ES2161751T3 - Anticuerpo monoclonal que se une especificamente al endotelio vascular tumoral y usos del mismo. - Google Patents

Anticuerpo monoclonal que se une especificamente al endotelio vascular tumoral y usos del mismo.

Info

Publication number
ES2161751T3
ES2161751T3 ES94901335T ES94901335T ES2161751T3 ES 2161751 T3 ES2161751 T3 ES 2161751T3 ES 94901335 T ES94901335 T ES 94901335T ES 94901335 T ES94901335 T ES 94901335T ES 2161751 T3 ES2161751 T3 ES 2161751T3
Authority
ES
Spain
Prior art keywords
same
monoclonal antibody
glycoprotein
tumor vascular
vascular endothelium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94901335T
Other languages
English (en)
Inventor
Pilar Garin-Chesa
Wolfgang J Rettig
Lloyd J Old
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Institute for Cancer Research Ltd
Sloan Kettering Institute for Cancer Research
Ludwig Institute for Cancer Research New York
Memorial Sloan Kettering Cancer Center
Original Assignee
Ludwig Institute for Cancer Research Ltd
Sloan Kettering Institute for Cancer Research
Ludwig Institute for Cancer Research New York
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Institute for Cancer Research Ltd, Sloan Kettering Institute for Cancer Research, Ludwig Institute for Cancer Research New York, Memorial Sloan Kettering Cancer Center filed Critical Ludwig Institute for Cancer Research Ltd
Application granted granted Critical
Publication of ES2161751T3 publication Critical patent/ES2161751T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/857—Fish; fish eggs; shell fish; crustacea

Abstract

EL INVENTO COMPRENDE ANTICUERPOS MONOCLONICOS QUE SE FIJAN ESPECIFICAMENTE AL ANTIGENO DE LA SUPERFICIE DE UNA CELULA CARACTERISTICA DE UN TUMOR VASCULAR DEL ENDOTELIO. EL ANTIGENO, REFERIDO COMO ENDOSIALIN ES UNA GLICOPROTEINA Y TIENE UN PESO MOLECULAR DE APROXIMADAMENTE 165 KDA COMO DETERMINA EL SDS-PAGE. LA PARTE PROTEINICA DE LA MOLECULA TIENE UN PESO MOLECUALR DE APROXIMADAMENTE 95 KDA. TAMBIEN SE MUESTRAN VARIOS USOS DEL ANTICUERPO MONOCLONICO Y DEL ANTIGENO.
ES94901335T 1992-11-13 1993-11-09 Anticuerpo monoclonal que se une especificamente al endotelio vascular tumoral y usos del mismo. Expired - Lifetime ES2161751T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/976,405 US5342757A (en) 1992-11-13 1992-11-13 Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof

Publications (1)

Publication Number Publication Date
ES2161751T3 true ES2161751T3 (es) 2001-12-16

Family

ID=25524065

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901335T Expired - Lifetime ES2161751T3 (es) 1992-11-13 1993-11-09 Anticuerpo monoclonal que se une especificamente al endotelio vascular tumoral y usos del mismo.

Country Status (12)

Country Link
US (2) US5342757A (es)
EP (1) EP0673255B1 (es)
JP (1) JP3541296B2 (es)
AT (1) ATE204480T1 (es)
AU (1) AU671884B2 (es)
CA (1) CA2149120C (es)
DE (1) DE69330643T2 (es)
DK (1) DK0673255T3 (es)
ES (1) ES2161751T3 (es)
GR (1) GR3036906T3 (es)
PT (1) PT673255E (es)
WO (1) WO1994011023A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US5660827A (en) * 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
ES2193143T3 (es) * 1992-03-05 2003-11-01 Univ Texas Uso de inmunoconjugados para la diagnosis y/o terapia de tumores vascularizaos.
US6093399A (en) * 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US6036955A (en) * 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US6004555A (en) * 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
DK0746613T3 (da) * 1994-03-08 2006-09-25 Sloan Kettering Inst Cancer Rekombinante humaniserede antistoffer mod FB5
US5536641A (en) * 1994-05-17 1996-07-16 Memorial Sloane Kittering Cancer Center Monoclonal antibody specific for vascular endothelial cell antigen endoglyx-1 and uses thereof for detection of, and isolation of, vascular endothelial cells
US6524553B2 (en) * 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
WO1999058162A2 (en) 1998-03-31 1999-11-18 Du Pont Pharmaceuticals Company Pharmaceuticals for the imaging of angiogenic disorders
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
CA2349333A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) * 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
JP2002532440A (ja) 1998-12-18 2002-10-02 デュポン ファーマシューティカルズ カンパニー ビトロネクチン受容体拮抗剤薬剤
EP1307557A2 (en) * 2000-08-02 2003-05-07 The Johns Hopkins University Endothelial cell expression patterns
US7074175B2 (en) 2001-07-25 2006-07-11 Erik Schroeder Handy Thermotherapy via targeted delivery of nanoscale magnetic particles
US7731648B2 (en) 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
US6997863B2 (en) 2001-07-25 2006-02-14 Triton Biosystems, Inc. Thermotherapy via targeted delivery of nanoscale magnetic particles
US7951061B2 (en) 2001-07-25 2011-05-31 Allan Foreman Devices for targeted delivery of thermotherapy, and methods related thereto
EP1534331B1 (en) * 2002-06-21 2014-10-29 Johns Hopkins University School of Medicine Membrane associated tumor endothelium markers
WO2004078942A2 (en) * 2003-03-04 2004-09-16 Kirin Beer Kabushiki Kaisha Endothelial cell specific antibodies and uses thereof
AU2005311660B2 (en) * 2004-12-03 2011-07-07 Morphotek, Inc. Use of endosialin binding proteins to isolate endosialin positive cells
WO2006116451A2 (en) 2005-04-22 2006-11-02 Morphotek, Inc. Antibodies with immune effector activity and that internalize in endosialin-positive cells
LT2620451T (lt) * 2007-04-05 2017-01-10 Morphotek, Inc. Endosialino prijungimo prie ligandų slopinimo būdai
WO2010118203A2 (en) * 2009-04-09 2010-10-14 Morphotek, Inc. Endosialin binding molecules
SE535982C2 (sv) * 2009-12-15 2013-03-19 Theravac Pharmaceuticals Ab Ett nytt vaccin som angriper tumörkärl som ett effektivt redskap i tumörterapi
JP2013543379A (ja) 2010-09-29 2013-12-05 モルフォテック， インコーポレイテッド 操作されたヒトエンドシアリン発現齧歯動物
EP3543258B1 (en) * 2012-03-30 2023-09-13 Eisai R&D Management Co., Ltd. Tem-1 diagnostic antibodies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0746613T3 (da) * 1994-03-08 2006-09-25 Sloan Kettering Inst Cancer Rekombinante humaniserede antistoffer mod FB5

Also Published As

Publication number Publication date
AU5596594A (en) 1994-06-08
US5437865A (en) 1995-08-01
EP0673255B1 (en) 2001-08-22
EP0673255A4 (en) 1996-08-21
ATE204480T1 (de) 2001-09-15
CA2149120C (en) 2005-09-27
DK0673255T3 (da) 2001-12-10
GR3036906T3 (en) 2002-01-31
US5342757A (en) 1994-08-30
JPH08505764A (ja) 1996-06-25
EP0673255A1 (en) 1995-09-27
PT673255E (pt) 2002-02-28
CA2149120A1 (en) 1994-05-26
WO1994011023A1 (en) 1994-05-26
JP3541296B2 (ja) 2004-07-07
DE69330643D1 (de) 2001-09-27
AU671884B2 (en) 1996-09-12
DE69330643T2 (de) 2002-07-04

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