JP2012530055A5 - - Google Patents
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- JP2012530055A5 JP2012530055A5 JP2012515141A JP2012515141A JP2012530055A5 JP 2012530055 A5 JP2012530055 A5 JP 2012530055A5 JP 2012515141 A JP2012515141 A JP 2012515141A JP 2012515141 A JP2012515141 A JP 2012515141A JP 2012530055 A5 JP2012530055 A5 JP 2012530055A5
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- JP
- Japan
- Prior art keywords
- tau
- subject
- immunogenic
- amino acid
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101000854943 Enterobacteria phage T4 Valyl-tRNA ligase modifier Proteins 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 40
- 102000013498 tau Proteins Human genes 0.000 claims description 36
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- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims description 4
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- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18589509P | 2009-06-10 | 2009-06-10 | |
| US61/185,895 | 2009-06-10 | ||
| PCT/US2010/038184 WO2010144711A2 (en) | 2009-06-10 | 2010-06-10 | Immunological targeting of pathological tau proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015230384A Division JP6174667B2 (ja) | 2009-06-10 | 2015-11-26 | 病理学的タウタンパク質の免疫学的標的化方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530055A JP2012530055A (ja) | 2012-11-29 |
| JP2012530055A5 true JP2012530055A5 (enExample) | 2013-07-25 |
| JP5917394B2 JP5917394B2 (ja) | 2016-05-11 |
Family
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Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515141A Active JP5917394B2 (ja) | 2009-06-10 | 2010-06-10 | 病理学的タウタンパク質の免疫学的標的化方法 |
| JP2015230384A Active JP6174667B2 (ja) | 2009-06-10 | 2015-11-26 | 病理学的タウタンパク質の免疫学的標的化方法 |
| JP2017132595A Active JP6518727B2 (ja) | 2009-06-10 | 2017-07-06 | 病理学的タウタンパク質の免疫学的標的化方法 |
| JP2019080694A Active JP6795649B2 (ja) | 2009-06-10 | 2019-04-22 | 病理学的タウタンパク質の免疫学的標的化方法 |
| JP2020188406A Active JP7229980B2 (ja) | 2009-06-10 | 2020-11-12 | 病理学的タウタンパク質の免疫学的標的化方法 |
| JP2022159988A Active JP7539446B2 (ja) | 2009-06-10 | 2022-10-04 | 病理学的タウタンパク質の免疫学的標的化方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015230384A Active JP6174667B2 (ja) | 2009-06-10 | 2015-11-26 | 病理学的タウタンパク質の免疫学的標的化方法 |
| JP2017132595A Active JP6518727B2 (ja) | 2009-06-10 | 2017-07-06 | 病理学的タウタンパク質の免疫学的標的化方法 |
| JP2019080694A Active JP6795649B2 (ja) | 2009-06-10 | 2019-04-22 | 病理学的タウタンパク質の免疫学的標的化方法 |
| JP2020188406A Active JP7229980B2 (ja) | 2009-06-10 | 2020-11-12 | 病理学的タウタンパク質の免疫学的標的化方法 |
| JP2022159988A Active JP7539446B2 (ja) | 2009-06-10 | 2022-10-04 | 病理学的タウタンパク質の免疫学的標的化方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8748386B2 (enExample) |
| EP (3) | EP4218794A3 (enExample) |
| JP (6) | JP5917394B2 (enExample) |
| CN (2) | CN102596221B (enExample) |
| CA (3) | CA3239368A1 (enExample) |
| EA (1) | EA032675B1 (enExample) |
| WO (1) | WO2010144711A2 (enExample) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009062152A1 (en) * | 2007-11-09 | 2009-05-14 | Washington University In St. Louis | Methods for measuring the metabolism of cns derived biomolecules in vivo |
| UA107571C2 (xx) | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| EP4218794A3 (en) * | 2009-06-10 | 2023-09-13 | New York University | Immunological targeting of pathological tau proteins |
| MX2012001194A (es) * | 2009-07-30 | 2012-03-07 | Pfizer Vaccines Llc | Peptidos tau antigenicos y usos de los mismos. |
| US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| DK2625198T3 (en) * | 2010-10-07 | 2015-09-28 | Ac Immune Sa | Antibodies that recognize the phosphorylated tau |
| AU2013205313B2 (en) * | 2010-10-07 | 2016-05-19 | Ac Immune S.A. | Phosphospecific antibodies recognising tau |
| LT2627672T (lt) * | 2010-10-11 | 2018-12-10 | Biogen International Neuroscience Gmbh | Žmogaus antikūnai prieš tau baltymą |
| WO2012106363A2 (en) * | 2011-01-31 | 2012-08-09 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| EP2701743A4 (en) * | 2011-04-27 | 2015-08-19 | Univ Northwestern | FOR PATHOLOGICAL TAU-DIMERE AND PREAFIBRILLARY PATHOLOGICAL TAU-OLIGOMER SELECTIVE ANTIBODIES AND THEIR USES IN THE APPLICATION, DIAGNOSIS AND MONITORING OF TAUOPATHIES |
| GB201111361D0 (en) * | 2011-07-04 | 2011-08-17 | Nordic Bioscience As | Biochemical markers for neurodegenerative conditions |
| GB201112056D0 (en) * | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
| SMT201800109T1 (it) * | 2011-09-19 | 2018-05-02 | Axon Neuroscience Se | Terapia a base di proteine e diagnosi di una patologia mediata da tau nella malattia di alzheimer |
| JP6358953B2 (ja) * | 2011-10-07 | 2018-07-18 | エーシー イミューン エス．エー． | タウを認識するホスホ特異的抗体 |
| WO2013059786A1 (en) * | 2011-10-21 | 2013-04-25 | The Ohio State University | Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease |
| BR112014015323B1 (pt) | 2011-12-20 | 2022-09-27 | Janssen Biotech, Inc | Anticorpos anti-phf-tau, seu método de produção, polinucleotídeo isolado que codifica uma vh de anticorpo, e vetor |
| RU2644242C2 (ru) | 2012-04-05 | 2018-02-08 | Ац Иммуне С.А. | Гуманизированное тау-антитело |
| SI2857039T1 (sl) * | 2012-05-31 | 2020-03-31 | Osaka City University | Terapevtsko sredstvo ali profilaktično sredstvo za demenco |
| WO2014008404A1 (en) | 2012-07-03 | 2014-01-09 | Washington University | Antibodies to tau |
| JP6290212B2 (ja) | 2012-08-16 | 2018-03-07 | アイピエリアン，インコーポレイティド | タウオパチーの処置方法 |
| AU2013305848B2 (en) * | 2012-08-21 | 2020-10-15 | Institute For Molecular Medicine, Inc. | Compositions and methods related to diseases associated with deposits of amyloid, Tau, and alpha-synuclein |
| US20140056901A1 (en) * | 2012-08-21 | 2014-02-27 | The Institute For Molecular Medicine | Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| US12024568B2 (en) | 2012-09-13 | 2024-07-02 | Cornell University | Treatment of brain cancers using central nervous system mediated gene transfer of monoclonal antibodies |
| US9200068B2 (en) * | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
| JP6284548B2 (ja) * | 2012-12-21 | 2018-02-28 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | ヒト抗タウ抗体 |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| JP6674888B2 (ja) * | 2013-03-13 | 2020-04-01 | プロセナ バイオサイエンシーズ リミテッド | タウ免疫療法 |
| EP2970452A2 (en) | 2013-03-15 | 2016-01-20 | AC Immune S.A. | Anti-tau antibodies and methods of use |
| US20160355573A1 (en) * | 2013-09-05 | 2016-12-08 | Cornell University | Gene therapy for alzheimer's and other neurodegenerative diseases and conditions |
| JP6629201B2 (ja) * | 2013-11-27 | 2020-01-15 | アイピエリアン，インコーポレイティド | タウオパチーの処置方法 |
| JP2017505756A (ja) * | 2013-12-13 | 2017-02-23 | ザ ジェネラル ホスピタル コーポレイション | 可溶性高分子量（ｈｍｗ）タウ種およびその用途 |
| JP2017512056A (ja) * | 2014-02-10 | 2017-05-18 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ヒト・タウに結合する抗体および該抗体を使用してヒト・タウを定量するためのアッセイ |
| NZ630610A (en) | 2014-02-14 | 2019-05-31 | Ipierian Inc | Tau peptides, anti-tau antibodies, and methods of use thereof |
| ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| CA2952745A1 (en) * | 2014-06-26 | 2015-12-30 | Janssen Vaccines & Prevention B.V. | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| TW202136296A (zh) | 2014-06-27 | 2021-10-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| US10132818B2 (en) | 2014-07-08 | 2018-11-20 | New York University | Tau imaging ligands and their uses in the diagnosis and treatment of tauopathy |
| BR112017006419A2 (pt) | 2014-09-30 | 2017-12-19 | Univ Washington | medições cinéticas de tau |
| EP3258950B1 (en) | 2015-02-20 | 2025-10-29 | Amylonix AB | Alzheimer abeta peptide binding polypeptide |
| TWI669314B (zh) | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對ｔａｕ之抗體及其用途 |
| US20180050097A1 (en) * | 2015-03-25 | 2018-02-22 | Stc. Unm | Immunotherapy compositions and methods for treatment of tauopathy and transgenic mouse |
| JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| CN107849105B (zh) | 2015-07-06 | 2021-09-17 | Ucb生物制药有限责任公司 | Tau结合抗体 |
| JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| FI3334761T3 (fi) * | 2015-08-13 | 2023-08-14 | Univ New York | Vasta-ainepohjaisia molekyylejä, jotka ovat selektiivisiä Taun {p}Ser404-epitoopille, ja niiden käyttöjä tauopatian diagnosoinnissa ja hoidossa |
| JP6913078B2 (ja) * | 2015-08-13 | 2021-08-04 | ニューヨーク・ユニバーシティ | タウの短縮型Ａｓｐ４２１エピトープに特異的な、抗体を基にした分子、ならびにタウ異常症の診断および治療におけるそれらの使用 |
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- 2010-06-10 EP EP10786852.3A patent/EP2440234A4/en not_active Ceased
- 2010-06-10 CA CA3239368A patent/CA3239368A1/en active Pending
- 2010-06-10 EP EP17197129.4A patent/EP3329932A1/en not_active Withdrawn
- 2010-06-10 EA EA201171397A patent/EA032675B1/ru not_active IP Right Cessation
- 2010-06-10 CN CN201080036213.XA patent/CN102596221B/zh active Active
- 2010-06-10 CA CA3120504A patent/CA3120504A1/en active Pending
- 2010-06-10 CN CN201610638487.5A patent/CN106390107B/zh active Active
- 2010-06-10 WO PCT/US2010/038184 patent/WO2010144711A2/en not_active Ceased
- 2010-06-10 US US12/813,297 patent/US8748386B2/en active Active
- 2010-06-10 CA CA2765099A patent/CA2765099A1/en not_active Abandoned
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