JP2021177771A5 - - Google Patents
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- JP2021177771A5 JP2021177771A5 JP2021118254A JP2021118254A JP2021177771A5 JP 2021177771 A5 JP2021177771 A5 JP 2021177771A5 JP 2021118254 A JP2021118254 A JP 2021118254A JP 2021118254 A JP2021118254 A JP 2021118254A JP 2021177771 A5 JP2021177771 A5 JP 2021177771A5
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- Japan
- Prior art keywords
- polypeptide
- binding domain
- domain
- antigen binding
- agent according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 239000003795 chemical substances by application Substances 0.000 claims 16
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 4
- 230000004068 intracellular signaling Effects 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000005809 anti-tumor immunity Effects 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 239000012642 immune effector Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 230000031146 intracellular signal transduction Effects 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361819141P | 2013-05-03 | 2013-05-03 | |
| US61/819,141 | 2013-05-03 | ||
| US201361876492P | 2013-09-11 | 2013-09-11 | |
| US61/876,492 | 2013-09-11 | ||
| JP2019079616A JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019079616A Division JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021177771A JP2021177771A (ja) | 2021-11-18 |
| JP2021177771A5 true JP2021177771A5 (https=) | 2022-03-24 |
| JP7221338B2 JP7221338B2 (ja) | 2023-02-13 |
Family
ID=51844005
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512083A Active JP6856188B2 (ja) | 2013-05-03 | 2014-05-02 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
| JP2019079616A Pending JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
| JP2021118254A Active JP7221338B2 (ja) | 2013-05-03 | 2021-07-16 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512083A Active JP6856188B2 (ja) | 2013-05-03 | 2014-05-02 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
| JP2019079616A Pending JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10358494B2 (https=) |
| EP (2) | EP3663320A1 (https=) |
| JP (3) | JP6856188B2 (https=) |
| KR (1) | KR102098985B1 (https=) |
| CN (2) | CN105377897A (https=) |
| AU (2) | AU2014259675B2 (https=) |
| BR (1) | BR112015027567B1 (https=) |
| DK (1) | DK2992020T3 (https=) |
| ES (1) | ES2777940T3 (https=) |
| HU (1) | HUE048312T2 (https=) |
| IL (1) | IL242315B (https=) |
| MX (1) | MX370173B (https=) |
| PL (1) | PL2992020T3 (https=) |
| PT (1) | PT2992020T (https=) |
| WO (1) | WO2014179759A1 (https=) |
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| CN105377897A (zh) * | 2013-05-03 | 2016-03-02 | 俄亥俄州创新基金会 | Cs1-特异性嵌合抗原受体工程化的免疫效应细胞 |
| US10189908B2 (en) | 2014-02-05 | 2019-01-29 | The University Of Chicago | Chimeric antigen receptors recognizing cancer-specific TN glycopeptide variants |
| KR102558502B1 (ko) | 2014-12-05 | 2023-07-20 | 시티 오브 호프 | Ｃｓ1 표적화된 키메라 항원 수용체-변형된 ｔ 세포 |
| JP6797803B2 (ja) * | 2014-12-31 | 2020-12-09 | セルジーン コーポレイション | ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 |
| WO2016123143A1 (en) | 2015-01-26 | 2016-08-04 | The University Of Chicago | CAR T-CELLS RECOGNIZING CANCER-SPECIFIC IL 13Rα2 |
| CN107683289B (zh) | 2015-01-26 | 2021-08-06 | 芝加哥大学 | IL13Rα2结合剂和其在癌症治疗中的用途 |
| JP6849600B6 (ja) | 2015-01-29 | 2021-06-30 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | キメラ抗原受容体、組成物及び方法 |
| WO2016134371A2 (en) | 2015-02-20 | 2016-08-25 | Ohio State Innovation Foundation | Bivalent antibody directed against nkg2d and tumor associated antigens |
| US11045543B2 (en) | 2015-04-06 | 2021-06-29 | Cytoimmune Therapeutics, Inc. | EGFR-directed car therapy for glioblastoma |
| US10752670B2 (en) * | 2015-05-20 | 2020-08-25 | Cellectis | Anti-GD3 specific chimeric antigen receptors for cancer immunotherapy |
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| JP7010487B2 (ja) | 2015-08-17 | 2022-03-03 | ソウル大学校産学協力団 | 抗コチニン抗体が連結したキメラ抗原受容体およびその使用 |
| EP4289944A3 (en) * | 2015-10-08 | 2024-03-13 | National University Corporation Tokai National Higher Education and Research System | Method for preparing genetically-modified t cells which express chimeric antigen receptor |
| EP3402495A4 (en) * | 2016-01-15 | 2019-06-19 | Etubics Corporation | METHOD AND COMPOSITIONS FOR T-CELL IMMUNOTHERAPY |
| EP3408297A2 (en) | 2016-01-29 | 2018-12-05 | Med Manor Organics, (P) Ltd | A chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof |
| EP3433269B1 (en) | 2016-03-23 | 2023-09-27 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
| CN121102467A (zh) | 2016-04-22 | 2025-12-12 | 克莱格医学有限公司 | 用于细胞免疫疗法的组合物和方法 |
| JP7086928B2 (ja) | 2016-07-25 | 2022-06-20 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 改変されたナチュラルキラー細胞を生成する方法および使用方法 |
| US12516292B2 (en) | 2016-07-25 | 2026-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing modified natural killer cells and methods of use |
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| EP3567101A4 (en) * | 2017-01-05 | 2020-12-02 | Korea Research Institute of Bioscience and Biotechnology | NATURAL KILLER CELL EXPRESSING AN ANTI-COTININ CHEMERIC ANTIGEN RECEPTOR |
| MX2019011225A (es) * | 2017-03-20 | 2020-01-21 | Células t modificadas por el receptor de antígeno quimérico dirigidas a cs1 para el tratamiento de la amiloidosis al. | |
| ES2963635T3 (es) * | 2017-03-28 | 2024-04-01 | Ohio State Innovation Foundation | Vacunas de péptido PD1 humano y usos de las mismas |
| WO2018189360A1 (en) | 2017-04-13 | 2018-10-18 | Cellectis | New sequence specific reagents targeting ccr5 in primary hematopoietic cells |
| KR20200027508A (ko) * | 2017-07-07 | 2020-03-12 | 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 | 돌연변이된 cd28 공동자극 도메인을 갖는 키메라 항원 수용체 |
| WO2019014624A1 (en) * | 2017-07-14 | 2019-01-17 | The Johns Hopkins University | Engineered tsc2 |
| TWI676483B (zh) * | 2017-08-06 | 2019-11-11 | 強普生技股份有限公司 | 醫藥套組及其用途 |
| WO2019069125A1 (en) * | 2017-10-06 | 2019-04-11 | Oslo Universitetssykehus Hf | CHIMERIC ANTIGEN RECEPTORS |
| US20200283501A1 (en) | 2017-10-26 | 2020-09-10 | Regents Of The University Of Minnesota | Recombinant immune cells, methods of making, and methods of use |
| US12077598B2 (en) | 2018-03-16 | 2024-09-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Chimeric antigen receptors with mutated CD28 phosphorylation sites |
| CN112566643A (zh) | 2018-06-12 | 2021-03-26 | 加利福尼亚大学董事会 | 用于治疗癌症的单链双特异性嵌合抗原受体 |
| WO2019241315A1 (en) | 2018-06-12 | 2019-12-19 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| WO2020009868A1 (en) * | 2018-07-03 | 2020-01-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-slamf7 chimeric antigen receptors |
| EP3818148A4 (en) * | 2018-07-05 | 2022-09-28 | Emory University | TRANSDUCTION OF CONGENITAL IMMUNE COMPETENT CELLS USING AAV6 |
| CN112469734A (zh) * | 2018-08-03 | 2021-03-09 | 南京驯鹿医疗技术有限公司 | 表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 |
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| MX2021010840A (es) | 2019-03-08 | 2022-01-19 | Obsidian Therapeutics Inc | Composiciones de anhidrasa carbónica 2 (ca2) humana y métodos de regulación ajustable. |
| KR102691932B1 (ko) | 2019-04-03 | 2024-08-06 | 프리시젼 바이오사이언시스 인코포레이티드 | 마이크로RNA-적응 shRNA(shRNAmiR)를 포함하는 유전자-변형 면역 세포 |
| JP2022537670A (ja) | 2019-06-12 | 2022-08-29 | オブシディアン セラピューティクス， インコーポレイテッド | Ｃａ２の組成物および調整可能な制御方法 |
| EP3983537A1 (en) | 2019-06-12 | 2022-04-20 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| SG11202111943UA (en) | 2019-07-02 | 2021-11-29 | Hutchinson Fred Cancer Res | Recombinant ad35 vectors and related gene therapy improvements |
| CN112442126B (zh) * | 2019-09-04 | 2022-07-29 | 杭州济元基因科技有限公司 | 一种抗人cs1抗原的单克隆抗体及其car-t细胞 |
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| WO2022002919A1 (en) * | 2020-06-29 | 2022-01-06 | Julius-Maximilians-Universität Würzburg | Slamf7 cars |
| CN114286691B (zh) | 2020-08-06 | 2024-08-06 | 武汉思安医疗技术有限公司 | Cs1-抗体和抗cs1-car-t细胞 |
| WO2022063302A1 (zh) * | 2020-09-25 | 2022-03-31 | 克莱格医学有限公司 | 免疫细胞活性调节 |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| CN116410331B (zh) * | 2021-12-31 | 2024-01-30 | 合源生物科技(天津)有限公司 | 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用 |
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| WO2026006370A1 (en) * | 2024-06-28 | 2026-01-02 | Immunitybio, Inc. | Anti-slamf7 antibodies and therapeutics |
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| US20040038339A1 (en) * | 2000-03-24 | 2004-02-26 | Peter Kufer | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
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| WO2013051718A1 (ja) * | 2011-10-07 | 2013-04-11 | 国立大学法人三重大学 | キメラ抗原受容体 |
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| CA2861491C (en) * | 2012-02-13 | 2020-08-25 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| BR112015013193A2 (pt) | 2012-12-07 | 2017-07-11 | Solazyme Inc | ácido nucleico recombinante, cassete de expressão, célula, método para obter óleo microbiano, óleo microbiano, e, método para obter óleo microbiano. |
| CN103224561A (zh) | 2013-01-16 | 2013-07-31 | 天津大学 | 葡萄球菌肠毒素小分子抗体及制备方法及用途 |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| CN105377897A (zh) * | 2013-05-03 | 2016-03-02 | 俄亥俄州创新基金会 | Cs1-特异性嵌合抗原受体工程化的免疫效应细胞 |
| CN105829349B (zh) | 2013-10-15 | 2023-02-03 | 斯克利普斯研究所 | 肽嵌合抗原受体t细胞开关和其用途 |
| KR20200131844A (ko) * | 2018-03-16 | 2020-11-24 | 사이토이뮨 테라퓨틱스 인코퍼레이티드 | 이중특이적 항체 car 세포 면역요법 |
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2014
- 2014-05-02 CN CN201480030178.9A patent/CN105377897A/zh active Pending
- 2014-05-02 BR BR112015027567-2A patent/BR112015027567B1/pt active IP Right Grant
- 2014-05-02 ES ES14791494T patent/ES2777940T3/es active Active
- 2014-05-02 EP EP20150396.8A patent/EP3663320A1/en not_active Withdrawn
- 2014-05-02 EP EP14791494.9A patent/EP2992020B1/en active Active
- 2014-05-02 PT PT147914949T patent/PT2992020T/pt unknown
- 2014-05-02 KR KR1020157033493A patent/KR102098985B1/ko active Active
- 2014-05-02 US US14/888,877 patent/US10358494B2/en active Active
- 2014-05-02 MX MX2015015182A patent/MX370173B/es active IP Right Grant
- 2014-05-02 CN CN202210255676.XA patent/CN115028735A/zh active Pending
- 2014-05-02 HU HUE14791494A patent/HUE048312T2/hu unknown
- 2014-05-02 WO PCT/US2014/036684 patent/WO2014179759A1/en not_active Ceased
- 2014-05-02 JP JP2016512083A patent/JP6856188B2/ja active Active
- 2014-05-02 DK DK14791494.9T patent/DK2992020T3/da active
- 2014-05-02 AU AU2014259675A patent/AU2014259675B2/en active Active
- 2014-05-02 PL PL14791494T patent/PL2992020T3/pl unknown
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2015
- 2015-10-28 IL IL242315A patent/IL242315B/en active IP Right Grant
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2017
- 2017-05-17 US US15/597,436 patent/US10227409B2/en active Active
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2019
- 2019-04-18 JP JP2019079616A patent/JP2019146579A/ja active Pending
- 2019-05-31 AU AU2019203823A patent/AU2019203823B2/en active Active
- 2019-07-09 US US16/506,327 patent/US11845794B2/en active Active
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2021
- 2021-07-16 JP JP2021118254A patent/JP7221338B2/ja active Active