ES2122248T3 - Inhibicion de la hiperplasia de la intima que emplea anticuerpos de receptores del factor de crecimiento derivado de plaquetas. - Google Patents
Inhibicion de la hiperplasia de la intima que emplea anticuerpos de receptores del factor de crecimiento derivado de plaquetas.Info
- Publication number
- ES2122248T3 ES2122248T3 ES94909627T ES94909627T ES2122248T3 ES 2122248 T3 ES2122248 T3 ES 2122248T3 ES 94909627 T ES94909627 T ES 94909627T ES 94909627 T ES94909627 T ES 94909627T ES 2122248 T3 ES2122248 T3 ES 2122248T3
- Authority
- ES
- Spain
- Prior art keywords
- hyperplasia
- platelets
- intimate
- receptors
- inhibition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE DESCRIBEN METODOS DE INHIBICION DE HIPERPLASIA INTIMA EN LA VASCULATURA DE MAMIFEROS, INCLUYENDO PRIMATES. LOS METODOS COMPRENDEN LA ADMINISTRACION AL MAMIFERO DE UN ANTICUERPO RECEPTOR ANTI-PDGF, COMO UN ANTICUERPO RECEPTOR ANTI-PDGF-ALFA O UN ANTICUERPO RECEPTOR ANTI-PDGF-BETA. LOS METODOS SON UTILES EN LA REDUCCION DE LA HIPERPLASIA INTIMA DEBIDO A, POR EJEMPLO, LESIONES VASCULARES RESULTANTES DE ANGIOPLASTIA, ENDARTERECTOMIA, ATERECTOMIA DE REDUCCION O ANASTOMOSIS DE UN INJERTO VASCULAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2350493A | 1993-02-25 | 1993-02-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2122248T3 true ES2122248T3 (es) | 1998-12-16 |
Family
ID=21815476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94909627T Expired - Lifetime ES2122248T3 (es) | 1993-02-25 | 1994-02-17 | Inhibicion de la hiperplasia de la intima que emplea anticuerpos de receptores del factor de crecimiento derivado de plaquetas. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0686044B1 (es) |
JP (1) | JP2944218B2 (es) |
AT (1) | ATE170402T1 (es) |
CA (1) | CA2156825C (es) |
DE (1) | DE69413009T2 (es) |
DK (1) | DK0686044T3 (es) |
ES (1) | ES2122248T3 (es) |
WO (1) | WO1994019016A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6228600B1 (en) | 1992-07-20 | 2001-05-08 | The United States Of America As Represented By The Department Of Health And Human Services | Immunoassays for the alpha platelet-derived growth factor receptor |
US7252929B2 (en) | 1989-02-09 | 2007-08-07 | United States Of America, As Represented By The Secretary, Dept Of Health & Human Services | Methods for identifying alpha PDGFR agonists and antagonists |
US5976534A (en) * | 1993-02-25 | 1999-11-02 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin |
US5882644A (en) * | 1996-03-22 | 1999-03-16 | Protein Design Labs, Inc. | Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof |
WO1998035697A1 (en) * | 1997-02-14 | 1998-08-20 | Roche Diagnostics Gmbh | Improved method for the reduction of neointima formation after angioplasty |
AU1454199A (en) * | 1997-11-07 | 1999-05-31 | Massachusetts Institute Of Technology | Pdgf-mediated microvascular communication and methods of use thereof |
CA2396628A1 (en) | 2000-01-25 | 2001-08-02 | Edwards Lifesciences Corporation | Delivery systems for treatment of restenosis and anastomotic intimal hyperplasia |
US6990848B2 (en) * | 2002-08-05 | 2006-01-31 | Trxoler Electronic Laboratories, Inc. | System and method for determining material properties of samples |
EP2100618B1 (en) | 2005-06-17 | 2014-02-12 | ImClone LLC | An anti-PDGFRalpha antibody for use in the treatment of metastatic bone cancer |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0619738B1 (en) * | 1991-12-02 | 2003-07-09 | Millennium Pharmaceuticals, Inc. | Inhibitory immunoglobulin polypeptides to human pdgf beta receptor |
-
1994
- 1994-02-17 DE DE69413009T patent/DE69413009T2/de not_active Expired - Fee Related
- 1994-02-17 DK DK94909627T patent/DK0686044T3/da active
- 1994-02-17 ES ES94909627T patent/ES2122248T3/es not_active Expired - Lifetime
- 1994-02-17 EP EP94909627A patent/EP0686044B1/en not_active Expired - Lifetime
- 1994-02-17 JP JP6519074A patent/JP2944218B2/ja not_active Expired - Fee Related
- 1994-02-17 WO PCT/US1994/001611 patent/WO1994019016A1/en active IP Right Grant
- 1994-02-17 AT AT94909627T patent/ATE170402T1/de not_active IP Right Cessation
- 1994-02-17 CA CA002156825A patent/CA2156825C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69413009T2 (de) | 1999-03-25 |
DK0686044T3 (da) | 2000-10-09 |
EP0686044B1 (en) | 1998-09-02 |
JPH08507063A (ja) | 1996-07-30 |
ATE170402T1 (de) | 1998-09-15 |
DE69413009D1 (de) | 1998-10-08 |
EP0686044A1 (en) | 1995-12-13 |
CA2156825C (en) | 2003-10-21 |
CA2156825A1 (en) | 1994-09-01 |
WO1994019016A1 (en) | 1994-09-01 |
JP2944218B2 (ja) | 1999-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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