IT202200011546A1 - Sequenze di RNA non codificanti in grado di aumentare l'espressione delle proteine CHD8 e CHD2 - Google Patents

Sequenze di RNA non codificanti in grado di aumentare l'espressione delle proteine CHD8 e CHD2 Download PDF

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Publication number
IT202200011546A1
IT202200011546A1 IT102022000011546A IT202200011546A IT202200011546A1 IT 202200011546 A1 IT202200011546 A1 IT 202200011546A1 IT 102022000011546 A IT102022000011546 A IT 102022000011546A IT 202200011546 A IT202200011546 A IT 202200011546A IT 202200011546 A1 IT202200011546 A1 IT 202200011546A1
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IT
Italy
Prior art keywords
chd8
chd2
proteins
expression
increasing
Prior art date
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IT102022000011546A
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English (en)
Inventor
Marta Biagioli
Leva Francesca Di
Michele Arnoldi
Stefano Gustincich
Original Assignee
Univ Degli Studi Di Trento
Fondazione St Italiano Tecnologia
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Publication date
Application filed by Univ Degli Studi Di Trento, Fondazione St Italiano Tecnologia filed Critical Univ Degli Studi Di Trento
Priority to IT102022000011546A priority Critical patent/IT202200011546A1/it
Publication of IT202200011546A1 publication Critical patent/IT202200011546A1/it
Priority to PCT/IT2023/050128 priority patent/WO2023233437A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/04—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; involved in cellular and subcellular movement (3.6.4)
    • C12Y306/04012—DNA helicase (3.6.4.12)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT102022000011546A 2022-06-01 2022-06-01 Sequenze di RNA non codificanti in grado di aumentare l'espressione delle proteine CHD8 e CHD2 IT202200011546A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102022000011546A IT202200011546A1 (it) 2022-06-01 2022-06-01 Sequenze di RNA non codificanti in grado di aumentare l'espressione delle proteine CHD8 e CHD2
PCT/IT2023/050128 WO2023233437A1 (en) 2022-06-01 2023-05-23 Non-coding rna sequences capable of increasing the expression of chd8 and chd2 proteins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102022000011546A IT202200011546A1 (it) 2022-06-01 2022-06-01 Sequenze di RNA non codificanti in grado di aumentare l'espressione delle proteine CHD8 e CHD2

Publications (1)

Publication Number Publication Date
IT202200011546A1 true IT202200011546A1 (it) 2022-09-01

Family

ID=83355583

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102022000011546A IT202200011546A1 (it) 2022-06-01 2022-06-01 Sequenze di RNA non codificanti in grado di aumentare l'espressione delle proteine CHD8 e CHD2

Country Status (2)

Country Link
IT (1) IT202200011546A1 (it)
WO (1) WO2023233437A1 (it)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012087983A1 (en) * 2010-12-20 2012-06-28 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2012133947A1 (en) 2011-03-30 2012-10-04 Riken Functional nucleic acid molecule and use thereof
US20180305689A1 (en) * 2015-04-22 2018-10-25 Mina Therapeutics Limited Sarna compositions and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020102679A1 (en) * 2000-05-24 2002-08-01 Jiangchun Xu Compositions and methods for the therapy and diagnosis of ovarian cancer
JP2007535966A (ja) * 2004-05-04 2007-12-13 ダコ デンマーク アクティーゼルスカブ 染色体異常を検出するための方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012087983A1 (en) * 2010-12-20 2012-06-28 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2012133947A1 (en) 2011-03-30 2012-10-04 Riken Functional nucleic acid molecule and use thereof
US20180305689A1 (en) * 2015-04-22 2018-10-25 Mina Therapeutics Limited Sarna compositions and methods of use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Protein Chromatography : Methods and Protocols", vol. 2434, 25 February 2022, SPRINGER NEW YORK, New York, NY, ISBN: 978-1-4939-6412-3, ISSN: 1064-3745, article ARECHAVALA-GOMEZA VIRGINIA ET AL: "Antisense RNA Design, Delivery, and Analysis", XP093011359 *
ARNOLDI M ET AL: "SINEUPs technology: a new route to possibly treat haploinsufficiency-induced Epilepsy and Autism Spectrum Disorders (ASDs)", EUROPEAN JOURNAL OF HUMAN GENETICS; 52ND CONFERENCE OF THE EUROPEAN-SOCIETY-OF-HUMAN-GENETICS (ESHG); GOTHENBURG, SWEDEN; JUNE 15 -18, 2019, KARGER, BASEL, CH, vol. 27, no. Suppl. 2, 30 September 2019 (2019-09-30), pages 1084 - 1085, XP009532448, ISSN: 1018-4813 *
STRAUSBERG ROBERT ET AL: "wm08b07.x1 NCI_CGAP_Ut4 Homo sapiens cDNA clone IMAGE:2435317 3' simil - Nucleotide - NCBI", 8 January 2011 (2011-01-08), XP093012104, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/nuccore/AI886219> [retrieved on 20230108] *

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WO2023233437A1 (en) 2023-12-07

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