JP2019527537A5 - - Google Patents
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- JP2019527537A5 JP2019527537A5 JP2018564975A JP2018564975A JP2019527537A5 JP 2019527537 A5 JP2019527537 A5 JP 2019527537A5 JP 2018564975 A JP2018564975 A JP 2018564975A JP 2018564975 A JP2018564975 A JP 2018564975A JP 2019527537 A5 JP2019527537 A5 JP 2019527537A5
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- Prior art keywords
- seq
- car
- domain
- polypeptide
- antigen receptor
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 208000035475 disorder Diseases 0.000 claims 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 125000006850 spacer group Chemical group 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 230000000139 costimulatory effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 4
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 4
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 210000002865 immune cell Anatomy 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010034016 Paronychia Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 101800001707 Spacer peptide Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 102000046935 human TNFRSF17 Human genes 0.000 claims 1
- 210000003519 mature b lymphocyte Anatomy 0.000 claims 1
- 210000001806 memory b lymphocyte Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022106290A JP7646604B2 (ja) | 2016-06-07 | 2022-06-30 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
| JP2024154170A JP7805409B2 (ja) | 2016-06-07 | 2024-09-06 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16173401 | 2016-06-07 | ||
| EP16173401.7 | 2016-06-07 | ||
| PCT/EP2017/063862 WO2017211900A1 (en) | 2016-06-07 | 2017-06-07 | Chimeric antigen receptor and car-t cells that bind bcma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022106290A Division JP7646604B2 (ja) | 2016-06-07 | 2022-06-30 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019527537A JP2019527537A (ja) | 2019-10-03 |
| JP2019527537A5 true JP2019527537A5 (https=) | 2020-06-11 |
Family
ID=56112891
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564975A Pending JP2019527537A (ja) | 2016-06-07 | 2017-06-07 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ−ｔ細胞 |
| JP2022106290A Active JP7646604B2 (ja) | 2016-06-07 | 2022-06-30 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
| JP2024154170A Active JP7805409B2 (ja) | 2016-06-07 | 2024-09-06 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022106290A Active JP7646604B2 (ja) | 2016-06-07 | 2022-06-30 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
| JP2024154170A Active JP7805409B2 (ja) | 2016-06-07 | 2024-09-06 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12048718B2 (https=) |
| EP (1) | EP3463396B1 (https=) |
| JP (3) | JP2019527537A (https=) |
| KR (2) | KR102497013B1 (https=) |
| CN (1) | CN109641012A (https=) |
| AU (1) | AU2017276706B2 (https=) |
| CA (1) | CA3026778A1 (https=) |
| SG (2) | SG10202012157QA (https=) |
| WO (1) | WO2017211900A1 (https=) |
Families Citing this family (82)
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| SG10202012157QA (en) * | 2016-06-07 | 2021-01-28 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Chimeric antigen receptor and car-t cells that bind bcma |
| EP3622092A4 (en) | 2017-05-11 | 2021-06-23 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF |
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2017
- 2017-06-07 SG SG10202012157QA patent/SG10202012157QA/en unknown
- 2017-06-07 JP JP2018564975A patent/JP2019527537A/ja active Pending
- 2017-06-07 KR KR1020187038249A patent/KR102497013B1/ko active Active
- 2017-06-07 AU AU2017276706A patent/AU2017276706B2/en active Active
- 2017-06-07 US US16/307,854 patent/US12048718B2/en active Active
- 2017-06-07 WO PCT/EP2017/063862 patent/WO2017211900A1/en not_active Ceased
- 2017-06-07 KR KR1020237003879A patent/KR20230042703A/ko not_active Ceased
- 2017-06-07 CA CA3026778A patent/CA3026778A1/en active Pending
- 2017-06-07 EP EP17729846.0A patent/EP3463396B1/en active Active
- 2017-06-07 SG SG11201810697QA patent/SG11201810697QA/en unknown
- 2017-06-07 CN CN201780035831.4A patent/CN109641012A/zh active Pending
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2022
- 2022-06-30 JP JP2022106290A patent/JP7646604B2/ja active Active
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2024
- 2024-05-17 US US18/667,995 patent/US12351640B2/en active Active
- 2024-09-06 JP JP2024154170A patent/JP7805409B2/ja active Active
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