivo tergated mutagenesis |
| US10227610B2 (en) | 2013-02-25 | 2019-03-12 | Sangamo Therapeutics, Inc. | Methods and compositions for enhancing nuclease-mediated gene disruption |
| CN113684185A (zh) | 2013-02-26 | 2021-11-23 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| EP2922393B2 (en) * | 2013-02-27 | 2022-12-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Gene editing in the oocyte by cas9 nucleases |
| WO2014134412A1 (en) | 2013-03-01 | 2014-09-04 | Regents Of The University Of Minnesota | Talen-based gene correction |
| RU2662932C2 (ru) | 2013-03-14 | 2018-07-31 | Карибо Биосайенсиз, Инк. | Композиции и способы с участием нуклеиновых кислот, нацеленных на нуклеиновые кислоты |
| US20160138027A1 (en) | 2013-03-14 | 2016-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1) |
| CN112301024A (zh) | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
| US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| US9937207B2 (en) | 2013-03-21 | 2018-04-10 | Sangamo Therapeutics, Inc. | Targeted disruption of T cell receptor genes using talens |
| EP4286517A3 (en) | 2013-04-04 | 2024-03-13 | President and Fellows of Harvard College | Therapeutic uses of genome editing with crispr/cas systems |
| US11311575B2 (en) | 2013-05-13 | 2022-04-26 | Cellectis | Methods for engineering highly active T cell for immunotherapy |
| AU2014266833B2 (en) | 2013-05-13 | 2020-07-02 | Cellectis | Methods for engineering highly active T cell for immunotherapy |
| CN105683376A (zh) | 2013-05-15 | 2016-06-15 | 桑格摩生物科学股份有限公司 | 用于治疗遗传病状的方法和组合物 |
| AU2014273082B2 (en) | 2013-05-29 | 2018-11-08 | Cellectis | A method for producing precise DNA cleavage using Cas9 nickase activity |
| WO2014191128A1 (en) * | 2013-05-29 | 2014-12-04 | Cellectis | Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system |
| ES2883131T3 (es) | 2013-05-29 | 2021-12-07 | Cellectis | Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN |
| JP6195474B2 (ja) | 2013-05-31 | 2017-09-13 | ギガフォトン株式会社 | 極端紫外光生成装置及び極端紫外光生成システムにおけるレーザシステムの制御方法 |
| CN105492611A (zh) | 2013-06-17 | 2016-04-13 | 布罗德研究所有限公司 | 用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物 |
| WO2014204723A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions |
| MX374532B (es) | 2013-06-17 | 2025-03-06 | Broad Inst Inc | Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos. |
| RU2716420C2 (ru) | 2013-06-17 | 2020-03-11 | Те Брод Инститьют Инк. | Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени |
| WO2014204724A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
| EP3725885A1 (en) | 2013-06-17 | 2020-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| CN105683379A (zh) | 2013-06-17 | 2016-06-15 | 布罗德研究所有限公司 | 用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化 |
| WO2015002293A1 (ja) | 2013-07-05 | 2015-01-08 | 学校法人岩手医科大学 | Ｗｎｔシグナル阻害剤 |
| EP3019595A4 (en) | 2013-07-09 | 2016-11-30 | THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS | |
| EP3666892A1 (en) | 2013-07-10 | 2020-06-17 | President and Fellows of Harvard College | Orthogonal cas9 proteins for rna-guided gene regulation and editing |
| WO2015006774A2 (en) | 2013-07-12 | 2015-01-15 | Oms Investments, Inc. | Plants comprising events pp009-401, pp009-415, and pp009-469, compositions, sequences, and methods for detection thereof |
| US11306328B2 (en) | 2013-07-26 | 2022-04-19 | President And Fellows Of Harvard College | Genome engineering |
| WO2015021426A1 (en) | 2013-08-09 | 2015-02-12 | Sage Labs, Inc. | A crispr/cas system-based novel fusion protein and its application in genome editing |
| CN120574876A (zh) | 2013-08-22 | 2025-09-02 | 纳幕尔杜邦公司 | 使用向导rna/cas内切核酸酶系统的植物基因组修饰及其使用方法 |
| CN104427476B (zh) | 2013-09-10 | 2019-05-07 | 中兴通讯股份有限公司 | 位置信息上报方法、集群服务处理方法及系统 |
| WO2015048577A2 (en) | 2013-09-27 | 2015-04-02 | Editas Medicine, Inc. | Crispr-related methods and compositions |
| WO2015048690A1 (en) | 2013-09-27 | 2015-04-02 | The Regents Of The University Of California | Optimized small guide rnas and methods of use |
| DE102013111099B4 (de) | 2013-10-08 | 2023-11-30 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA |
| US20150098954A1 (en) | 2013-10-08 | 2015-04-09 | Elwha Llc | Compositions and Methods Related to CRISPR Targeting |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| CA2930877A1 (en) | 2013-11-18 | 2015-05-21 | Crispr Therapeutics Ag | Crispr-cas system materials and methods |
| US10787684B2 (en) | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| JP2016538001A (ja) | 2013-11-28 | 2016-12-08 | ホライズン・ジェノミクス・ゲーエムベーハー | 体細胞半数体ヒト細胞株 |
| CN106061488B (zh) | 2013-12-02 | 2021-04-09 | 菲奥医药公司 | 癌症的免疫治疗 |
| EP3470089A1 (en) | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
| JP6712948B2 (ja) * | 2013-12-12 | 2020-06-24 | ザ・ブロード・インスティテュート・インコーポレイテッド | 組成物、及びヌクレオチドリピート障害におけるｃｒｉｓｐｒ−ｃａｓ系の使用方法 |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| EP3083958B1 (en) * | 2013-12-19 | 2019-04-17 | Amyris, Inc. | Methods for genomic integration |
| WO2015121454A1 (en) | 2014-02-14 | 2015-08-20 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
| CN103820454B (zh) | 2014-03-04 | 2016-03-30 | 上海金卫生物技术有限公司 | CRISPR-Cas9特异性敲除人PD1基因的方法以及用于特异性靶向PD1基因的sgRNA |
| JP6681837B2 (ja) | 2014-03-11 | 2020-04-15 | セレクティスＣｅｌｌｅｃｔｉｓ | 同種移植に適合するｔ細胞を作製するための方法 |
| US20170335281A1 (en) * | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| AU2015231041B2 (en) | 2014-03-20 | 2020-07-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tumor-infiltrating lymphocytes for adoptive cell therapy |
| JP2017512481A (ja) | 2014-04-08 | 2017-05-25 | ノースカロライナ ステート ユニバーシティーＮｏｒｔｈ Ｃａｒｏｌｉｎａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ | Ｃｒｉｓｐｒ関連遺伝子を用いた、ｒｎａ依存性の転写抑制のための方法および組成物 |
| US10253311B2 (en) | 2014-04-10 | 2019-04-09 | The Regents Of The University Of California | Methods and compositions for using argonaute to modify a single stranded target nucleic acid |
| WO2015161276A2 (en) * | 2014-04-18 | 2015-10-22 | Editas Medicine, Inc. | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| CA2946312A1 (en) | 2014-04-23 | 2015-10-29 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| CA2945388A1 (en) | 2014-04-23 | 2015-10-29 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) for use in therapy and methods for making the same |
| WO2015188056A1 (en) | 2014-06-05 | 2015-12-10 | Sangamo Biosciences, Inc. | Methods and compositions for nuclease design |
| EP3154555A4 (en) | 2014-06-10 | 2018-02-28 | Monash University | Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer |
| EP3155116A4 (en) | 2014-06-10 | 2017-12-27 | Massachusetts Institute Of Technology | Method for gene editing |
| TWI530276B (zh) | 2014-07-08 | 2016-04-21 | 原相科技股份有限公司 | 具去噪功能之生理偵測模組及其生理偵測方法 |
| KR20170032406A (ko) | 2014-07-15 | 2017-03-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료를 위한 조작된 세포 |
| EP3188763B1 (en) | 2014-09-02 | 2020-05-13 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification |
| WO2016040900A1 (en) | 2014-09-14 | 2016-03-17 | Washington University | Personalized cancer vaccines and methods therefor |
| DK3194570T3 (da) | 2014-09-16 | 2021-09-13 | Sangamo Therapeutics Inc | Fremgangsmåder og sammensætninger til nukleasemedieret genommodificering og -korrektion i hæmatopoietiske stamceller |
| EP3201340B1 (en) | 2014-10-01 | 2020-12-02 | The General Hospital Corporation | Methods for increasing efficiency of nuclease-induced homology-directed repair |
| AU2014407539B2 (en) | 2014-10-02 | 2020-10-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation |
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| US20170335331A1 (en) | 2014-10-31 | 2017-11-23 | The Trustees Of The University Of Pennsylvania | Altering Gene Expression in CART Cells and Uses Thereof |
| EP3018200A1 (en) | 2014-11-07 | 2016-05-11 | Fondazione Matilde Tettamanti e Menotti de Machi Onlus | Improved method for the generation of genetically modified cells |
| CA2969619A1 (en) * | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| EP3034092A1 (en) | 2014-12-17 | 2016-06-22 | Université de Lausanne | Adoptive immunotherapy for treating cancer |
| EP3233918A1 (en) | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
| JP2018500037A (ja) * | 2014-12-31 | 2018-01-11 | シンセティック ジェノミクス インコーポレーテッド | 高効率なインビボゲノム編集のための組成物及び方法 |
| EP3242938B1 (en) | 2015-01-09 | 2020-01-08 | Bio-Rad Laboratories, Inc. | Detection of genome editing |
| CN107429263A (zh) | 2015-01-15 | 2017-12-01 | 斯坦福大学托管董事会 | 调控基因组编辑的方法 |
| KR102422108B1 (ko) | 2015-01-20 | 2022-07-19 | 삼성디스플레이 주식회사 | 유기 발광 표시 장치 |
| WO2016123578A1 (en) | 2015-01-30 | 2016-08-04 | The Regents Of The University Of California | Protein delivery in primary hematopoietic cells |
| WO2016133779A1 (en) | 2015-02-16 | 2016-08-25 | The Trustees Of The University Of Pennsylvania | A fully-human t cell receptor specific for the 369-377 epitope derived from the her2/neu (erbb2) receptor protein |
| AU2016243583B2 (en) | 2015-03-27 | 2022-03-10 | President And Fellows Of Harvard College | Modified T cells and methods of making and using the same |
| CA2985650A1 (en) | 2015-05-13 | 2016-11-17 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Enhancing endonuclease based gene editing in primary cells |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| JP7033453B2 (ja) * | 2015-06-30 | 2022-03-10 | セレクティス | 特異的エンドヌクレアーゼを使用した遺伝子不活化によってｎｋ細胞の機能性を改善する方法 |
| AU2016291778B2 (en) | 2015-07-13 | 2021-05-06 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| GB2592821B (en) | 2015-07-31 | 2022-01-12 | Univ Minnesota | Modified cells and methods of therapy |
| ES2879287T3 (es) | 2015-09-15 | 2021-11-22 | Us Health | Receptores de células T que reconocen KRAS mutado restringido a HLA-cw8 |
| EP3827838B1 (en) | 2015-12-16 | 2023-06-07 | The Walter and Eliza Hall Institute of Medical Research | Inhibition of cytokine-induced sh2 protein in nk cells |
| EP3402495A4 (en) * | 2016-01-15 | 2019-06-19 | Etubics Corporation | METHOD AND COMPOSITIONS FOR T-CELL IMMUNOTHERAPY |
| US9570114B1 (en) | 2016-01-15 | 2017-02-14 | HGST Netherlands B.V. | Laminated film-packed hard disk drive for hermetic sealing |
| US11746349B2 (en) | 2016-02-09 | 2023-09-05 | President And Fellows Of Harvard College | DNA-guided gene editing and regulation |
| SG11201808812RA (en) | 2016-04-15 | 2018-11-29 | Univ Pennsylvania | Novel aav8 mutant capsids and compositions containing same |
| US20200208111A1 (en) | 2016-06-09 | 2020-07-02 | Branden S. Moriarity | Genome-edited nk cell and methods of making and using |
| MA45595A (fr) | 2016-07-07 | 2019-05-15 | Iovance Biotherapeutics Inc | Protéines de liaison au ligand (1) de mort programmée (1) (pd-l1) et leurs procédés d'utilisation |
| RU2019104074A (ru) | 2016-07-15 | 2020-08-18 | Посейда Терапьютикс, Инк. | Химерные рецепторы антигенов и способы их применения |
| CN106480027A (zh) | 2016-09-30 | 2017-03-08 | 重庆高圣生物医药有限责任公司 | CRISPR/Cas9 靶向敲除人PD‑1基因及其特异性gRNA |
| CN110520530A (zh) | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
| AU2017347854B2 (en) | 2016-10-27 | 2022-12-08 | Intima Bioscience, Inc. | Viral methods of T cell therapy |
| WO2018109207A1 (en) | 2016-12-16 | 2018-06-21 | Uniqure Ip B.V. | Immunoadsorption |
| US10550405B2 (en) | 2017-03-15 | 2020-02-04 | The University Of North Carolina At Chapel Hill | Rational polyploid adeno-associated virus vectors and methods of making and using the same |
| EP3645021A4 (en) | 2017-06-30 | 2021-04-21 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| CA3074872A1 (en) | 2017-09-07 | 2019-03-14 | The Board Of Trustees Of The Leland Stanford Junior University | Nuclease systems for genetic engineering |
| BR112020008568A2 (pt) | 2017-11-09 | 2020-10-06 | Sangamo Therapeutics, Inc. | modificação genética de gene de proteína contendo sh2 indutível por citoquina (cish) |
-
2016
- 2016-07-29 GB GB2107651.8A patent/GB2592821B/en active Active
- 2016-07-29 IL IL295616A patent/IL295616A/en unknown
- 2016-07-29 EP EP16833645.1A patent/EP3328399B1/en active Active
- 2016-07-29 JP JP2018525531A patent/JP7409773B2/ja active Active
- 2016-07-29 US US15/224,159 patent/US20170119820A1/en not_active Abandoned
- 2016-07-29 WO PCT/US2016/044856 patent/WO2017023801A1/en not_active Ceased
- 2016-07-29 EP EP23211577.4A patent/EP4339287A3/en active Pending
- 2016-07-29 US US15/224,151 patent/US10166255B2/en active Active
- 2016-07-29 GB GB1803280.5A patent/GB2557123B/en active Active
- 2016-07-29 WO PCT/US2016/044858 patent/WO2017023803A1/en not_active Ceased
- 2016-07-29 CA CA2993431A patent/CA2993431A1/en active Pending
- 2016-07-29 CN CN201680059180.8A patent/CN108472314A/zh active Pending
- 2016-07-29 GB GB2107650.0A patent/GB2595063B/en active Active
- 2016-07-29 IL IL257105A patent/IL257105B/en unknown
- 2016-08-29 US US15/250,514 patent/US10406177B2/en active Active
- 2016-09-02 US US15/256,086 patent/US11147837B2/en active Active
-
2018
- 2018-11-05 US US16/180,867 patent/US11903966B2/en active Active
- 2018-11-06 US US16/182,146 patent/US11642374B2/en active Active
- 2018-11-06 US US16/182,189 patent/US11642375B2/en active Active
-
2020
- 2020-06-12 US US16/900,363 patent/US20200306309A1/en not_active Abandoned
- 2020-06-12 US US16/900,372 patent/US11266692B2/en active Active
- 2020-06-12 US US16/900,368 patent/US11925664B2/en active Active
- 2020-08-26 US US17/003,081 patent/US11583556B2/en active Active
-
2021
- 2021-09-14 JP JP2021149724A patent/JP2022000036A/ja active Pending
- 2021-09-17 US US17/478,615 patent/US20220125843A1/en active Pending
-
2022
- 2022-02-17 US US17/674,378 patent/US20220362297A1/en active Pending
-
2023
- 2023-10-02 JP JP2023171191A patent/JP2024001104A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018522072A5 (https=) | ||
| Ma et al. | Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity | |
| CN107630006B (zh) | 一种制备tcr与hla双基因敲除的t细胞的方法 | |
| JP7459111B2 (ja) | 改変ｔ細胞、その調製方法および使用 | |
| JP6608807B2 (ja) | Ｒｎａガイドｃａｓヌクレアーゼ系を用いることによって免疫療法のためにｔ細胞を操作するための方法 | |
| Wang et al. | CMVpp65 vaccine enhances the antitumor efficacy of adoptively transferred CD19-redirected CMV-specific T cells | |
| JP2019176869A5 (https=) | ||
| Afolabi et al. | Exploiting the CRISPR‐Cas9 gene‐editing system for human cancers and immunotherapy | |
| WO2020092057A1 (en) | Compositions and methods for rapid and modular generation of chimeric antigen receptor t cells | |
| KR20190038479A (ko) | 유전자 조작된 세포 및 그의 제조방법 | |
| KR20240043810A (ko) | 세포 치료에 사용하기 위한 면역학적으로 식별 가능한 세포 표면 변이체 | |
| JP2018537112A5 (https=) | ||
| JP2016539929A5 (https=) | ||
| AU2019376903A1 (en) | Anti-LIV1 immune cell cancer therapy | |
| Sim et al. | Tumor-infiltrating lymphocyte therapy for melanoma: rationale and issues for further clinical development | |
| EP4196579A1 (en) | Compositions and methods for engineering and selection of car t cells with desired phenotypes | |
| JP2023532917A (ja) | Ｂ細胞のｂ２ｍ遺伝子座を編集するための方法および組成物 | |
| AU2021369494A1 (en) | Safe harbor loci | |
| Yang et al. | Optimized two‐step electroporation process to achieve efficient nonviral‐mediated gene insertion into primary T cells | |
| Kath et al. | CAR NK-92 cell–mediated depletion of residual TCR+ cells for ultrapure allogeneic TCR-deleted CAR T-cell products | |
| Gress et al. | Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse after Hematopoietic Stem Cell Transplantation: Part I. Biology of Relapse after Transplantation | |
| US20240307444A1 (en) | Methods and compositions for improved immunotherapies | |
| Wang et al. | CAR-T therapy in HIV: pioneering advances and Navigating challenges | |
| US20250270546A1 (en) | Guide rnas and uses thereof | |
| IL315188A (en) | Methods and compositions comprising fusion proteins for improved immunotherapies |