JP2015505823A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015505823A5 JP2015505823A5 JP2014543617A JP2014543617A JP2015505823A5 JP 2015505823 A5 JP2015505823 A5 JP 2015505823A5 JP 2014543617 A JP2014543617 A JP 2014543617A JP 2014543617 A JP2014543617 A JP 2014543617A JP 2015505823 A5 JP2015505823 A5 JP 2015505823A5
- Authority
- JP
- Japan
- Prior art keywords
- amyloid
- variant
- polypeptide
- pharmaceutical composition
- wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161564602P | 2011-11-29 | 2011-11-29 | |
| US61/564,602 | 2011-11-29 | ||
| US201261708709P | 2012-10-02 | 2012-10-02 | |
| US61/708,709 | 2012-10-02 | ||
| US201261730316P | 2012-11-27 | 2012-11-27 | |
| US61/730,316 | 2012-11-27 | ||
| PCT/US2012/066793 WO2013082114A1 (en) | 2011-11-29 | 2012-11-28 | Use of p3 of bacteriophage as amyloid binding agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017074284A Division JP6440765B2 (ja) | 2011-11-29 | 2017-04-04 | アミロイド結合剤としてのバクテリオファージのｐ３の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015505823A JP2015505823A (ja) | 2015-02-26 |
| JP2015505823A5 true JP2015505823A5 (enExample) | 2015-12-03 |
| JP6220344B2 JP6220344B2 (ja) | 2017-10-25 |
Family
ID=47326403
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543617A Active JP6220344B2 (ja) | 2011-11-29 | 2012-11-28 | アミロイド結合剤としてのバクテリオファージのｐ３の使用 |
| JP2017074284A Active JP6440765B2 (ja) | 2011-11-29 | 2017-04-04 | アミロイド結合剤としてのバクテリオファージのｐ３の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017074284A Active JP6440765B2 (ja) | 2011-11-29 | 2017-04-04 | アミロイド結合剤としてのバクテリオファージのｐ３の使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9493515B2 (enExample) |
| EP (1) | EP2785364B1 (enExample) |
| JP (2) | JP6220344B2 (enExample) |
| KR (1) | KR20140100543A (enExample) |
| CN (2) | CN104093414A (enExample) |
| AU (1) | AU2012346056B2 (enExample) |
| BR (1) | BR112014013086A2 (enExample) |
| CA (1) | CA2857539C (enExample) |
| EA (2) | EA201792608A3 (enExample) |
| IL (1) | IL232867B (enExample) |
| IN (1) | IN2014CN04587A (enExample) |
| MX (1) | MX362175B (enExample) |
| PH (1) | PH12014501200B1 (enExample) |
| SG (2) | SG10201709849TA (enExample) |
| WO (1) | WO2013082114A1 (enExample) |
| ZA (1) | ZA201403863B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9493515B2 (en) | 2011-11-29 | 2016-11-15 | Proclara Biosciences, Inc. | Bacteriophage gene 3 protein compositions and use as amyloid binding agents |
| EA033666B1 (ru) | 2012-10-02 | 2019-11-14 | Proclara Biosciences Inc | Амилоидсвязывающие белки и их применение |
| JP2016526044A (ja) * | 2013-05-28 | 2016-09-01 | ニューロファージ ファーマシューティカルズ， インコーポレイテッド | 低減された免疫原性を有する修飾されたバクテリオファージｇ３ｐアミノ酸配列を含むポリペプチド |
| KR20170085132A (ko) | 2014-12-03 | 2017-07-21 | 프로클라라 바이오사이언시즈, 인크. | 글리코실화 신호가 결핍된 변형된 박테리오파지 ｇ3ｐ 아미노산 서열을 포함하는 폴리펩티드 |
| CA3003911C (en) * | 2015-11-25 | 2021-05-04 | Eli Lilly And Company | Phage display vectors and methods of use |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| KR102421210B1 (ko) * | 2017-07-14 | 2022-07-18 | 지씨이 홀딩 에이비 | 전자 게이지 |
| EP3806884B1 (en) | 2018-06-15 | 2023-08-02 | Amyl Therapeutics | General amyloid interaction motif (gaim) |
| CN120641092A (zh) | 2022-12-02 | 2025-09-12 | 阿尔泽恩股份有限公司 | 用于用曲米沙特治疗神经变性病症的方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
| US4215051A (en) | 1979-08-29 | 1980-07-29 | Standard Oil Company (Indiana) | Formation, purification and recovery of phthalic anhydride |
| DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
| EP0401384B1 (en) | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
| DE59010908D1 (de) | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| AU1674292A (en) | 1991-03-15 | 1992-10-21 | Synergen, Inc. | Pegylation of polypeptides |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| ATE311895T1 (de) | 1992-05-26 | 2005-12-15 | Immunex Corp | Neue zytokine die cd30 binden |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| AU776910B2 (en) | 1998-12-08 | 2004-09-23 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Modifying protein immunogenicity |
| US20020052311A1 (en) | 1999-09-03 | 2002-05-02 | Beka Solomon | Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders |
| US8022270B2 (en) | 2000-07-31 | 2011-09-20 | Biolex Therapeutics, Inc. | Expression of biologically active polypeptides in duckweed |
| PL362324A1 (en) | 2001-02-19 | 2004-10-18 | Merck Patent Gmbh | Artificial fusion proteins with reduced immunogenicity |
| WO2002070548A2 (en) | 2001-03-08 | 2002-09-12 | Merck Patent Gmbh | Modified human granulocyte macrophage colony stimulating factor (gm-csf) with reduced immunogenicity |
| EP1532265A2 (de) | 2002-08-20 | 2005-05-25 | Sungene GmbH & Co. KGaA | Verfahren zur herstellung von ketocarotinoiden in genetisch veränderten organismen |
| DE10238846A1 (de) * | 2002-08-20 | 2004-03-04 | Nemod Immuntherapie Ag | Aktive Fusionsproteine und Verfahren zu ihrer Herstellung |
| JP5096169B2 (ja) * | 2005-02-01 | 2012-12-12 | ラモット・アット・テルアビブ・ユニバーシティ | アミロイド沈着に付随する炎症および活性化されたマイクログリアにかかわる脳の炎症の処置法 |
| NZ568012A (en) * | 2005-12-12 | 2012-07-27 | Ac Immune Sa | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| US20090304726A1 (en) | 2006-02-15 | 2009-12-10 | Ramot At Tel Aviv University Ltd. | Viral display vehicles for treating multiple sclerosis |
| MX2008010612A (es) | 2006-02-15 | 2009-03-20 | Ramot At Tel Aviv University | Bacteriofago filamentoso que exhibe proteina a como aglutinante de anticuerpos e inmunocomplejos para el suministro hacia el cerebro. |
| WO2007109733A2 (en) * | 2006-03-21 | 2007-09-27 | The Johns Hopkins University | Diagnostic and prognostic markers and treatment strategies for multiple sclerosis |
| JPWO2007114139A1 (ja) * | 2006-04-06 | 2009-08-13 | 文昭 内山 | 新規繊維状ファージによるファージディスプレイ |
| US20090324554A1 (en) | 2006-07-21 | 2009-12-31 | Ramot At Tel Aviv University Ltd. | Method for inhibiting or treating a disease associated with intracellular formation of protein fibrillar or aggregates |
| KR101485202B1 (ko) | 2006-10-11 | 2015-01-22 | 안티토페 리미티드 | Ｔ 세포 에피토프 데이터베이스들 |
| US20110182948A1 (en) | 2008-05-22 | 2011-07-28 | Beka Solomon | Method for treating disease characterized by plaque |
| EP2303920A4 (en) * | 2008-07-25 | 2011-11-09 | Abbott Lab | SS-AMYLOID PEPTIDE ANALOGUES, OLIGOMERS THEREOF, PREPARATION METHODS AND COMPOSITIONS COMPRISING THE SAME OR OLIGOMERIC ANALOGUES, AND USES THEREOF |
| JP2012503983A (ja) * | 2008-09-26 | 2012-02-16 | ワイス・エルエルシー | 適合性ディスプレイベクター系 |
| AU2009316326A1 (en) | 2008-11-24 | 2010-05-27 | Ramot At Tel-Aviv University Ltd. | Method for treating Parkinson' s disease using filamentous bacteriophage |
| WO2011084714A2 (en) | 2009-12-17 | 2011-07-14 | Biogen Idec Ma Inc. | STABILIZED ANTI-TNF-ALPHA scFv MOLECULES OR ANTI-TWEAK scFv MOLECULES AND USES THEREOF |
| BR112013023040A2 (pt) | 2011-03-11 | 2018-10-23 | Univ Ramot | bacteriófago filamentoso, composição farmacêutica, e, métodos para reduzir a formação de fibrilas de proteína tau ou para desagregar fibrilas pré-formadas de proteína tau em um paciente, e para tratar uma tauopatia degenerativa. |
| US8856364B2 (en) | 2011-03-11 | 2014-10-07 | Google Inc. | Conducting opportunistic network updates on a mobile device |
| US9493515B2 (en) | 2011-11-29 | 2016-11-15 | Proclara Biosciences, Inc. | Bacteriophage gene 3 protein compositions and use as amyloid binding agents |
| EA033666B1 (ru) | 2012-10-02 | 2019-11-14 | Proclara Biosciences Inc | Амилоидсвязывающие белки и их применение |
| JP2016526044A (ja) | 2013-05-28 | 2016-09-01 | ニューロファージ ファーマシューティカルズ， インコーポレイテッド | 低減された免疫原性を有する修飾されたバクテリオファージｇ３ｐアミノ酸配列を含むポリペプチド |
| KR20170085132A (ko) | 2014-12-03 | 2017-07-21 | 프로클라라 바이오사이언시즈, 인크. | 글리코실화 신호가 결핍된 변형된 박테리오파지 ｇ3ｐ 아미노산 서열을 포함하는 폴리펩티드 |
-
2012
- 2012-11-28 US US14/361,157 patent/US9493515B2/en active Active
- 2012-11-28 EP EP12799008.3A patent/EP2785364B1/en active Active
- 2012-11-28 EA EA201792608A patent/EA201792608A3/ru unknown
- 2012-11-28 CN CN201280066659.6A patent/CN104093414A/zh active Pending
- 2012-11-28 CA CA2857539A patent/CA2857539C/en active Active
- 2012-11-28 KR KR1020147017548A patent/KR20140100543A/ko not_active Ceased
- 2012-11-28 SG SG10201709849TA patent/SG10201709849TA/en unknown
- 2012-11-28 WO PCT/US2012/066793 patent/WO2013082114A1/en not_active Ceased
- 2012-11-28 CN CN202210423575.9A patent/CN114748605A/zh active Pending
- 2012-11-28 SG SG11201402425TA patent/SG11201402425TA/en unknown
- 2012-11-28 JP JP2014543617A patent/JP6220344B2/ja active Active
- 2012-11-28 MX MX2014006337A patent/MX362175B/es active IP Right Grant
- 2012-11-28 AU AU2012346056A patent/AU2012346056B2/en active Active
- 2012-11-28 BR BR112014013086-8A patent/BR112014013086A2/pt not_active Application Discontinuation
- 2012-11-28 EA EA201491063A patent/EA029602B1/ru unknown
-
2014
- 2014-05-27 ZA ZA2014/03863A patent/ZA201403863B/en unknown
- 2014-05-28 PH PH12014501200A patent/PH12014501200B1/en unknown
- 2014-05-29 IL IL232867A patent/IL232867B/en active IP Right Grant
- 2014-06-18 IN IN4587CHN2014 patent/IN2014CN04587A/en unknown
-
2015
- 2015-07-13 US US14/797,724 patent/US9493516B2/en active Active
-
2016
- 2016-10-07 US US15/288,237 patent/US10151762B2/en active Active
-
2017
- 2017-04-04 JP JP2017074284A patent/JP6440765B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Eck et al. | Regulation of TDP-43 phosphorylation in aging and disease | |
| Scheckel et al. | Prions, prionoids and protein misfolding disorders | |
| Moreth et al. | Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets? | |
| Kim et al. | BRI2 (ITM2b) inhibits Aβ deposition in vivo | |
| JP6283366B2 (ja) | アミロイド結合剤としてのバクテリオファージ融合タンパク質のｐ３の使用 | |
| Li et al. | Characterization of two VQIXXK motifs for tau fibrillization in vitro | |
| Neff et al. | Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders | |
| JP6220344B2 (ja) | アミロイド結合剤としてのバクテリオファージのｐ３の使用 | |
| Diaz-Espinoza et al. | Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo | |
| Sharma et al. | Effect of disease-associated P123H and V70M mutations on β-synuclein fibrillation | |
| Roque et al. | Histone H1 favors folding and parallel fibrillar aggregation of the 1–42 Amyloid-β Peptide | |
| Eigenbrod et al. | Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice | |
| Daude et al. | Wild‐type Shadoo proteins convert to amyloid‐like forms under native conditions | |
| Barreca et al. | Therapeutic trajectories in human prion diseases | |
| Paganetti et al. | Transgenic expression of β1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice | |
| Zaccagnini | In silico and in vitro screening of acridine and phenothiazine derivatives as anti-prion agents | |
| CN120153082A (zh) | 展示靶向β淀粉样蛋白的肽基序的M13噬菌体、其方法和用途 | |
| Noble | Biochemical and Structural Studies of Prion Protein Misfolding | |
| RS56559B1 (sr) | Upotreba p3 fuzionih proteina bakteriofaga kao vezujućih agenasa amiloida | |
| HK1213775B (en) | Use of p3 of bacteriophage fusion proteins as amyloid binding agents | |
| HK1197655B (en) | Use of p3 of bacteriophage as amyloid binding agents | |
| HK1197655A (en) | Use of p3 of bacteriophage as amyloid binding agents |