CR20130160A - Anticuerpos fosfoespecificos que reconocen tau - Google Patents
Anticuerpos fosfoespecificos que reconocen tauInfo
- Publication number
- CR20130160A CR20130160A CR20130160A CR20130160A CR20130160A CR 20130160 A CR20130160 A CR 20130160A CR 20130160 A CR20130160 A CR 20130160A CR 20130160 A CR20130160 A CR 20130160A CR 20130160 A CR20130160 A CR 20130160A
- Authority
- CR
- Costa Rica
- Prior art keywords
- antibodies recognizing
- phosphospecific antibodies
- recognizing tau
- tau
- phosphospecific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10186810 | 2010-10-07 | ||
EP11174248 | 2011-07-15 | ||
PCT/EP2011/067604 WO2012045882A2 (en) | 2010-10-07 | 2011-10-07 | Pharmaceutical composition |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20130160A true CR20130160A (es) | 2013-09-03 |
Family
ID=44947048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20130160A CR20130160A (es) | 2010-10-07 | 2013-04-05 | Anticuerpos fosfoespecificos que reconocen tau |
Country Status (28)
Country | Link |
---|---|
US (2) | US9304138B2 (es) |
EP (2) | EP2625198B1 (es) |
JP (2) | JP6371526B2 (es) |
KR (1) | KR101988672B1 (es) |
CN (1) | CN103502272B (es) |
AR (1) | AR085198A1 (es) |
AU (1) | AU2011311516B2 (es) |
BR (1) | BR112013008333B1 (es) |
CA (1) | CA2812865C (es) |
CL (1) | CL2013000951A1 (es) |
CO (1) | CO6710903A2 (es) |
CR (1) | CR20130160A (es) |
DK (1) | DK2625198T3 (es) |
EC (1) | ECSP13012609A (es) |
ES (1) | ES2548686T3 (es) |
HK (2) | HK1187928A1 (es) |
HU (1) | HUE027649T2 (es) |
IL (1) | IL225568A (es) |
MX (1) | MX338421B (es) |
MY (1) | MY164376A (es) |
PE (1) | PE20140218A1 (es) |
PL (1) | PL2625198T3 (es) |
RU (1) | RU2603078C2 (es) |
SG (1) | SG189136A1 (es) |
SI (1) | SI2625198T1 (es) |
TW (1) | TW201216985A (es) |
WO (1) | WO2012045882A2 (es) |
ZA (1) | ZA201302432B (es) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10266585B2 (en) * | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
CA2812865C (en) * | 2010-10-07 | 2021-01-26 | Ac Immune S.A. | Phosphospecific antibodies recognising tau |
JP2014503178A (ja) | 2010-10-11 | 2014-02-13 | バイオジェン アイデック インターナショナル ニューロサイエンス ゲーエムベーハー | ヒト抗タウ抗体 |
CA2826286C (en) * | 2011-01-31 | 2021-09-21 | Intellect Neurosciences Inc. | Treatment of tauopathies |
GB201112056D0 (en) * | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
EP3135689B1 (en) | 2011-10-07 | 2018-12-19 | AC Immune S.A. | Phosphospecific antibodies recognising tau |
US9371376B2 (en) | 2011-12-20 | 2016-06-21 | Janssen Biotech, Inc. | Anti-PHF-tau antibodies and their uses |
BR112014024769A2 (pt) * | 2012-04-05 | 2017-12-12 | Ac Immune Sa | anticorpo humanizado tau |
JP6345655B2 (ja) | 2012-07-03 | 2018-06-20 | ワシントン・ユニバーシティWashington University | タウに対する抗体 |
WO2014016737A1 (en) * | 2012-07-24 | 2014-01-30 | Pfizer Inc. | Novel chicken monoclonal antibodies against human phosphorylated tau and uses thereof |
CA2882034C (en) * | 2012-08-16 | 2019-10-29 | Ipierian, Inc. | Methods of treating a tauopathy |
WO2014043480A1 (en) | 2012-09-13 | 2014-03-20 | Crystal Ronald G | Treatment of brain cancers using central nervous system mediated gene transfer of monoclonal antibodies |
US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
SG10201705104UA (en) | 2012-12-21 | 2017-07-28 | Biogen Int Neuroscience Gmbh | Human anti-tau antibodies |
US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
MX2015012872A (es) * | 2013-03-15 | 2016-02-03 | Ac Immune Sa | Anticuerpos anti-tau y metodos de uso. |
JP6824735B2 (ja) | 2013-06-06 | 2021-02-03 | ピエール、ファーブル、メディカマン | 抗C10orf54抗体およびその使用方法 |
GB201312226D0 (en) * | 2013-07-08 | 2013-08-21 | Adx Neurosciences | Improved antibodies |
US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
WO2015081085A2 (en) * | 2013-11-27 | 2015-06-04 | Ipierian, Inc. | Methods of treating a tauopathy |
BR112016013562A2 (pt) | 2013-12-20 | 2017-10-03 | Hoffmann La Roche | Anticorpos anti-tau(ps422) humanizados, seus usos, e formulações farmacêuticas |
WO2015122922A1 (en) | 2014-02-14 | 2015-08-20 | Ipierian, Inc. | Tau peptides, anti-tau antibodies, and methods of use thereof |
US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
TWI664190B (zh) | 2014-06-27 | 2019-07-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
US10830775B2 (en) | 2014-09-30 | 2020-11-10 | Washington University | Tau kinetic measurements |
RU2020126237A (ru) * | 2014-11-19 | 2020-12-01 | Аксон Ньюросайенс Се | Гуманизированные тау-антитела при болезни альцгеймера |
US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
AR103713A1 (es) | 2015-02-26 | 2017-05-31 | Lilly Co Eli | Anticuerpos contra tau y sus usos |
MA44955A (fr) | 2015-06-05 | 2019-03-20 | Ac Immune Sa | Anticorps anti-tau et leurs méthodes d'utilisation |
EP3744732A1 (en) | 2015-06-24 | 2020-12-02 | F. Hoffmann-La Roche AG | Humanized anti-tau(ps422) antibodies and methods of use |
KR20180025962A (ko) | 2015-07-06 | 2018-03-09 | 유씨비 바이오파마 에스피알엘 | 타우 결합 항체 |
JO3711B1 (ar) * | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
EP3334761B1 (en) * | 2015-08-13 | 2023-07-19 | New York University | Antibody-based molecules selective for the {p}ser404 epitope of tau and their uses in the diagnosis and treatment of tauopathy |
ES2862427T3 (es) * | 2016-07-12 | 2021-10-07 | H Lundbeck As | Anticuerpos específicos para tau hiperfosforilada y métodos de uso de los mismos |
EP3496750A2 (en) | 2016-08-09 | 2019-06-19 | Eli Lilly and Company | Combination therapy |
AU2017373889A1 (en) * | 2016-12-07 | 2019-06-06 | Ac Immune Sa | Anti-Tau antibodies and methods of use |
KR102645073B1 (ko) | 2016-12-07 | 2024-03-11 | 제넨테크, 인크. | 항-타우 항체 및 이의 이용 방법 |
JP7217710B2 (ja) * | 2017-01-04 | 2023-02-03 | ハー・ルンドベック・アクチエゼルスカベット | 眼疾患の治療のための過リン酸化タウに特異的な抗体 |
EP3583123A1 (en) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
JOP20180014A1 (ar) * | 2017-02-27 | 2019-01-30 | Teijin Pharma Ltd | جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه |
EA039569B1 (ru) * | 2017-03-14 | 2022-02-11 | Х. Лундбекк А/С | Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения |
JOP20180021A1 (ar) | 2017-03-16 | 2019-01-30 | Janssen Biotech Inc | الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها |
WO2018217630A1 (en) * | 2017-05-21 | 2018-11-29 | University Of Tennessee Research Foundation | Methods and compositions for targeting tissue lesions |
CA3077247A1 (en) | 2017-10-16 | 2019-04-25 | Eisai R & D Management Co., Ltd. | Anti-tau antibodies and uses thereof |
EP3718462A4 (en) * | 2017-11-28 | 2021-08-18 | Mie University | DETECTION PROCESS |
EP3829634A1 (en) | 2018-07-31 | 2021-06-09 | Eli Lilly and Company | Combination therapy |
WO2020073917A1 (en) * | 2018-10-09 | 2020-04-16 | Single Cell Technology, Inc. | Anti-bcma antibodies |
AU2018446059A1 (en) * | 2018-10-17 | 2021-05-20 | The University Of Queensland | Methods and compositions for treating tauopathies |
US12016885B2 (en) | 2018-11-06 | 2024-06-25 | Alsatech, Inc. | Method of solubilizing TDP-43 protein aggregates in amyotrophic lateral sclerosis using a microvascular endothelial cell expressing an anti-TDP-43 Fab |
WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
US11155609B2 (en) | 2019-04-05 | 2021-10-26 | TauC3 Biologies Limited | Anti-TAUC3 antibodies and uses thereof |
US20220162301A1 (en) * | 2019-04-12 | 2022-05-26 | PhanesTherapeutics, Inc. | Humanized anti-folate receptor 1 chimeric antigen receptors and uses thereof |
CN110028583B (zh) * | 2019-05-07 | 2020-09-11 | 温州医科大学 | 抗Tau抗体及其在治疗阿尔茨海默病、创伤性脑损伤中的应用 |
WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
CN112752251B (zh) * | 2019-10-29 | 2022-05-06 | 中国移动通信有限公司研究院 | 一种ue标识符的分配方法、装置和计算机可读存储介质 |
TW202136297A (zh) * | 2020-02-05 | 2021-10-01 | 日商大日本住友製藥股份有限公司 | Tau蛋白病變及失智症相關疾病之判定藥及判定方法 |
BR112022026575A2 (pt) | 2020-06-25 | 2023-01-17 | Merck Sharp & Dohme Llc | Anticorpos de alta afinidade que alvejam tau fosforilado em serina 413 |
AU2021403010A1 (en) * | 2020-12-16 | 2023-07-13 | Voyager Therapeutics, Inc. | Tau binding compounds |
EP4014997A1 (en) | 2020-12-16 | 2022-06-22 | Consejo Superior de Investigaciones Científicas (CSIC) | Stard1 inhibitors for the treatment of lysosomal disorders |
CA3208580A1 (en) * | 2021-03-18 | 2022-09-22 | Hector De Jesus RINCON ARANO | Anti-alpp/alppl2 antibodies and antibody-drug conjugates |
WO2023092004A1 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
WO1993011231A1 (en) | 1991-12-06 | 1993-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Tools for the diagnosis and treatment of alzheimer's disease |
CA2141216A1 (en) | 1992-07-27 | 1994-02-03 | Michael J. Micklus | Targeting of liposomes to the blood-brain barrier |
WO1996013590A2 (en) | 1994-10-21 | 1996-05-09 | Innogenetics N.V. | New sequences of hepatitis c virus genotypes and their use as prophylactic, therapeutic and diagnostic agents |
US5756662A (en) | 1995-03-14 | 1998-05-26 | Corixa Corporation | Compounds and methods for the detection of T. cruzi infection |
US20020086009A1 (en) * | 1996-03-13 | 2002-07-04 | Koichi Ishiguro | Anti-phosphorylated tau protein antibodies and methods for detecting alzheimer`s disease with the use of the same |
WO1998022120A1 (en) * | 1996-11-19 | 1998-05-28 | The Wistar Institute Of Anatomy & Biology | Diagnostic and therapeutic reagents for alzheimer's disease |
EP1301531A2 (en) * | 2000-07-11 | 2003-04-16 | Molecular Geriatrics Corporation | Reagents and methods for identification of binding agents |
US6514221B2 (en) | 2000-07-27 | 2003-02-04 | Brigham And Women's Hospital, Inc. | Blood-brain barrier opening |
WO2002017930A2 (en) | 2000-08-30 | 2002-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Glucocorticoid blocking agents for increasing blood-brain barrier permeability |
US7034036B2 (en) | 2000-10-30 | 2006-04-25 | Pain Therapeutics, Inc. | Inhibitors of ABC drug transporters at the blood-brain barrier |
US20030083299A1 (en) | 2000-11-04 | 2003-05-01 | Ferguson Ian A. | Non-invasive delivery of polypeptides through the blood-brain barrier |
DE10121982B4 (de) | 2001-05-05 | 2008-01-24 | Lts Lohmann Therapie-Systeme Ag | Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung |
US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
US20030162695A1 (en) | 2002-02-27 | 2003-08-28 | Schatzberg Alan F. | Glucocorticoid blocking agents for increasing blood-brain barrier permeability |
CN101284136A (zh) | 2002-12-03 | 2008-10-15 | 布朗歇特洛克菲勒神经科学研究所 | 传输物质穿过血脑屏障的人工低密度脂蛋白载体 |
WO2004058239A1 (en) | 2002-12-24 | 2004-07-15 | Neurochem (International) Limited | Therapeutic formulations for the treatment of beta-amyloid related diseases |
EP1663239A4 (en) | 2003-09-10 | 2008-07-23 | Cedars Sinai Medical Center | KALIUM CHANNEL-MEDIATED FEEDING OF MEDICINES BY THE BLOOD BRAIN BARRIER |
US7238788B2 (en) * | 2004-02-18 | 2007-07-03 | University Of Iowa Foundation | Antibodies to phosphorylated tau, methods of making and methods of use |
EP2465872A3 (en) * | 2004-10-25 | 2012-12-19 | Merck Sharp & Dohme Corporation | Anti-ADDL antibodies and uses thereof |
US8012936B2 (en) * | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
WO2008140639A2 (en) | 2007-02-08 | 2008-11-20 | Oligomerix, Inc. | Biomarkers and assays for alzheimer's disease |
US9555032B2 (en) | 2007-06-13 | 2017-01-31 | Research Development Foundation | Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating CRF receptor signaling |
KR20100115340A (ko) * | 2007-10-19 | 2010-10-27 | 이무나스 파마 가부시키가이샤 | Aβ 올리고머에 특이적으로 결합하는 항체 및 그의 이용 |
WO2010106127A2 (en) * | 2009-03-18 | 2010-09-23 | Ac Immune S.A. | Method for therapeutic use |
UA107571C2 (xx) * | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
CA2765099A1 (en) * | 2009-06-10 | 2010-12-16 | New York University | Phosphorylated tau peptide for use in the treatment of tauopathy |
JP2013500326A (ja) | 2009-07-30 | 2013-01-07 | ファイザー バクシーンズ エルエルシー | 抗原性タウペプチドおよびその使用 |
CA2812865C (en) * | 2010-10-07 | 2021-01-26 | Ac Immune S.A. | Phosphospecific antibodies recognising tau |
-
2011
- 2011-10-07 CA CA2812865A patent/CA2812865C/en active Active
- 2011-10-07 EP EP11773704.9A patent/EP2625198B1/en active Active
- 2011-10-07 CN CN201180058969.9A patent/CN103502272B/zh active Active
- 2011-10-07 PE PE2013000800A patent/PE20140218A1/es not_active Application Discontinuation
- 2011-10-07 MY MYPI2013700539A patent/MY164376A/en unknown
- 2011-10-07 ES ES11773704.9T patent/ES2548686T3/es active Active
- 2011-10-07 US US13/500,608 patent/US9304138B2/en active Active
- 2011-10-07 RU RU2013120544/10A patent/RU2603078C2/ru active
- 2011-10-07 MX MX2013003800A patent/MX338421B/es active IP Right Grant
- 2011-10-07 AU AU2011311516A patent/AU2011311516B2/en active Active
- 2011-10-07 HU HUE11773704A patent/HUE027649T2/en unknown
- 2011-10-07 WO PCT/EP2011/067604 patent/WO2012045882A2/en active Application Filing
- 2011-10-07 DK DK11773704.9T patent/DK2625198T3/en active
- 2011-10-07 SG SG2013023031A patent/SG189136A1/en unknown
- 2011-10-07 EP EP15177523.6A patent/EP2987807A3/en not_active Withdrawn
- 2011-10-07 KR KR1020137011715A patent/KR101988672B1/ko active IP Right Grant
- 2011-10-07 JP JP2013532226A patent/JP6371526B2/ja active Active
- 2011-10-07 PL PL11773704T patent/PL2625198T3/pl unknown
- 2011-10-07 TW TW100136670A patent/TW201216985A/zh unknown
- 2011-10-07 SI SI201130615T patent/SI2625198T1/sl unknown
- 2011-10-07 BR BR112013008333-6A patent/BR112013008333B1/pt active IP Right Grant
- 2011-10-11 AR ARP110103735A patent/AR085198A1/es unknown
-
2013
- 2013-03-04 ZA ZA2013/02432A patent/ZA201302432B/en unknown
- 2013-04-04 IL IL225568A patent/IL225568A/en active IP Right Grant
- 2013-04-05 CR CR20130160A patent/CR20130160A/es unknown
- 2013-04-05 CO CO13089514A patent/CO6710903A2/es unknown
- 2013-04-08 CL CL2013000951A patent/CL2013000951A1/es unknown
- 2013-05-07 EC ECSP13012609 patent/ECSP13012609A/es unknown
-
2014
- 2014-01-27 HK HK14100845.1A patent/HK1187928A1/zh unknown
-
2016
- 2016-02-17 US US15/045,804 patent/US10100104B2/en active Active
- 2016-04-25 HK HK16104710.3A patent/HK1216897A1/zh unknown
-
2017
- 2017-01-20 JP JP2017008740A patent/JP2017113004A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CR20130160A (es) | Anticuerpos fosfoespecificos que reconocen tau | |
LTPA2019518I1 (lt) | Antikūnai prieš IL-23 | |
LTPA2019011I1 (lt) | CGRP antikūnai | |
CY2017025I2 (el) | Αντιδοτα αντιπηκτικων | |
HK1200469A1 (en) | Phosphospecific antibodies recognising tau tau | |
BR112012030311A2 (pt) | anticorpo | |
DK3284754T3 (da) | Anti-cd38-antistoffer | |
IT1403054B1 (it) | Bottiglia. | |
DK3741883T3 (da) | Antistofbiblioteker | |
DK2651436T3 (da) | Mycobakterie antigen sammensætning. | |
CR20130228A (es) | Anticuerpos neutralizadores anti-ccl20 | |
AT509318B8 (de) | Abtrennverfahren | |
CO6791565A2 (es) | Anticuerpos anti-notch1 | |
DK2568821T3 (da) | Æggeskal-membran-separationsfremgangsmåde | |
BRPI0909633A2 (pt) | anticorpos anti-tyrp1 | |
IT1398416B1 (it) | Dispositivo elettrovalvolare. | |
DK2560767T3 (da) | Separator | |
IT1399382B1 (it) | Dispositivo. | |
FR2958509B1 (fr) | Canne | |
BR112013013105A2 (pt) | reconhecimento de posição | |
IT1398646B1 (it) | Dispositivo di separazione | |
FI9582U1 (fi) | Savupeltimoduuli | |
IT1401345B1 (it) | Bomboletta. | |
FR2966838B1 (fr) | Canne echantillon | |
FI20100138A0 (fi) | Määritysmenetelmä |