CY1122324T1 - Διαβιβαστης εκφρασης car και τ-κυτταρα εκφρασης car - Google Patents

Διαβιβαστης εκφρασης car και τ-κυτταρα εκφρασης car

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Publication number
CY1122324T1
CY1122324T1 CY20191101239T CY191101239T CY1122324T1 CY 1122324 T1 CY1122324 T1 CY 1122324T1 CY 20191101239 T CY20191101239 T CY 20191101239T CY 191101239 T CY191101239 T CY 191101239T CY 1122324 T1 CY1122324 T1 CY 1122324T1
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CY
Cyprus
Prior art keywords
car
nucleic acid
acid encoding
expressing
cells
Prior art date
Application number
CY20191101239T
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English (en)
Inventor
Koji Tamada
Yukimi SAKODA
Keishi ADACHI
Original Assignee
Yamaguchi University
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Publication date
Application filed by Yamaguchi University filed Critical Yamaguchi University
Publication of CY1122324T1 publication Critical patent/CY1122324T1/el

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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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Abstract

Ένα αντικείμενο της παρούσας εφεύρεσης είναι να παρασχεθούν Τ-κύτταρα έκφρασης CAR που συν-εκφράζουν ένα χιμαιρικό υποδοχέα αντιγόνου (CAR) και έναν παράγοντα ενίσχυσης της ανοσολογικής λειτουργίας Τ-κυττάρων και τα οποία έχουν μία υψηλή επίδραση επαγωγής ανοσίας και αντικαρκινική δραστικότητα και να παρασχεθεί ένας διαβιβαστής έκφρασης CAR για την παρασκευή των Τ-κυττάρων που εκφράζουν CAR. Παρασκευάζονται ένας διαβιβαστής έκφρασης CAR που εμπεριέχει ένα νουκλεϊνικό οξύ που κωδικοποιεί ένα χιμαιρικό υποδοχέα αντιγόνου (CAR) και ένα νουκλεϊνικό οξύ που κωδικοποιεί έναν παράγοντα ενίσχυσης της ανοσολογικής λειτουργίας Τ-κυττάρων, όπου το νουκλεϊνικό οξύ που κωδικοποιεί έναν παράγοντα ενίσχυσης της ανοσολογικής λειτουργίας είναι ένα νουκλεϊνικό οξύ που κωδικοποιεί την ιντερλευκίνη-7 και ένα νουκλεϊνικό οξύ που κωδικοποιεί την CCL19, ένα νουκλεϊνικό οξύ που κωδικοποιεί έναν κυρίαρχο αρνητικό μεταλλάκτη της SHP-1 ή ένα νουκλεϊνικό οξύ που κωδικοποιεί έναν κυρίαρχο αρνητικό μεταλλάκτη της SHP-2 ή ένα Τ-κύτταρο που εκφράζει CAR το οποίο εισάγεται με το διαβιβαστή έκφρασης CAR.
CY20191101239T 2014-10-09 2019-11-26 Διαβιβαστης εκφρασης car και τ-κυτταρα εκφρασης car CY1122324T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014208200 2014-10-09
PCT/JP2015/005080 WO2016056228A1 (ja) 2014-10-09 2015-10-06 Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞

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CY1122324T1 true CY1122324T1 (el) 2021-01-27

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