DE69413009D1 - Verwendung von antikörpern gegen pdgf-rezeptoren zur inhibierung von hyperplasie der intima - Google Patents
Verwendung von antikörpern gegen pdgf-rezeptoren zur inhibierung von hyperplasie der intimaInfo
- Publication number
- DE69413009D1 DE69413009D1 DE69413009T DE69413009T DE69413009D1 DE 69413009 D1 DE69413009 D1 DE 69413009D1 DE 69413009 T DE69413009 T DE 69413009T DE 69413009 T DE69413009 T DE 69413009T DE 69413009 D1 DE69413009 D1 DE 69413009D1
- Authority
- DE
- Germany
- Prior art keywords
- intima
- antibodies against
- pdgf
- receptor antibody
- pdgf receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2350493A | 1993-02-25 | 1993-02-25 | |
PCT/US1994/001611 WO1994019016A1 (en) | 1993-02-25 | 1994-02-17 | Inhibition of intimal hyperplasia using antibodies to pdgf receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69413009D1 true DE69413009D1 (de) | 1998-10-08 |
DE69413009T2 DE69413009T2 (de) | 1999-03-25 |
Family
ID=21815476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69413009T Expired - Fee Related DE69413009T2 (de) | 1993-02-25 | 1994-02-17 | Verwendung von antikörpern gegen pdgf-rezeptoren zur inhibierung von hyperplasie der intima |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0686044B1 (de) |
JP (1) | JP2944218B2 (de) |
AT (1) | ATE170402T1 (de) |
CA (1) | CA2156825C (de) |
DE (1) | DE69413009T2 (de) |
DK (1) | DK0686044T3 (de) |
ES (1) | ES2122248T3 (de) |
WO (1) | WO1994019016A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6228600B1 (en) | 1992-07-20 | 2001-05-08 | The United States Of America As Represented By The Department Of Health And Human Services | Immunoassays for the alpha platelet-derived growth factor receptor |
US7252929B2 (en) | 1989-02-09 | 2007-08-07 | United States Of America, As Represented By The Secretary, Dept Of Health & Human Services | Methods for identifying alpha PDGFR agonists and antagonists |
US5976534A (en) * | 1993-02-25 | 1999-11-02 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin |
US5882644A (en) * | 1996-03-22 | 1999-03-16 | Protein Design Labs, Inc. | Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof |
WO1998035697A1 (en) * | 1997-02-14 | 1998-08-20 | Roche Diagnostics Gmbh | Improved method for the reduction of neointima formation after angioplasty |
AU1454199A (en) * | 1997-11-07 | 1999-05-31 | Massachusetts Institute Of Technology | Pdgf-mediated microvascular communication and methods of use thereof |
JP2003520830A (ja) | 2000-01-25 | 2003-07-08 | エドワーズ ライフサイエンシーズ コーポレイション | 再狭窄および吻合内膜過形成処置のための送達系 |
US6990848B2 (en) * | 2002-08-05 | 2006-01-31 | Trxoler Electronic Laboratories, Inc. | System and method for determining material properties of samples |
ES2452115T3 (es) | 2005-06-17 | 2014-03-31 | Imclone Llc | Un anticuerpo anti-PDGFRalfa para su uso en el tratamiento de cáncer de huesos metastásico |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2124958C (en) * | 1991-12-02 | 2007-02-13 | Vanitha Ramakrishnan | Inhibitory immunoglobulin polypeptides to human pdgf beta receptor |
-
1994
- 1994-02-17 ES ES94909627T patent/ES2122248T3/es not_active Expired - Lifetime
- 1994-02-17 JP JP6519074A patent/JP2944218B2/ja not_active Expired - Fee Related
- 1994-02-17 DK DK94909627T patent/DK0686044T3/da active
- 1994-02-17 DE DE69413009T patent/DE69413009T2/de not_active Expired - Fee Related
- 1994-02-17 CA CA002156825A patent/CA2156825C/en not_active Expired - Fee Related
- 1994-02-17 AT AT94909627T patent/ATE170402T1/de not_active IP Right Cessation
- 1994-02-17 EP EP94909627A patent/EP0686044B1/de not_active Expired - Lifetime
- 1994-02-17 WO PCT/US1994/001611 patent/WO1994019016A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ES2122248T3 (es) | 1998-12-16 |
CA2156825A1 (en) | 1994-09-01 |
ATE170402T1 (de) | 1998-09-15 |
WO1994019016A1 (en) | 1994-09-01 |
DE69413009T2 (de) | 1999-03-25 |
EP0686044A1 (de) | 1995-12-13 |
JP2944218B2 (ja) | 1999-08-30 |
EP0686044B1 (de) | 1998-09-02 |
DK0686044T3 (da) | 2000-10-09 |
CA2156825C (en) | 2003-10-21 |
JPH08507063A (ja) | 1996-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |