JP2012522754A5 - - Google Patents
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- Publication number
- JP2012522754A5 JP2012522754A5 JP2012502694A JP2012502694A JP2012522754A5 JP 2012522754 A5 JP2012522754 A5 JP 2012522754A5 JP 2012502694 A JP2012502694 A JP 2012502694A JP 2012502694 A JP2012502694 A JP 2012502694A JP 2012522754 A5 JP2012522754 A5 JP 2012522754A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- disease
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09157303.0 | 2009-04-03 | ||
| EP09157303 | 2009-04-03 | ||
| PCT/EP2010/054418 WO2010115843A2 (en) | 2009-04-03 | 2010-04-01 | Pharmaceutical composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015129383A Division JP2015214559A (ja) | 2009-04-03 | 2015-06-29 | 薬学的組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522754A JP2012522754A (ja) | 2012-09-27 |
| JP2012522754A5 true JP2012522754A5 (enExample) | 2013-05-09 |
| JP5810076B2 JP5810076B2 (ja) | 2015-11-11 |
Family
ID=42269736
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502694A Active JP5810076B2 (ja) | 2009-04-03 | 2010-04-01 | 薬学的組成物 |
| JP2015129383A Withdrawn JP2015214559A (ja) | 2009-04-03 | 2015-06-29 | 薬学的組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015129383A Withdrawn JP2015214559A (ja) | 2009-04-03 | 2015-06-29 | 薬学的組成物 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US8647631B2 (enExample) |
| EP (2) | EP3097925B1 (enExample) |
| JP (2) | JP5810076B2 (enExample) |
| KR (2) | KR101770436B1 (enExample) |
| CN (2) | CN105524160B (enExample) |
| AU (1) | AU2010233856B2 (enExample) |
| BR (1) | BRPI1015088B1 (enExample) |
| CA (1) | CA2757345C (enExample) |
| CL (2) | CL2011002457A1 (enExample) |
| CO (1) | CO6390113A2 (enExample) |
| CR (1) | CR20110509A (enExample) |
| DK (2) | DK2413957T3 (enExample) |
| EC (1) | ECSP11011367A (enExample) |
| ES (2) | ES2738623T3 (enExample) |
| HU (2) | HUE030428T2 (enExample) |
| IL (1) | IL215451A (enExample) |
| MA (1) | MA34120B1 (enExample) |
| MX (1) | MX2011010353A (enExample) |
| MY (1) | MY171300A (enExample) |
| NZ (1) | NZ595856A (enExample) |
| PL (2) | PL3097925T3 (enExample) |
| PT (2) | PT2413957T (enExample) |
| RU (1) | RU2582916C2 (enExample) |
| SG (1) | SG175037A1 (enExample) |
| SI (2) | SI3097925T1 (enExample) |
| UA (1) | UA107571C2 (enExample) |
| WO (1) | WO2010115843A2 (enExample) |
| ZA (1) | ZA201107776B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
| US9605054B2 (en) | 2009-02-23 | 2017-03-28 | The Board Of Trustees Of The University Of Illinois | Composition and method for treating a tauopathy |
| MX2011009654A (es) * | 2009-03-18 | 2011-10-12 | Ac Immune Sa | Metodo para uso terapeutico. |
| UA107571C2 (xx) | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| EP4218794A3 (en) * | 2009-06-10 | 2023-09-13 | New York University | Immunological targeting of pathological tau proteins |
| WO2012020124A1 (en) * | 2010-08-12 | 2012-02-16 | Ac Immune S.A. | Vaccine engineering |
| AU2013205313B2 (en) * | 2010-10-07 | 2016-05-19 | Ac Immune S.A. | Phosphospecific antibodies recognising tau |
| WO2012045882A2 (en) * | 2010-10-07 | 2012-04-12 | Ac Immune S.A. | Pharmaceutical composition |
| EP2632434B1 (en) | 2010-10-26 | 2025-08-20 | AC Immune S.A. | Liposome-based construct comprising a peptide modified through hydrophobic moieties |
| GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
| EP3275461A1 (en) * | 2011-09-19 | 2018-01-31 | Axon Neuroscience SE | Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease field |
| JP6358953B2 (ja) | 2011-10-07 | 2018-07-18 | エーシー イミューン エス．エー． | タウを認識するホスホ特異的抗体 |
| CA2869438C (en) | 2012-04-05 | 2021-08-17 | Ac Immune S.A. | Humanized tau antibody |
| TWI700296B (zh) * | 2012-05-31 | 2020-08-01 | 公立大學法人大阪市立大學 | 失智症治療劑或預防劑 |
| EP2870176A4 (en) | 2012-07-03 | 2016-09-28 | Univ Washington | ANTIBODIES DIRECTED AGAINST TAU |
| EP2885010B1 (en) | 2012-08-16 | 2020-01-01 | Ipierian, Inc. | Methods of treating a tauopathy |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| MX374811B (es) | 2013-03-15 | 2025-03-06 | Ac Immune Sa | Anticuerpos anti-tau y métodos de uso. |
| CR20160270A (es) | 2013-12-20 | 2016-09-05 | Hoffmann La Roche | ANTICUERPOS ANTI-TAU (pS422) HUMANIZADOS Y MÉTODOS DE UTILIZACIÓN |
| CN105939722A (zh) | 2014-02-14 | 2016-09-14 | 伊皮埃里安股份有限公司 | Tau肽，抗Tau抗体，及其使用方法 |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| TWI734975B (zh) | 2014-06-27 | 2021-08-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| EP3166688B1 (en) | 2014-07-08 | 2024-08-21 | New York University | Tau imaging ligands and their uses in the diagnosis and treatment of tauopathy |
| AR103713A1 (es) | 2015-02-26 | 2017-05-31 | Lilly Co Eli | Anticuerpos contra tau y sus usos |
| NZ775762A (en) | 2015-06-05 | 2025-02-28 | Genentech Inc | Anti-tau antibodies and methods of use |
| ES2809728T3 (es) | 2015-06-24 | 2021-03-05 | Hoffmann La Roche | Anticuerpos anti-tau(pS422) humanizados y procedimientos de uso |
| CA2991264C (en) | 2015-07-06 | 2023-10-10 | Ucb Biopharma Sprl | Tau-binding antibodies |
| US10988528B2 (en) | 2015-08-13 | 2021-04-27 | New York University | Antibody-based molecules specific for the truncated ASP421 epitope of Tau and their uses in the diagnosis and treatment of tauopathy |
| JP6949102B2 (ja) | 2016-08-09 | 2021-10-13 | イーライ リリー アンド カンパニー | 併用療法 |
| CN110214184B (zh) | 2016-12-01 | 2024-07-02 | 桑格摩生物治疗股份有限公司 | τ蛋白调节剂以及用于其递送的方法和组合物 |
| EP3551220B1 (en) | 2016-12-07 | 2025-01-29 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| EP3551655A2 (en) | 2016-12-07 | 2019-10-16 | Genentech, Inc. | Anti-tau antibodies and methods of their use |
| JP2018139530A (ja) | 2017-02-27 | 2018-09-13 | 帝人ファーマ株式会社 | 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤 |
| JP6851549B2 (ja) | 2017-10-16 | 2021-03-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗タウ抗体及びその使用 |
| TW202333768A (zh) * | 2017-10-25 | 2023-09-01 | 美商健生醫藥公司 | Tau胜肽之組成物及其用途 |
| EP3829634A1 (en) | 2018-07-31 | 2021-06-09 | Eli Lilly and Company | Combination therapy |
| IL326834A (en) | 2018-10-02 | 2026-04-01 | Sangamo Therapeutics Inc | Artificial zinc finger protein transcription factors repressing mapt expression for the prevention and/or treatment of tauopathies |
| CA3118692A1 (en) | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
| SG11202108312PA (en) | 2019-02-08 | 2021-08-30 | Ac Immune Sa | Method of safe administration of phosphorylated tau peptide vaccine |
| MX2021012994A (es) * | 2019-04-24 | 2022-03-04 | Janssen Pharmaceuticals Inc | Administracion heterologa de vacunas tau. |
| GB2585252A (en) | 2019-07-05 | 2021-01-06 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
| CN116723856A (zh) | 2020-06-25 | 2023-09-08 | 默沙东有限责任公司 | 靶向丝氨酸413处磷酸化的tau的高亲和力抗体 |
| US20240101654A1 (en) * | 2020-12-29 | 2024-03-28 | Neurimmune Ag | Human anti-tau antibodies |
| CN119136838A (zh) | 2022-02-28 | 2024-12-13 | 特瑞德姆生物科技有限责任两合公司 | 由至少一种β-葡聚糖或甘露聚糖组成或包含至少一种β-葡聚糖或甘露聚糖的偶联物 |
| KR102856378B1 (ko) * | 2022-09-30 | 2025-09-08 | 주식회사 젬백스앤카엘 | 4r 타우병증의 치료 또는 예방용 펩티드 |
| WO2025109524A1 (en) | 2023-11-22 | 2025-05-30 | Ac Immune Sa | Assays and methods for assessing vaccine preparations |
| WO2026102093A1 (en) | 2024-11-07 | 2026-05-15 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811310A (en) * | 1986-09-30 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva Univ. | The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease |
| US7408027B1 (en) * | 1991-12-06 | 2008-08-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften | Tools for the diagnosis and treatment of Alzheimer's disease |
| AU690092B2 (en) * | 1992-12-14 | 1998-04-23 | N.V. Innogenetics S.A. | Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications |
| US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| GB9506197D0 (en) * | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| WO1997034145A1 (fr) * | 1996-03-13 | 1997-09-18 | Mitsubishi Chemical Corporation | Anticorps a proteine tau antiphosphorylee et procede de detection de la maladie d'alzheimer l'utilisant |
| WO1998022120A1 (en) | 1996-11-19 | 1998-05-28 | The Wistar Institute Of Anatomy & Biology | Diagnostic and therapeutic reagents for alzheimer's disease |
| EA003739B1 (ru) * | 1997-12-03 | 2003-08-28 | Байоджен, Инк. | Гидрофобно-модифицированные белки, способы их получения и их применение |
| AU2001273361A1 (en) | 2000-07-11 | 2002-01-21 | Molecular Geriatrics Corporation | Reagents and methods for identification of binding agents |
| KR20050101537A (ko) | 2002-12-24 | 2005-10-24 | 뉴로켐 (인터내셔널) 리미티드 | 베타-아밀로이드 관련 질환의 치료를 위한 치료 제제 |
| US8663650B2 (en) * | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
| US20050261475A1 (en) * | 2004-02-13 | 2005-11-24 | Harvard Medical School | Solid-phase capture-release-tag methods for phosphoproteomic analyses |
| US7238788B2 (en) * | 2004-02-18 | 2007-07-03 | University Of Iowa Foundation | Antibodies to phosphorylated tau, methods of making and methods of use |
| CA2633399C (en) * | 2005-12-12 | 2016-01-26 | Ac Immune S.A. | Therapeutic vaccine |
| WO2007068105A1 (en) | 2005-12-12 | 2007-06-21 | Robarts Research Institute | Method of diagnosing amyotrophic lateral sclerosis |
| US8012936B2 (en) * | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| US20080220449A1 (en) | 2007-02-08 | 2008-09-11 | Oligomerix, Inc. | Biomarkers and assays for Alzheimer's disease |
| KR20100115340A (ko) | 2007-10-19 | 2010-10-27 | 이무나스 파마 가부시키가이샤 | Ａβ 올리고머에 특이적으로 결합하는 항체 및 그의 이용 |
| MX2011009654A (es) * | 2009-03-18 | 2011-10-12 | Ac Immune Sa | Metodo para uso terapeutico. |
| UA107571C2 (xx) | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| EP4218794A3 (en) | 2009-06-10 | 2023-09-13 | New York University | Immunological targeting of pathological tau proteins |
| CN102596236B (zh) | 2009-07-30 | 2015-06-24 | 辉瑞疫苗有限责任公司 | 抗原性Tau肽及其用途 |
-
2010
- 2010-01-04 UA UAA201112528A patent/UA107571C2/ru unknown
- 2010-04-01 MY MYPI2011004748A patent/MY171300A/en unknown
- 2010-04-01 DK DK10713172.4T patent/DK2413957T3/en active
- 2010-04-01 KR KR1020117026246A patent/KR101770436B1/ko active Active
- 2010-04-01 MX MX2011010353A patent/MX2011010353A/es active IP Right Grant
- 2010-04-01 SG SG2011071909A patent/SG175037A1/en unknown
- 2010-04-01 AU AU2010233856A patent/AU2010233856B2/en active Active
- 2010-04-01 SI SI201031931T patent/SI3097925T1/sl unknown
- 2010-04-01 EP EP16179161.1A patent/EP3097925B1/en active Active
- 2010-04-01 CN CN201510822296.XA patent/CN105524160B/zh active Active
- 2010-04-01 JP JP2012502694A patent/JP5810076B2/ja active Active
- 2010-04-01 BR BRPI1015088-9A patent/BRPI1015088B1/pt active IP Right Grant
- 2010-04-01 SI SI201031297A patent/SI2413957T1/sl unknown
- 2010-04-01 PL PL16179161T patent/PL3097925T3/pl unknown
- 2010-04-01 CN CN201080024398.2A patent/CN102946899B/zh active Active
- 2010-04-01 RU RU2011144307/15A patent/RU2582916C2/ru active
- 2010-04-01 US US13/262,793 patent/US8647631B2/en active Active
- 2010-04-01 KR KR1020157007957A patent/KR20150041203A/ko not_active Ceased
- 2010-04-01 ES ES16179161T patent/ES2738623T3/es active Active
- 2010-04-01 WO PCT/EP2010/054418 patent/WO2010115843A2/en not_active Ceased
- 2010-04-01 MA MA34202A patent/MA34120B1/fr unknown
- 2010-04-01 PT PT107131724T patent/PT2413957T/pt unknown
- 2010-04-01 PL PL10713172T patent/PL2413957T3/pl unknown
- 2010-04-01 HU HUE10713172A patent/HUE030428T2/en unknown
- 2010-04-01 DK DK16179161.1T patent/DK3097925T3/da active
- 2010-04-01 EP EP10713172.4A patent/EP2413957B1/en active Active
- 2010-04-01 NZ NZ595856A patent/NZ595856A/en unknown
- 2010-04-01 PT PT16179161T patent/PT3097925T/pt unknown
- 2010-04-01 ES ES10713172.4T patent/ES2595371T3/es active Active
- 2010-04-01 CA CA2757345A patent/CA2757345C/en active Active
- 2010-04-01 HU HUE16179161A patent/HUE044981T2/hu unknown
-
2011
- 2011-09-28 CR CR20110509A patent/CR20110509A/es unknown
- 2011-09-30 CO CO11129267A patent/CO6390113A2/es not_active Application Discontinuation
- 2011-10-02 IL IL215451A patent/IL215451A/en active IP Right Grant
- 2011-10-03 EC ECSP11011367 patent/ECSP11011367A/es unknown
- 2011-10-03 CL CL2011002457A patent/CL2011002457A1/es unknown
- 2011-10-24 ZA ZA2011/07776A patent/ZA201107776B/en unknown
-
2013
- 2013-09-16 US US14/028,415 patent/US20140255412A1/en not_active Abandoned
- 2013-10-08 CL CL2013002888A patent/CL2013002888A1/es unknown
-
2014
- 2014-12-19 US US14/577,325 patent/US20150259406A1/en not_active Abandoned
-
2015
- 2015-06-29 JP JP2015129383A patent/JP2015214559A/ja not_active Withdrawn
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