JP2020108398A5 - - Google Patents
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- JP2020108398A5 JP2020108398A5 JP2020048623A JP2020048623A JP2020108398A5 JP 2020108398 A5 JP2020108398 A5 JP 2020108398A5 JP 2020048623 A JP2020048623 A JP 2020048623A JP 2020048623 A JP2020048623 A JP 2020048623A JP 2020108398 A5 JP2020108398 A5 JP 2020108398A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid encoding
- car
- producing
- interleukin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000039446 nucleic acids Human genes 0.000 claims 30
- 108020004707 nucleic acids Proteins 0.000 claims 30
- 150000007523 nucleic acids Chemical class 0.000 claims 30
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 24
- 210000001744 T-lymphocyte Anatomy 0.000 claims 15
- 102100036842 C-C motif chemokine 19 Human genes 0.000 claims 10
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims 10
- 102000000704 Interleukin-7 Human genes 0.000 claims 10
- 108010002586 Interleukin-7 Proteins 0.000 claims 10
- 229940100994 interleukin-7 Drugs 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 9
- 239000013604 expression vector Substances 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021213604A JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2024113188A JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014208200 | 2014-10-09 | ||
| JP2014208200 | 2014-10-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017111736A Division JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213604A Division JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020108398A JP2020108398A (ja) | 2020-07-16 |
| JP2020108398A5 true JP2020108398A5 (https=) | 2021-02-12 |
| JP7008350B2 JP7008350B2 (ja) | 2022-02-10 |
Family
ID=55652864
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552830A Active JP6161098B2 (ja) | 2014-10-09 | 2015-10-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2017111736A Active JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2020048623A Active JP7008350B2 (ja) | 2014-10-09 | 2020-03-19 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2021213604A Active JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A Active JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2024113188A Active JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552830A Active JP6161098B2 (ja) | 2014-10-09 | 2015-10-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2017111736A Active JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213604A Active JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A Active JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2024113188A Active JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10316102B2 (https=) |
| EP (2) | EP3597742B1 (https=) |
| JP (6) | JP6161098B2 (https=) |
| KR (1) | KR101890638B1 (https=) |
| CN (1) | CN107109421B (https=) |
| AU (1) | AU2015329444B2 (https=) |
| BR (1) | BR112017006710B1 (https=) |
| CA (1) | CA2962375C (https=) |
| CY (2) | CY1122324T1 (https=) |
| DK (2) | DK3205720T3 (https=) |
| ES (2) | ES2927366T3 (https=) |
| HR (2) | HRP20221211T1 (https=) |
| HU (2) | HUE046710T2 (https=) |
| IL (1) | IL251504B (https=) |
| LT (2) | LT3205720T (https=) |
| MX (1) | MX358472B (https=) |
| MY (1) | MY167722A (https=) |
| NZ (1) | NZ730382A (https=) |
| PH (1) | PH12017500596B1 (https=) |
| PL (2) | PL3597742T3 (https=) |
| PT (2) | PT3597742T (https=) |
| RS (2) | RS63601B1 (https=) |
| RU (1) | RU2670147C1 (https=) |
| SG (1) | SG11201702391RA (https=) |
| SI (2) | SI3205720T1 (https=) |
| SM (1) | SMT201900663T1 (https=) |
| TW (1) | TWI688651B (https=) |
| WO (1) | WO2016056228A1 (https=) |
| ZA (1) | ZA201701968B (https=) |
Families Citing this family (54)
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|---|---|---|---|---|
| MY167722A (en) * | 2014-10-09 | 2018-09-21 | Univ Yamaguchi | Car expression vector and car-expressing t cells |
| GB201509413D0 (en) * | 2015-06-01 | 2015-07-15 | Ucl Business Plc | Fusion protein |
| JP2019508036A (ja) | 2016-02-16 | 2019-03-28 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 免疫療法組成物及び方法 |
| KR20240116832A (ko) * | 2016-03-17 | 2024-07-30 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 면역 기능 제어 인자를 발현하는 면역 담당 세포 및 발현 벡터 |
| WO2018119518A1 (en) * | 2017-01-01 | 2018-07-05 | Lee Chi Yu Gregory | Rp215 chimeric antigen receptor construct and methods of making and using same |
| BR112019013947A2 (pt) | 2017-01-10 | 2020-02-11 | Yamaguchi University | Anticorpo, receptor de antígeno quimérico, célula imunocompetente, gene de anticorpo, vetor, célula hospedeira, método para detectar gpc3, e, kit para a detecção de gpc3. |
| US20210122831A1 (en) * | 2017-03-27 | 2021-04-29 | Noile-Immune Biotech, Inc. | Chimeric antigen receptor |
| CN108484777B (zh) * | 2017-03-31 | 2022-07-12 | 李吉祐 | 人源化rp215单克隆抗体的嵌合抗原受体构建体及核酸分子与应用 |
| KR102790597B1 (ko) | 2017-10-10 | 2025-04-07 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 메모리 기능을 갖는 t세포 또는 b세포의 증강제, 악성 종양 재발 억제제 및 t세포 또는 b세포에 메모리 기능을 유도하는 유도제 |
| IL275453B2 (en) * | 2017-12-24 | 2024-06-01 | Noile Immune Biotech Inc | Immunocompetent cell that expresses a cell surface molecule specifically recognizing human mesothelin, il-7 and ccl19 |
| MX2020006843A (es) * | 2017-12-27 | 2020-09-03 | Takeda Pharmaceuticals Co | Nanoparticula de lipido que contiene acido nucleico y uso de la misma. |
| CN108641001A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 结肠癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108641000A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 肝癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108659133A (zh) * | 2018-04-26 | 2018-10-16 | 上海怡豪生物科技有限公司 | 肺癌的双靶点car-t治疗载体及其构建方法和应用 |
| CA3100446A1 (en) * | 2018-05-15 | 2019-11-21 | Carsgen Therapeutics Co., Ltd. | Genetically engineered cell and application thereof |
| KR20190141511A (ko) * | 2018-06-14 | 2019-12-24 | 주식회사 녹십자랩셀 | 신규 펩티드, 이를 포함하는 키메라 항원 수용체 및 이를 발현하는 면역 세포 |
| CN108866004A (zh) * | 2018-06-26 | 2018-11-23 | 奥妙生物技术（广州）有限公司 | Shp-1敲除的t细胞及其构建方法 |
| AU2019291882A1 (en) | 2018-06-28 | 2020-11-26 | Dana-Farber Cancer Institute, Inc. | Targeting of multiple antigens with multiplex CAR T cells in solid and liquid malignancies |
| JPWO2020017479A1 (ja) * | 2018-07-17 | 2021-08-02 | ノイルイミューン・バイオテック株式会社 | 抗ｇｐｃ３一本鎖抗体を含むｃａｒ |
| CN109055430A (zh) * | 2018-08-14 | 2018-12-21 | 杭州荣泽生物科技有限公司 | 一种共表达il18和ccl19蛋白及靶向muc1基因car-t细胞的制备方法 |
| BR112021003640A2 (pt) | 2018-08-31 | 2021-05-18 | Noile-Immune Biotech, Inc. | célula t, medicamento, vetor de expressão, e, métodos para produzir uma célula de t car e para tratar câncer |
| WO2020050667A1 (ko) * | 2018-09-05 | 2020-03-12 | 공석경 | 고형암을 위한 키메라 항원 수용체 및 키메라 항원 수용체가 발현된 t 세포 |
| US20220096544A1 (en) * | 2018-09-20 | 2022-03-31 | Cafa Therapeutics Limited | Chemokine expressing cell and use thereof |
| WO2020077356A1 (en) * | 2018-10-12 | 2020-04-16 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs) COMPOSITIONS AND METHODS OF USE THEREOF |
| CN109504660B (zh) * | 2018-11-02 | 2021-08-06 | 温州启星生物技术有限公司 | 一种第四代car-t细胞及其构建方法和应用 |
| EP3883955A1 (en) * | 2018-11-19 | 2021-09-29 | Board of Regents, The University of Texas System | A modular, polycistronic vector for car and tcr transduction |
| WO2020183131A1 (en) * | 2019-03-08 | 2020-09-17 | Autolus Limited | Compositions and methods comprising engineered chimeric antigen receptor and modulator of car |
| KR20210150446A (ko) * | 2019-04-04 | 2021-12-10 | 상하이 파마슈티컬스 홀딩 컴퍼니 리미티드 | 종양 항원 인식 수용체를 함유하는 면역 세포 및 이의 적용 |
| CN112080526A (zh) * | 2019-06-14 | 2020-12-15 | 南京艾德免疫治疗研究院有限公司 | 表达il-7和car的表达载体及免疫细胞 |
| CN112080525A (zh) * | 2019-06-14 | 2020-12-15 | 南京艾德免疫治疗研究院有限公司 | 一种改良型嵌合抗原受体t细胞的制备 |
| JP7769325B2 (ja) * | 2019-07-23 | 2025-11-13 | 株式会社東芝 | Ｃａｒ－ｔ細胞の製造方法、核酸導入キャリア及びキット |
| JP7436056B2 (ja) | 2019-10-28 | 2024-02-21 | ノイルイミューン・バイオテック株式会社 | がんを治療するための医薬、組み合わせ医薬、医薬組成物、免疫応答性細胞、核酸送達媒体、及び製品 |
| CN110922490B (zh) * | 2019-12-05 | 2023-03-03 | 浙江启新生物技术有限公司 | 分泌白介素7和趋化因子21的car表达载体及应用 |
| KR20210103975A (ko) * | 2020-02-14 | 2021-08-24 | (주)이뮤노텍바이오팜코리아 | 외부에서 도입된 세포 신호 조절 인자를 과발현하는 면역 세포 및 이들의 용도 |
| JP2021142156A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2021142159A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2021142158A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| CN113528483B (zh) * | 2020-04-22 | 2024-08-16 | 复星凯特生物科技有限公司 | Shp2特异性失活突变蛋白及其在car-t治疗中应用 |
| GB202006820D0 (en) * | 2020-05-07 | 2020-06-24 | Autolus Ltd | Cell |
| WO2021256522A1 (ja) | 2020-06-17 | 2021-12-23 | 国立大学法人京都大学 | キメラ抗原受容体発現免疫担当細胞 |
| KR102297396B1 (ko) | 2020-07-29 | 2021-09-06 | (주)티카로스 | 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포 |
| EP4261225A4 (en) | 2020-12-10 | 2024-11-13 | Eutilex Co., Ltd. | ANTI-PD-1 ANTIBODY AND ITS USES |
| CN114717203B (zh) * | 2020-12-22 | 2023-06-27 | 广东东阳光药业有限公司 | 一种hIL7/hCCL19双基因重组溶瘤病毒及其制备方法和用途 |
| CN114716548B (zh) | 2021-01-05 | 2024-11-05 | (株)爱恩德生物 | 抗-fgfr3抗体及其用途 |
| CN112961248B (zh) * | 2021-02-22 | 2022-03-18 | 广州百暨基因科技有限公司 | 共表达IL-7和CCR2b的嵌合抗原受体融合蛋白及其应用 |
| KR102568745B1 (ko) | 2021-05-18 | 2023-08-24 | 주식회사 바이오솔루션 | 세포외소포체 분비능이 증진된 면역세포 및 이를 활용한 면역 항암요법 |
| CA3227581A1 (en) | 2021-07-29 | 2023-02-02 | Takeda Pharmaceutical Company Limited | Engineered immune cell that specifically targets mesothelin and uses thereof |
| CN113913385A (zh) * | 2021-09-01 | 2022-01-11 | 苏州璞惠卓越生物科技有限公司 | 一种抑制蛋白阻断型嵌合抗原受体修饰的免疫细胞及其用途 |
| CN113921082B (zh) * | 2021-10-27 | 2023-04-07 | 云舟生物科技(广州)股份有限公司 | 基因搜索权重调整方法、计算机存储介质及电子设备 |
| WO2023081455A2 (en) * | 2021-11-08 | 2023-05-11 | Memorial Sloan-Kettering Cancer Center | Immune cells expressing glucose transporter 5 (gluts) and compositions and methods including the same |
| CN119234037A (zh) * | 2022-05-20 | 2024-12-31 | 武田药品工业株式会社 | 生产工程化免疫细胞的方法 |
| US12006353B2 (en) | 2022-07-25 | 2024-06-11 | Long Chen | Application of SCFV protein, car gene expression vector, CAR-T cell and application thereof |
| IL318546A (en) | 2022-07-26 | 2025-03-01 | Aimed Bio Inc | Anti-ROR1 antibody and its uses |
| CN115505601B (zh) * | 2022-10-17 | 2024-05-28 | 深圳市先康达生命科学有限公司 | 一种两级SynNotch逻辑调控结构及其应用 |
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| JPS5857318A (ja) * | 1981-10-01 | 1983-04-05 | Nippon Koutai Kenkyusho:Kk | 癌細胞障害性リンパ球の製造法 |
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| KR20050118057A (ko) * | 2004-04-24 | 2005-12-15 | 김상희 | 아세틸디아실글리세롤류의 화합물을 유효성분으로함유하는 항암제 및 건강식품 |
| TWI436775B (zh) * | 2007-08-24 | 2014-05-11 | Oncotherapy Science Inc | 以抗原胜肽合併化療藥劑治療胰臟癌 |
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| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
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| EP2694549B1 (en) | 2011-04-08 | 2018-08-15 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
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| EP3692794A1 (en) * | 2011-09-16 | 2020-08-12 | Baylor College of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| WO2013051718A1 (ja) | 2011-10-07 | 2013-04-11 | 国立大学法人三重大学 | キメラ抗原受容体 |
| JP6850528B2 (ja) | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| MX2014010185A (es) * | 2012-02-22 | 2014-11-14 | Univ Pennsylvania | Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion. |
| CN102625373A (zh) * | 2012-02-22 | 2012-08-01 | 中兴通讯股份有限公司 | 一种智能载波管理方法及装置 |
| MY167722A (en) * | 2014-10-09 | 2018-09-21 | Univ Yamaguchi | Car expression vector and car-expressing t cells |
-
2015
- 2015-10-06 MY MYPI2017701137A patent/MY167722A/en unknown
- 2015-10-06 CA CA2962375A patent/CA2962375C/en active Active
- 2015-10-06 JP JP2016552830A patent/JP6161098B2/ja active Active
- 2015-10-06 SM SM20190663T patent/SMT201900663T1/it unknown
- 2015-10-06 US US15/513,870 patent/US10316102B2/en active Active
- 2015-10-06 MX MX2017004393A patent/MX358472B/es active IP Right Grant
- 2015-10-06 KR KR1020177009895A patent/KR101890638B1/ko active Active
- 2015-10-06 PT PT191961960T patent/PT3597742T/pt unknown
- 2015-10-06 SI SI201530950T patent/SI3205720T1/sl unknown
- 2015-10-06 RS RS20220895A patent/RS63601B1/sr unknown
- 2015-10-06 NZ NZ730382A patent/NZ730382A/en unknown
- 2015-10-06 AU AU2015329444A patent/AU2015329444B2/en active Active
- 2015-10-06 SI SI201531887T patent/SI3597742T1/sl unknown
- 2015-10-06 LT LT15849416T patent/LT3205720T/lt unknown
- 2015-10-06 EP EP19196196.0A patent/EP3597742B1/en active Active
- 2015-10-06 DK DK15849416.1T patent/DK3205720T3/da active
- 2015-10-06 HR HRP20221211TT patent/HRP20221211T1/hr unknown
- 2015-10-06 RU RU2017114545A patent/RU2670147C1/ru active
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- 2015-10-06 CN CN201580053922.1A patent/CN107109421B/zh active Active
- 2015-10-06 EP EP15849416.1A patent/EP3205720B1/en active Active
- 2015-10-06 HU HUE15849416A patent/HUE046710T2/hu unknown
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- 2015-10-06 BR BR112017006710A patent/BR112017006710B1/pt active IP Right Grant
- 2015-10-06 WO PCT/JP2015/005080 patent/WO2016056228A1/ja not_active Ceased
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- 2015-10-06 DK DK19196196.0T patent/DK3597742T3/da active
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2017
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2019
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2020
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2021
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2022
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2023
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2024
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