JP2017086084A5 - - Google Patents
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- JP2017086084A5 JP2017086084A5 JP2017017360A JP2017017360A JP2017086084A5 JP 2017086084 A5 JP2017086084 A5 JP 2017086084A5 JP 2017017360 A JP2017017360 A JP 2017017360A JP 2017017360 A JP2017017360 A JP 2017017360A JP 2017086084 A5 JP2017086084 A5 JP 2017086084A5
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- JP
- Japan
- Prior art keywords
- rodent
- human
- mouse
- antibody
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 32
- 238000003780 insertion Methods 0.000 claims description 22
- 230000037431 insertion Effects 0.000 claims description 22
- 230000000977 initiatory effect Effects 0.000 claims description 7
- 239000012634 fragment Substances 0.000 claims description 6
- 230000006801 homologous recombination Effects 0.000 claims description 5
- 238000002744 homologous recombination Methods 0.000 claims description 5
- 241000283984 Rodentia Species 0.000 claims 27
- 241000699666 Mus <mouse, genus> Species 0.000 claims 19
- 108020004414 DNA Proteins 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 4
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 4
- 230000003053 immunization Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 108091092195 Intron Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002779 inactivation Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000006798 recombination Effects 0.000 claims 2
- 238000005215 recombination Methods 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 241000282577 Pan troglodytes Species 0.000 claims 1
- 102000018120 Recombinases Human genes 0.000 claims 1
- 108010091086 Recombinases Proteins 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 description 4
- 239000013612 plasmid Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019197622A JP6930695B2 (ja) | 2009-07-08 | 2019-10-30 | 動物モデルおよび治療用分子 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22396009P | 2009-07-08 | 2009-07-08 | |
| US61/223,960 | 2009-07-08 | ||
| GBGB0911846.4A GB0911846D0 (en) | 2009-07-08 | 2009-07-08 | Animal models and therapeutic molecules |
| GB0911846.4 | 2009-07-08 | ||
| GB0913102A GB0913102D0 (en) | 2009-07-28 | 2009-07-28 | Animal models and therapeutic molesules |
| GB0913102.0 | 2009-07-28 | ||
| US35566610P | 2010-06-17 | 2010-06-17 | |
| US61/355,666 | 2010-06-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015022430A Division JP6088562B2 (ja) | 2009-07-08 | 2015-02-06 | 動物モデルおよび治療用分子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019197622A Division JP6930695B2 (ja) | 2009-07-08 | 2019-10-30 | 動物モデルおよび治療用分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017086084A JP2017086084A (ja) | 2017-05-25 |
| JP2017086084A5 true JP2017086084A5 (enExample) | 2019-07-04 |
| JP6612275B2 JP6612275B2 (ja) | 2019-11-27 |
Family
ID=43428834
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519063A Active JP5944312B2 (ja) | 2009-07-08 | 2010-07-07 | 動物モデルおよび治療用分子 |
| JP2015022430A Active JP6088562B2 (ja) | 2009-07-08 | 2015-02-06 | 動物モデルおよび治療用分子 |
| JP2017017360A Active JP6612275B2 (ja) | 2009-07-08 | 2017-02-02 | 動物モデルおよび治療用分子 |
| JP2019197622A Active JP6930695B2 (ja) | 2009-07-08 | 2019-10-30 | 動物モデルおよび治療用分子 |
| JP2020102977A Active JP7141427B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
| JP2020102976A Active JP6876853B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
| JP2020102978A Active JP6876854B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519063A Active JP5944312B2 (ja) | 2009-07-08 | 2010-07-07 | 動物モデルおよび治療用分子 |
| JP2015022430A Active JP6088562B2 (ja) | 2009-07-08 | 2015-02-06 | 動物モデルおよび治療用分子 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019197622A Active JP6930695B2 (ja) | 2009-07-08 | 2019-10-30 | 動物モデルおよび治療用分子 |
| JP2020102977A Active JP7141427B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
| JP2020102976A Active JP6876853B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
| JP2020102978A Active JP6876854B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
Country Status (22)
| Country | Link |
|---|---|
| US (33) | US20120204278A1 (enExample) |
| EP (19) | EP3028565B1 (enExample) |
| JP (7) | JP5944312B2 (enExample) |
| KR (1) | KR101875233B1 (enExample) |
| CN (2) | CN102638971B (enExample) |
| AU (4) | AU2010269978B2 (enExample) |
| BR (1) | BR112012000536A2 (enExample) |
| CA (1) | CA2767436A1 (enExample) |
| CY (1) | CY1126083T1 (enExample) |
| DK (12) | DK2421357T3 (enExample) |
| ES (10) | ES2948572T3 (enExample) |
| HR (2) | HRP20130253T1 (enExample) |
| HU (2) | HUE055817T2 (enExample) |
| LT (1) | LT3241435T (enExample) |
| NO (1) | NO2792236T3 (enExample) |
| NZ (1) | NZ597481A (enExample) |
| PL (4) | PL3241435T3 (enExample) |
| PT (4) | PT3241435T (enExample) |
| SG (2) | SG177380A1 (enExample) |
| SI (2) | SI3241435T1 (enExample) |
| SM (1) | SMT201300046B (enExample) |
| WO (1) | WO2011004192A1 (enExample) |
Families Citing this family (131)
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| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
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| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| EP3028565B1 (en) | 2009-07-08 | 2017-09-27 | Kymab Limited | Animal models and therapeutic molecules |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SMT201900372T1 (it) | 2010-02-08 | 2019-09-09 | Regeneron Pharma | Topo con catena leggera comune |
| KR102004106B1 (ko) | 2010-03-31 | 2019-07-25 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
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| HUE068728T2 (hu) * | 2011-08-05 | 2025-01-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
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| EP2757875B2 (en) * | 2011-09-19 | 2023-03-22 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| GB2495083A (en) * | 2011-09-26 | 2013-04-03 | Kymab Ltd | Human VpreB and chimaeric surrogate light chains in transgenic non-human vertebrates |
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| CA2850745C (en) | 2011-10-03 | 2022-12-13 | Duke University | Vaccine |
| PL3216871T3 (pl) * | 2011-10-17 | 2022-03-21 | Regeneron Pharmaceuticals, Inc. | Ograniczony łańcuch ciężki immonoglobuliny pochodzącej od myszy |
| CN104011071B (zh) * | 2011-10-28 | 2017-11-07 | 瑞泽恩制药公司 | T细胞受体基因修饰小鼠 |
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| KR102295746B1 (ko) * | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
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