BR112022018677A2 - Receptor de antígeno quimérico combinado que alveja cd19 e cd20 e aplicação do mesmo - Google Patents

Receptor de antígeno quimérico combinado que alveja cd19 e cd20 e aplicação do mesmo

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Publication number
BR112022018677A2
BR112022018677A2 BR112022018677A BR112022018677A BR112022018677A2 BR 112022018677 A2 BR112022018677 A2 BR 112022018677A2 BR 112022018677 A BR112022018677 A BR 112022018677A BR 112022018677 A BR112022018677 A BR 112022018677A BR 112022018677 A2 BR112022018677 A2 BR 112022018677A2
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Prior art keywords
targets
antigen receptor
chimeric antigen
present
application
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BR112022018677A
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English (en)
Inventor
Yao Yihong
Huang Jiaqi
Yao Xin
Zhu Shigui
Li Yanfeng
Wei Yutian
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Cellular Biomedicine Group Hk Ltd
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Publication of BR112022018677A2 publication Critical patent/BR112022018677A2/pt

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
    • A—HUMAN NECESSITIES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464424—CD20
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
    • A61K2239/29—Multispecific CARs
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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Abstract

RECEPTOR DE ANTÍGENO QUIMÉRICO COMBINADO QUE ALVEJA CD19 E CD20 E APLICAÇÃO DO MESMO. A presente invenção fornece um receptor de antígeno quimérico combinado que alveja CD19 e CD20 e aplicação do mesmo. Especificamente, a presente invenção fornece um receptor de antígeno quimérico combinado que alveja CD19 e CD20, que compreende um scFv que alveja CD19 e um scFv que alveja CD20, uma região de dobradiça, uma região transmembranas e um domínio de sinalização intracelular. A presente invenção fornece uma molécula de ácido nucleico que codifica o receptor de antígeno quimérico e um vetor de expressão correspondente, uma célula T de CAR, e aplicações da mesma. Os resultados experimentais mostram que o receptor de antígeno quimérico fornecido pela presente invenção mostra capacidade de extermínio extremamente alta contra células tumorais. O receptor de antígeno quimérico da presente invenção alveja células positivadas para CD19 e/ou CD20 e pode ser usado para tratar linfoma, leucemia e outras doenças de célula B positivadas para CD19 e/ou CD20.
BR112022018677A 2020-03-17 2021-03-17 Receptor de antígeno quimérico combinado que alveja cd19 e cd20 e aplicação do mesmo BR112022018677A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN202010188038.1A CN113402612A (zh) 2020-03-17 2020-03-17 靶向cd19和cd20的联合嵌合抗原受体及其应用
US16/877,069 US11207349B2 (en) 2020-03-17 2020-05-18 Combined chimeric antigen receptor targeting CD19 and CD20 and application thereof
PCT/CN2020/109645 WO2021184673A1 (en) 2020-03-17 2020-08-17 Combined chimeric antigen receptor targeting cd19 and cd20 and application thereof
US202163154032P 2021-02-26 2021-02-26
PCT/US2021/022779 WO2021188681A1 (en) 2020-03-17 2021-03-17 Combined chimeric antigen receptor targeting cd19 and cd20 and applications thereof

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BR112022018677A2 true BR112022018677A2 (pt) 2023-02-23

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US (5) US11207349B2 (pt)
EP (1) EP3989986A4 (pt)
JP (3) JP2023518134A (pt)
KR (2) KR20230053705A (pt)
CN (2) CN113402612A (pt)
AU (2) AU2021238330B2 (pt)
BR (1) BR112022018677A2 (pt)
CA (2) CA3169235A1 (pt)
CL (1) CL2022002522A1 (pt)
CO (1) CO2022014259A2 (pt)
CR (1) CR20220507A (pt)
DO (1) DOP2022000195A (pt)
EC (1) ECSP22079948A (pt)
IL (1) IL296473A (pt)
MX (1) MX2022011554A (pt)
NZ (1) NZ793365A (pt)
PE (1) PE20231643A1 (pt)
WO (2) WO2021184673A1 (pt)

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