JP2018504143A5 - - Google Patents
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- JP2018504143A5 JP2018504143A5 JP2017557488A JP2017557488A JP2018504143A5 JP 2018504143 A5 JP2018504143 A5 JP 2018504143A5 JP 2017557488 A JP2017557488 A JP 2017557488A JP 2017557488 A JP2017557488 A JP 2017557488A JP 2018504143 A5 JP2018504143 A5 JP 2018504143A5
- Authority
- JP
- Japan
- Prior art keywords
- epitope
- hsp70
- binding domain
- antigen receptor
- chimeric antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101710163595 Chaperone protein DnaK Proteins 0.000 claims 8
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims 8
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims 8
- 210000002865 immune cell Anatomy 0.000 claims 8
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 229960000397 bevacizumab Drugs 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 108020001756 ligand binding domains Proteins 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 102000018932 HSP70 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010027992 HSP70 Heat-Shock Proteins Proteins 0.000 claims 1
- 229960000446 abciximab Drugs 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 229960000548 alemtuzumab Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229960004669 basiliximab Drugs 0.000 claims 1
- 229960000455 brentuximab vedotin Drugs 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229960002806 daclizumab Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960002224 eculizumab Drugs 0.000 claims 1
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 229960003816 muromonab-cd3 Drugs 0.000 claims 1
- 229960005027 natalizumab Drugs 0.000 claims 1
- 229960000402 palivizumab Drugs 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 210000004896 polypeptide structure Anatomy 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229960003876 ranibizumab Drugs 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 229960005267 tositumomab Drugs 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201570044 | 2015-01-26 | ||
| DKPA201570044 | 2015-01-26 | ||
| PCT/EP2016/051468 WO2016120217A1 (en) | 2015-01-26 | 2016-01-25 | Anti-hsp70 specific chimeric antigen receptors (cars) for cancer immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018504143A JP2018504143A (ja) | 2018-02-15 |
| JP2018504143A5 true JP2018504143A5 (https=) | 2019-03-07 |
Family
ID=52396337
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557487A Active JP6884709B2 (ja) | 2015-01-26 | 2016-01-25 | 操作された免疫細胞の選別／枯渇のための、ｍＡｂが推進するキメラ抗原受容体系 |
| JP2017557489A Active JP6779909B2 (ja) | 2015-01-26 | 2016-01-25 | がん免疫治療のための抗ＣＬＬ１特異的単鎖キメラ抗原受容体（ｓｃＣＡＲ） |
| JP2017557491A Pending JP2018504145A (ja) | 2015-01-26 | 2016-01-25 | 再発性／難治性急性骨髄性リンパ腫または芽球性形質細胞様樹状細胞新生物を処置するための、ｃｄ１２３に結合するキメラ抗原受容体を賦与された、操作されたｔ細胞受容体ノックアウト免疫細胞 |
| JP2017557488A Pending JP2018504143A (ja) | 2015-01-26 | 2016-01-25 | がん免疫治療のための抗ｈｓｐ７０特異的キメラ抗原受容体（ｃａｒ） |
| JP2017557490A Withdrawn JP2018504144A (ja) | 2015-01-26 | 2016-01-25 | Ｃｌｌ１特異的多鎖キメラ抗原受容体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557487A Active JP6884709B2 (ja) | 2015-01-26 | 2016-01-25 | 操作された免疫細胞の選別／枯渇のための、ｍＡｂが推進するキメラ抗原受容体系 |
| JP2017557489A Active JP6779909B2 (ja) | 2015-01-26 | 2016-01-25 | がん免疫治療のための抗ＣＬＬ１特異的単鎖キメラ抗原受容体（ｓｃＣＡＲ） |
| JP2017557491A Pending JP2018504145A (ja) | 2015-01-26 | 2016-01-25 | 再発性／難治性急性骨髄性リンパ腫または芽球性形質細胞様樹状細胞新生物を処置するための、ｃｄ１２３に結合するキメラ抗原受容体を賦与された、操作されたｔ細胞受容体ノックアウト免疫細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557490A Withdrawn JP2018504144A (ja) | 2015-01-26 | 2016-01-25 | Ｃｌｌ１特異的多鎖キメラ抗原受容体 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US20180000914A1 (https=) |
| EP (5) | EP3250602A1 (https=) |
| JP (5) | JP6884709B2 (https=) |
| KR (3) | KR102661969B1 (https=) |
| CN (5) | CN107438618A (https=) |
| AU (5) | AU2016212161A1 (https=) |
| BR (2) | BR112017013981A2 (https=) |
| CA (4) | CA2973532A1 (https=) |
| DK (2) | DK3250606T3 (https=) |
| ES (2) | ES2869972T3 (https=) |
| IL (3) | IL252937B (https=) |
| MX (3) | MX381908B (https=) |
| RU (3) | RU2731543C2 (https=) |
| WO (5) | WO2016120218A1 (https=) |
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