JP2017113004A5 - - Google Patents
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- JP2017113004A5 JP2017113004A5 JP2017008740A JP2017008740A JP2017113004A5 JP 2017113004 A5 JP2017113004 A5 JP 2017113004A5 JP 2017008740 A JP2017008740 A JP 2017008740A JP 2017008740 A JP2017008740 A JP 2017008740A JP 2017113004 A5 JP2017113004 A5 JP 2017113004A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- tau protein
- functional part
- immune complex
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102000013498 tau Proteins Human genes 0.000 claims description 22
- 108010026424 tau Proteins Proteins 0.000 claims description 22
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims description 8
- 102000057063 human MAPT Human genes 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 6
- 238000003745 diagnosis Methods 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000746 body region Anatomy 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 101000854943 Enterobacteria phage T4 Valyl-tRNA ligase modifier Proteins 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 208000034799 Tauopathies Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10186810.7 | 2010-10-07 | ||
| EP10186810 | 2010-10-07 | ||
| EP11174248 | 2011-07-15 | ||
| EP11174248.2 | 2011-07-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532226A Division JP6371526B2 (ja) | 2010-10-07 | 2011-10-07 | タウを認識するリン酸化部位特異的抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017113004A JP2017113004A (ja) | 2017-06-29 |
| JP2017113004A5 true JP2017113004A5 (enExample) | 2019-03-14 |
Family
ID=44947048
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532226A Active JP6371526B2 (ja) | 2010-10-07 | 2011-10-07 | タウを認識するリン酸化部位特異的抗体 |
| JP2017008740A Pending JP2017113004A (ja) | 2010-10-07 | 2017-01-20 | 薬学的組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532226A Active JP6371526B2 (ja) | 2010-10-07 | 2011-10-07 | タウを認識するリン酸化部位特異的抗体 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US9304138B2 (enExample) |
| EP (2) | EP2625198B1 (enExample) |
| JP (2) | JP6371526B2 (enExample) |
| KR (1) | KR101988672B1 (enExample) |
| CN (1) | CN103502272B (enExample) |
| AR (1) | AR085198A1 (enExample) |
| AU (1) | AU2011311516B2 (enExample) |
| BR (1) | BR112013008333B1 (enExample) |
| CA (1) | CA2812865C (enExample) |
| CL (1) | CL2013000951A1 (enExample) |
| CO (1) | CO6710903A2 (enExample) |
| CR (1) | CR20130160A (enExample) |
| DK (1) | DK2625198T3 (enExample) |
| EC (1) | ECSP13012609A (enExample) |
| ES (1) | ES2548686T3 (enExample) |
| HK (1) | HK1216897A1 (enExample) |
| HU (1) | HUE027649T2 (enExample) |
| IL (1) | IL225568A (enExample) |
| MX (1) | MX338421B (enExample) |
| MY (1) | MY164376A (enExample) |
| PE (1) | PE20140218A1 (enExample) |
| PH (1) | PH12013500615A1 (enExample) |
| PL (1) | PL2625198T3 (enExample) |
| RU (1) | RU2603078C2 (enExample) |
| SG (1) | SG189136A1 (enExample) |
| SI (1) | SI2625198T1 (enExample) |
| TW (1) | TW201216985A (enExample) |
| WO (1) | WO2012045882A2 (enExample) |
| ZA (1) | ZA201302432B (enExample) |
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| UA107571C2 (xx) * | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| EP4218794A3 (en) | 2009-06-10 | 2023-09-13 | New York University | Immunological targeting of pathological tau proteins |
| MX2012001194A (es) | 2009-07-30 | 2012-03-07 | Pfizer Vaccines Llc | Peptidos tau antigenicos y usos de los mismos. |
| DK2625198T3 (en) * | 2010-10-07 | 2015-09-28 | Ac Immune Sa | Antibodies that recognize the phosphorylated tau |
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