JP2018512876A - ｓａＲＮＡ組成物および使用方法 - Google Patents

ｓａＲＮＡ組成物および使用方法 Download PDF

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JP2018512876A
JP2018512876A JP2017555233A JP2017555233A JP2018512876A JP 2018512876 A JP2018512876 A JP 2018512876A JP 2017555233 A JP2017555233 A JP 2017555233A JP 2017555233 A JP2017555233 A JP 2017555233A JP 2018512876 A JP2018512876 A JP 2018512876A
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sarna
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target
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nucleotides
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JP2018512876A6 (ja
JP2018512876A5 (enExample
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サトロム、ポール
バッケン ストブナー、エンドレ
バッケン ストブナー、エンドレ
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ミナ セラピューティクス リミテッド
ミナ セラピューティクス リミテッド
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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JP2017555233A 2015-04-22 2016-04-21 ｓａＲＮＡ組成物および使用方法 Pending JP2018512876A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201562150897P 2015-04-22 2015-04-22
US201562150895P 2015-04-22 2015-04-22
US201562150900P 2015-04-22 2015-04-22
US201562150908P 2015-04-22 2015-04-22
US201562150892P 2015-04-22 2015-04-22
US201562150893P 2015-04-22 2015-04-22
US201562150904P 2015-04-22 2015-04-22
US62/150,897 2015-04-22
US62/150,904 2015-04-22
US62/150,900 2015-04-22
US62/150,893 2015-04-22
US62/150,892 2015-04-22
US62/150,908 2015-04-22
US62/150,895 2015-04-22
PCT/GB2016/051116 WO2016170348A2 (en) 2015-04-22 2016-04-21 Sarna compositions and methods of use

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JP2018512876A6 JP2018512876A6 (ja) 2018-10-11
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JP2020162713A Pending JP2021035360A (ja) 2015-04-22 2020-08-19 ｓａＲＮＡ組成物および使用方法
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EP (1) EP3286318A2 (enExample)
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CN108753967A (zh) * 2018-06-08 2018-11-06 复旦大学附属中山医院 一种用于肝癌检测的基因集及其panel检测设计方法
CN109097466A (zh) * 2018-09-21 2018-12-28 王赞鑫 与主动脉夹层疾病相关的snp位点及其应用
CN109207585A (zh) * 2018-11-01 2019-01-15 中国人民解放军第Oo医院 免疫性血小板减少症lncRNA标志物及试剂盒和应用
CN110184358A (zh) * 2019-06-25 2019-08-30 台州市立医院 甲状腺癌早期诊断用的oit3基因及其应用
KR20210089178A (ko) * 2018-10-30 2021-07-15 소마로직, 인크. 샘플 품질 평가 방법
JP2022517803A (ja) * 2019-01-17 2022-03-10 エフ．ホフマン－ラ ロシュ アーゲー Ｅ３ユビキチンリガーゼ（ｕｂｅ３ａ）のタンパク質標的
JP2022552940A (ja) * 2019-09-20 2022-12-21 ラクティゲン セラピューティクス 血小板減少症を治療するための核酸分子及びその応用
JP2023514292A (ja) * 2020-02-14 2023-04-05 カーディオミックス エス．アール．エル． ブルガダ症候群の診断のためのバイオマーカーセット
JP2023550697A (ja) * 2020-10-30 2023-12-05 ▲復▼旦大学 免疫応答調節または抗腫瘍のための薬剤の調製におけるｉｔｐｒｉｐｌ１のモジュレーターとしての使用
WO2024005158A1 (ja) * 2022-06-30 2024-01-04 武田薬品工業株式会社 オリゴヌクレオチド
JP2024500823A (ja) * 2020-12-23 2024-01-10 イーライ リリー アンド カンパニー Ｒｎａ治療薬及びその使用方法
JP2024543933A (ja) * 2022-01-14 2024-11-26 タスリー・ステム・セル・バイオロジー・ラボラトリー・タスリー・グループ・リミテッド 間葉系間質細胞品質評価方法

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KR20240122922A (ko) 2013-03-27 2024-08-13 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
EP4105236A1 (en) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease
JP6929791B2 (ja) 2015-02-09 2021-09-01 デューク ユニバーシティ エピゲノム編集のための組成物および方法
KR102787119B1 (ko) 2015-11-30 2025-03-27 듀크 유니버시티 유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법
US11286533B2 (en) * 2015-12-20 2022-03-29 The National Institute for Biotechnology in the Negev Ltd. Biomarkers of chronic lymphocytic leukemia and use thereof
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CN109462996A (zh) 2016-03-17 2019-03-12 西达-赛奈医疗中心 通过rnaset2诊断炎性肠病的方法
KR102775461B1 (ko) 2016-04-01 2025-02-28 어비디티 바이오사이언시스 인크. 핵산-폴리펩타이드 조성물 및 이의 용도
US20190127713A1 (en) 2016-04-13 2019-05-02 Duke University Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
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GB201611738D0 (en) * 2016-07-05 2016-08-17 Cambridge Entpr Ltd Biomarkers for inflammatory bowel disease
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CN106834288B (zh) * 2016-12-16 2020-08-21 南京医科大学 一种长非编码rna及其在诊断/治疗胃癌中的应用
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CN106929508B (zh) * 2017-02-17 2020-08-21 张灏 一种激活PTPRO基因表达的saRNA及其转运载体
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KR20250117473A (ko) 2017-11-30 2025-08-04 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 유방암 검출방법
HRP20250804T1 (hr) * 2017-12-01 2025-09-12 The Texas A&M University System Antisense liječenje angelmanovog sindroma
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CN118638787A (zh) 2017-12-06 2024-09-13 艾维迪提生物科学公司 治疗肌萎缩和强直性肌营养不良的组合物和方法
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CN107937550B (zh) * 2018-01-08 2020-06-02 青岛泱深生物医药有限公司 一种与乳腺癌发生发展相关的生物标志物及其应用
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CN110468200B (zh) * 2018-05-10 2023-02-28 复旦大学附属肿瘤医院 一种用于癌症预后的多基因检测试剂盒
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CN108424969B (zh) * 2018-06-06 2022-07-15 深圳市颐康生物科技有限公司 一种生物标志物、诊断或预估死亡风险的方法
WO2020002691A1 (en) * 2018-06-28 2020-01-02 United Kingdom Research And Innovation TREATMENT OF CARDIOMYOPATHY THROUGH MODULATION OF HYPOXIA-INDUCED eRNA ACTIVITY
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