PE20140218A1 - Composicion farmaceutica - Google Patents

Composicion farmaceutica

Info

Publication number
PE20140218A1
PE20140218A1 PE2013000800A PE2013000800A PE20140218A1 PE 20140218 A1 PE20140218 A1 PE 20140218A1 PE 2013000800 A PE2013000800 A PE 2013000800A PE 2013000800 A PE2013000800 A PE 2013000800A PE 20140218 A1 PE20140218 A1 PE 20140218A1
Authority
PE
Peru
Prior art keywords
seq
antibody
sequence
pharmaceutical composition
cdr1
Prior art date
Application number
PE2013000800A
Other languages
English (en)
Inventor
Andrea Pfeifer
Andreas Muhs
Leuven Fred Van
Maria Pihlgren
Oskar Adolfsson
Original Assignee
Ac Inmune S A
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44947048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20140218(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ac Inmune S A, Univ Leuven Kath filed Critical Ac Inmune S A
Publication of PE20140218A1 publication Critical patent/PE20140218A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

SE REFIERE A UN ANTICUERPO QUE RECONOCE Y SE UNE ESPECIFICAMENTE CON UN FOSFO-EPITOPE EN LA PROTEINA TAU DE MAMIFERO O EN UNO DE SUS FRAGMENTOS FUNCIONALES, EN DONDE DICHO ANTICUERPO TIENE UNA ALTA AFINIDAD DE UNION CON LA PROTEINA TAU SOLUBLE Y MODULA LOS NIVELES TAU SOLUBLE E INSOLUBLE, DICHO ANTICUERPO COMPRENDE UN PRIMER DOMINIO DE UNION QUE CONTIENE UN CDR1 CON LA SECUENCIA SEQ ID NO: 21, 24, 27, 28, 29, ENTRE OTROS; CDR2 CON LA SECUENCIA SEQ ID NO: 22, 25, 30, 33 ENTRE OTROS Y UN CDR3 CON LA SEQ ID NO: 23, 26, 31, 34 ENTRE OTROS Y UN SEGUNDO DOMINIO DE UNION QUE CONTIENE UN CDR1 CON LA SECUENCIA SEQ ID NO: 12, 15, 18, 70, 78, 89 ENTRE OTROS; CDR2 CON LA SECUENCIA SEQ ID NO: 13, 16, 19 ENTRE OTROS Y UN CDR3 CON LA SECUENCIA SEQ ID NO: 14, 17, 20, 72 ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS QUE SON CAUSADOS POR LA FORMACION DE LESIONES NEUROFIBRILARES.
PE2013000800A 2010-10-07 2011-10-07 Composicion farmaceutica PE20140218A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10186810 2010-10-07
EP11174248 2011-07-15

Publications (1)

Publication Number Publication Date
PE20140218A1 true PE20140218A1 (es) 2014-03-01

Family

ID=44947048

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013000800A PE20140218A1 (es) 2010-10-07 2011-10-07 Composicion farmaceutica

Country Status (28)

Country Link
US (2) US9304138B2 (es)
EP (2) EP2987807A3 (es)
JP (2) JP6371526B2 (es)
KR (1) KR101988672B1 (es)
CN (1) CN103502272B (es)
AR (1) AR085198A1 (es)
AU (1) AU2011311516B2 (es)
BR (1) BR112013008333B1 (es)
CA (1) CA2812865C (es)
CL (1) CL2013000951A1 (es)
CO (1) CO6710903A2 (es)
CR (1) CR20130160A (es)
DK (1) DK2625198T3 (es)
EC (1) ECSP13012609A (es)
ES (1) ES2548686T3 (es)
HK (2) HK1187928A1 (es)
HU (1) HUE027649T2 (es)
IL (1) IL225568A (es)
MX (1) MX338421B (es)
MY (1) MY164376A (es)
PE (1) PE20140218A1 (es)
PL (1) PL2625198T3 (es)
RU (1) RU2603078C2 (es)
SG (1) SG189136A1 (es)
SI (1) SI2625198T1 (es)
TW (1) TW201216985A (es)
WO (1) WO2012045882A2 (es)
ZA (1) ZA201302432B (es)

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Publication number Publication date
EP2987807A3 (en) 2016-06-01
EP2625198A2 (en) 2013-08-14
AU2011311516B2 (en) 2015-06-11
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BR112013008333A2 (pt) 2021-09-21
SG189136A1 (en) 2013-05-31
TW201216985A (en) 2012-05-01
US9304138B2 (en) 2016-04-05
EP2987807A2 (en) 2016-02-24
AR085198A1 (es) 2013-09-18
MX2013003800A (es) 2013-06-28
MX338421B (es) 2016-04-15
CA2812865A1 (en) 2012-04-12
JP2017113004A (ja) 2017-06-29
WO2012045882A3 (en) 2012-05-31
RU2013120544A (ru) 2014-11-20
US20160304590A1 (en) 2016-10-20
JP6371526B2 (ja) 2018-08-08
SI2625198T1 (sl) 2015-11-30
JP2014502141A (ja) 2014-01-30
WO2012045882A2 (en) 2012-04-12
IL225568A0 (en) 2013-06-27
KR20130115279A (ko) 2013-10-21
MY164376A (en) 2017-12-15
ECSP13012609A (es) 2013-07-31
CR20130160A (es) 2013-09-03
DK2625198T3 (en) 2015-09-28
CA2812865C (en) 2021-01-26
ZA201302432B (en) 2016-07-27
US10100104B2 (en) 2018-10-16
IL225568A (en) 2017-06-29
RU2603078C2 (ru) 2016-11-20
HK1187928A1 (zh) 2014-04-17
CN103502272B (zh) 2016-06-15
HK1216897A1 (zh) 2016-12-09
ES2548686T3 (es) 2015-10-20
AU2011311516A1 (en) 2013-04-18
US20120276009A1 (en) 2012-11-01
HUE027649T2 (en) 2016-10-28
PL2625198T3 (pl) 2015-12-31
CO6710903A2 (es) 2013-07-15
CL2013000951A1 (es) 2014-01-03
CN103502272A (zh) 2014-01-08
BR112013008333B1 (pt) 2022-10-11
KR101988672B1 (ko) 2019-06-12

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