JP6174489B2 - 高可溶性レプチン - Google Patents

高可溶性レプチン Download PDF

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Publication number
JP6174489B2
JP6174489B2 JP2013531786A JP2013531786A JP6174489B2 JP 6174489 B2 JP6174489 B2 JP 6174489B2 JP 2013531786 A JP2013531786 A JP 2013531786A JP 2013531786 A JP2013531786 A JP 2013531786A JP 6174489 B2 JP6174489 B2 JP 6174489B2
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seq
leptin
polypeptide
sequence
amino acid
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Japanese (ja)
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JP2013543497A5 (OSRAM
JP2013543497A (ja
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メアリー・エリクソン
Original Assignee
アエゲリオン ファーマシューティカルズ，インコーポレイテッド
アエゲリオン ファーマシューティカルズ，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013531786A 2010-09-28 2011-09-28 高可溶性レプチン Active JP6174489B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38740210P 2010-09-28 2010-09-28
US61/387,402 2010-09-28
US42209110P 2010-12-10 2010-12-10
US61/422,091 2010-12-10
PCT/US2011/053774 WO2012050925A2 (en) 2010-09-28 2011-09-28 Highly soluble leptins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016235165A Division JP6608799B2 (ja) 2010-09-28 2016-12-02 高可溶性レプチン

Publications (3)

Publication Number Publication Date
JP2013543497A JP2013543497A (ja) 2013-12-05
JP2013543497A5 JP2013543497A5 (OSRAM) 2014-11-13
JP6174489B2 true JP6174489B2 (ja) 2017-08-02

Family

ID=45938879

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2013531789A Pending JP2014502252A (ja) 2010-09-28 2011-09-28 作用持続時間が増した改変ポリペプチド
JP2013531786A Active JP6174489B2 (ja) 2010-09-28 2011-09-28 高可溶性レプチン
JP2016235165A Active JP6608799B2 (ja) 2010-09-28 2016-12-02 高可溶性レプチン
JP2017036849A Active JP6412183B2 (ja) 2010-09-28 2017-02-28 作用持続時間が増した改変ポリペプチド
JP2019193539A Pending JP2020033366A (ja) 2010-09-28 2019-10-24 高可溶性レプチン

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2013531789A Pending JP2014502252A (ja) 2010-09-28 2011-09-28 作用持続時間が増した改変ポリペプチド

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2016235165A Active JP6608799B2 (ja) 2010-09-28 2016-12-02 高可溶性レプチン
JP2017036849A Active JP6412183B2 (ja) 2010-09-28 2017-02-28 作用持続時間が増した改変ポリペプチド
JP2019193539A Pending JP2020033366A (ja) 2010-09-28 2019-10-24 高可溶性レプチン

Country Status (14)

Country Link
US (6) US20130203661A1 (OSRAM)
EP (4) EP3305315A1 (OSRAM)
JP (5) JP2014502252A (OSRAM)
CN (2) CN103403019B (OSRAM)
BR (3) BR112013007385B1 (OSRAM)
CA (3) CA2813087C (OSRAM)
CY (2) CY1119023T1 (OSRAM)
DK (3) DK2621515T3 (OSRAM)
EA (2) EA024507B1 (OSRAM)
ES (3) ES2873253T3 (OSRAM)
MX (2) MX351128B (OSRAM)
PL (1) PL3241558T3 (OSRAM)
PT (2) PT2621515T (OSRAM)
WO (2) WO2012050930A2 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017081939A (ja) * 2010-09-28 2017-05-18 アエゲリオン ファーマシューティカルズ，インコーポレイテッド 高可溶性レプチン

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CN104662035A (zh) * 2012-09-25 2015-05-27 阿菲博迪公司 白蛋白结合多肽
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KR20180045001A (ko) 2015-09-22 2018-05-03 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 개질된 세포독소 및 이의 치료 용도
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KR102613874B1 (ko) * 2017-01-30 2023-12-15 알렉시온 파마슈티칼스, 인코포레이티드 1가 항-프로페르딘 항체 및 항체 단편
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