|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
US5585362A
(en)
|
1989-08-22 |
1996-12-17 |
The Regents Of The University Of Michigan |
Adenovirus vectors for gene therapy
|
|
US5350674A
(en)
|
1992-09-04 |
1994-09-27 |
Becton, Dickinson And Company |
Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
|
|
US6074841A
(en)
|
1996-08-19 |
2000-06-13 |
Millennium Biotherapeutics, Inc. |
Don-1 gene and polypeptides and uses therefor
|
|
US6410319B1
(en)
|
1998-10-20 |
2002-06-25 |
City Of Hope |
CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
|
|
HK1047109A1
(zh)
|
1999-10-15 |
2003-02-07 |
University Of Massachusetts |
作为指定基因干预工具的rna干预轨迹基因
|
|
US6326193B1
(en)
|
1999-11-05 |
2001-12-04 |
Cambria Biosciences, Llc |
Insect control agent
|
|
AU2001275474A1
(en)
|
2000-06-12 |
2001-12-24 |
Akkadix Corporation |
Materials and methods for the control of nematodes
|
|
ATE338124T1
(de)
|
2000-11-07 |
2006-09-15 |
Hope City |
Cd19-spezifische umgezielte immunzellen
|
|
US8287864B2
(en)
|
2002-02-14 |
2012-10-16 |
Immunomedics, Inc. |
Structural variants of antibodies for improved therapeutic characteristics
|
|
US7446190B2
(en)
|
2002-05-28 |
2008-11-04 |
Sloan-Kettering Institute For Cancer Research |
Nucleic acids encoding chimeric T cell receptors
|
|
BRPI0315295C1
(pt)
|
2002-10-17 |
2021-05-25 |
Genmab As |
anticorpo monoclonal humano isolado, célula hospedeira procariótica, composição farmacêutica, molécula biespecífica, usos de um anticorpo, métodos in vitro de detectar a presença de antígeno de cd20 ou uma célula que expressa cd20 em uma amostra, kit, e, vetor de expressão
|
|
CA2534639C
(en)
|
2003-07-31 |
2013-07-30 |
Immunomedics, Inc. |
Anti-cd19 antibodies
|
|
MXPA06004035A
(es)
|
2003-10-16 |
2006-08-31 |
Micromet Ag |
Aglutinantes cd3 de-inmunizados multi-especificos.
|
|
US20130266551A1
(en)
|
2003-11-05 |
2013-10-10 |
St. Jude Children's Research Hospital, Inc. |
Chimeric receptors with 4-1bb stimulatory signaling domain
|
|
US7435596B2
(en)
|
2004-11-04 |
2008-10-14 |
St. Jude Children's Research Hospital, Inc. |
Modified cell line and method for expansion of NK cell
|
|
NZ573646A
(en)
|
2006-06-12 |
2012-04-27 |
Wyeth Llc |
Single-chain multivalent binding proteins with effector function
|
|
CA2656620C
(en)
|
2006-07-04 |
2018-03-13 |
Genmab A/S |
Cd20 binding molecules for the treatment of copd
|
|
SI2856876T1
(en)
|
2007-03-30 |
2018-04-30 |
Memorial Sloan-Kettering Cancer Center |
Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
|
|
JP2010532764A
(ja)
|
2007-07-06 |
2010-10-14 |
トゥルビオン・ファーマシューティカルズ・インコーポレーテッド |
Ｃ末端に配置された特異的結合性ドメインを有する結合性ペプチド
|
|
MX2010000970A
(es)
|
2007-07-31 |
2010-03-09 |
Regeneron Pharma |
Anticuerpos humanos contra cd20 humano y metodo para utilizarlos.
|
|
DK2211904T3
(en)
|
2007-10-19 |
2016-10-24 |
Seattle Genetics Inc |
Cd19-binding agents and uses thereof
|
|
EP2205277B1
(en)
|
2007-10-22 |
2017-07-26 |
Genmab A/S |
Novel antibody therapies
|
|
CN101544694A
(zh)
|
2008-03-28 |
2009-09-30 |
上海中信国健药业有限公司 |
抗cd20四价抗体、其制备方法和应用
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
CA2861491C
(en)
*
|
2012-02-13 |
2020-08-25 |
Seattle Children's Hospital D/B/A Seattle Children's Research Institute |
Bispecific chimeric antigen receptors and therapeutic uses thereof
|
|
BR112014029417B1
(pt)
|
2012-05-25 |
2023-03-07 |
Cellectis |
Método ex vivo para a preparação de células t para imunoterapia
|
|
AU2013289883B2
(en)
|
2012-07-13 |
2018-11-01 |
Zymeworks Bc Inc. |
Bispecific asymmetric heterodimers comprising anti-CD3 constructs
|
|
BR122020002986A8
(pt)
|
2012-08-20 |
2023-04-18 |
Seattle Childrens Hospital Dba Seattle Childrens Res Inst |
Método e composições para imunoterapia celular
|
|
DK2956175T3
(da)
|
2013-02-15 |
2017-11-27 |
Univ California |
Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf
|
|
US9499855B2
(en)
|
2013-03-14 |
2016-11-22 |
Elwha Llc |
Compositions, methods, and computer systems related to making and administering modified T cells
|
|
UY35468A
(es)
|
2013-03-16 |
2014-10-31 |
Novartis Ag |
Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
|
|
JP2015092865A
(ja)
|
2013-11-13 |
2015-05-18 |
国立大学法人名古屋大学 |
ヒト化抗ｃｄ２０キメラ抗原レセプター
|
|
NZ759969A
(en)
*
|
2013-12-20 |
2022-12-23 |
Fred Hutchinson Cancer Center |
Tagged chimeric effector molecules and receptors thereof
|
|
CN113307880B
(zh)
|
2014-01-13 |
2025-07-04 |
希望之城公司 |
在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法
|
|
GB201407852D0
(en)
*
|
2014-05-02 |
2014-06-18 |
Iontas Ltd |
Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
|
|
ES2836743T3
(es)
|
2014-06-02 |
2021-06-28 |
Us Health |
Receptores de antígeno quiméricos que seleccionan como diana CD-19
|
|
TWI719942B
(zh)
|
2014-07-21 |
2021-03-01 |
瑞士商諾華公司 |
使用ｃｄ３３嵌合抗原受體治療癌症
|
|
TWI751102B
(zh)
*
|
2014-08-28 |
2022-01-01 |
美商奇諾治療有限公司 |
對ｃｄ１９具專一性之抗體及嵌合抗原受體
|
|
MX392487B
(es)
|
2014-10-20 |
2025-03-21 |
Juno Therapeutics Inc |
Métodos y composiciones para dosificación en terapia celular adoptiva.
|
|
ES2819553T3
(es)
|
2014-12-03 |
2021-04-16 |
Juno Therapeutics Inc |
Métodos y composiciones para terapia celular adoptiva
|
|
FI3240805T3
(fi)
|
2014-12-15 |
2025-02-17 |
Univ California |
Cd19- ja cd20-vasteellinen bispesifinen tai-veräjän kimeerinen antigeenireseptori
|
|
CA2969384A1
(en)
|
2014-12-17 |
2016-06-23 |
Cellectis |
Inhibitory chimeric antigen receptor (icar or n-car) expressing non-t cell transduction domain
|
|
US10544220B2
(en)
|
2015-01-08 |
2020-01-28 |
Genmab A/S |
Bispecific antibodies against CD3 and CD20
|
|
WO2016126608A1
(en)
|
2015-02-02 |
2016-08-11 |
Novartis Ag |
Car-expressing cells against multiple tumor antigens and uses thereof
|
|
EP3253799B1
(en)
|
2015-02-05 |
2020-12-02 |
Molecular Templates, Inc. |
Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
|
|
WO2016134284A1
(en)
|
2015-02-19 |
2016-08-25 |
University Of Florida Research Foundation, Inc. |
Chimeric antigen receptors and uses thereof
|
|
MA41613A
(fr)
|
2015-02-23 |
2018-01-02 |
Abbvie Stemcentrx Llc |
Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs
|
|
GB201503742D0
(en)
|
2015-03-05 |
2015-04-22 |
Ucl Business Plc |
Chimeric antigen receptor
|
|
JP6961490B2
(ja)
|
2015-04-08 |
2021-11-05 |
ノバルティス アーゲー |
Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法
|
|
GB201506223D0
(en)
|
2015-04-13 |
2015-05-27 |
Ucl Business Plc |
Chimeric protein
|
|
US11091546B2
(en)
*
|
2015-04-15 |
2021-08-17 |
The Scripps Research Institute |
Optimized PNE-based chimeric receptor T cell switches and uses thereof
|
|
EP3288569A4
(en)
*
|
2015-04-29 |
2018-12-19 |
Fred Hutchinson Cancer Research Center |
Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
|
|
WO2016179319A1
(en)
|
2015-05-04 |
2016-11-10 |
Cellerant Therapeutics, Inc. |
Chimeric antigen receptors with ctla4 signal transduction domains
|
|
EP4286511A3
(en)
|
2015-06-12 |
2024-03-06 |
Lentigen Technology, Inc. |
Method to treat cancer with engineered t-cells
|
|
US10493139B2
(en)
*
|
2015-07-24 |
2019-12-03 |
Innovative Cellular Therapeutics CO., LTD. |
Humanized anti-CD19 antibody and use thereof with chimeric antigen receptor
|
|
JP6751493B2
(ja)
|
2015-08-05 |
2020-09-09 |
セルレブメド インコーポレーテッド |
キメラ抗原受容体及びキメラ抗原受容体が発現されたｔ細胞
|
|
AU2016306209B2
(en)
|
2015-08-07 |
2023-07-06 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Bispecific CAR T-cells for solid tumor targeting
|
|
CN105384825B
(zh)
*
|
2015-08-11 |
2018-06-01 |
南京传奇生物科技有限公司 |
一种基于单域抗体的双特异性嵌合抗原受体及其应用
|
|
EP3340995A4
(en)
|
2015-08-28 |
2019-04-03 |
The Trustees Of The University Of Pennsylvania |
METHOD AND COMPOSITIONS FOR CELLS FOR EXPRESSING A CHIMERIC INTRA-CELLULAR SIGNAL MOLECULE
|
|
US10508143B1
(en)
|
2015-10-30 |
2019-12-17 |
Aleta Biotherapeutics Inc. |
Compositions and methods for treatment of cancer
|
|
BR112018008442A2
(pt)
*
|
2015-11-05 |
2018-11-06 |
Juno Therapeutics Inc |
receptores quiméricos contendo domínios induto-res de traf e composições e métodos relacionados
|
|
KR20180118175A
(ko)
|
2016-03-04 |
2018-10-30 |
노파르티스 아게 |
다중 키메라 항원 수용체 (car) 분자를 발현하는 세포 및 그에 따른 용도
|
|
JP7065782B2
(ja)
|
2016-03-18 |
2022-05-12 |
フレッド ハッチンソン キャンサー リサーチ センター |
Ｃｄ２０免疫療法のための組成物および方法
|
|
KR20230148844A
(ko)
*
|
2016-03-29 |
2023-10-25 |
유니버시티 오브 써던 캘리포니아 |
암을 표적하는 키메라 항원 수용체
|
|
US11768203B2
(en)
*
|
2016-03-31 |
2023-09-26 |
University Of Southern California |
Highly sensitive and specific luciferase based reporter assay for antigen detection
|
|
ES2891578T3
(es)
|
2016-04-01 |
2022-01-28 |
Kite Pharma Inc |
Antígeno quimérico y receptores de células T y métodos de uso
|
|
CN107868791B
(zh)
*
|
2016-09-26 |
2021-11-23 |
阿思科力(苏州)生物科技有限公司 |
一种加强型Slit2 CAR-T和CAR-NK细胞制备方法和应用
|
|
BR112019006781A2
(pt)
*
|
2016-10-07 |
2019-07-30 |
Novartis Ag |
receptores de antígeno quiméricos para o tratamento de câncer
|
|
CN107936120B
(zh)
*
|
2016-10-13 |
2021-03-09 |
上海赛比曼生物科技有限公司 |
Cd19靶向性的嵌合抗原受体及其制法和应用
|
|
EP3336107A1
(en)
*
|
2016-12-15 |
2018-06-20 |
Miltenyi Biotec GmbH |
Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor
|
|
CN108250301A
(zh)
|
2016-12-29 |
2018-07-06 |
天津天锐生物科技有限公司 |
一种多靶点嵌合抗原受体
|
|
CN108276493B
(zh)
|
2016-12-30 |
2023-11-14 |
南京传奇生物科技有限公司 |
一种嵌合抗原受体及其应用
|
|
CN108395482B
(zh)
|
2017-02-08 |
2021-02-05 |
西比曼生物科技（香港）有限公司 |
一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
|
|
US20200306375A1
(en)
*
|
2017-02-22 |
2020-10-01 |
Aleta Biotherapeutics Inc. |
Compositions and methods for tumor transduction
|
|
KR20190133017A
(ko)
|
2017-03-27 |
2019-11-29 |
에프. 호프만-라 로슈 아게 |
개선된 항원 결합 수용체 구성
|
|
AU2018257894A1
(en)
|
2017-04-24 |
2019-10-31 |
Kite Pharma, Inc. |
Humanized antigen-binding domains against CD19 and methods of use
|
|
US11434290B2
(en)
|
2017-06-08 |
2022-09-06 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Chimeric antigen receptors with enhanced NFκB signaling
|
|
WO2019028051A1
(en)
|
2017-07-31 |
2019-02-07 |
Lentigen Technology, Inc. |
COMPOSITIONS AND METHODS FOR TREATING CANCER BY ANTI-CD19 / CD20 IMMUNOTHERAPY
|
|
CN109423495A
(zh)
|
2017-08-24 |
2019-03-05 |
上海恒润达生生物科技有限公司 |
一种双靶向嵌合抗原受体及其用途
|
|
ES2960419T3
(es)
|
2017-09-15 |
2024-03-04 |
Lentigen Tech Inc |
Composiciones y métodos de tratamiento de cáncer con inmunoterapia anti-CD19
|
|
CN117721084A
(zh)
|
2017-10-12 |
2024-03-19 |
美商生物细胞基因治疗有限公司 |
靶向多种抗原的复合嵌合抗原受体（cCAR）及其组成和使用方法
|
|
TW201922256A
(zh)
*
|
2017-10-27 |
2019-06-16 |
中國大陸商浙江導明醫藥科技有限公司 |
治療淋巴樣惡性疾病之方法
|
|
EP3710471A1
(en)
|
2017-11-16 |
2020-09-23 |
Kite Pharma, Inc. |
Modified chimeric antigen receptors and methods of use
|
|
MA51428A
(fr)
|
2017-12-22 |
2020-11-04 |
Bluebird Bio Inc |
Récepteur d'antigène chimérique multivalent
|
|
CN108315305B
(zh)
|
2017-12-26 |
2020-11-06 |
沣潮医药科技（上海）有限公司 |
携带嵌合抗原受体的免疫细胞外泌体的制备方法及其应用
|
|
CN109971725B
(zh)
|
2017-12-28 |
2024-02-02 |
上海细胞治疗研究院 |
抗体修饰的嵌合抗原受体修饰t细胞及其用途
|
|
CN108285486A
(zh)
|
2018-01-15 |
2018-07-17 |
浙江阿思科力生物科技有限公司 |
以cd20为靶点的特异性抗体、car-nk细胞及其制备和应用
|
|
CN108017717B
(zh)
|
2018-01-24 |
2019-08-16 |
首都医科大学宣武医院 |
一种用于体外高效定向扩增的嵌合抗原受体及其应用
|
|
CN111094358A
(zh)
|
2018-02-11 |
2020-05-01 |
江苏恒瑞医药股份有限公司 |
一种分离的嵌合抗原受体以及包含其的修饰t细胞及用途
|
|
CN108715616A
(zh)
*
|
2018-04-27 |
2018-10-30 |
上海恒润达生生物科技有限公司 |
靶向人源化间皮素的嵌合抗原受体方法和用途
|
|
WO2019210153A1
(en)
|
2018-04-27 |
2019-10-31 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
|
CN110404061B
(zh)
|
2018-04-28 |
2023-09-12 |
北京永泰瑞科生物科技有限公司 |
改进的t细胞治疗方法
|
|
CN110526983B
(zh)
|
2018-05-24 |
2022-02-11 |
北京马力喏生物科技有限公司 |
改良型抗cd19 car-t细胞
|
|
EP3802798A4
(en)
|
2018-05-31 |
2022-05-11 |
Washington University |
CHIMERIC ANTIGEN RECEPTOR T CELLS (CAR-T) FOR TREATMENT OF CANCER
|
|
CN110606893B
(zh)
|
2018-06-15 |
2022-11-15 |
北昊干细胞与再生医学研究院有限公司 |
一种靶向cd19和cd20双抗原的嵌合性抗原受体t细胞治疗肿瘤的方法
|
|
US12036242B2
(en)
|
2018-07-05 |
2024-07-16 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
CAR T cells that target B-cell antigens
|
|
EP3829312A4
(en)
|
2018-08-04 |
2022-07-06 |
Abcyte Therapeutics Inc. |
MULTIFUNCTIONAL AND MULTI-TARGETING CAR SYSTEM AND METHODS OF USE
|
|
WO2020061796A1
(en)
|
2018-09-26 |
2020-04-02 |
Hrain Biotechnology Co., Ltd. |
Bcma-and-cd19-targeting chimeric antigen receptor and uses thereof
|
|
US20210388100A1
(en)
|
2018-10-01 |
2021-12-16 |
Adicet Bio, Inc. |
Compositions and methods regarding engineered and non-engineered gamma delta t-cells for treatment of hematological tumors
|
|
CN109536455B
(zh)
|
2018-12-11 |
2020-02-21 |
武汉波睿达生物科技有限公司 |
一种car-nk细胞及其制备方法和应用
|
|
AU2019397033B2
(en)
*
|
2018-12-12 |
2023-06-29 |
Kite Pharma, Inc. |
Chimeric antigen receptors and CAR-T cells and methods of use
|
|
CN109575143B
(zh)
*
|
2018-12-29 |
2022-06-17 |
博生吉医药科技(苏州)有限公司 |
双特异性cd20-cd19-car及其应用
|
|
CN113330038A
(zh)
|
2019-01-22 |
2021-08-31 |
亘喜生物科技（上海）有限公司 |
Cd20组合靶向的工程化免疫细胞
|
|
CN119306795A
(zh)
|
2019-03-25 |
2025-01-14 |
免疫功坊股份有限公司 |
带有金属结合区的复合多肽及其分子构建体
|
|
CN112390891B
(zh)
|
2019-08-14 |
2022-06-03 |
苏州方德门达新药开发有限公司 |
嵌合抗原受体及其构建方法和应用
|
|
CN110845623B
(zh)
*
|
2019-10-11 |
2021-07-09 |
厦门大学 |
一种egfr特异性嵌合抗原受体及其应用
|
|
US20230104705A1
(en)
|
2020-03-17 |
2023-04-06 |
Cellular Biomedicine Group Inc. |
Combined chimeric antigen receptor targeting cd19 and cd20 and application thereof
|
|
US20230212255A1
(en)
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