ATE234324T1 - Monoklonale antikörper gegen ein epitop einer gewissen unterklasse oder form von phosphoryliertem tau, hybridome die diese sezernieren,antigenerkennung durch diese antikörper und deren verwendung - Google Patents
Monoklonale antikörper gegen ein epitop einer gewissen unterklasse oder form von phosphoryliertem tau, hybridome die diese sezernieren,antigenerkennung durch diese antikörper und deren verwendungInfo
- Publication number
- ATE234324T1 ATE234324T1 AT95928494T AT95928494T ATE234324T1 AT E234324 T1 ATE234324 T1 AT E234324T1 AT 95928494 T AT95928494 T AT 95928494T AT 95928494 T AT95928494 T AT 95928494T AT E234324 T1 ATE234324 T1 AT E234324T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- monoclonal antibodies
- antibodies
- epitope
- relates
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 210000004408 hybridoma Anatomy 0.000 title 1
- 102000013498 tau Proteins Human genes 0.000 abstract 3
- 108010026424 tau Proteins Proteins 0.000 abstract 3
- 230000001900 immune effect Effects 0.000 abstract 2
- 210000002682 neurofibrillary tangle Anatomy 0.000 abstract 2
- 208000014644 Brain disease Diseases 0.000 abstract 1
- 238000011888 autopsy Methods 0.000 abstract 1
- 238000001574 biopsy Methods 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001605 fetal effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94870131 | 1994-07-29 | ||
PCT/EP1995/003032 WO1996004309A1 (en) | 1994-07-29 | 1995-07-31 | Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE234324T1 true ATE234324T1 (de) | 2003-03-15 |
Family
ID=8218661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95928494T ATE234324T1 (de) | 1994-07-29 | 1995-07-31 | Monoklonale antikörper gegen ein epitop einer gewissen unterklasse oder form von phosphoryliertem tau, hybridome die diese sezernieren,antigenerkennung durch diese antikörper und deren verwendung |
Country Status (8)
Country | Link |
---|---|
US (1) | US6121003A (de) |
EP (1) | EP0772634B1 (de) |
JP (1) | JPH10506381A (de) |
AT (1) | ATE234324T1 (de) |
AU (1) | AU710952B2 (de) |
CA (1) | CA2195672A1 (de) |
DE (1) | DE69529906D1 (de) |
WO (1) | WO1996004309A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6821740B2 (en) * | 1998-02-25 | 2004-11-23 | Becton, Dickinson And Company | Flow cytometric methods for the concurrent detection of discrete functional conformations of PRB in single cells |
US6797478B1 (en) * | 1998-03-05 | 2004-09-28 | University Of Cincinnati | Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies |
JP4624559B2 (ja) * | 1998-09-08 | 2011-02-02 | イノジェネティックス・ナムローゼ・フェンノートシャップ | 初期cnsダメージのマーカーとしてのタウ |
EP1216417A1 (de) * | 1999-09-28 | 2002-06-26 | Evotec OAI AG | Quantitative analyse und typisierung subzellulärer partikel |
CA2397991C (en) | 2000-01-24 | 2017-10-24 | Innogenetics N.V. | Diagnosis of tauopathies |
US20030162230A1 (en) * | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
ES2352668T3 (es) | 2002-08-14 | 2011-02-22 | Mitsubishi Chemical Medience Corporation | Anticuerpo específico para una proteína tau del sistema nervioso central. |
NZ582769A (en) * | 2002-10-09 | 2011-11-25 | Dmi Biosciences Inc | Diagnosis and monitoring of inflammation, ischemia and appendicitis |
US7238788B2 (en) * | 2004-02-18 | 2007-07-03 | University Of Iowa Foundation | Antibodies to phosphorylated tau, methods of making and methods of use |
CA2599731A1 (en) * | 2005-03-03 | 2006-09-08 | Dmi Biosciences, Inc. | Quantification of proteins |
WO2011053565A2 (en) * | 2009-10-29 | 2011-05-05 | Biomedical Sciences Research Centre "Alexander Fleming" | Compositions and methods for detecting a tauopathy |
CA2813493C (en) | 2010-10-11 | 2019-07-09 | University Of Zurich | Human anti-tau antibodies |
WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
EA027975B1 (ru) | 2011-12-20 | 2017-09-29 | Янссен Байотек, Инк. | Анти-псф-тау-антитела и их применение |
CA2877397A1 (en) | 2012-07-03 | 2014-01-09 | Washington University | Antibodies to tau |
MY176838A (en) | 2012-08-16 | 2020-08-24 | Ipierian Inc | Methods of treating a tauopathy |
US9200068B2 (en) | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
LT2935326T (lt) | 2012-12-21 | 2020-12-10 | Biogen Ma Inc. | Žmogaus antikūnai prieš tau baltymą |
US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
NZ630610A (en) | 2014-02-14 | 2019-05-31 | Ipierian Inc | Tau peptides, anti-tau antibodies, and methods of use thereof |
WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
TW202136296A (zh) | 2014-06-27 | 2021-10-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
KR20180027566A (ko) | 2015-07-06 | 2018-03-14 | 유씨비 바이오파마 에스피알엘 | 타우 결합 항체 |
JOP20180021A1 (ar) | 2017-03-16 | 2019-01-30 | Janssen Biotech Inc | الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها |
JP7399096B2 (ja) | 2018-03-05 | 2023-12-15 | ヤンセン ファーマシューティカ エヌ.ベー. | 神経変性を検出するためのアッセイ |
WO2022144406A1 (en) | 2020-12-29 | 2022-07-07 | Neurimmune Ag | Human anti-tau antibodies |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8724412D0 (en) * | 1987-10-19 | 1987-11-25 | Medical Res Council | Protein |
WO1993008302A1 (en) * | 1991-10-25 | 1993-04-29 | Itt Automotive Europe Gmbh | Monoclonal antibodies directed against the microtubule-associated protein tau |
DE69233767D1 (de) * | 1991-12-06 | 2009-09-17 | Max Planck Gesellschaft | Verwendung von Protein-Kinasen zur Diagnose und Behandlung der Alzheimer-Krankheit |
EP0544942A1 (de) * | 1991-12-06 | 1993-06-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Neue Werkzeuge für die Diagnose und die Behandlung der Alzheimer-Krankheit |
JP2879975B2 (ja) * | 1992-12-14 | 1999-04-05 | エヌ・ブイ・インノジェネティクス・ソシエテ・アノニム | 微小管関連タンパク質タウに対するモノクローナル抗体、これらの抗体を分泌するハイブリドーマ、これらのモノクローナル抗体による抗原認識及びこれらの応用 |
CA2116460A1 (en) * | 1993-03-02 | 1994-09-03 | Mitsubishi Chemical Corporation | Preventive or therapeutic agents for alzheimer's disease, a screening method of alzheimer's disease and tau-protein kinase i originated from human being |
CA2178212C (en) * | 1993-12-21 | 2011-06-14 | Marc Vandermeeren | Monoclonal antibodies specific for phf-tau, hybridomas secreting them, antigen recognition by these antibodies and their applications |
-
1995
- 1995-07-31 US US08/776,404 patent/US6121003A/en not_active Expired - Fee Related
- 1995-07-31 CA CA002195672A patent/CA2195672A1/en not_active Abandoned
- 1995-07-31 EP EP95928494A patent/EP0772634B1/de not_active Expired - Lifetime
- 1995-07-31 AU AU32234/95A patent/AU710952B2/en not_active Ceased
- 1995-07-31 JP JP8506190A patent/JPH10506381A/ja not_active Withdrawn
- 1995-07-31 DE DE69529906T patent/DE69529906D1/de not_active Expired - Lifetime
- 1995-07-31 AT AT95928494T patent/ATE234324T1/de not_active IP Right Cessation
- 1995-07-31 WO PCT/EP1995/003032 patent/WO1996004309A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JPH10506381A (ja) | 1998-06-23 |
EP0772634A1 (de) | 1997-05-14 |
EP0772634B1 (de) | 2003-03-12 |
DE69529906D1 (de) | 2003-04-17 |
AU3223495A (en) | 1996-03-04 |
US6121003A (en) | 2000-09-19 |
WO1996004309A1 (en) | 1996-02-15 |
CA2195672A1 (en) | 1996-02-15 |
AU710952B2 (en) | 1999-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE234324T1 (de) | Monoklonale antikörper gegen ein epitop einer gewissen unterklasse oder form von phosphoryliertem tau, hybridome die diese sezernieren,antigenerkennung durch diese antikörper und deren verwendung | |
ATE165866T1 (de) | Monoklonale antikörper gegen das mikrotubulusassoziierte tauprotein,hybridomen, die diese antikörper sezernieren, antigenerkennung durch diese monoklonalen antikörper und deren verwendung | |
US6864062B2 (en) | Purified antigen for Alzheimer's disease and methods of obtaining and using same | |
Yen et al. | Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides. | |
Lee et al. | Monoclonal antibodies to gel‐excised glial filament protein and their reactivities with other intermediate filament proteins | |
US20050124016A1 (en) | Antibodies specific for toxic amyloid beta protein oligomers | |
ATE165395T1 (de) | Inhibitoren des tumorwachstums aus geweben, methoden ihrer herstellung und verwendungen | |
DK0610330T3 (da) | Monoklonale antistoffer mod microtubulus-associeret protein tau | |
DE69030947D1 (de) | Monoklonaler Antikörper spezifisch für ein humanes atherom-assoziiertes Antigen | |
DE69531311D1 (de) | Monoklonale antikörper spezifisch für endprodukte der fortgeschrittenen glycosylation in biologischen proben | |
DE69129460D1 (de) | Verwendung von Anti-ICAM Antikörpern zur Herstellung eines Präparats für die BEHANDLUNG VON ENDOTOXINSCHOCK | |
Radl | Animal model of human disease. Benign monoclonal gammopathy (idiopathic paraproteinemia). | |
GR3025630T3 (en) | Monoclonal antibody against human IgE | |
Noronha et al. | Myelin‐associated glycoprotein shares an antigenic determinant with a glycoprotein of human melanoma cells | |
Tsutsumi et al. | Iocalized amyloidosis of the seminal vesicle: Identification of lactoferrin immunoreactivity in the amyloid material | |
ATE137864T1 (de) | Immunobestimmung von menschlichem osteocalcin, reagenz und satz dafür | |
EP0854152A1 (de) | Immunoassay zum Nachweis von MIA | |
NO883854L (no) | Monoklonalt antistoff og fremgangsmaate for dets fremstilling. | |
Mudawwar et al. | Regulation of monoclonal immunoglobulin G synthesis by antiidiotypic antibody in a patient with hypogammaglobulinemia. | |
RU2227297C2 (ru) | Моноклональные антитела против s100 | |
EP0434809B1 (de) | Verfahren zum nachweis von leberzirrhose | |
DE10230550A1 (de) | Carbohydrate Deficient Transferrin (CDT)-spezifische Antikörper, ihre Herstellung und Verwendung | |
DE3840968C2 (de) | ||
JPH02131574A (ja) | ミニクローン | |
Baumal et al. | Experimental murine amyloidosis: a model system for studying amyloid formation. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |