JP2018521663A5 - - Google Patents
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- Publication number
- JP2018521663A5 JP2018521663A5 JP2018503642A JP2018503642A JP2018521663A5 JP 2018521663 A5 JP2018521663 A5 JP 2018521663A5 JP 2018503642 A JP2018503642 A JP 2018503642A JP 2018503642 A JP2018503642 A JP 2018503642A JP 2018521663 A5 JP2018521663 A5 JP 2018521663A5
- Authority
- JP
- Japan
- Prior art keywords
- immune response
- response cell
- cell according
- binding element
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021114022A JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1513540.3 | 2015-07-31 | ||
| GBGB1513540.3A GB201513540D0 (en) | 2015-07-31 | 2015-07-31 | Therapeutic agents |
| PCT/GB2016/052324 WO2017021701A1 (en) | 2015-07-31 | 2016-07-28 | Therapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021114022A Division JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521663A JP2018521663A (ja) | 2018-08-09 |
| JP2018521663A5 true JP2018521663A5 (https=) | 2019-08-29 |
| JP7053037B2 JP7053037B2 (ja) | 2022-04-12 |
Family
ID=54062973
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503642A Active JP7053037B2 (ja) | 2015-07-31 | 2016-07-28 | 治療薬 |
| JP2021114022A Pending JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021114022A Pending JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US10703794B2 (https=) |
| EP (2) | EP3939992A1 (https=) |
| JP (2) | JP7053037B2 (https=) |
| KR (1) | KR102411571B1 (https=) |
| CN (1) | CN107735407B (https=) |
| AU (1) | AU2016303355B2 (https=) |
| DK (1) | DK3328880T3 (https=) |
| ES (1) | ES2883633T3 (https=) |
| GB (1) | GB201513540D0 (https=) |
| IL (1) | IL256511B (https=) |
| MX (1) | MX2018001009A (https=) |
| RU (1) | RU2747733C1 (https=) |
| SG (1) | SG10201912416QA (https=) |
| WO (1) | WO2017021701A1 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| GB201514874D0 (en) | 2015-08-20 | 2015-10-07 | Autolus Ltd | Cell |
| MA46995A (fr) | 2016-12-03 | 2019-10-09 | Acerta Pharma Bv | Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase |
| EP3336107A1 (en) * | 2016-12-15 | 2018-06-20 | Miltenyi Biotec GmbH | Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor |
| EP3559039A1 (en) | 2016-12-22 | 2019-10-30 | Università Degli Studi Magna Graecia Catanzaro | A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of cd43 |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| KR102660336B1 (ko) | 2017-03-27 | 2024-04-26 | 내셔널 유니버시티 오브 싱가포르 | 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 |
| AU2018275894B2 (en) | 2017-06-02 | 2025-04-24 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| EP3658578A1 (en) * | 2017-07-26 | 2020-06-03 | Cellectis | Methods of antigen-dependent chimeric antigen receptor (car) immune cell selection |
| CN109971724B (zh) * | 2017-12-28 | 2023-10-31 | 上海细胞治疗研究院 | 靶向ErbB受体家族且自表达PD-1抗体的CAR-T细胞及其用途 |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| CN112055717B (zh) | 2018-04-02 | 2024-04-26 | 新加坡国立大学 | 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子 |
| CN110615842B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含共刺激受体的嵌合抗原受体及应用 |
| EP3587454A1 (en) * | 2018-06-27 | 2020-01-01 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors that bind to prostate specific membrane antigen |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| US12590148B2 (en) | 2018-11-26 | 2026-03-31 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| GB201900858D0 (en) * | 2019-01-22 | 2019-03-13 | Price Nicola Kaye | Receptors providing targeted costimulation for adoptive cell therapy |
| GB201902277D0 (en) | 2019-02-19 | 2019-04-03 | King S College London | Therapeutic agents |
| AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| CN113811327A (zh) * | 2019-03-11 | 2021-12-17 | 卢西德生物有限公司 | MUC1平行CAR(pCAR)治疗剂 |
| EP3962527A4 (en) | 2019-04-30 | 2023-11-01 | Senti Biosciences, Inc. | CHIMERIC RECEPTORS AND METHODS OF USE THEREOF |
| EP4013857A1 (en) * | 2019-08-13 | 2022-06-22 | King's College London | Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily |
| EP4021485A1 (en) * | 2019-08-28 | 2022-07-06 | King's College London | B cell targeted parallel car (pcar) therapeutic agents |
| GB202003277D0 (en) | 2020-03-06 | 2020-04-22 | King S College London | Therapeutic agents |
| EP4136119A4 (en) * | 2020-04-17 | 2024-09-11 | Regeneron Pharmaceuticals, Inc. | MODIFIED CCR POLYPEPTIDES AND USES THEREOF |
| EP4185610A2 (en) * | 2020-07-21 | 2023-05-31 | Allogene Therapeutics, Inc. | Chimeric antigen receptors with enhanced signaling and activities and uses thereof |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| WO2022083668A1 (en) * | 2020-10-21 | 2022-04-28 | Nanjing Legend Biotech Co., Ltd. | Use of a chimeric co-stimulatory receptor for cell therapy |
| US20240342282A1 (en) * | 2021-08-13 | 2024-10-17 | Ludwig-Maximilians-Universität München | Anti-csf1r car expressing lymphocytes for targeted tumor therapy |
| KR20240055733A (ko) * | 2021-08-18 | 2024-04-29 | 레전드 바이오테크 아일랜드 리미티드 | Tlr 수용체를 발현하는 변형된 면역 세포 |
| JP7732840B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732843B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732842B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732839B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732841B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| WO2023084073A1 (en) | 2021-11-15 | 2023-05-19 | Neogene Therapeutics B.V. | Engineered t cells with reduced tgf-beta receptor signaling |
| TW202334400A (zh) | 2021-12-30 | 2023-09-01 | 美商Ｔｒ１Ｘ股份有限公司 | 表現il-10及嵌合抗原受體之cd4+ t細胞及其用途 |
| CN118510814A (zh) * | 2022-05-10 | 2024-08-16 | 星尘生物科技(上海)有限公司 | 一种嵌合抗原受体及其应用 |
| CN116804210A (zh) * | 2022-12-08 | 2023-09-26 | 复旦大学附属中山医院 | 一种肠道病毒载体及其应用 |
| WO2024209084A1 (en) | 2023-04-05 | 2024-10-10 | Kings College London | Parallel chimeric antigen receptors (pcars) and adaptor chimeric antigen receptors comprising alternative signalling domains and methods of use thereof |
| GB202403718D0 (en) | 2024-03-14 | 2024-05-01 | King S College London | Therapeutic agents |
| WO2026015450A1 (en) | 2024-07-06 | 2026-01-15 | Tr1X, Inc. | Cd4+ t cells expressing il-10 and chimeric antigen receptors and uses thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU708339B2 (en) * | 1995-02-24 | 1999-08-05 | General Hospital Corporation, The | Redirection of cellular immunity by receptor chimeras |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| GB0520068D0 (en) | 2005-10-03 | 2005-11-09 | Cancer Res Technology | av peptide ligand |
| CA2682527C (en) | 2007-03-30 | 2017-07-11 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes |
| WO2010085660A2 (en) | 2009-01-23 | 2010-07-29 | Roger Williams Hospital | Viral vectors encoding multiple highly homologous non-viral polypeptides and the use of same |
| US8465743B2 (en) | 2009-10-01 | 2013-06-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| CN110200997A (zh) | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| EP3549611B1 (en) | 2011-07-29 | 2021-06-30 | The Trustees of the University of Pennsylvania | Switch costimulatory receptors |
| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| MX2014010185A (es) | 2012-02-22 | 2014-11-14 | Univ Pennsylvania | Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion. |
| CA3205751A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| CN103483452B (zh) | 2012-06-12 | 2021-08-13 | 上海细胞治疗集团有限公司 | 双信号独立的嵌合抗原受体及其用途 |
| CN104769103B (zh) | 2012-09-04 | 2018-06-08 | 塞勒克提斯公司 | 多链嵌合抗原受体和其用途 |
| WO2014055442A2 (en) | 2012-10-01 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
| AU2013327136A1 (en) * | 2012-10-02 | 2015-04-16 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| SG11201507026WA (en) | 2013-02-06 | 2015-10-29 | Anthrogenesis Corp | Modified t lymphocytes having improved specificity |
| EP4303232A3 (en) | 2013-02-15 | 2024-04-17 | The Regents of The University of California | Chimeric antigen receptor and methods of use thereof |
| WO2014138348A1 (en) | 2013-03-06 | 2014-09-12 | The Trustees Of The University Of Pennsylvania | Iikaros inhibition to augment adoptive t cell transfer |
| WO2014164544A1 (en) | 2013-03-09 | 2014-10-09 | Baylor College Of Medicine | Vascular-targeted t-cell therapy |
| WO2014151960A2 (en) | 2013-03-14 | 2014-09-25 | Bellicum Pharmaceuticals, Inc. | Methods for controlling t cell proliferation |
| CA2909701C (en) | 2013-04-17 | 2022-12-06 | Baylor College Of Medicine | Immunosuppressive tgf-.beta. signal converter |
| MX389160B (es) | 2013-10-31 | 2025-03-20 | Hutchinson Fred Cancer Res | Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas. |
| US20160296562A1 (en) | 2013-11-21 | 2016-10-13 | Ucl Business Plc | Cell |
| US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| JP6401291B2 (ja) * | 2013-12-26 | 2018-10-10 | バーダス テクノロジーズ プライベート リミテッドＶｅｒｄｕｓ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｐｔｅ．Ｌｔｄ． | 流体処理装置および流体処理装置によって気流を冷却する方法 |
| WO2015164627A1 (en) | 2014-04-23 | 2015-10-29 | Discovery Genomics, Inc. | Chimeric antigen receptors specific to avb6 integrin and methods of use thereof to treat cancer |
| AU2015289644A1 (en) * | 2014-07-15 | 2017-02-02 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| TWI750110B (zh) | 2014-07-21 | 2021-12-21 | 瑞士商諾華公司 | 使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症 |
| US10828353B2 (en) | 2015-01-31 | 2020-11-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| JP6949728B2 (ja) | 2015-05-29 | 2021-10-13 | ジュノー セラピューティクス インコーポレイテッド | 遺伝子操作された細胞における阻害相互作用を調節するための組成物および方法 |
| GB201513540D0 (en) * | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| CN113811327A (zh) | 2019-03-11 | 2021-12-17 | 卢西德生物有限公司 | MUC1平行CAR(pCAR)治疗剂 |
-
2015
- 2015-07-31 GB GBGB1513540.3A patent/GB201513540D0/en not_active Ceased
-
2016
- 2016-07-28 ES ES16750211T patent/ES2883633T3/es active Active
- 2016-07-28 JP JP2018503642A patent/JP7053037B2/ja active Active
- 2016-07-28 KR KR1020187005607A patent/KR102411571B1/ko active Active
- 2016-07-28 SG SG10201912416QA patent/SG10201912416QA/en unknown
- 2016-07-28 MX MX2018001009A patent/MX2018001009A/es unknown
- 2016-07-28 EP EP21177321.3A patent/EP3939992A1/en not_active Withdrawn
- 2016-07-28 AU AU2016303355A patent/AU2016303355B2/en active Active
- 2016-07-28 US US15/749,016 patent/US10703794B2/en active Active
- 2016-07-28 DK DK16750211.1T patent/DK3328880T3/da active
- 2016-07-28 CN CN201680039617.1A patent/CN107735407B/zh active Active
- 2016-07-28 WO PCT/GB2016/052324 patent/WO2017021701A1/en not_active Ceased
- 2016-07-28 EP EP16750211.1A patent/EP3328880B1/en active Active
- 2016-07-28 RU RU2018105137A patent/RU2747733C1/ru active
-
2017
- 2017-12-24 IL IL256511A patent/IL256511B/en unknown
-
2020
- 2020-05-18 US US16/877,008 patent/US10899818B2/en active Active
- 2020-05-18 US US16/877,035 patent/US10865231B2/en active Active
- 2020-12-10 US US17/118,045 patent/US11802143B2/en active Active
-
2021
- 2021-07-09 JP JP2021114022A patent/JP2021168675A/ja active Pending
-
2024
- 2024-01-22 US US18/418,864 patent/US12509499B2/en active Active
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