JP2017081939A5

JP2017081939A5 -

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Publication number: JP2017081939A5
Authority: JP; Japan
Prior art keywords: seq; amino acid; chimeric polypeptide; sequence; leptin
Prior art date: 2016-12-02
Legal status : Granted

Application number

JP2016235165A

Other languages

English (en)

Japanese (ja)

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JP6608799B2 (ja

JP2017081939A (ja

Filing date

2016-12-02

Publication date

2017-10-12

2016-12-02 Application filed filed Critical

2017-05-18 Publication of JP2017081939A publication Critical patent/JP2017081939A/ja

2017-10-12 Publication of JP2017081939A5 publication Critical patent/JP2017081939A5/ja

2019-11-20 Application granted granted Critical

2019-11-20 Publication of JP6608799B2 publication Critical patent/JP6608799B2/ja

Status Active legal-status Critical Current

2031-09-28 Anticipated expiration legal-status Critical

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NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical group O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 40
108090000765 processed proteins & peptides Proteins 0.000 claims 38
229920001184 polypeptide Polymers 0.000 claims 37
102000004196 processed proteins & peptides Human genes 0.000 claims 37
125000003275 alpha amino acid group Chemical group 0.000 claims 36
101001063991 Homo sapiens Leptin Proteins 0.000 claims 24
102000049953 human LEP Human genes 0.000 claims 24
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 16
102000016267 Leptin Human genes 0.000 claims 14
108010092277 Leptin Proteins 0.000 claims 14
229940039781 leptin Drugs 0.000 claims 13
241000894007 species Species 0.000 claims 10
238000006467 substitution reaction Methods 0.000 claims 10
201000010099 disease Diseases 0.000 claims 8
208000035475 disorder Diseases 0.000 claims 8
238000000034 method Methods 0.000 claims 7
150000001413 amino acids Chemical class 0.000 claims 5
208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
206010049287 Lipodystrophy acquired Diseases 0.000 claims 3
208000008589 Obesity Diseases 0.000 claims 3
230000007812 deficiency Effects 0.000 claims 3
208000006132 lipodystrophy Diseases 0.000 claims 3
235000020824 obesity Nutrition 0.000 claims 3
208000024827 Alzheimer disease Diseases 0.000 claims 2
201000000736 Amenorrhea Diseases 0.000 claims 2
206010001928 Amenorrhoea Diseases 0.000 claims 2
208000032928 Dyslipidaemia Diseases 0.000 claims 2
208000031226 Hyperlipidaemia Diseases 0.000 claims 2
208000017170 Lipid metabolism disease Diseases 0.000 claims 2
206010033307 Overweight Diseases 0.000 claims 2
231100000540 amenorrhea Toxicity 0.000 claims 2
206010012601 diabetes mellitus Diseases 0.000 claims 2
208000010706 fatty liver disease Diseases 0.000 claims 2
230000002267 hypothalamic effect Effects 0.000 claims 2
206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
208000023105 Huntington disease Diseases 0.000 claims 1
208000001145 Metabolic Syndrome Diseases 0.000 claims 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
201000010390 abdominal obesity-metabolic syndrome 1 Diseases 0.000 claims 1
208000011661 metabolic syndrome X Diseases 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1

JP2016235165A 2010-09-28 2016-12-02 高可溶性レプチン Active JP6608799B2 (ja)