JP2025065142A5 - - Google Patents

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JP2025065142A5
JP2025065142A5 JP2025004349A JP2025004349A JP2025065142A5 JP 2025065142 A5 JP2025065142 A5 JP 2025065142A5 JP 2025004349 A JP2025004349 A JP 2025004349A JP 2025004349 A JP2025004349 A JP 2025004349A JP 2025065142 A5 JP2025065142 A5 JP 2025065142A5
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seq
nucleic acid
fragment
amino acid
antibody
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JP2025004349A
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JP2025065142A (ja
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Priority claimed from PCT/US2017/063048 external-priority patent/WO2018098306A1/en
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JP2025004349A 2016-11-22 2025-01-10 T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 Pending JP2025065142A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662425398P 2016-11-22 2016-11-22
US62/425,398 2016-11-22
US201762543696P 2017-08-10 2017-08-10
US62/543,696 2017-08-10
PCT/US2017/063048 WO2018098306A1 (en) 2016-11-22 2017-11-22 Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies
JP2019547605A JP7778468B2 (ja) 2016-11-22 2017-11-22 T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断
JP2023012793A JP2023059873A (ja) 2016-11-22 2023-01-31 T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断

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JP2023012793A Division JP2023059873A (ja) 2016-11-22 2023-01-31 T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断

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JP2025065142A JP2025065142A (ja) 2025-04-17
JP2025065142A5 true JP2025065142A5 (https=) 2025-05-09

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JP2019547605A Active JP7778468B2 (ja) 2016-11-22 2017-11-22 T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断
JP2023012793A Pending JP2023059873A (ja) 2016-11-22 2023-01-31 T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断
JP2025004349A Pending JP2025065142A (ja) 2016-11-22 2025-01-10 T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断

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JP2019547605A Active JP7778468B2 (ja) 2016-11-22 2017-11-22 T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断
JP2023012793A Pending JP2023059873A (ja) 2016-11-22 2023-01-31 T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断

Country Status (10)

Country Link
US (4) US10550183B2 (https=)
EP (1) EP3545082A4 (https=)
JP (3) JP7778468B2 (https=)
KR (2) KR20190085528A (https=)
CN (3) CN118581046A (https=)
AU (3) AU2017363278B2 (https=)
CA (1) CA3043752A1 (https=)
NZ (1) NZ752984A (https=)
SG (2) SG11201903830TA (https=)
WO (1) WO2018098306A1 (https=)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11304288B2 (en) 2014-01-31 2022-04-12 Monolith Materials, Inc. Plasma torch design
US11987712B2 (en) 2015-02-03 2024-05-21 Monolith Materials, Inc. Carbon black generating system
CN113713091A (zh) 2015-02-06 2021-11-30 新加坡国立大学 工程免疫细胞及其用途和生产方法
CN111601447A (zh) 2015-07-29 2020-08-28 巨石材料公司 Dc等离子体焰炬电力设计方法和设备
CN108350280A (zh) 2015-08-07 2018-07-31 巨石材料公司 炭黑的制造方法
US20170066923A1 (en) 2015-09-09 2017-03-09 Monolith Materials, Inc. Circular few layer graphene
NZ750256A (en) 2016-08-03 2026-02-27 Dipersio John F Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
SG11201903830TA (en) 2016-11-22 2019-05-30 Nat Univ Singapore Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies
CA3287539A1 (en) 2017-06-21 2026-03-02 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF
US20190038733A1 (en) 2017-08-10 2019-02-07 National University Of Singapore T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof
KR20210008408A (ko) 2018-05-23 2021-01-21 싱가포르국립대학교 T-세포 악성 종양의 면역요법을 위한 cd2 표면 발현 및 키메라 항원 수용체의 발현에 대한 차단
US10227576B1 (en) * 2018-06-13 2019-03-12 Caribou Biosciences, Inc. Engineered cascade components and cascade complexes
US12227776B2 (en) 2018-06-13 2025-02-18 Caribou Biosciences, Inc. Engineered cascade components and cascade complexes
KR102665280B1 (ko) * 2018-10-31 2024-05-10 난트퀘스트, 인크. Cd19-car 발현 nk 세포에 의한 cd19-양성 림프성 악성종양의 제거
SG11202104524YA (en) * 2018-11-01 2021-05-28 Gracell Biotechnologies Shanghai Co Ltd Compositions and methods for t cell engineering
KR20210091250A (ko) 2018-11-14 2021-07-21 메디식스 테라퓨틱스 피티이 엘티디. Car-t 세포를 생성하기 위한 이중유전자 벡터 및 이의 용도
CN109652379B (zh) * 2018-12-29 2022-08-16 博生吉医药科技(苏州)有限公司 Cd7嵌合抗原受体修饰的nk-92mi细胞及其应用
CA3139346A1 (en) 2019-05-07 2020-11-12 Gracell Biotechnologies (Shanghai) Co., Ltd. Engineered immune cell targeting bcma and use thereof
GB201914611D0 (en) * 2019-10-09 2019-11-20 Autolus Ltd Engineered immune cell
KR20220095193A (ko) * 2019-10-11 2022-07-06 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 조절 가능한 세포 국재화를 위한 재조합 폴리펩티드
CN120905142A (zh) * 2019-11-20 2025-11-07 卡瑟里克斯私人有限公司 用于提供具有增强功能的免疫细胞的方法
CA3160759A1 (en) * 2019-12-05 2021-06-10 Vycellix, Inc. Modulators of the immune escape mechanism for universal cell therapy
US20230019849A1 (en) * 2019-12-09 2023-01-19 St. Jude Children's Research Hospital, Inc. Method for Preparing CD7-Negative, CD3-Positive T Cells
US12312407B2 (en) * 2020-01-30 2025-05-27 St Phi Therapeutics Co., Ltd. Universal T cells and the method of use thereof
CN114525259B (zh) * 2020-11-03 2025-02-14 南京北恒生物科技有限公司 靶向cd7的嵌合抗原受体及其用途
CN112300282A (zh) * 2020-11-03 2021-02-02 南京北恒生物科技有限公司 靶向cd7的人源化抗体及其用途
CA3201499A1 (en) 2020-11-13 2022-05-19 Catamaran Bio, Inc. Genetically modified natural killer cells and methods of use thereof
CN114525306B (zh) * 2020-11-23 2025-01-28 博生吉医药科技(苏州)有限公司 一种cd7-car-t细胞的制备方法及应用
AU2021386367A1 (en) 2020-11-24 2023-06-22 Les Laboratoires Servier Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
CN115786271B (zh) * 2021-01-12 2025-07-22 上海雅科生物科技有限公司 靶向cd7的工程化免疫细胞、嵌合抗原受体、cd7阻断分子及应用
IL304904A (en) * 2021-02-01 2023-10-01 St Phi Therapeutics Co Ltd Target protein degradation system and its use
US20240082306A1 (en) * 2021-02-03 2024-03-14 Bioheng Therapeutics Limited Novel chimeric antigen receptor and use thereof
CN112980800A (zh) * 2021-03-08 2021-06-18 河北森朗生物科技有限公司 Car-t细胞、其构建方法及其应用
CN115044617B (zh) * 2021-03-08 2024-08-13 河北森朗生物科技有限公司 Car t细胞的制备方法、car t细胞及其应用
CN112662631B (zh) * 2021-03-16 2021-06-29 合源生物科技(天津)有限公司 一种car-t细胞灌流培养方法
EP4326293A4 (en) 2021-04-22 2025-03-12 Baylor College of Medicine METHODS FOR MODIFYING IMMUNE CELLS HAVING REDUCED FRATRICIDAL ACTIVITY
US20250222026A1 (en) * 2021-06-08 2025-07-10 Beijing Meikang Geno-Immune Biotechnology Co., Ltd. Cd7-based humanized chimeric antigen receptor and use thereof
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023155852A1 (zh) * 2022-02-17 2023-08-24 上海优替济生生物医药有限公司 经修饰的免疫效应细胞及其用途
CN114560943B (zh) * 2022-02-28 2022-12-16 先进生物(苏州)有限公司 Cd7-car-t细胞及其制备方法和应用
US20250099504A1 (en) * 2022-03-29 2025-03-27 Institute Of Hematology And Blood Diseases Hospital , Chinese Academy Of Medical Sciences Antibody that specifically binds to cd7 and use thereof in preparing chimeric antigen receptor
CN117004603A (zh) * 2022-04-28 2023-11-07 南京北恒生物科技有限公司 一种cd7基因被敲除的工程化免疫细胞及其用途
CN120787162A (zh) 2022-05-20 2025-10-14 诺华股份有限公司 抗肿瘤化合物的抗体-药物缀合物及其使用方法
US20260061065A1 (en) 2022-05-20 2026-03-05 Novartis Ag Antibody drug conjugates
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
CN116179495B (zh) * 2022-11-28 2025-06-06 上海恩凯细胞技术有限公司 转基因免疫细胞及其应用
WO2024119157A1 (en) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
KR20260016952A (ko) 2023-05-23 2026-02-04 사나 바이오테크놀로지, 인크. 탠덤 퓨소젠 및 관련 지질 입자
US12311033B2 (en) 2023-05-31 2025-05-27 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
WO2025076127A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
TW202540186A (zh) 2023-11-22 2025-10-16 瑞士商諾華公司 抗cd7抗體藥物結合物及其使用方法
EP4559937A1 (en) * 2023-11-24 2025-05-28 Universitat de Barcelona Cd7 targeting moieties for the treatment of cd7 positive cancer
WO2025179294A2 (en) 2024-02-22 2025-08-28 Capstan Therapeutics, Inc. Immune engineering amplification
WO2025184529A1 (en) 2024-03-01 2025-09-04 Sana Biotechnology, Inc. Viral particles with fusogen display and related compositions and methods
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2018248A1 (en) 1989-06-07 1990-12-07 Clyde W. Shearman Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
CA2304208A1 (en) 1997-09-19 1999-03-25 Dana-Farber Cancer Institute, Inc. Intrabody-mediated control of immune reactions
CA2386270A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
AU2001275474A1 (en) 2000-06-12 2001-12-24 Akkadix Corporation Materials and methods for the control of nematodes
CA2427858A1 (en) * 2000-11-03 2002-05-10 University Of Vermont And State Agricultural College Compositions for inhibiting grb7
AU2002361390A1 (en) 2001-12-14 2003-06-30 Friedrich-Alexander-Universitaet Erlangen-Nuernberg Anti-cd7 immunotoxin as fusion protein
WO2005017163A2 (en) 2003-08-15 2005-02-24 Imperial College Innovations Limited Phenotypic knockout of cell-surface proteins
US20130266551A1 (en) 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
US7435596B2 (en) 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell
EP2287195B1 (en) 2004-07-01 2019-05-15 Novo Nordisk A/S Pan-kir2dl nk-receptor antibodies and their use in diagnostik and therapy
WO2006047637A1 (en) 2004-10-27 2006-05-04 Medimmune, Inc. Use of modulators of epha2 and ephrina1 for the treatment and prevention of infections
US20070036773A1 (en) 2005-08-09 2007-02-15 City Of Hope Generation and application of universal T cells for B-ALL
WO2007044616A2 (en) 2005-10-06 2007-04-19 Xencor, Inc. Optimized anti-cd30 antibodies
CN101675075B (zh) 2007-03-01 2014-06-18 西福根有限公司 重组抗表皮生长因子受体抗体组合物
DK2185574T3 (da) 2007-09-07 2013-08-05 Agensys Inc Antistoffer og relaterede molekyler, der bindes til 24P4C12-proteiner
EP2628753A1 (en) 2008-01-24 2013-08-21 Novo Nordisk A/S Humanized anti-human NKG2A monoclonal antibody
ES2826883T3 (es) 2009-10-14 2021-05-19 Janssen Biotech Inc Métodos de maduración por afinidad de anticuerpos
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2013126712A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
EP3241902B1 (en) 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
EP2906684B8 (en) 2012-10-10 2020-09-02 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
WO2014093831A2 (en) * 2012-12-14 2014-06-19 Thomson Reuters (Markets) Llc Dynamic function builder
KR101521224B1 (ko) * 2012-12-20 2015-05-19 한양대학교 산학협력단 T 세포 특이적인 인간화 단일조각항체 전달체
WO2014106123A1 (en) 2012-12-27 2014-07-03 Aduro Biotech, Inc. Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof
SG11201507026WA (en) 2013-02-06 2015-10-29 Anthrogenesis Corp Modified t lymphocytes having improved specificity
PT2961831T (pt) 2013-02-26 2020-10-12 Memorial Sloan Kettering Cancer Center Composições e métodos para imunoterapêutica
PL3546572T3 (pl) 2013-05-13 2024-07-22 Cellectis Chimeryczny receptor antygenowy swoisty względem cd19 i jego zastosowania
WO2014191128A1 (en) 2013-05-29 2014-12-04 Cellectis Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
EP3057986B1 (en) 2013-10-17 2017-12-27 National University of Singapore Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors
US20160296562A1 (en) 2013-11-21 2016-10-13 Ucl Business Plc Cell
ES3063961T3 (en) 2014-02-14 2026-04-21 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
CA2943008C (en) 2014-03-19 2021-03-30 Cellectis Cd123 specific chimeric antigen receptors for cancer immunotherapy
GB201405845D0 (en) 2014-04-01 2014-05-14 Ucl Business Plc Signalling system
AU2015289644A1 (en) 2014-07-15 2017-02-02 Juno Therapeutics, Inc. Engineered cells for adoptive cell therapy
JP2017531430A (ja) 2014-10-07 2017-10-26 セレクティスCellectis Carによって誘導される免疫細胞の活性を調節するための方法
KR102376244B1 (ko) 2014-12-24 2022-03-21 오토러스 리미티드 세포
CN113713091A (zh) 2015-02-06 2021-11-30 新加坡国立大学 工程免疫细胞及其用途和生产方法
JP7237449B2 (ja) 2015-02-27 2023-03-13 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体(CARs)の構成およびその使用方法
KR102133857B1 (ko) 2015-03-02 2020-07-20 이노베이티브 셀룰러 테라퓨틱스 코퍼레이션 리미티드 Pd-l1에 의해 유도된 면역관용의 감소
GB201507104D0 (en) 2015-04-27 2015-06-10 Ucl Business Plc Nucleic acid construct
GB2592821B (en) 2015-07-31 2022-01-12 Univ Minnesota Modified cells and methods of therapy
WO2017112877A1 (en) * 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity
AU2017225733A1 (en) 2016-03-04 2018-09-27 Novartis Ag Cells expressing multiple chimeric antigen receptor (CAR) molecules and uses therefore
US11390658B2 (en) * 2016-06-06 2022-07-19 St. Jude Children's Research Hospital Anti-CD7 chimeric antigen receptor and method of use thereof
CA2937157A1 (en) 2016-07-25 2018-01-25 Ucl Business Ltd Protein-based t-cell receptor knockdown
NZ750256A (en) * 2016-08-03 2026-02-27 Dipersio John F Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
SG11201903830TA (en) 2016-11-22 2019-05-30 Nat Univ Singapore Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies
US20190038733A1 (en) 2017-08-10 2019-02-07 National University Of Singapore T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof
KR20210091250A (ko) 2018-11-14 2021-07-21 메디식스 테라퓨틱스 피티이 엘티디. Car-t 세포를 생성하기 위한 이중유전자 벡터 및 이의 용도

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