JP2019528077A5 - - Google Patents
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- JP2019528077A5 JP2019528077A5 JP2019510951A JP2019510951A JP2019528077A5 JP 2019528077 A5 JP2019528077 A5 JP 2019528077A5 JP 2019510951 A JP2019510951 A JP 2019510951A JP 2019510951 A JP2019510951 A JP 2019510951A JP 2019528077 A5 JP2019528077 A5 JP 2019528077A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- host cell
- chimeric
- antigen
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022057245A JP2022106714A (ja) | 2016-08-23 | 2022-03-30 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662378614P | 2016-08-23 | 2016-08-23 | |
| US62/378,614 | 2016-08-23 | ||
| PCT/US2017/048040 WO2018039247A1 (en) | 2016-08-23 | 2017-08-22 | Proteolytically cleavable chimeric polypeptides and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022057245A Division JP2022106714A (ja) | 2016-08-23 | 2022-03-30 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528077A JP2019528077A (ja) | 2019-10-10 |
| JP2019528077A5 true JP2019528077A5 (https=) | 2020-09-24 |
| JP7500195B2 JP7500195B2 (ja) | 2024-06-17 |
Family
ID=61245300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019510951A Active JP7500195B2 (ja) | 2016-08-23 | 2017-08-22 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
| JP2022057245A Ceased JP2022106714A (ja) | 2016-08-23 | 2022-03-30 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022057245A Ceased JP2022106714A (ja) | 2016-08-23 | 2022-03-30 | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11401332B2 (https=) |
| EP (1) | EP3504245A4 (https=) |
| JP (2) | JP7500195B2 (https=) |
| KR (2) | KR102637610B1 (https=) |
| CN (1) | CN109843929B (https=) |
| AU (1) | AU2017316649A1 (https=) |
| CA (1) | CA3034093A1 (https=) |
| SG (2) | SG10201913583QA (https=) |
| WO (1) | WO2018039247A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013540757A (ja) | 2010-09-24 | 2013-11-07 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | カプセル化された作用物質の放出を制御する能力を有するナノ構造ゲル |
| CN107530424A (zh) | 2015-02-20 | 2018-01-02 | 俄亥俄州国家创新基金会 | 针对nkg2d和肿瘤相关抗原的二价抗体 |
| AU2016246457B2 (en) | 2015-04-06 | 2020-10-15 | Cytoimmune Therapeutics, Inc. | EGFR-directed car therapy for glioblastoma |
| CN110225760B (zh) * | 2016-09-15 | 2023-11-07 | 埃里西拉医疗公司 | T细胞免疫疗法 |
| MX2019003462A (es) * | 2016-09-28 | 2019-08-16 | Gavish Galilee Bio Appl Ltd | Una plataforma universal para el tratamiento con car que se dirige a una novedosa firma antigenica del cancer. |
| WO2018144991A1 (en) | 2017-02-03 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
| US11807662B2 (en) * | 2017-05-16 | 2023-11-07 | The Johns Hopkins University | MANAbodies and methods of using |
| US11325957B2 (en) * | 2017-06-19 | 2022-05-10 | Cell Design Labs, Inc. | Methods and compositions for reducing the immunogenicity of chimeric notch receptors |
| CA3092355A1 (en) * | 2018-03-16 | 2019-09-19 | Cytoimmune Therapeutics, Inc. | Bispecific antibody car cell immunotherapy |
| GB201804291D0 (en) * | 2018-03-16 | 2018-05-02 | Evox Therapeutics Ltd | Cell-mediated exosome delivery |
| JP2021520352A (ja) | 2018-04-04 | 2021-08-19 | アリヴィオ セラピューティクス， インコーポレイテッド | 生物製剤の制御送達用の自己組織化ゲルおよびその製造方法 |
| AU2019247830B2 (en) * | 2018-04-06 | 2026-02-19 | The Regents Of The University Of California | Trans-antigen targeting in heterogeneous cancers and methods of use thereof |
| CA3096202A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating egfrviii expressing glioblastomas |
| CA3095757A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating glioblastomas |
| AU2019252878B2 (en) * | 2018-04-10 | 2024-02-22 | Stichting Sanquin Bloedvoorziening | Chimeric Notch receptors |
| US20210317479A1 (en) | 2018-09-06 | 2021-10-14 | The Broad Institute, Inc. | Nucleic acid assemblies for use in targeted delivery |
| US12466892B2 (en) | 2018-11-08 | 2025-11-11 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
| CA3121911A1 (en) * | 2018-12-06 | 2020-06-11 | The Board Of Trustees Of The Leland Stanford Junior University | Regulatable cell surface receptors and related compositions and methods |
| CN113164578B (zh) * | 2019-01-03 | 2024-04-30 | 南京传奇生物科技有限公司 | 表达鞭毛蛋白多肽的经修饰的免疫细胞 |
| JP7739261B2 (ja) * | 2019-08-09 | 2025-09-16 | エイ２・バイオセラピューティクス・インコーポレイテッド | ヘテロ接合性の喪失に応答する細胞表面受容体 |
| CN114729025A (zh) * | 2019-09-24 | 2022-07-08 | 加利福尼亚大学董事会 | 用于配体依赖性转录调控的新型受体 |
| EP4034254A4 (en) * | 2019-09-24 | 2023-11-01 | The Regents of the University of California | RECEPTORS WITH HETEROLOGUE TRANSMEMBRANE DOMAIN |
| CN114761084B (zh) * | 2019-09-24 | 2023-10-27 | 加利福尼亚大学董事会 | 具有铰链结构域的Notch受体 |
| WO2021061791A1 (en) * | 2019-09-24 | 2021-04-01 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| CN110716044B (zh) * | 2019-10-23 | 2023-04-18 | 郑州大学 | 一种用于食管鳞癌早期筛查和诊断的血清蛋白标志物、试剂盒及检测方法 |
| US12195723B2 (en) | 2019-11-08 | 2025-01-14 | The Broad Institute, Inc. | Engineered antigen presenting cells and uses thereof |
| CN110970090B (zh) * | 2019-11-18 | 2021-06-29 | 华中科技大学 | 一种用于判断待处理多肽与阳性数据集肽段相似度的方法 |
| WO2021119539A1 (en) * | 2019-12-12 | 2021-06-17 | Senti Biosciences, Inc. | Method and compositions for regulated armoring of cells |
| CN115151644B (zh) * | 2019-12-27 | 2024-06-21 | 国立大学法人神户大学 | 癌基因治疗药 |
| US20230183709A1 (en) * | 2020-04-09 | 2023-06-15 | The Regents Of The University Of California | Humanized notch receptors with hinge domain |
| US20230226213A1 (en) * | 2020-06-18 | 2023-07-20 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating cells and cellular membranes |
| KR102859550B1 (ko) | 2020-08-20 | 2025-09-16 | 에이투 바이오쎄라퓨틱스, 인크. | Ceacam 양성 암을 치료하기 위한 조성물 및 방법 |
| WO2022040454A1 (en) | 2020-08-20 | 2022-02-24 | A2 Biotherapeutics, Inc. | Compositions and methods for treating mesothelin positive cancers |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| AU2021392032A1 (en) | 2020-12-03 | 2023-06-22 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| US20240150755A1 (en) * | 2021-02-26 | 2024-05-09 | Salk Institute For Biological Studies | Modulating regulatory t cell function in autoimmune disease and cancer |
| AU2022244245A1 (en) * | 2021-03-23 | 2023-10-05 | The Regents Of The University Of California | Synthetic intermembrane proteolysis receptors for custom antigen-induced transcriptional regulation |
| WO2022204326A1 (en) * | 2021-03-24 | 2022-09-29 | The Regents Of The University Of California | Humanized synthetic notch receptors with augmented transactivation domains and uses thereof |
| CN114045272B (zh) * | 2021-03-24 | 2024-12-06 | 深圳市新靶向生物科技有限公司 | 一种与乳腺癌驱动基因突变相关的抗原肽组合及其应用 |
| AU2022366987A1 (en) | 2021-10-14 | 2024-05-16 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
| CN114107253B (zh) * | 2021-12-17 | 2024-03-15 | 复旦大学附属华山医院 | 一种利用工程细胞进行基因编辑的系统及方法 |
| CN114736308B (zh) * | 2022-03-15 | 2022-12-27 | 四川宜美康科技有限公司 | 球虫抗原肽/il5的融合蛋白基因工程菌的制备及用途 |
| CN117510615B (zh) * | 2023-01-31 | 2025-01-07 | 上海恩凯细胞技术有限公司 | SynNotch受体及其用途 |
| WO2025076422A1 (en) * | 2023-10-05 | 2025-04-10 | The Regents Of The University Of California | Regulated expression of card11-pik3r3 fusion protein |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| GB0112818D0 (en) * | 2001-05-25 | 2001-07-18 | Lorantis Ltd | Conjugate |
| GB0220658D0 (en) | 2002-09-05 | 2002-10-16 | Lorantis Ltd | Immunotherapy |
| EA018260B1 (ru) | 2006-09-29 | 2013-06-28 | Онкомед Фармасьютикалз, Инк. | Антитела к дельта-подобному лиганду 4 человека и их применение |
| EP2195658A2 (en) | 2007-09-28 | 2010-06-16 | Royal College of Surgeons in Ireland | A method of assessing colorectal cancer status in an individual |
| CN104402998A (zh) | 2008-07-08 | 2015-03-11 | 昂考梅德药品有限公司 | 分离的抗体 |
| CA2796464C (en) | 2010-04-16 | 2021-08-03 | Immune Disease Institute, Inc. | Sustained polypeptide expression from synthetic, modified rnas and uses thereof |
| AU2013327136A1 (en) | 2012-10-02 | 2015-04-16 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| MX389160B (es) | 2013-10-31 | 2025-03-20 | Hutchinson Fred Cancer Res | Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas. |
| US9730935B2 (en) | 2013-12-13 | 2017-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting a non-canonical notch signaling pathway for cancer treatment |
| ES3012974T3 (en) | 2014-01-08 | 2025-04-10 | Univ Leland Stanford Junior | Targeted therapy for lung cancer |
| EP3656864A1 (en) | 2014-02-14 | 2020-05-27 | Board of Regents, The University of Texas System | Chimeric antigen receptors and methods of making |
| US10196608B2 (en) | 2014-02-21 | 2019-02-05 | Cellectis | Method for in situ inhibition of regulatory T cells |
| US20160152725A1 (en) * | 2014-02-25 | 2016-06-02 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins specific for hla-a2-restricted wilms tumor 1 peptide |
| ES2781175T3 (es) * | 2014-07-31 | 2020-08-31 | Novartis Ag | Subconjunto optimizado de células T que contienen un receptor de antígeno quimérico |
| WO2016033331A1 (en) | 2014-08-28 | 2016-03-03 | Bioatla, Llc | Conditionally active chimeric antigen receptors for modified t-cells |
| CA2959428A1 (en) * | 2014-09-19 | 2016-03-24 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
| WO2016093243A1 (ja) | 2014-12-09 | 2016-06-16 | 北海道公立大学法人札幌医科大学 | 腫瘍抗原ペプチド |
| WO2016138034A1 (en) | 2015-02-24 | 2016-09-01 | The Regents Of The University Of California | Binding-triggered transcriptional switches and methods of use thereof |
| WO2017193059A1 (en) | 2016-05-06 | 2017-11-09 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
-
2017
- 2017-08-22 JP JP2019510951A patent/JP7500195B2/ja active Active
- 2017-08-22 US US16/325,657 patent/US11401332B2/en active Active
- 2017-08-22 WO PCT/US2017/048040 patent/WO2018039247A1/en not_active Ceased
- 2017-08-22 CA CA3034093A patent/CA3034093A1/en active Pending
- 2017-08-22 SG SG10201913583QA patent/SG10201913583QA/en unknown
- 2017-08-22 KR KR1020237006942A patent/KR102637610B1/ko active Active
- 2017-08-22 AU AU2017316649A patent/AU2017316649A1/en not_active Abandoned
- 2017-08-22 KR KR1020197005928A patent/KR20190051956A/ko not_active Ceased
- 2017-08-22 EP EP17844296.8A patent/EP3504245A4/en active Pending
- 2017-08-22 SG SG11201901528RA patent/SG11201901528RA/en unknown
- 2017-08-22 CN CN201780063755.8A patent/CN109843929B/zh active Active
-
2022
- 2022-03-30 JP JP2022057245A patent/JP2022106714A/ja not_active Ceased
- 2022-06-15 US US17/841,595 patent/US12358988B2/en active Active
-
2025
- 2025-06-10 US US19/234,169 patent/US20250304698A1/en active Pending
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