JP7500195B2 - タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 - Google Patents

タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 Download PDF

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JP7500195B2
JP7500195B2 JP2019510951A JP2019510951A JP7500195B2 JP 7500195 B2 JP7500195 B2 JP 7500195B2 JP 2019510951 A JP2019510951 A JP 2019510951A JP 2019510951 A JP2019510951 A JP 2019510951A JP 7500195 B2 JP7500195 B2 JP 7500195B2
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polypeptide
cell
amino acids
antigen
chimeric
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JP2019528077A5 (https=
JP2019528077A (ja
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エー． リム，ウェンデル
ティー． ロイバル，コレ
ゼット． ウィリアムズ，ジャスパー
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University of California San Diego UCSD
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JP2019510951A 2016-08-23 2017-08-22 タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 Active JP7500195B2 (ja)

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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013540757A (ja) 2010-09-24 2013-11-07 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド カプセル化された作用物質の放出を制御する能力を有するナノ構造ゲル
CN107530424A (zh) 2015-02-20 2018-01-02 俄亥俄州国家创新基金会 针对nkg2d和肿瘤相关抗原的二价抗体
AU2016246457B2 (en) 2015-04-06 2020-10-15 Cytoimmune Therapeutics, Inc. EGFR-directed car therapy for glioblastoma
CN110225760B (zh) * 2016-09-15 2023-11-07 埃里西拉医疗公司 T细胞免疫疗法
MX2019003462A (es) * 2016-09-28 2019-08-16 Gavish Galilee Bio Appl Ltd Una plataforma universal para el tratamiento con car que se dirige a una novedosa firma antigenica del cancer.
WO2018144991A1 (en) 2017-02-03 2018-08-09 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
US11807662B2 (en) * 2017-05-16 2023-11-07 The Johns Hopkins University MANAbodies and methods of using
US11325957B2 (en) * 2017-06-19 2022-05-10 Cell Design Labs, Inc. Methods and compositions for reducing the immunogenicity of chimeric notch receptors
CA3092355A1 (en) * 2018-03-16 2019-09-19 Cytoimmune Therapeutics, Inc. Bispecific antibody car cell immunotherapy
GB201804291D0 (en) * 2018-03-16 2018-05-02 Evox Therapeutics Ltd Cell-mediated exosome delivery
JP2021520352A (ja) 2018-04-04 2021-08-19 アリヴィオ セラピューティクス， インコーポレイテッド 生物製剤の制御送達用の自己組織化ゲルおよびその製造方法
AU2019247830B2 (en) * 2018-04-06 2026-02-19 The Regents Of The University Of California Trans-antigen targeting in heterogeneous cancers and methods of use thereof
CA3096202A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating egfrviii expressing glioblastomas
CA3095757A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating glioblastomas
AU2019252878B2 (en) * 2018-04-10 2024-02-22 Stichting Sanquin Bloedvoorziening Chimeric Notch receptors
US20210317479A1 (en) 2018-09-06 2021-10-14 The Broad Institute, Inc. Nucleic acid assemblies for use in targeted delivery
US12466892B2 (en) 2018-11-08 2025-11-11 The Regents Of The University Of California Systems and methods for targeting cancer cells
CA3121911A1 (en) * 2018-12-06 2020-06-11 The Board Of Trustees Of The Leland Stanford Junior University Regulatable cell surface receptors and related compositions and methods
CN113164578B (zh) * 2019-01-03 2024-04-30 南京传奇生物科技有限公司 表达鞭毛蛋白多肽的经修饰的免疫细胞
JP7739261B2 (ja) * 2019-08-09 2025-09-16 エイ２・バイオセラピューティクス・インコーポレイテッド ヘテロ接合性の喪失に応答する細胞表面受容体
CN114729025A (zh) * 2019-09-24 2022-07-08 加利福尼亚大学董事会 用于配体依赖性转录调控的新型受体
EP4034254A4 (en) * 2019-09-24 2023-11-01 The Regents of the University of California RECEPTORS WITH HETEROLOGUE TRANSMEMBRANE DOMAIN
CN114761084B (zh) * 2019-09-24 2023-10-27 加利福尼亚大学董事会 具有铰链结构域的Notch受体
WO2021061791A1 (en) * 2019-09-24 2021-04-01 The Regents Of The University Of California Notch receptors with zinc finger-containing transcriptional effector
CN110716044B (zh) * 2019-10-23 2023-04-18 郑州大学 一种用于食管鳞癌早期筛查和诊断的血清蛋白标志物、试剂盒及检测方法
US12195723B2 (en) 2019-11-08 2025-01-14 The Broad Institute, Inc. Engineered antigen presenting cells and uses thereof
CN110970090B (zh) * 2019-11-18 2021-06-29 华中科技大学 一种用于判断待处理多肽与阳性数据集肽段相似度的方法
WO2021119539A1 (en) * 2019-12-12 2021-06-17 Senti Biosciences, Inc. Method and compositions for regulated armoring of cells
CN115151644B (zh) * 2019-12-27 2024-06-21 国立大学法人神户大学 癌基因治疗药
US20230183709A1 (en) * 2020-04-09 2023-06-15 The Regents Of The University Of California Humanized notch receptors with hinge domain
US20230226213A1 (en) * 2020-06-18 2023-07-20 Flagship Pioneering Innovations Vi, Llc Methods and compositions for modulating cells and cellular membranes
KR102859550B1 (ko) 2020-08-20 2025-09-16 에이투 바이오쎄라퓨틱스, 인크. Ceacam 양성 암을 치료하기 위한 조성물 및 방법
WO2022040454A1 (en) 2020-08-20 2022-02-24 A2 Biotherapeutics, Inc. Compositions and methods for treating mesothelin positive cancers
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
US20240150755A1 (en) * 2021-02-26 2024-05-09 Salk Institute For Biological Studies Modulating regulatory t cell function in autoimmune disease and cancer
AU2022244245A1 (en) * 2021-03-23 2023-10-05 The Regents Of The University Of California Synthetic intermembrane proteolysis receptors for custom antigen-induced transcriptional regulation
WO2022204326A1 (en) * 2021-03-24 2022-09-29 The Regents Of The University Of California Humanized synthetic notch receptors with augmented transactivation domains and uses thereof
CN114045272B (zh) * 2021-03-24 2024-12-06 深圳市新靶向生物科技有限公司 一种与乳腺癌驱动基因突变相关的抗原肽组合及其应用
AU2022366987A1 (en) 2021-10-14 2024-05-16 Arsenal Biosciences, Inc. Immune cells having co-expressed shrnas and logic gate systems
CN114107253B (zh) * 2021-12-17 2024-03-15 复旦大学附属华山医院 一种利用工程细胞进行基因编辑的系统及方法
CN114736308B (zh) * 2022-03-15 2022-12-27 四川宜美康科技有限公司 球虫抗原肽/il5的融合蛋白基因工程菌的制备及用途
CN117510615B (zh) * 2023-01-31 2025-01-07 上海恩凯细胞技术有限公司 SynNotch受体及其用途
WO2025076422A1 (en) * 2023-10-05 2025-04-10 The Regents Of The University Of California Regulated expression of card11-pik3r3 fusion protein

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014158469A (ja) 2006-09-29 2014-09-04 Oncomed Pharmaceutical Inc 癌の診断および処置のための組成物および方法
WO2016019300A1 (en) 2014-07-31 2016-02-04 Novartis Ag Subset-optimized chimeric antigen receptor-containing t-cells
US20160081314A1 (en) 2014-09-19 2016-03-24 Regeneron Pharmaceuticals, Inc. Chimeric Antigen Receptors
WO2016093243A1 (ja) 2014-12-09 2016-06-16 北海道公立大学法人札幌医科大学 腫瘍抗原ペプチド
JP2016517848A (ja) 2013-04-10 2016-06-20 フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ ポリペプチド及びイムノモジュレーション

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
GB0112818D0 (en) * 2001-05-25 2001-07-18 Lorantis Ltd Conjugate
GB0220658D0 (en) 2002-09-05 2002-10-16 Lorantis Ltd Immunotherapy
EP2195658A2 (en) 2007-09-28 2010-06-16 Royal College of Surgeons in Ireland A method of assessing colorectal cancer status in an individual
CN104402998A (zh) 2008-07-08 2015-03-11 昂考梅德药品有限公司 分离的抗体
CA2796464C (en) 2010-04-16 2021-08-03 Immune Disease Institute, Inc. Sustained polypeptide expression from synthetic, modified rnas and uses thereof
AU2013327136A1 (en) 2012-10-02 2015-04-16 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
US10144770B2 (en) * 2013-10-17 2018-12-04 National University Of Singapore Chimeric receptors and uses thereof in immune therapy
MX389160B (es) 2013-10-31 2025-03-20 Hutchinson Fred Cancer Res Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas.
US9730935B2 (en) 2013-12-13 2017-08-15 The Board Of Trustees Of The Leland Stanford Junior University Targeting a non-canonical notch signaling pathway for cancer treatment
ES3012974T3 (en) 2014-01-08 2025-04-10 Univ Leland Stanford Junior Targeted therapy for lung cancer
EP3656864A1 (en) 2014-02-14 2020-05-27 Board of Regents, The University of Texas System Chimeric antigen receptors and methods of making
US10196608B2 (en) 2014-02-21 2019-02-05 Cellectis Method for in situ inhibition of regulatory T cells
US20160152725A1 (en) * 2014-02-25 2016-06-02 Memorial Sloan-Kettering Cancer Center Antigen-binding proteins specific for hla-a2-restricted wilms tumor 1 peptide
WO2016033331A1 (en) 2014-08-28 2016-03-03 Bioatla, Llc Conditionally active chimeric antigen receptors for modified t-cells
WO2016138034A1 (en) 2015-02-24 2016-09-01 The Regents Of The University Of California Binding-triggered transcriptional switches and methods of use thereof
WO2017193059A1 (en) 2016-05-06 2017-11-09 The Regents Of The University Of California Systems and methods for targeting cancer cells

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014158469A (ja) 2006-09-29 2014-09-04 Oncomed Pharmaceutical Inc 癌の診断および処置のための組成物および方法
JP2016517848A (ja) 2013-04-10 2016-06-20 フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ ポリペプチド及びイムノモジュレーション
WO2016019300A1 (en) 2014-07-31 2016-02-04 Novartis Ag Subset-optimized chimeric antigen receptor-containing t-cells
US20160081314A1 (en) 2014-09-19 2016-03-24 Regeneron Pharmaceuticals, Inc. Chimeric Antigen Receptors
WO2016093243A1 (ja) 2014-12-09 2016-06-16 北海道公立大学法人札幌医科大学 腫瘍抗原ペプチド

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ｃｅｌｌ， ２０１６ Ｆｅｂ １１， ｖｏｌ． １６４， ｎｏ． ４， ｐｐ． ７７０－７７９
Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ ＵＳＡ， ２００８ Ｄｅｃ ２３， ｖｏｌ． １０５， ｎｏ． ５１， ｐｐ． ２０４２８－２０４

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