ES2118373T3 - Anticuerpos monoclonales dirigidos contra la proteina tau asociada a microtubulos, hibridomas que segregan estos anticuerpos, reconocimiento de antigenos por estos anticuerpos monoclonales y sus aplicaciones. - Google Patents

Anticuerpos monoclonales dirigidos contra la proteina tau asociada a microtubulos, hibridomas que segregan estos anticuerpos, reconocimiento de antigenos por estos anticuerpos monoclonales y sus aplicaciones.

Info

Publication number
ES2118373T3
ES2118373T3 ES94903752T ES94903752T ES2118373T3 ES 2118373 T3 ES2118373 T3 ES 2118373T3 ES 94903752 T ES94903752 T ES 94903752T ES 94903752 T ES94903752 T ES 94903752T ES 2118373 T3 ES2118373 T3 ES 2118373T3
Authority
ES
Spain
Prior art keywords
monoclonal antibodies
tau protein
pct
antibodies
hybridomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94903752T
Other languages
English (en)
Inventor
Marc Vandermeeren
Marc Mercken
Eugeen Vanmechelen
De Voorde Andre Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujirebio Europe NV SA
Original Assignee
Innogenetics NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics NV SA filed Critical Innogenetics NV SA
Application granted granted Critical
Publication of ES2118373T3 publication Critical patent/ES2118373T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein

Abstract

EL INVENTO SE REFIERE A UN ANTICUERPO MONOCLONAL QUE FORMA UN COMPLEJO INMUNOLOGICO CON UN EPITOPO DE UN ANTIGENO PERTENECIENTE TANTO A UNA PROTEINA TAU HUMANA NORMAL COMO A UNA PROTEINA TAU HUMANA FOSFORILADA ANORMALMENTE, SIENDO POSIBLE OBTENER DICHA PROTEINA TAU DE SER OBTENIDA DE UN CEREBRO HOMOGENEIZADO, HABIENDO SIDO AISLADO ESTE ULTIMO DEL CORTEX CEREBRAL HUMANO. LOS ANTICUERPOS MONOCLONALES DEL INVENTO PUEDEN SER USADOS PARA DETECTAR TAU Y ANORMALMENTE FOSFORILATADO TAU EN EXTRACTOS CEREBRALES Y EN FLUIDO CEREBROESPINAL NO CONCENTRADO.
ES94903752T 1992-12-14 1993-12-10 Anticuerpos monoclonales dirigidos contra la proteina tau asociada a microtubulos, hibridomas que segregan estos anticuerpos, reconocimiento de antigenos por estos anticuerpos monoclonales y sus aplicaciones. Expired - Lifetime ES2118373T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92403403 1992-12-14

Publications (1)

Publication Number Publication Date
ES2118373T3 true ES2118373T3 (es) 1998-09-16

Family

ID=8211736

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94903752T Expired - Lifetime ES2118373T3 (es) 1992-12-14 1993-12-10 Anticuerpos monoclonales dirigidos contra la proteina tau asociada a microtubulos, hibridomas que segregan estos anticuerpos, reconocimiento de antigenos por estos anticuerpos monoclonales y sus aplicaciones.

Country Status (9)

Country Link
US (1) US5843779A (es)
EP (1) EP0673418B1 (es)
JP (1) JP2879975B2 (es)
AT (1) ATE165866T1 (es)
AU (1) AU690092B2 (es)
DE (1) DE69318420T2 (es)
DK (1) DK0673418T3 (es)
ES (1) ES2118373T3 (es)
WO (1) WO1994013795A1 (es)

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* Cited by examiner, † Cited by third party
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US5811310A (en) * 1986-09-30 1998-09-22 Albert Einstein College Of Medicine Of Yeshiva Univ. The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
WO1993008302A1 (en) * 1991-10-25 1993-04-29 Itt Automotive Europe Gmbh Monoclonal antibodies directed against the microtubule-associated protein tau
ATE234324T1 (de) * 1994-07-29 2003-03-15 Innogenetics Nv Monoklonale antikörper gegen ein epitop einer gewissen unterklasse oder form von phosphoryliertem tau, hybridome die diese sezernieren,antigenerkennung durch diese antikörper und deren verwendung
US6797478B1 (en) 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
EP1112500B1 (en) * 1998-09-08 2004-09-22 Innogenetics N.V. Tau as a marker for early cns damage
WO2000043791A2 (en) 1999-01-25 2000-07-27 Minerva Biotechnologies Corporation Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
EP1216417A1 (de) * 1999-09-28 2002-06-26 Evotec OAI AG Quantitative analyse und typisierung subzellulärer partikel
JP5247963B2 (ja) * 2000-01-24 2013-07-24 インノジェネティクス・エヌ・ブイ タウオパチーの診断
US20030162230A1 (en) 2000-09-27 2003-08-28 Reagan Kevin J. Method for quantifying phosphokinase activity on proteins
EP1606404A4 (en) * 2003-03-12 2006-04-12 Assay Designs Inc PHOSPHOKINASETEST
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
WO2005080986A1 (en) * 2004-02-18 2005-09-01 University Of Iowa Research Foundation Antibodies to phosphorylated tau, methods of making and methods of use
US20070178447A1 (en) * 2006-01-31 2007-08-02 Bethyl Laboratories, Inc. Method for decreasing interference in results of immunochemical methods
SG174871A1 (en) * 2009-03-18 2011-11-28 Ac Immune Sa Method for therapeutic use
UA107571C2 (xx) * 2009-04-03 2015-01-26 Фармацевтична композиція
SG189174A1 (en) 2010-10-11 2013-05-31 Biogen Idec Internat Neuroscience Gmbh Human anti-tau antibodies
GB201111361D0 (en) * 2011-07-04 2011-08-17 Nordic Bioscience As Biochemical markers for neurodegenerative conditions
KR102132041B1 (ko) 2012-04-05 2020-07-09 에이씨 이뮨 에스.에이. 인간화된 타우 항체
DK2885010T3 (da) 2012-08-16 2020-02-03 Ipierian Inc Fremgangsmåder til behandling med tauopati
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
SG10201705104UA (en) 2012-12-21 2017-07-28 Biogen Int Neuroscience Gmbh Human anti-tau antibodies
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
MX2015012225A (es) 2013-03-13 2016-01-08 Prothena Biosciences Ltd Inmunoterapia tau.
WO2014150877A2 (en) 2013-03-15 2014-09-25 Ac Immune S.A. Anti-tau antibodies and methods of use
JP2017512751A (ja) 2014-02-14 2017-05-25 アイピエリアン，インコーポレイティド タウペプチド、抗タウ抗体、およびそれらの使用方法
SG11201808434WA (en) 2016-05-02 2018-10-30 Prothena Biosciences Ltd Antibodies recognizing tau
PL3452507T3 (pl) 2016-05-02 2023-01-09 Prothena Biosciences Limited Immunoterapia tau
MX2019013045A (es) 2017-05-02 2020-02-12 Prothena Biosciences Ltd Anticuerpos que reconocen tau.
MX2020004338A (es) 2017-10-25 2020-10-14 Janssen Pharmaceuticals Inc Composiciones de peptidos tau fosforilados y sus usos.
JPWO2020105700A1 (ja) 2018-11-22 2021-10-07 富士レビオ株式会社 抗体コンジュゲート
SG11202108312PA (en) 2019-02-08 2021-08-30 Ac Immune Sa Method of safe administration of phosphorylated tau peptide vaccine
SG11202108414UA (en) 2019-03-03 2021-08-30 Prothena Biosciences Ltd Antibodies recognizing tau
JOP20210284A1 (ar) 2019-04-24 2023-01-30 Janssen Pharmaceuticals Inc الإعطاء غير المتجانس للقاحات تاو
WO2021065306A1 (ja) * 2019-09-30 2021-04-08 ニプロ株式会社 血液試料を検体とするタウタンパク質検出方法
AU2021257848A1 (en) 2020-04-15 2022-12-01 Voyager Therapeutics, Inc. Tau binding compounds
CN111349617B (zh) * 2020-05-25 2020-09-22 苏州仁端生物医药科技有限公司 一种分泌抗Tau或pTau-181/231/396单克隆抗体杂交瘤细胞株及其应用
TW202239765A (zh) 2020-12-16 2022-10-16 美商航海家醫療公司 Tau結合化合物
US20240101654A1 (en) 2020-12-29 2024-03-28 Neurimmune Ag Human anti-tau antibodies
CN113005096B (zh) * 2021-01-19 2022-10-14 华中科技大学 分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株
WO2023250388A1 (en) 2022-06-22 2023-12-28 Voyager Therapeutics, Inc. Tau binding compounds
WO2024059739A1 (en) 2022-09-15 2024-03-21 Voyager Therapeutics, Inc. Tau binding compounds

Also Published As

Publication number Publication date
AU5809794A (en) 1994-07-04
JPH08502898A (ja) 1996-04-02
DE69318420D1 (de) 1998-06-10
ATE165866T1 (de) 1998-05-15
EP0673418A1 (en) 1995-09-27
EP0673418B1 (en) 1998-05-06
DK0673418T3 (da) 1999-03-01
DE69318420T2 (de) 1999-01-28
WO1994013795A1 (en) 1994-06-23
JP2879975B2 (ja) 1999-04-05
AU690092B2 (en) 1998-04-23
US5843779A (en) 1998-12-01

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