|
EP2734621B1
(en)
|
2011-07-22 |
2019-09-04 |
President and Fellows of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
EP3653212B1
(en)
|
2012-12-20 |
2023-04-26 |
Purdue Research Foundation |
Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
|
|
CA2908697C
(en)
|
2013-04-16 |
2023-12-12 |
Regeneron Pharmaceuticals, Inc. |
Targeted modification of rat genome
|
|
ES2883131T3
(es)
|
2013-05-29 |
2021-12-07 |
Cellectis |
Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
EP3418379B1
(en)
|
2013-09-18 |
2020-12-09 |
Kymab Limited |
Methods, cells & organisms
|
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
|
JP2016536021A
(ja)
|
2013-11-07 |
2016-11-24 |
エディタス・メディシン，インコーポレイテッド |
ＣＲＩＳＰＲ関連方法および支配ｇＲＮＡのある組成物
|
|
CA2929181A1
(en)
*
|
2013-11-13 |
2015-05-21 |
Novartis Ag |
Mtor inhibitors for enhancing the immune response
|
|
US10801070B2
(en)
|
2013-11-25 |
2020-10-13 |
The Broad Institute, Inc. |
Compositions and methods for diagnosing, evaluating and treating cancer
|
|
US11725237B2
(en)
|
2013-12-05 |
2023-08-15 |
The Broad Institute Inc. |
Polymorphic gene typing and somatic change detection using sequencing data
|
|
SG10201700961TA
(en)
|
2013-12-11 |
2017-04-27 |
Regeneron Pharma |
Methods and compositions for the targeted modification of a genome
|
|
EP3080260B1
(en)
|
2013-12-12 |
2019-03-06 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
JP7060324B2
(ja)
|
2013-12-20 |
2022-04-26 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
ネオ抗原ワクチンによる併用療法
|
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
DE212015000061U1
(de)
|
2014-02-11 |
2017-09-03 |
The Regents Of The University Of Colorado, A Body Corporate |
CRISPR-ermöglichtes Multiplex Genom Engineering
|
|
US10836998B2
(en)
|
2014-02-14 |
2020-11-17 |
Cellectis |
Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
|
|
WO2015155686A2
(en)
|
2014-04-08 |
2015-10-15 |
North Carolina State University |
Methods and compositions for rna-directed repression of transcription using crispr-associated genes
|
|
EP3129473B8
(en)
|
2014-04-11 |
2020-12-23 |
Cellectis |
Method for generating immune cells resistant to arginine and/or tryptophan depleted microenvironment
|
|
JP2017513477A
(ja)
*
|
2014-04-14 |
2017-06-01 |
マックスサイト インコーポレーティッド |
ゲノムｄｎａを改変するための方法および組成物
|
|
US20170175128A1
(en)
*
|
2014-04-18 |
2017-06-22 |
Editas Medicine, Inc. |
Crispr-cas-related methods, compositions and components for cancer immunotherapy
|
|
WO2016011210A2
(en)
|
2014-07-15 |
2016-01-21 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
CA2956224A1
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US10450584B2
(en)
|
2014-08-28 |
2019-10-22 |
North Carolina State University |
Cas9 proteins and guiding features for DNA targeting and genome editing
|
|
AU2015339743C1
(en)
|
2014-10-31 |
2021-04-22 |
The Trustees Of The University Of Pennsylvania |
Altering gene expression in modified T cells and uses thereof
|
|
EP3025719B1
(en)
|
2014-11-26 |
2018-09-26 |
Miltenyi Biotec GmbH |
Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
|
|
GB201421096D0
(en)
*
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
US10900034B2
(en)
|
2014-12-03 |
2021-01-26 |
Agilent Technologies, Inc. |
Guide RNA with chemical modifications
|
|
EP4310097A3
(en)
|
2014-12-05 |
2024-04-03 |
Memorial Sloan Kettering Cancer Center |
Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof
|
|
PT3227339T
(pt)
*
|
2014-12-05 |
2022-01-14 |
Eureka Therapeutics Inc |
Recetores de antigénio quiméricos que têm como alvo o recetor 4 acoplado a proteína g e utilizações dos mesmos
|
|
SG11201704550XA
(en)
|
2014-12-05 |
2017-07-28 |
Memorial Sloan Kettering Cancer Center |
Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof
|
|
CA2969877A1
(en)
|
2014-12-05 |
2016-06-09 |
Memorial Sloan-Kettering Cancer Center |
Antibodies targeting b-cell maturation antigen and methods of use
|
|
KR20230159637A
(ko)
|
2014-12-05 |
2023-11-21 |
메모리얼 슬로안 케터링 캔서 센터 |
G-단백질 커플화 수용체를 표적화하는 항체 및 이의 사용 방법
|
|
EP3233095A2
(en)
*
|
2014-12-17 |
2017-10-25 |
Cellectis |
INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR OR N-CAR) EXPRESSING NON-T CELL TRANSDUCTION DOMAIN
|
|
EP4636401A2
(en)
|
2014-12-19 |
2025-10-22 |
The Broad Institute, Inc. |
Methods for profiling the t-cell-receptor repertoire
|
|
WO2016100975A1
(en)
|
2014-12-19 |
2016-06-23 |
Massachsetts Institute Ot Technology |
Molecular biomarkers for cancer immunotherapy
|
|
US20190054117A1
(en)
*
|
2014-12-19 |
2019-02-21 |
Novartis Ag |
Dimerization switches and uses thereof
|
|
US20180002435A1
(en)
*
|
2015-01-26 |
2018-01-04 |
Cellectis |
mAb-DRIVEN CHIMERIC ANTIGEN RECEPTOR SYSTEMS FOR SORTING/DEPLETING ENGINEERED IMMUNE CELLS
|
|
JP6886404B2
(ja)
*
|
2015-01-30 |
2021-06-16 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ |
初代造血細胞におけるタンパク質送達
|
|
AU2016214301B2
(en)
*
|
2015-02-06 |
2022-05-19 |
Cellectis |
Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles
|
|
CN113713091A
(zh)
|
2015-02-06 |
2021-11-30 |
新加坡国立大学 |
工程免疫细胞及其用途和生产方法
|
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
|
US20180245073A1
(en)
*
|
2015-02-23 |
2018-08-30 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
KR20170137079A
(ko)
*
|
2015-03-11 |
2017-12-12 |
셀렉티스 |
그것들의 지속을 증가시키기 위한 동종이계 t 세포의 조작 및/또는 환자들 내로 이식 방법들
|
|
CN115537396A
(zh)
*
|
2015-03-27 |
2022-12-30 |
哈佛学院校长同事会 |
经过修饰的t细胞及其制备和使用方法
|
|
US20180080051A1
(en)
*
|
2015-03-31 |
2018-03-22 |
Exeligen Scientific, Inc. |
Cas 9 retroviral integrase and cas 9 recombinase systems for targeted incorporation of a dna sequence into a genome of a cell or organism
|
|
KR102888521B1
(ko)
|
2015-04-06 |
2025-11-19 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna
|
|
JP6921001B2
(ja)
|
2015-04-13 |
2021-08-18 |
ファイザー・インク |
Ｂ細胞成熟抗原を標的にするキメラ抗原受容体
|
|
KR20170135966A
(ko)
*
|
2015-04-13 |
2017-12-08 |
맥스시티 인코포레이티드 |
게놈 dna를 변형시키기 위한 방법 및 조성물
|
|
WO2016167300A1
(ja)
*
|
2015-04-13 |
2016-10-20 |
国立大学法人東京大学 |
光依存的に又は薬物存在下でヌクレアーゼ活性若しくはニッカーゼ活性を示す、又は標的遺伝子の発現を抑制若しくは活性化するポリペプチドのセット
|
|
CN107921148A
(zh)
|
2015-05-08 |
2018-04-17 |
哈佛学院校长同事会 |
通用供体干细胞和相关方法
|
|
MX2017014822A
(es)
|
2015-05-18 |
2018-04-30 |
Tcr2 Therapeutics Inc |
Composiciones y métodos para la reprogramación del tcr con proteínas de fusión.
|
|
MX2017014700A
(es)
|
2015-05-20 |
2018-08-15 |
Broad Inst Inc |
Neoantigenos compartidos.
|
|
WO2016185443A1
(en)
|
2015-05-20 |
2016-11-24 |
Novartis Ag |
Pharmaceutical combination of everolimus with dactolisib
|
|
MX2017015239A
(es)
*
|
2015-05-29 |
2018-02-19 |
Juno Therapeutics Inc |
Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas.
|
|
AU2016270649B2
(en)
|
2015-05-29 |
2022-04-21 |
North Carolina State University |
Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids
|
|
ES2960226T3
(es)
|
2015-06-15 |
2024-03-01 |
Univ North Carolina State |
Métodos y composiciones para la administración eficiente de ácidos nucleicos y antimicrobianos basados en ARN
|
|
AU2016278959A1
(en)
*
|
2015-06-17 |
2018-01-18 |
The Uab Research Foundation |
CRISPR/Cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
|
JP2018518182A
(ja)
|
2015-06-17 |
2018-07-12 |
ザ ユーエービー リサーチ ファンデーション |
ゲノム編集のためのｃｒｉｓｐｒ／ｃａｓ９複合体
|
|
WO2016205749A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
WO2016205688A2
(en)
|
2015-06-18 |
2016-12-22 |
Bowles Robert D |
Rna-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
US11414657B2
(en)
|
2015-06-29 |
2022-08-16 |
Ionis Pharmaceuticals, Inc. |
Modified CRISPR RNA and modified single CRISPR RNA and uses thereof
|
|
JP7245647B2
(ja)
*
|
2015-07-15 |
2023-03-24 |
ジュノー セラピューティクス インコーポレイテッド |
養子細胞療法用の操作された細胞
|
|
US20170020922A1
(en)
*
|
2015-07-16 |
2017-01-26 |
Batu Biologics Inc. |
Gene editing for immunological destruction of neoplasia
|
|
US10676735B2
(en)
|
2015-07-22 |
2020-06-09 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
IL295616A
(en)
*
|
2015-07-31 |
2022-10-01 |
Us Health |
Adapted cells and treatment methods
|
|
MX2018001776A
(es)
*
|
2015-08-11 |
2018-06-06 |
Cellectis |
Celulas para inmunoterapia modificadas geneticamente para dirigirse al antigeno cd38 y para la inactivacion del gen cd38.
|
|
CN108351350B
(zh)
|
2015-08-25 |
2022-02-18 |
杜克大学 |
使用rna指导型内切核酸酶改善基因组工程特异性的组合物和方法
|
|
WO2017040324A1
(en)
*
|
2015-08-28 |
2017-03-09 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for cells expressing a chimeric intracellular signaling molecule
|
|
HK1259026A1
(zh)
|
2015-09-18 |
2019-11-22 |
综合医院公司以麻省总医院名义经营 |
用於治疗癌症的抗趋除剂的局部递送
|
|
WO2017049266A2
(en)
*
|
2015-09-18 |
2017-03-23 |
The Regents Of The University Of California |
Methods for autocatalytic genome editing and neutralizing autocatalytic genome editing and compositions thereof
|
|
WO2017058751A1
(en)
|
2015-09-28 |
2017-04-06 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
EP3356520B1
(en)
|
2015-10-02 |
2022-03-23 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Lentiviral protein delivery system for rna-guided genome editing
|
|
DK3359184T3
(da)
*
|
2015-10-05 |
2020-06-15 |
Prec Biosciences Inc |
Genetisk modificerede celler, der omfatter et modificeret gen fra konstant alfaregion i human t-cellereceptor
|
|
DK3359660T3
(en)
|
2015-10-05 |
2020-02-17 |
Prec Biosciences Inc |
Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene
|
|
WO2017069958A2
(en)
|
2015-10-09 |
2017-04-27 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
US11970710B2
(en)
|
2015-10-13 |
2024-04-30 |
Duke University |
Genome engineering with Type I CRISPR systems in eukaryotic cells
|
|
MX2018004546A
(es)
|
2015-10-16 |
2019-04-15 |
Univ Columbia |
Composiciones y métodos para la inhibicion de antígenos específicos de linaje.
|
|
AU2016340078A1
(en)
*
|
2015-10-16 |
2018-04-12 |
Temple University - Of The Commonwealth System Of Higher Education |
Methods and compositions utilizing Cpf1 for RNA-guided gene editing
|
|
WO2017070429A1
(en)
*
|
2015-10-22 |
2017-04-27 |
Regents Of The University Of Minnesota |
Methods involving editing polynucleotides that encode t cell receptor
|
|
EP4434589A3
(en)
|
2015-10-23 |
2025-05-14 |
President and Fellows of Harvard College |
Evolved cas9 proteins for gene editing
|
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
AU2016349280B2
(en)
*
|
2015-11-04 |
2023-10-05 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for gene editing in hematopoietic stem cells
|
|
WO2017087708A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
|
IL259576B
(en)
|
2015-12-04 |
2022-09-01 |
Novartis Ag |
grna molecule containing tracr and crrna, pharmaceutical composition containing it and method for preparing cells for immunotherapy
|
|
BR112018011336A2
(pt)
|
2015-12-04 |
2018-12-04 |
Memorial Sloan-Kettering Cancer Center |
anticorpo anti-fcrl5 isolado ou um fragmento de ligação ao antígeno do mesmo, anticorpo scfv anti-fcrl5 isolado, anticorpo isolado ou porção de ligação ao antígeno do mesmo, composição, imunoconjugado, molécula biespecífica, ácido nucleico isolado, vetor de expressão, célula hospedeira, método para detectar fcrl5 em uma célula ou tecido inteiro, método para tratar câncer em um indivíduo, uso do anticorpo ou fragmento de ligação ao antígeno do mesmo, kit para tratar câncer
|
|
WO2017106528A2
(en)
*
|
2015-12-18 |
2017-06-22 |
Sangamo Biosciences, Inc. |
Targeted disruption of the t cell receptor
|
|
WO2017112620A1
(en)
|
2015-12-22 |
2017-06-29 |
North Carolina State University |
Methods and compositions for delivery of crispr based antimicrobials
|
|
CN106967681B
(zh)
*
|
2016-01-13 |
2020-06-05 |
北京马力喏生物科技有限公司 |
治疗脑胶质母细胞瘤的治疗组合物
|
|
CN106967685B
(zh)
*
|
2016-01-13 |
2020-06-02 |
北京马力喏生物科技有限公司 |
共表达抗EGFRvIII嵌合抗原受体和免疫检查点抑制分子的转基因淋巴细胞及其用途
|
|
EA201891641A1
(ru)
|
2016-01-21 |
2019-01-31 |
Пфайзер Инк. |
Химерные антигенные рецепторы, нацеленные на вариант iii рецептора эпидермального фактора роста
|
|
KR102587132B1
(ko)
*
|
2016-03-04 |
2023-10-11 |
에디타스 메디신, 인코포레이티드 |
암 면역요법을 위한 crispr-cpf1-관련 방법, 조성물 및 구성성분
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
CA3020330A1
(en)
*
|
2016-04-07 |
2017-10-12 |
Bluebird Bio, Inc. |
Chimeric antigen receptor t cell compositions
|
|
EP3439675A4
(en)
|
2016-04-08 |
2019-12-18 |
Purdue Research Foundation |
METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
WO2017178585A1
(en)
*
|
2016-04-15 |
2017-10-19 |
Cellectis |
A method of engineering drug-specific hypersensitive t-cells for immunotherapy by gene inactivation
|
|
SG11201808831TA
(en)
|
2016-04-15 |
2018-11-29 |
Memorial Sloan Kettering Cancer Center |
Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
|
|
EP3446119A1
(en)
|
2016-04-18 |
2019-02-27 |
The Broad Institute Inc. |
Improved hla epitope prediction
|
|
CN107304434A
(zh)
*
|
2016-04-25 |
2017-10-31 |
上海宇玫博生物科技有限公司 |
一种免疫细胞治疗的双功能新型载体
|
|
CA3022611A1
(en)
*
|
2016-05-06 |
2017-11-09 |
Juno Therapeutics, Inc. |
Genetically engineered cells and methods of making the same
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
CN109688820B
(zh)
|
2016-06-24 |
2023-01-10 |
科罗拉多州立大学董事会（法人团体） |
用于生成条形码化组合文库的方法
|
|
WO2018007263A1
(en)
*
|
2016-07-06 |
2018-01-11 |
Cellectis |
Sequential gene editing in primary immune cells
|
|
EP4275747A3
(en)
|
2016-07-19 |
2024-01-24 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
CA3032498A1
(en)
|
2016-08-02 |
2018-02-08 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
WO2018027036A1
(en)
|
2016-08-03 |
2018-02-08 |
Dipersio John F |
Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
|
|
JP7231935B2
(ja)
|
2016-08-03 |
2023-03-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
アデノシン核酸塩基編集因子およびそれらの使用
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
WO2018031762A1
(en)
*
|
2016-08-10 |
2018-02-15 |
Duke University |
Compositions, systems and methods for programming immune cell function through targeted gene regulation
|
|
ES2998057T3
(en)
|
2016-08-12 |
2025-02-18 |
Toolgen Inc |
Manipulated immunoregulatory element and immunity altered thereby
|
|
WO2018035364A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute Inc. |
Product and methods useful for modulating and evaluating immune responses
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
WO2018049025A2
(en)
|
2016-09-07 |
2018-03-15 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
CN109715199A
(zh)
|
2016-09-14 |
2019-05-03 |
詹森生物科技公司 |
包含bcma特异性iii型纤连蛋白结构域的嵌合抗原受体及其用途
|
|
WO2018064208A1
(en)
|
2016-09-28 |
2018-04-05 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
MA46354A
(fr)
|
2016-10-03 |
2019-08-07 |
Juno Therapeutics Inc |
Molécules se liant spécifiquement au vph
|
|
MX2019003899A
(es)
|
2016-10-07 |
2019-08-14 |
Tcr2 Therapeutics Inc |
Composiciones y metodos para reprogramacion de receptores de linfocitos t mediante el uso de proteinas de fusion.
|
|
WO2018067991A1
(en)
|
2016-10-07 |
2018-04-12 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
AU2017342543B2
(en)
|
2016-10-14 |
2024-06-27 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
EP4338799A3
(en)
|
2016-10-18 |
2024-06-05 |
Regents of the University of Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
WO2018073393A2
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
|
|
WO2018073394A1
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Cell death inducing chimeric antigen receptors
|
|
US11873511B2
(en)
|
2016-10-19 |
2024-01-16 |
Cellectis |
Targeted gene insertion for improved immune cells therapy
|
|
JP7236380B2
(ja)
*
|
2016-10-19 |
2023-03-09 |
セレクティス |
治療に適したｔａｌエフェクターヌクレアーゼ（ｔａｌｅｎ）改変同種異系細胞
|
|
WO2018073391A1
(en)
*
|
2016-10-19 |
2018-04-26 |
Cellectis |
Targeted gene insertion for improved immune cells therapy
|
|
CA3042179A1
(en)
|
2016-10-31 |
2018-05-03 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Method for treating autoimmune disease using cd4 t-cells with engineered stabilization of expression of endogenous foxp3 gene
|
|
EP3321280B8
(en)
|
2016-11-10 |
2021-03-10 |
Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts |
Immune modulators for reducing immune-resistance in melanoma and other proliferative diseases
|
|
EP3538550A1
(en)
|
2016-11-10 |
2019-09-18 |
Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts |
Or10h1 modulators and uses thereof
|
|
US12227578B2
(en)
|
2016-11-11 |
2025-02-18 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through T cell action
|
|
EP3544996A2
(en)
|
2016-11-22 |
2019-10-02 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
CN118581046A
(zh)
|
2016-11-22 |
2024-09-03 |
新加坡国立大学 |
用于t细胞恶性肿瘤免疫疗法的cd7表达阻滞剂和嵌合抗原受体
|
|
WO2018096402A1
(en)
|
2016-11-23 |
2018-05-31 |
Novartis Ag |
Methods of enhancing immune response with everolimus, dactolisib or both
|
|
US20200087681A1
(en)
*
|
2016-12-21 |
2020-03-19 |
Ucl Business Plc |
Therapeutic cells
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
CN107760680B
(zh)
*
|
2016-12-28 |
2020-09-22 |
北京微旋基因技术有限公司 |
特异性靶向TIM-3基因的sgRNA和特异性敲除TIM-3基因的方法
|
|
WO2018140391A1
(en)
|
2017-01-24 |
2018-08-02 |
The Broad Institute, Inc. |
Compositions and methods for detecting a mutant variant of a polynucleotide
|
|
WO2018140890A1
(en)
*
|
2017-01-29 |
2018-08-02 |
Zequn Tang |
Methods of immune modulation against foreign and/or auto antigens
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
US11649288B2
(en)
|
2017-02-07 |
2023-05-16 |
Seattle Children's Hospital |
Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
|
|
CN110461335A
(zh)
|
2017-02-17 |
2019-11-15 |
弗雷德哈钦森癌症研究中心 |
用于治疗bcma相关癌症和自身免疫性失调的联合疗法
|
|
ES3010559T3
(en)
|
2017-02-28 |
2025-04-03 |
Endocyte Inc |
Compositions and methods for car t cell therapy
|
|
BR112019017751A2
(pt)
|
2017-02-28 |
2020-04-07 |
Vor Biopharma, Inc. |
composições e métodos de inibição de proteínas de linhagem específica
|
|
CN110662556A
(zh)
|
2017-03-09 |
2020-01-07 |
哈佛大学的校长及成员们 |
癌症疫苗
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
CA3054621A1
(en)
|
2017-03-22 |
2018-09-27 |
Novartis Ag |
Compositions and methods for immunooncology
|
|
WO2018176009A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
US11963966B2
(en)
|
2017-03-31 |
2024-04-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
ES2979232T3
(es)
|
2017-03-31 |
2024-09-25 |
Cellectis Sa |
Células inmunitarias con receptor de antígeno quimérico anti-CD22 universal
|
|
US11913075B2
(en)
|
2017-04-01 |
2024-02-27 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
|
CN118370809A
(zh)
|
2017-04-03 |
2024-07-23 |
百欧恩泰美国公司 |
蛋白质抗原及其用途
|
|
WO2018191553A1
(en)
|
2017-04-12 |
2018-10-18 |
Massachusetts Eye And Ear Infirmary |
Tumor signature for metastasis, compositions of matter methods of use thereof
|
|
DK3391907T3
(da)
|
2017-04-20 |
2020-03-09 |
Iomx Therapeutics Ag |
Intracellulær kinase sik3, der er associeret med resistens over for antitumorimmunresponser, og anvendelser deraf
|
|
AU2018264636B2
(en)
|
2017-05-08 |
2022-03-17 |
Toolgen Incorporated |
Artificially manipulated immune cell
|
|
US12226479B2
(en)
|
2017-05-11 |
2025-02-18 |
The General Hospital Corporation |
Methods and compositions of use of CD8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
IL270415B2
(en)
|
2017-05-12 |
2024-08-01 |
Crispr Therapeutics Ag |
Materials and methods for cell engineering and their uses in immuno-oncology
|
|
US11166985B2
(en)
|
2017-05-12 |
2021-11-09 |
Crispr Therapeutics Ag |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
|
WO2018213726A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
CN110770348B
(zh)
*
|
2017-06-01 |
2023-12-15 |
浙江煦顼技术有限公司 |
嵌合抗原受体细胞的制备及其用途
|
|
US12296012B2
(en)
|
2017-06-02 |
2025-05-13 |
Pfizer Inc. |
Chimeric antigen receptors targeting FLT3
|
|
WO2018232195A1
(en)
|
2017-06-14 |
2018-12-20 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
MX2019015188A
(es)
|
2017-06-15 |
2020-08-03 |
Univ California |
Inserciones de adn no virales orientadas.
|
|
EP4302768A3
(en)
*
|
2017-06-22 |
2024-05-01 |
Board Of Regents, The University Of Texas System |
Methods for producing regulatory immune cells and uses thereof
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US11235004B2
(en)
|
2017-06-30 |
2022-02-01 |
Innovative Cellular Therapeutics Holdings, Ltd. |
Lymphocyte cell lines and uses thereof
|
|
CA3068465A1
(en)
|
2017-06-30 |
2019-01-03 |
Precision Biosciences, Inc. |
Genetically-modified t cells comprising a modified intron in the t cell receptor alpha gene
|
|
EP3645021A4
(en)
|
2017-06-30 |
2021-04-21 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
|
CA3067914A1
(en)
|
2017-06-30 |
2019-01-03 |
Cellectis |
Cellular immunotherapy for repetitive administration
|
|
WO2019014581A1
(en)
|
2017-07-14 |
2019-01-17 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF A CYTOTOXIC LYMPHOCYTE
|
|
US11161897B2
(en)
|
2017-07-17 |
2021-11-02 |
Janssen Biotech, Inc. |
Antigen binding regions against fibronectin type III domains and methods of using the same
|
|
US11732274B2
(en)
|
2017-07-28 |
2023-08-22 |
President And Fellows Of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
US12404505B2
(en)
|
2017-09-05 |
2025-09-02 |
Regeneron Pharmaceuticals, Inc. |
Delivery of a gene-editing system with a single retroviral particle and methods of generation and use
|
|
CN111194350A
(zh)
*
|
2017-09-18 |
2020-05-22 |
博雅辑因（北京）生物科技有限公司 |
一种基因编辑t细胞及其用途
|
|
CA3076337A1
(en)
|
2017-09-19 |
2019-03-28 |
Massachusetts Institute Of Technology |
Compositions for chimeric antigen receptor t cell therapy and uses thereof
|
|
KR20200066616A
(ko)
|
2017-09-21 |
2020-06-10 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적화된 핵산 편집을 위한 시스템, 방법 및 조성물
|
|
US12043870B2
(en)
|
2017-10-02 |
2024-07-23 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
|
CN111954679A
(zh)
|
2017-10-03 |
2020-11-17 |
朱诺治疗学股份有限公司 |
Hpv特异性结合分子
|
|
KR20200121782A
(ko)
|
2017-10-16 |
2020-10-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
CN111511903B
(zh)
*
|
2017-10-19 |
2024-10-11 |
塞勒克提斯公司 |
用于改善的免疫细胞疗法的nk抑制剂基因的靶向基因整合
|
|
JP2021501156A
(ja)
*
|
2017-10-27 |
2021-01-14 |
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア |
Ｔ細胞疲弊を予防および逆転するためのエピジェネティック標的および転写標的の同定
|
|
JP7101419B2
(ja)
|
2017-10-27 |
2022-07-15 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
内因性ｔ細胞受容体の標的置換
|
|
US11326156B2
(en)
|
2017-11-01 |
2022-05-10 |
Allogene Therapeutics, Inc. |
Modified caspase-9 polypeptides and methods of use thereof
|
|
KR20200074997A
(ko)
|
2017-11-01 |
2020-06-25 |
주노 쎄러퓨티크스 인코퍼레이티드 |
B-세포 성숙 항원에 특이적인 항체 및 키메릭 항원 수용체
|
|
KR102845789B1
(ko)
|
2017-11-01 |
2025-08-14 |
주노 쎄러퓨티크스 인코퍼레이티드 |
B 세포 성숙 항원에 특이적인 키메라 항원 수용체 및 암호화 폴리뉴클레오타이드
|
|
CN109750035B
(zh)
*
|
2017-11-02 |
2020-06-05 |
上海邦耀生物科技有限公司 |
靶向并引导Cas9蛋白高效切割TCR及B2M基因座的sgRNA
|
|
US12193994B2
(en)
|
2017-11-06 |
2025-01-14 |
Juno Therapeutics, Inc. |
Combination of a cell therapy and a gamma secretase inhibitor
|
|
EP3710039A4
(en)
|
2017-11-13 |
2021-08-04 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
|
|
US12171783B2
(en)
|
2017-11-13 |
2024-12-24 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in H3K27M gliomas
|
|
WO2019118508A1
(en)
|
2017-12-12 |
2019-06-20 |
The Trustees Of The University Of Pennsylvania |
Genetically modified immune cells targeting ny-eso-1 and methods of use thereof
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019126186A1
(en)
|
2017-12-18 |
2019-06-27 |
Neon Therapeutics, Inc. |
Neoantigens and uses thereof
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
EP3508499A1
(en)
|
2018-01-08 |
2019-07-10 |
iOmx Therapeutics AG |
Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof
|
|
US11679129B2
(en)
|
2018-01-12 |
2023-06-20 |
Curocell, Inc. |
Enhanced immune cells using dual shRNA and composition including the same
|
|
AU2019209428B2
(en)
|
2018-01-22 |
2025-06-26 |
Endocyte, Inc. |
Methods of use for CAR T cells
|
|
PT110526B
(pt)
|
2018-01-26 |
2021-02-04 |
Univ Nova De Lisboa |
Anticorpo, fragmento funcional ou sonda do mesmo contra antigénios tumorais
|
|
PE20210708A1
(es)
|
2018-02-01 |
2021-04-16 |
Pfizer |
Anticuerpos especificos para cd70 y sus usos
|
|
IL276396B2
(en)
|
2018-02-01 |
2026-01-01 |
Pfizer |
Chimeric antigen receptors against CD70
|
|
CA3090089A1
(en)
|
2018-02-06 |
2019-08-15 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
|
|
TW202000229A
(zh)
|
2018-02-23 |
2020-01-01 |
美商安德賽特公司 |
Car t細胞療法之順序方法
|
|
US20200224160A1
(en)
*
|
2018-02-27 |
2020-07-16 |
Sorrento Therapeutics, Inc. |
Process for dna integration using rna-guided endonucleases
|
|
EP3759129A1
(en)
|
2018-02-28 |
2021-01-06 |
Pfizer Inc |
Il-15 variants and uses thereof
|
|
EP3765040A4
(en)
*
|
2018-03-13 |
2021-12-01 |
Regents of the University of Minnesota |
LYMPHOHEMATOPOIETIC MANIPULATION USING CAS9 BASE EDITORS
|
|
CN118325839A
(zh)
|
2018-03-27 |
2024-07-12 |
宾夕法尼亚大学董事会 |
具有增强功能的修饰的免疫细胞及其筛选方法
|
|
KR20210029707A
(ko)
|
2018-04-05 |
2021-03-16 |
주노 쎄러퓨티크스 인코퍼레이티드 |
재조합 수용체를 발현하는 세포의 생산 방법 및 관련 조성물
|
|
TWI840351B
(zh)
|
2018-04-05 |
2024-05-01 |
美商奇諾治療有限公司 |
T細胞受體及表現其之工程化細胞
|
|
EP3775237A1
(en)
|
2018-04-05 |
2021-02-17 |
Juno Therapeutics, Inc. |
T cells expressing a recombinant receptor, related polynucleotides and methods
|
|
US11786554B2
(en)
|
2018-04-12 |
2023-10-17 |
Precision Biosciences, Inc. |
Optimized engineered nucleases having specificity for the human T cell receptor alpha constant region gene
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
JP7575950B2
(ja)
|
2018-04-27 |
2024-10-31 |
シアトル チルドレンズ ホスピタル ディー／ビー／エイ シアトル チルドレンズ リサーチ インスティテュート |
遺伝子編集されたｃｄ３４＋細胞におけるｆｏｘｐ３の発現
|
|
CA3099401A1
(en)
*
|
2018-05-07 |
2019-11-14 |
The Regents Of The University Of California |
Compositions and methods for modifying regulatory t cells
|
|
WO2019215500A1
(en)
|
2018-05-11 |
2019-11-14 |
Crispr Therapeutics Ag |
Methods and compositions for treating cancer
|
|
CN112654710A
(zh)
|
2018-05-16 |
2021-04-13 |
辛瑟高公司 |
用于指导rna设计和使用的方法和系统
|
|
CN112839671A
(zh)
*
|
2018-05-17 |
2021-05-25 |
明尼苏达大学董事会 |
抗药性免疫细胞及其使用方法
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
SG11202010996QA
(en)
|
2018-05-23 |
2020-12-30 |
Nat Univ Singapore |
Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies
|
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
WO2019237398A1
(zh)
*
|
2018-06-16 |
2019-12-19 |
深圳市博奥康生物科技有限公司 |
一种特异靶向人CD272基因的gRNA导向序列及其应用
|
|
EP3810182A4
(en)
|
2018-06-19 |
2022-08-24 |
BioNTech US Inc. |
Neoantigens and uses thereof
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
US12460244B2
(en)
|
2018-08-20 |
2025-11-04 |
The Broad Institute, Inc. |
Inhibitors of RNA-guided nuclease activity and uses thereof
|
|
WO2020068304A2
(en)
|
2018-08-20 |
2020-04-02 |
The Broad Institute, Inc. |
Inhibitors of rna-guided nuclease target binding and uses thereof
|
|
US20210324357A1
(en)
|
2018-08-20 |
2021-10-21 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
US11389485B2
(en)
|
2018-08-28 |
2022-07-19 |
Vor Biopharma Inc. |
Genetically engineered hematopoietic stem cells and uses thereof
|
|
AU2019327913A1
(en)
|
2018-08-29 |
2021-03-18 |
Nanjing Legend Biotech Co., Ltd. |
Anti-mesothelin chimeric antigen receptor (CAR) constructs and uses thereof
|
|
US11845958B2
(en)
*
|
2018-09-05 |
2023-12-19 |
Wisconsin Alumni Research Foundation |
Genetically modified genes and cells, and methods of using same for silencing virus gene expression
|
|
US20220016166A1
(en)
*
|
2018-09-21 |
2022-01-20 |
Cafa Therapeutics Limited |
T-cell expressing chimeric receptor
|
|
MX2021003435A
(es)
|
2018-09-28 |
2021-06-15 |
Massachusetts Inst Technology |
Moleculas inmunomoduladoras localizadas en el colageno y metodos de las mismas.
|
|
WO2020072253A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for screening for variant cells
|
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
US12264330B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for killing target cells
|
|
US12264313B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for genome modification and alteration of expression
|
|
WO2020072700A1
(en)
|
2018-10-02 |
2020-04-09 |
Dana-Farber Cancer Institute, Inc. |
Hla single allele lines
|
|
AU2019362879B2
(en)
*
|
2018-10-16 |
2026-02-19 |
Intellia Therapeutics, Inc. |
Compositions and methods for immunotherapy
|
|
WO2020081730A2
(en)
|
2018-10-16 |
2020-04-23 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating microenvironment
|
|
WO2020081922A1
(en)
|
2018-10-18 |
2020-04-23 |
University Of Utah Research Foundation |
Rna-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
MX2021005024A
(es)
|
2018-11-01 |
2021-07-21 |
Juno Therapeutics Inc |
Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b.
|
|
US20200268797A1
(en)
|
2018-11-30 |
2020-08-27 |
Janssen Biotech, Inc. |
Gamma delta t cells and uses thereof
|
|
WO2020131586A2
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
CN109722437B
(zh)
*
|
2018-12-29 |
2020-01-07 |
广州百暨基因科技有限公司 |
一种通用型car-t细胞及其制备方法和用途
|
|
CN109652378B
(zh)
*
|
2018-12-29 |
2020-04-24 |
广州百暨基因科技有限公司 |
一种功能增强的通用型car-t细胞及其制备方法和用途
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US20220154282A1
(en)
|
2019-03-12 |
2022-05-19 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
|
WO2020191079A1
(en)
|
2019-03-18 |
2020-09-24 |
The Broad Institute, Inc. |
Compositions and methods for modulating metabolic regulators of t cell pathogenicity
|
|
MX2021011426A
(es)
|
2019-03-19 |
2022-03-11 |
Broad Inst Inc |
Metodos y composiciones para editar secuencias de nucleótidos.
|
|
JP2022524221A
(ja)
*
|
2019-03-22 |
2022-04-28 |
スポットライト セラピューティクス |
標的指向活性遺伝子編集剤及び使用方法
|
|
US12516100B2
(en)
|
2019-04-12 |
2026-01-06 |
Board Of Regents, The University Of Texas System |
Methods for producing regulatory B cells and uses thereof
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US20220249558A1
(en)
|
2019-04-30 |
2022-08-11 |
Crispr Therapeutics Ag |
Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19
|
|
SG11202111360YA
(en)
|
2019-05-01 |
2021-11-29 |
Juno Therapeutics Inc |
Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods
|
|
AU2020265749A1
(en)
|
2019-05-01 |
2022-01-06 |
Juno Therapeutics, Inc. |
Cells expressing a chimeric receptor from a modified CD247 locus, related polynucleotides and methods
|
|
EP3736330A1
(en)
|
2019-05-08 |
2020-11-11 |
European Molecular Biology Laboratory |
Modified adeno-associated virus (aav) particles for gene therapy
|
|
WO2020236967A1
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Random crispr-cas deletion mutant
|
|
WO2020243371A1
(en)
|
2019-05-28 |
2020-12-03 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
|
US11642409B2
(en)
|
2019-06-26 |
2023-05-09 |
Massachusetts Insttute of Technology |
Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
|
|
EP3994171A1
(en)
|
2019-07-05 |
2022-05-11 |
iOmx Therapeutics AG |
Antibodies binding igc2 of igsf11 (vsig3) and uses thereof
|
|
US20220282333A1
(en)
|
2019-08-13 |
2022-09-08 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
|
US12421557B2
(en)
|
2019-08-16 |
2025-09-23 |
The Broad Institute, Inc. |
Methods for predicting outcomes and treating colorectal cancer using a cell atlas
|
|
MX2022002363A
(es)
|
2019-08-27 |
2022-06-14 |
Janssen Biotech Inc |
Sistema receptor de antígeno quimérico y usos de este.
|
|
US20220298501A1
(en)
|
2019-08-30 |
2022-09-22 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
US12551560B2
(en)
|
2019-09-09 |
2026-02-17 |
Scribe Therapeutics Inc. |
Compositions and methods for use in immunotherapy
|
|
WO2021061648A1
(en)
|
2019-09-23 |
2021-04-01 |
Massachusetts Institute Of Technology |
Methods and compositions for stimulation of endogenous t cell responses
|
|
US12297426B2
(en)
|
2019-10-01 |
2025-05-13 |
The Broad Institute, Inc. |
DNA damage response signature guided rational design of CRISPR-based systems and therapies
|
|
US12394502B2
(en)
|
2019-10-02 |
2025-08-19 |
The General Hospital Corporation |
Method for predicting HLA-binding peptides using protein structural features
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US12195725B2
(en)
|
2019-10-03 |
2025-01-14 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
|
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
|
CN115335399A
(zh)
|
2019-12-06 |
2022-11-11 |
朱诺治疗学股份有限公司 |
针对gprc5d靶结合结构域的抗独特型抗体以及相关组合物和方法
|
|
US11865168B2
(en)
|
2019-12-30 |
2024-01-09 |
Massachusetts Institute Of Technology |
Compositions and methods for treating bacterial infections
|
|
US20230340537A1
(en)
|
2020-01-17 |
2023-10-26 |
The Broad Institute, Inc. |
Small type ii-d cas proteins and methods of use thereof
|
|
US12165747B2
(en)
|
2020-01-23 |
2024-12-10 |
The Broad Institute, Inc. |
Molecular spatial mapping of metastatic tumor microenvironment
|
|
EP4100428A4
(en)
|
2020-02-04 |
2024-03-06 |
Seattle Children's Hospital (DBA Seattle Children's Research Institute) |
CHIMERIC ANTI-DINITROPHENOL ANTIGEN RECEPTORS
|
|
PE20230173A1
(es)
|
2020-03-03 |
2023-02-01 |
Janssen Biotech Inc |
CELULAS T (gama-delta) Y USOS DE ESTAS
|
|
WO2021183207A1
(en)
|
2020-03-10 |
2021-09-16 |
Massachusetts Institute Of Technology |
COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF NPM1c-POSITIVE CANCER
|
|
WO2021188384A1
(en)
*
|
2020-03-14 |
2021-09-23 |
Berkeley Lights, Inc. |
Methods of amplifying paired transcript sequences from single cells
|
|
US12433954B2
(en)
|
2020-05-01 |
2025-10-07 |
Massachusetts Institute Of Technology |
Methods of activating anti-CD19 chimeric antigen receptor (CAR) T cells using amphiphilic ligand conjugates comprising CAR-targeting protein sequence motifs
|
|
US20210340524A1
(en)
|
2020-05-01 |
2021-11-04 |
Massachusetts Institute Of Technology |
Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof
|
|
WO2021226558A1
(en)
|
2020-05-08 |
2021-11-11 |
The Broad Institute, Inc. |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
JP2023526278A
(ja)
|
2020-05-13 |
2023-06-21 |
ジュノー セラピューティクス インコーポレイテッド |
組み換え受容体を発現しているドナーバッチ細胞を産生するための方法
|
|
EP3910331A1
(en)
|
2020-05-15 |
2021-11-17 |
iOmx Therapeutics AG |
Intracellular kinase associated with resistance against t-cell mediated cytotoxicity, and uses thereof
|
|
EP4165180A4
(en)
|
2020-06-16 |
2024-10-23 |
Bio-Techne Corporation |
MODIFIED MAD7-DIRECTED ENDONUCLEASE
|
|
EP4171616A1
(en)
|
2020-06-26 |
2023-05-03 |
Juno Therapeutics GmbH |
Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
|
|
EP4175668A1
(en)
|
2020-07-06 |
2023-05-10 |
iOmx Therapeutics AG |
Antibodies binding igv of igsf11 (vsig3) and uses thereof
|
|
CN116194488A
(zh)
|
2020-07-21 |
2023-05-30 |
艾洛基治疗公司 |
具有增强的信号传导和活性的嵌合抗原受体和其用途
|
|
AU2021323392A1
(en)
*
|
2020-08-14 |
2022-12-08 |
Charité - Universitätsmedizin Berlin |
Immunosuppressant-resistant T-cells for adoptive immunotherapy
|
|
EP3957720A1
(en)
|
2020-08-21 |
2022-02-23 |
Charité - Universitätsmedizin Berlin |
Immunosuppressant-resistant t-cells for adoptive immunotherapy
|
|
JP2023549780A
(ja)
|
2020-11-04 |
2023-11-29 |
ジュノー セラピューティクス インコーポレイテッド |
改変されたインバリアントｃｄ３免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法
|
|
AU2021378075B2
(en)
|
2020-11-11 |
2025-03-27 |
Borea Therapeutics S.R.L. |
Modified viral particles for gene therapy
|
|
TW202237827A
(zh)
|
2020-12-03 |
2022-10-01 |
美商世紀治療股份有限公司 |
經基因工程改造之細胞及其用途
|
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
|
WO2022132756A1
(en)
*
|
2020-12-14 |
2022-06-23 |
Emendobio Inc. |
Biallelic knockout of trac
|
|
EP4039808A1
(en)
*
|
2021-02-08 |
2022-08-10 |
Ospedale San Raffaele S.r.l. |
Guide rnas and uses thereof
|
|
US20240108654A1
(en)
|
2021-03-03 |
2024-04-04 |
Juno Therapeutics, Inc. |
Combination of a t cell therapy and a dgk inhibitor
|
|
WO2022215978A1
(ko)
*
|
2021-04-05 |
2022-10-13 |
주식회사 셀렌진 |
Pdcd-1 유전자에 상보적인 가이드 rna 및 이의 용도
|
|
AU2022318664A1
(en)
|
2021-07-30 |
2024-02-29 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
WO2023010133A2
(en)
|
2021-07-30 |
2023-02-02 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin (fxn)
|
|
WO2023039586A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
|
KR20240099259A
(ko)
|
2021-10-14 |
2024-06-28 |
아스널 바이오사이언시스, 인크. |
공동 발현된 shrna 및 논리 게이트 시스템을 갖는 면역 세포
|
|
WO2023081715A1
(en)
|
2021-11-03 |
2023-05-11 |
Viracta Therapeutics, Inc. |
Combination of car t-cell therapy with btk inhibitors and methods of use thereof
|
|
WO2023081900A1
(en)
|
2021-11-08 |
2023-05-11 |
Juno Therapeutics, Inc. |
Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
|
|
WO2023137471A1
(en)
|
2022-01-14 |
2023-07-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
|
CA3247927A1
(en)
|
2022-01-14 |
2023-07-20 |
Tune Therapeutics, Inc. |
Compositions, systems and methods for programming T-lymphocyte phenotypes by targeted gene repression
|
|
JP2025506976A
(ja)
*
|
2022-03-04 |
2025-03-13 |
ツールゲン インコーポレイテッド |
低免疫原性幹細胞、幹細胞から分化または由来した低免疫原性細胞およびこの製造方法
|
|
EP4502177A4
(en)
|
2022-03-24 |
2026-03-18 |
Nanjing Legend Biotech Co Ltd |
METHOD FOR PREPARING A DNA BANK AND DETECTING A RETROVIRAL INTEGRATION SITE
|
|
US20230372395A1
(en)
|
2022-05-19 |
2023-11-23 |
Massachusetts Institute Of Technology |
Car cells targeting an inserted ligand
|
|
EP4544051A2
(en)
|
2022-06-24 |
2025-04-30 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression
|
|
CA3261865A1
(en)
|
2022-07-12 |
2024-01-18 |
Tune Therapeutics, Inc. |
TARGETED TRANSCRIPTIONAL ACTIVATION COMPOSITIONS, SYSTEMS AND METHODS
|
|
EP4573200A2
(en)
|
2022-08-19 |
2025-06-25 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression
|
|
EP4583876A1
(en)
|
2022-09-08 |
2025-07-16 |
Juno Therapeutics, Inc. |
Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing
|
|
CN120239746A
(zh)
|
2022-09-19 |
2025-07-01 |
图恩疗法股份有限公司 |
用于调节t细胞功能的组合物、系统和方法
|
|
EP4598949A1
(en)
|
2022-10-07 |
2025-08-13 |
The General Hospital Corporation |
Methods and compositions for high-throughput discovery of peptide-mhc targeting binding proteins
|
|
EP4615960A1
(en)
|
2022-11-09 |
2025-09-17 |
C3S2 GmbH |
Methods for manufacturing engineered immune cells
|
|
WO2024124044A1
(en)
|
2022-12-07 |
2024-06-13 |
The Brigham And Women’S Hospital, Inc. |
Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
|
|
EP4649093A2
(en)
|
2023-01-12 |
2025-11-19 |
National University of Singapore |
Blockade of cd8 expression and chimeric antigen receptors for immunotherapy of t-cell and nk-cell malignancies
|
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
|
CN121002052A
(zh)
|
2023-02-03 |
2025-11-21 |
C3S2 有限公司 |
用于非病毒生产工程化免疫细胞的方法
|
|
TW202511280A
(zh)
|
2023-07-21 |
2025-03-16 |
義大利商博雷亞醫療有限責任公司 |
製備表面修飾之病毒外殼之方法
|
|
WO2025021772A1
(en)
|
2023-07-21 |
2025-01-30 |
Borea Therapeutics S.R.L. |
Chemogenetic surface modified viral particles
|
|
LU504827B1
(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
WO2025038494A1
(en)
|
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|
|
WO2025059073A1
(en)
|
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|
|
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(en)
|
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Crispr enzymes and systems
|
|
WO2025096638A2
(en)
|
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Genetically modified tumor infilitrating lymphocytes and methods of producing and using the same
|
|
WO2025096907A1
(en)
*
|
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|
|
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(en)
|
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|
|
WO2025117544A1
(en)
|
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|
|
WO2025137646A1
(en)
|
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|
|
TW202548024A
(zh)
|
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義大利商博雷亞醫療有限責任公司 |
靶向ｃｎｓ中之組織
|
|
WO2025212519A1
(en)
|
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|
|
WO2025235851A1
(en)
|
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|
|
WO2025260068A1
(en)
|
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Lipid nanoparticle formulation for delivery of nucleic acids to cells
|
|
WO2026015647A1
(en)
|
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|
|
WO2026025092A1
(en)
|
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|