JP2016538344A - 癌処置としてのstingアゴニストの使用 - Google Patents
癌処置としてのstingアゴニストの使用 Download PDFInfo
- Publication number
- JP2016538344A JP2016538344A JP2016554555A JP2016554555A JP2016538344A JP 2016538344 A JP2016538344 A JP 2016538344A JP 2016554555 A JP2016554555 A JP 2016554555A JP 2016554555 A JP2016554555 A JP 2016554555A JP 2016538344 A JP2016538344 A JP 2016538344A
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- tumor
- sting
- cancer
- cells
- mice
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361906330P | 2013-11-19 | 2013-11-19 | |
| US61/906,330 | 2013-11-19 | ||
| PCT/US2014/066436 WO2015077354A1 (en) | 2013-11-19 | 2014-11-19 | Use of sting agonist as cancer treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016538344A true JP2016538344A (ja) | 2016-12-08 |
| JP2016538344A5 JP2016538344A5 (enExample) | 2018-02-01 |
Family
ID=53180098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554555A Pending JP2016538344A (ja) | 2013-11-19 | 2014-11-19 | 癌処置としてのstingアゴニストの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20160287623A1 (enExample) |
| EP (1) | EP3071209A4 (enExample) |
| JP (1) | JP2016538344A (enExample) |
| WO (1) | WO2015077354A1 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020505016A (ja) * | 2017-01-06 | 2020-02-20 | シンロジック オペレーティング カンパニー インコーポレイテッド | 腫瘍細胞において免疫モジュレーターおよび抗がん治療剤を産生するようにプログラムされた微生物 |
| JP2020530838A (ja) * | 2017-08-04 | 2020-10-29 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | がん治療のためのベンゾ[b]チオフェンSTINGアゴニスト |
| JP2020532542A (ja) * | 2017-08-31 | 2020-11-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗癌剤としての環状ジヌクレオチド |
| JP2020532529A (ja) * | 2017-08-31 | 2020-11-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗癌剤としての環状ジヌクレオチド |
| JP2021520345A (ja) * | 2018-04-03 | 2021-08-19 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物 |
| JP2022500476A (ja) * | 2018-09-21 | 2022-01-04 | シャンハイ ドーァ ノボ ファーマテック カンパニー,リミティド | 環状ジヌクレオチド類似体、その医薬組成物及び使用 |
| US11723932B2 (en) | 2016-01-11 | 2023-08-15 | Synlogic Operating Company, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
| JP2023553352A (ja) * | 2020-11-26 | 2023-12-21 | ザ プロヴォスト,フェローズ,ファンデーション スカラーズ,アンド ジ アザー メンバーズ オブ ボード,オブ ザ カレッジ オブ ザ ホーリー アンド アンディヴァイデッド トリニティ オブ クイーン エリザベス ニア ダブリン | ガンのための免疫療法 |
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| CN107648668B (zh) | 2010-10-06 | 2021-06-18 | 哈佛学院董事会 | 用于基于材料的细胞疗法的可注射的成孔水凝胶 |
| CN104244929B (zh) | 2012-04-16 | 2017-04-05 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| AU2013358892B2 (en) | 2012-12-13 | 2018-06-21 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| EP2943565B1 (en) | 2013-01-14 | 2018-03-28 | Fred Hutchinson Cancer Research Center | Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse |
| JP2016524593A (ja) | 2013-04-29 | 2016-08-18 | メモリアル スローン−ケタリング キャンサー センター | セカンドメッセンジャーのシグナル伝達を変えるための組成物及び方法 |
| ES2822584T3 (es) | 2013-05-03 | 2021-05-04 | Univ California | Inducción de dinucleótidos cíclicos del interferón tipo I |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| PE20160080A1 (es) | 2013-05-18 | 2016-02-21 | Aduro Biotech Inc | Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon |
| WO2015017652A1 (en) | 2013-07-31 | 2015-02-05 | Memorial Sloan-Kettering Cancer Center | Sting crystals and modulators |
| US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| JP6462006B2 (ja) | 2014-06-04 | 2019-01-30 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Stingのモジュレーターとしての環式ジヌクレオチド |
| CN107148424B (zh) | 2014-12-16 | 2021-01-08 | 凯拉治疗股份公司 | 用于诱导细胞因子的环状二核苷酸 |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US10449211B2 (en) | 2015-03-10 | 2019-10-22 | Aduro Biotech, Inc. | Compositions and methods for activating “stimulator of interferon gene”—dependent signalling |
| AU2016259020B2 (en) | 2015-05-07 | 2021-12-09 | Baylor College Of Medicine | Dendritic cell immunotherapy |
| WO2017011444A1 (en) * | 2015-07-13 | 2017-01-19 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for treating b cell cancers |
| US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| EA034786B1 (ru) | 2015-08-13 | 2020-03-20 | Мерк Шарп И Доум Корп. | Циклические динуклеотидные соединения в качестве агонистов sting |
| US10322177B2 (en) | 2015-10-07 | 2019-06-18 | Nant Holdings Ip, Llc | Activation of immune-related signaling pathways in cells via optofection |
| EP3368072A4 (en) | 2015-10-28 | 2019-07-03 | Aduro BioTech, Inc. | COMPOSITIONS AND METHOD FOR ACTIVATING SIGNALING DEPENDENT ON THE STIMULATOR OF THE INTERFERON GENE |
| RU2020113165A (ru) | 2015-12-03 | 2020-06-09 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Циклические пуриновые динуклеотиды в качестве модуляторов sting |
| SMT202500412T1 (it) | 2016-01-11 | 2025-11-10 | Innate Tumor Immunity Inc | Dinucleotidi ciclici per il trattamento di condizioni associate all’attività di sting quali il cancro |
| US10723756B2 (en) | 2016-01-11 | 2020-07-28 | Innate Tumor Immunity Inc. | Cyclic dinucleotides for treating conditions associated with STING activity such as cancer |
| NZ746112A (en) | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| JP2019510802A (ja) | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | タンパク質調節物質として有用な複素環アミド |
| CN113549110B (zh) | 2016-04-07 | 2024-08-16 | 葛兰素史密斯克莱知识产权发展有限公司 | 用作蛋白质调节剂的杂环酰胺 |
| US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| EP3493842A4 (en) | 2016-08-02 | 2020-07-29 | President and Fellows of Harvard College | BIOMATERIALS TO MODULATE IMMUNE RESPONSES |
| KR102497742B1 (ko) | 2016-08-30 | 2023-02-10 | 다나-파버 캔서 인스티튜트 인크. | 약물 전달 조성물 및 그의 용도 |
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| EP3523314A1 (de) | 2016-10-07 | 2019-08-14 | Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb GmbH | Benzimidazolhaltige cyclische dinukleotide, verfahren zu deren herstellung und ihre verwendung zur aktivierung von stimulator von interferongenen (sting)-abhängigen signalwegen |
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| JP7209697B2 (ja) | 2017-08-31 | 2023-01-20 | ブリストル-マイヤーズ スクイブ カンパニー | 抗癌剤としての環状ジヌクレオチド |
| JP2020532542A (ja) * | 2017-08-31 | 2020-11-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗癌剤としての環状ジヌクレオチド |
| JP2021520345A (ja) * | 2018-04-03 | 2021-08-19 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物 |
| JP7326319B2 (ja) | 2018-04-03 | 2023-08-15 | メルク・シャープ・アンド・ドーム・エルエルシー | Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物 |
| JP2022500476A (ja) * | 2018-09-21 | 2022-01-04 | シャンハイ ドーァ ノボ ファーマテック カンパニー,リミティド | 環状ジヌクレオチド類似体、その医薬組成物及び使用 |
| JP7218431B2 (ja) | 2018-09-21 | 2023-02-06 | シャンハイ ドーァ ノボ ファーマテック カンパニー,リミティド | 環状ジヌクレオチド類似体、その医薬組成物及び使用 |
| US12152051B2 (en) | 2018-09-21 | 2024-11-26 | Shanghai De Novo Pharmatech Co., Ltd. | Cyclic dinucleotide analogue, pharmaceutical composition thereof, and application |
| JP2023553352A (ja) * | 2020-11-26 | 2023-12-21 | ザ プロヴォスト,フェローズ,ファンデーション スカラーズ,アンド ジ アザー メンバーズ オブ ボード,オブ ザ カレッジ オブ ザ ホーリー アンド アンディヴァイデッド トリニティ オブ クイーン エリザベス ニア ダブリン | ガンのための免疫療法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3071209A4 (en) | 2017-08-16 |
| EP3071209A1 (en) | 2016-09-28 |
| US20180028553A1 (en) | 2018-02-01 |
| US20160287623A1 (en) | 2016-10-06 |
| WO2015077354A1 (en) | 2015-05-28 |
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